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1. 发明授权

US06197357B1 Refined vegetable oils and extracts thereof 失效
标题翻译：精制植物油及其提取物
公开(公告)号：US06197357B1
公开(公告)日：2001-03-06
申请号：US09087140
申请日：1998-05-28
申请人： Carl W. Lawton , Robert Nicolosi , Stephen McCarthy
发明人： Carl W. Lawton , Robert Nicolosi , Stephen McCarthy
IPC分类号： A23D902
CPC分类号： C11B3/06
摘要： A method of producing unsaponifiable rich refined vegetable oils by refining crude vegetable oils with a weak acid salt, e.g., a carbonate salt, to produce a refined vegetable oil and a soapstock is described. The refined oil can be further refined with a strong base to produce unsaponifiable rich concentrates.
摘要翻译：描述了通过用弱酸盐（例如碳酸盐）精炼粗植物油来生产不可皂化的丰富的精制植物油以生产精制植物油和皂片的方法。精炼的油可以进一步精炼与强碱，以产生不可皂化的富集料。

2. 发明申请

US20090306198A1 Anti-Oxidant Synergy Formulation Nanoemulsions to Treat Caner 审中-公开
标题翻译：抗氧化剂协同配方纳米乳剂治疗罐头
公开(公告)号：US20090306198A1
公开(公告)日：2009-12-10
申请号：US11991991
申请日：2006-09-13
申请人： Robert Nicolosi , Thomas Shea
发明人： Robert Nicolosi , Thomas Shea
IPC分类号： A61K31/355 , A61K47/24 , A61K31/19 , A61P35/00 , A61P39/06
CPC分类号： A61K9/1075 , A61K31/19 , A61K31/355 , A61K45/06 , A61K47/24 , A61K47/26 , A61K47/38 , A61K47/44
摘要： A uniform microfluidized nanoemulsion is disclosed containing a synergistic combination of two antioxidants and a cell membrane stabilizer phospholipid (i.e., an anti-oxidant synergy formulation; ASF). The microfluidized nanoemulsion improves the combination's cell membrane permeability by at least four-fold over conventional nanoemulsion compositions, which significantly increases the intracellular concentration of typically cell-impermeant antioxidants (i.e., for example, tocopherol) and/or systemic bioavailability. As a nanoemulsion, synergistic combination has greater anticancer efficacy than the same combination applied as a free solution.
摘要翻译：公开了一种均匀的微流化纳米乳剂，其包含两种抗氧化剂和细胞膜稳定剂磷脂（即抗氧化剂协同剂制剂; ASF）的协同组合。微流化纳米乳液将组合的细胞膜通透性提高至常规纳米乳剂组合物的四倍以上，这显着增加了典型的细胞不渗透抗氧化剂（例如生育酚）和/或全身生物利用度的细胞内浓度。作为纳米乳剂，协同组合具有比应用于游离溶液的相同组合更好的抗癌效能。

3. 发明申请

US20120164182A1 Botulinum nanoemulsions 有权
标题翻译：肉毒杆菌纳米乳剂
公开(公告)号：US20120164182A1
公开(公告)日：2012-06-28
申请号：US11607436
申请日：2006-12-01
申请人： Jonathan Edelson , Robert Nicolosi
发明人： Jonathan Edelson , Robert Nicolosi
IPC分类号： A61K8/64 , A61Q19/00 , A61Q19/08 , A61K8/06
CPC分类号： A61K8/06 , A61K8/64 , A61K38/4893 , A61K2800/21 , A61K2800/413 , A61K2800/91 , A61Q19/08 , B82Y5/00 , Y02A50/469
摘要： The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
摘要翻译：本文所述的实施方案是包含肉毒杆菌毒素的相关纳米乳剂。在一个实施方案中，纳米乳剂通过高压微流化制备，并且包含仅在10和300nm之间的粒度分布。本发明考虑的纳米乳剂可用于肌肉挛缩状态的美容和医学治疗。例如，肉毒杆菌毒素可以放松面部肌肉，使得皮肤皱纹变得更平滑和不太明显。此外，本发明考虑了可以自我施用的化妆品制剂，例如在家庭的隐私和没有医疗监督下。

