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1. 发明授权

US07177690B2 Implantable system having rechargeable battery indicator 有权
标题翻译：具有可充电电池指示器的可植入系统
公开(公告)号：US07177690B2
公开(公告)日：2007-02-13
申请号：US10356414
申请日：2003-01-31
申请人： Carla Mann Woods , James R Thacker , David K. L Peterson
发明人： Carla Mann Woods , James R Thacker , David K. L Peterson
IPC分类号： A61N1/378
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/36185 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37252 , A61N1/3787
摘要： A system and method for detecting the status of a rechargeable battery included within an implantable medical device. The medical device can incorporate a status indicator which signals the user concerning the battery status, e.g., low battery level. The signal may be audible or it may arise from an electrical stimulation that is perceptually distinguished from the operative, therapeutic stimulation. The external programmer may also incorporate a second battery status indicator that is visual, audible, or physically felt. Battery status data may be conveyed on visual displays on the external programmer by uploading this information from the medical device using a bi-directional telemetry link. Such battery status data are helpful to the user to indicate when the battery should be recharged and to the clinician to monitor patient compliance and to determine end-of-useful life of the rechargeable battery.
摘要翻译：一种用于检测包括在可植入医疗装置内的可再充电电池的状态的系统和方法。医疗设备可以包括状态指示器，其向用户通知有关电池状态的信号，例如电池电量低。该信号可能是可听见的，或者它可能由感觉上区别于手术治疗刺激的电刺激引起。外部编程器还可以包括视觉，听觉或物理感觉的第二电池状态指示器。电池状态数据可以通过使用双向遥测链路从医疗设备上传该信息而在外部编程器上的视觉显示器上传送。这样的电池状态数据有助于用户指示电池何时被再充电，并且临床医师监测患者的依从性并确定可再充电电池的使用寿命。

2. 发明授权

US07239920B1 Neural stimulation system providing auto adjustment of stimulus output as a function of sensed pressure changes 有权
标题翻译：神经刺激系统提供刺激输出的自动调整作为感测压力变化的函数
公开(公告)号：US07239920B1
公开(公告)日：2007-07-03
申请号：US10364434
申请日：2003-02-11
申请人： James R Thacker , Carla Mann Woods
发明人： James R Thacker , Carla Mann Woods
IPC分类号： A61N1/00
CPC分类号： A61B5/6885 , A61B5/03 , A61N1/08 , A61N1/36128
摘要： A neural stimulation system automatically corrects or adjusts the stimulus magnitude in order to maintain a comfortable and effective stimulation therapy. Auto correction of the stimulus magnitude is linked to the measurement of pressure in the vicinity of the electrode-tissue interface. Because the pressure near the electrode-tissue interface can provide a measure of the electrode contacts' proximity to the neural tissue, and hence quantity of electrical energy delivered to the neural tissue, a change in the measured pressure or pressure morphology indicates that the stimulation energy may need to be adjusted. Hence, changes in pressure provide a feedback mechanism that permit the system to effectively auto correct the stimulus amplitude in order to maintain a desired therapeutic effect.
摘要翻译：神经刺激系统自动校正或调整刺激量值，以保持舒适有效的刺激治疗。刺激大小的自动校正与电极组织界面附近的压力测量有关。因为电极 - 组织界面附近的压力可以提供电极接触件与神经组织接近的量度，并因此传递给神经组织的电能量，测量的压力或压力形态的变化表明刺激能量可能需要调整。因此，压力变化提供了一种反馈机制，其允许系统有效地自动校正刺激振幅，以便保持期望的治疗效果。

3. 发明授权

US07155284B1 Treatment of hypertension 有权
标题翻译：治疗高血压
公开(公告)号：US07155284B1
公开(公告)日：2006-12-26
申请号：US10346538
申请日：2003-01-16
申请人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
发明人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
IPC分类号： A61N1/18
CPC分类号： A61N1/36117 , A61N1/36135 , A61N1/37205 , A61N1/37211 , A61N1/3787
摘要： Treatment of hypertension includes implantation of the discharge portion(s) of a catheter and/or electrical stimulation electrode(s) adjacent the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and/or electrical pulses, are supplied by one or more implanted stimulators, through the catheter and possibly also a lead, tunneled subcutaneously between the stimulator and stimulation site. A microstimulator(s) may also/instead deliver electrical stimulation pulses. Stimulation sites include the carotid sinus and carotid body, among other locations. Treatments include drugs used for acute and/or chronic treatment of hypertension. In a number of embodiments, a need for or response to treatment is sensed, and the electrical and/or infusion pulses adjusted accordingly.
摘要翻译：高血压的治疗包括植入邻近待刺激的组织的导管和/或电刺激电极的放电部分。刺激脉冲，即药物输注脉冲和/或电脉冲由一个或多个注入的刺激器通过导管提供，并且可能还包括引线，在刺激器和刺激部位之间皮下隧穿。微型激励器也可以/替代地递送电刺激脉冲。刺激部位包括颈动脉窦和颈动脉体等。治疗包括用于急性和/或慢性治疗高血压的药物。在多个实施例中，感测对治疗的需要或响应，并且相应地调整电和/或输注脉冲。