4. 发明申请

US20080274195A1 Compositions and Methods for Making and Using Nanoemulsions 审中-公开
标题翻译：制备和使用纳米乳剂的组合物和方法
公开(公告)号：US20080274195A1
公开(公告)日：2008-11-06
申请号：US11996016
申请日：2006-07-11
申请人： Robert Nicolosi , Thomas Wilson
发明人： Robert Nicolosi , Thomas Wilson
IPC分类号： A61K9/14 , A61K31/01 , A01N25/00 , A61K31/56 , A61K35/60 , A61K31/355 , A61K31/047 , A61K38/16 , A01P1/00
CPC分类号： A61K9/1075 , B01F2003/0849 , Y10S977/773 , Y10S977/906
摘要： The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of incorporated compounds (i.e., pharmaceuticals or nutraceuticals) as reflected in various pharmacokinetic parameters including, but not limited to, decreased Tmax, increased Cmax, and increased AUC. The improved method of making these uniform nanoemulsions utilizes microfluidization which differs in both process and mechanics when compared to conventional milling and grinding techniques used to generate nanoparticulate compositions. Further, the improvement results, in part, from a novel step of mixing a substantially soluble compound into a heated dispersion medium. This is unlike current nanoparticulate composition methods that mix an insoluble compound with an unheated dispersion medium. Further, these nanoemulsions are observed to be bacterial-resistant and stable to extremes in both temperature and pH changes. Consequently, these nanoemulsions are expected to have a significantly prolonged shelf-life than currently available nanoemulsions.
摘要翻译：本发明公开了一种改进的纳米乳液，其包含非常小的粒子纳米尺寸直径的均匀和离散范围。这种均匀性导致了各种药代动力学参数中反映的掺入化合物（即药物或营养药物）的生物利用度的改善，其包括但不限于降低的最大值。，并增加AUC。与用于产生纳米颗粒组合物的常规研磨和研磨技术相比，制备这些均匀纳米乳液的改进方法利用微流化，其在工艺和力学上都不同。此外，改进结果部分地从将基本上可溶的化合物混合到加热的分散介质中的新步骤。这与将不溶性化合物与未加热的分散介质混合的当前纳米颗粒组合物方法不同。此外，观察到这些纳米乳液在温度和pH变化中都具有细菌抗性并且极端稳定。因此，预期这些纳米乳液比目前可获得的纳米乳液具有显着延长的保存期限。

5. 发明申请

US20100183726A1 COMPOSITIONS AND METHODS FOR TREATING CANCER WITH DACARBAZINE NANOEMULSIONS 审中-公开
标题翻译：用DACARBAZAN NANOEMULSION治疗癌症的组合物和方法
公开(公告)号：US20100183726A1
公开(公告)日：2010-07-22
申请号：US12309715
申请日：2007-08-02
申请人： Robert Nicolosi , Jean-Bosco Tagne
发明人： Robert Nicolosi , Jean-Bosco Tagne
IPC分类号： A61K9/107 , A61K31/655 , A61P35/00
CPC分类号： A61K9/107 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K31/655 , A61K45/06 , A61K47/26 , A61K47/44
摘要： A uniform microfluidized nanoemulsion is disclosed containing an anti-cancer agent, such as dacarbazine. The microfluidized nanoemulsion improves the combination's cell membrane permeability by at least four-fold over conventional nanoemulsion compositions, which significantly increases the intracellular concentration of anti-cancer agents. As a nanoemulsion, dacarbazine has a greater anti-cancer efficacy than when applied as a free solution.
摘要翻译：公开了含有抗癌剂如达卡巴嗪的均匀微流化纳米乳剂。微流化纳米乳液使组合的细胞膜通透性比常规纳米乳剂组合物提高了至少四倍，这显着增加了抗癌剂的细胞内浓度。作为纳米乳剂，达卡巴嗪具有比作为游离溶液应用时更大的抗癌功效。

6. 发明申请

US20050043312A1 Formulations for reducing neuronal degeneration 有权
标题翻译：用于减少神经元变性的制剂
公开(公告)号：US20050043312A1
公开(公告)日：2005-02-24
申请号：US10898393
申请日：2004-07-23
申请人： Thomas Shea , Robert Nicolosi , Eugene Rogers
发明人： Thomas Shea , Robert Nicolosi , Eugene Rogers
IPC分类号： A23L33/15 , A61K31/00 , A61K31/22 , A61K31/355 , A61K31/525
CPC分类号： A61K31/525 , A23L33/15 , A23V2002/00 , A61K31/00 , A61K31/22 , A61K31/355 , A61K2300/00 , A23V2250/704 , A23V2250/712 , A23V2250/0612
摘要： Nutriceutical and pharmaceutical formulations for treating neurodegenerative disorders such as Alzheimer's disease are provided. Nutriceutical formulations include two or more of folate, vitamin E, and acetyl-L-carnitine (ALCAR). Pharmaceutical formulations include two or more of 3-deaza-adenosine (DZA), N-acetyl-L-cysteine (NAC), and S-adenosylmethionine (SAM).
摘要翻译：提供了用于治疗神经变性疾病如阿尔茨海默病的营养制剂和药物制剂。营养制剂包括叶酸，维生素E和乙酰基左旋肉碱（ALCAR）中的两种或更多种。药物制剂包括3-脱氮腺苷（DZA），N-乙酰基-L-半胱氨酸（NAC）和S-腺苷甲硫氨酸（SAM）中的两种或更多种。

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