4. 发明授权

US07317948B1 Neural stimulation system providing auto adjustment of stimulus output as a function of sensed impedance 有权
标题翻译：神经刺激系统提供作为感测阻抗的函数的刺激输出的自动调整
公开(公告)号：US07317948B1
公开(公告)日：2008-01-08
申请号：US10364436
申请日：2003-02-11
申请人： John D H King , James R Thacker
发明人： John D H King , James R Thacker
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/08 , A61N1/36071 , A61N1/3615
摘要： A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.
摘要翻译：神经刺激系统自动校正或调整刺激量（刺激能量），以保持舒适有效的刺激疗法。由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

5. 发明授权

US07308303B2 Thrombolysis and chronic anticoagulation therapy 失效
标题翻译：溶栓和慢性抗凝治疗
公开(公告)号：US07308303B2
公开(公告)日：2007-12-11
申请号：US10285803
申请日：2002-11-01
申请人： Todd K Whitehurst , Kelly H McClure , James R Thacker
发明人： Todd K Whitehurst , Kelly H McClure , James R Thacker
IPC分类号： A61N1/00 , A61M5/00
CPC分类号： A61M5/14276 , A61M2205/3507 , A61M2205/3523 , A61M2205/8243 , A61M2230/04 , A61M2230/205 , A61M2230/30 , A61N1/362 , A61M2230/005
摘要： Thrombolytic and/or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and/or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.
摘要翻译：本发明的血栓溶解和/或抗凝治疗包括将导管的放电部分和可选的一个或多个电极植入在待刺激的邻近组织上。刺激脉冲，即药物输注脉冲和可选的电脉冲由远程植入的刺激器，以及通过在刺激器和刺激部位之间皮下隧穿的导管或引线提供。刺激部位包括冠状动脉，冠状动脉，脑动脉，其他血管，心脏腔，肠系膜血管，腿部深血管等位置。公开的治疗包括用于慢性治疗和/或预防血栓栓塞性疾病，用于急性治疗血栓栓塞症，用于急性治疗血栓形成的药物及其组合的药物。本发明减少或消除了血栓栓塞性疾病和相关疾病的发生，改善了血栓栓塞性疾病引起的症状，并改善了患者的生活质量。

6. 发明授权

US07363079B1 Power qualifier for electrical stimulation configurations 有权
标题翻译：电刺激配置的电源限定器
公开(公告)号：US07363079B1
公开(公告)日：2008-04-22
申请号：US10672660
申请日：2003-09-25
申请人： James R Thacker , Kerry Bradley
发明人： James R Thacker , Kerry Bradley
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/36185 , A61N1/378
摘要： At least one system and at least one method permit a clinician to view or hear power consumption data during a Spinal Cord Stimulation (SCS) system fitting procedure. For example, a clinician's programming computer includes a display of power consumption for each effective stimulation configuration under evaluation during fitting. A clinician performing the fitting procedure uses a programming computer to select various stimulation configurations. The power consumption of the SCS configuration(s) presently and/or previously exercised is displayed for the clinician. By comparing the power consumption for each configuration, the clinician may select a configuration consuming less power while providing effective therapy. Suggestions for low power configurations may be provided by the programming computer.
摘要翻译：至少一个系统和至少一种方法允许临床医生在脊髓刺激（SCS）系统拟合过程期间查看或听到功率消耗数据。例如，临床医生的编程计算机包括在装配期间评估的每个有效刺激配置的功率显示。执行装配程序的临床医生使用编程计算机来选择各种刺激配置。为临床医生显示当前和/或以前行使的SCS配置的功耗。通过比较每个配置的功耗，临床医生可以选择消耗较少功率的配置，同时提供有效的治疗。低功耗配置的建议可以由编程计算机提供。

7. 发明授权

US07904162B2 Monitoring, preventing, and treating rejection of transplanted organs 失效
标题翻译：监测，预防和治疗移植器官的排斥
公开(公告)号：US07904162B2
公开(公告)日：2011-03-08
申请号：US11246719
申请日：2005-10-07
申请人： Todd K Whitehurst , James P McGivern , Kelly H McClure , Goran N Marnfeldt , James R Thacker
发明人： Todd K Whitehurst , James P McGivern , Kelly H McClure , Goran N Marnfeldt , James R Thacker
IPC分类号： A61N1/08
CPC分类号： A61B5/413 , A61B5/053 , A61B5/0538 , A61B5/41 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4244 , A61B2560/0219 , A61M5/14276 , A61M5/1723 , A61N1/30 , A61N1/32
摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.
摘要翻译：可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至患者。在某些实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

8. 发明授权

US07877137B2 Thrombolysis and chronic anticoagulation therapy 失效
标题翻译：溶栓和慢性抗凝治疗
公开(公告)号：US07877137B2
公开(公告)日：2011-01-25
申请号：US11949752
申请日：2007-12-03
申请人： Todd K Whitehurst , Kelly H McClure , James R Thacker
发明人： Todd K Whitehurst , Kelly H McClure , James R Thacker
IPC分类号： A61N1/08
CPC分类号： A61M5/14276 , A61M2205/3507 , A61M2205/3523 , A61M2205/8243 , A61M2230/04 , A61M2230/205 , A61M2230/30 , A61N1/362 , A61M2230/005
摘要： Method and systems of treating a patient with at least one of a myocardial infarction, a stroke, and a pulmonary embolism include providing a stimulator coupled to at least one electrode and a catheter, configuring one or more stimulation parameters to treat at least one of a myocardial infarction, a stroke, and a pulmonary embolism, programming the stimulator with the one or more stimulation parameters, delivering with the stimulator via the catheter at least one drug to at least one tissue in accordance with the one or more stimulation parameters, and limiting perfusion of the at least one tissue by delivering electrical stimulation with the stimulator via the at least one electrode to the at least one tissue.
摘要翻译：用心肌梗死，中风和肺栓塞中的至少一种治疗患者的方法和系统包括提供耦合到至少一个电极和导管的刺激器，配置一个或多个刺激参数以治疗下列中的至少一个：心肌梗塞，中风和肺栓塞，用一个或多个刺激参数对刺激器进行编程，根据该一个或多个刺激参数，通过导管将至少一种药物通过导管递送至至少一个组织，并限制通过将所述刺激器经由所述至少一个电极递送到所述至少一个组织的电刺激来灌注所述至少一个组织。

9. 发明授权

US07321794B2 Method and system for treating atrial fibrillation 失效
标题翻译：治疗房颤的方法和系统
公开(公告)号：US07321794B2
公开(公告)日：2008-01-22
申请号：US10713511
申请日：2003-11-14
申请人： James R Thacker , Kelly H McClure , Todd K Whitehurst , Philip H Lee
发明人： James R Thacker , Kelly H McClure , Todd K Whitehurst , Philip H Lee
IPC分类号： A61N1/368
CPC分类号： A61N1/3622
摘要： An atrial, anti-arrhythmia system and method are provided. The system comprises: at least two electrodes attached to the atrium for providing independently controlled stimulus through each electrode; detection circuitry that can sense atrial fibrillation or the cardiac cycle; and stimulus generator that can deliver stimulation through at least two electrodes to stop atrial fibrillation. The method for treating atrial fibrillation has three possible modes: a first mode for detecting ongoing atrial fibrillation and stopping it; a second mode for detecting the cardiac cycle and delivering stimuli to the atrium after it has already begun to contract in order to suppress the onset of atrial fibrillation; and a third mode which applies pacing pulses to the atrium in a timed sequence to pace and contract the atrium faster than the native rate to preempt the initiation of atrial fibrillation.
摘要翻译：提供心房，抗心律失常系统和方法。该系统包括：至少两个连接到心房的电极，用于通过每个电极提供独立控制的刺激; 可以感测心房颤动或心动周期的检测电路; 和刺激发生器，其可以通过至少两个电极传递刺激以停止心房颤动。治疗心房颤动的方法有三种可能的模式：用于检测持续性心房颤动并停止的第一种模式; 用于检测心脏周期并在其已经开始收缩之后向心房递送刺激以抑制心房颤动发生的第二模式; 以及第三种模式，其以定时序列将起搏脉搏应用于心房，以使起搏和收缩心房比天然速率更快地抢占心房颤动的开始。

10. 发明授权

US07263402B2 System and method of rapid, comfortable parameter switching in spinal cord stimulation 有权
标题翻译：快速，舒适的脊髓刺激参数切换的系统和方法
公开(公告)号：US07263402B2
公开(公告)日：2007-08-28
申请号：US10212585
申请日：2002-08-05
申请人： James R Thacker , John D King , Kerry Bradley
发明人： James R Thacker , John D King , Kerry Bradley
IPC分类号： A61N1/18
CPC分类号： A61N1/36071 , A61N1/0551
摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.
摘要翻译：用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。估计的感知水平是基于以前的刺激结果。然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

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