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2. 发明申请

US20070037755A1 Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors 有权
标题翻译：依泽替米贝的组合物和治疗胆固醇相关良性和恶性肿瘤的方法
公开(公告)号：US20070037755A1
公开(公告)日：2007-02-15
申请号：US11485773
申请日：2006-07-13
申请人： Carl Schaffner , Keith Solomon , Michael Freeman
发明人： Carl Schaffner , Keith Solomon , Michael Freeman
IPC分类号： A61K31/7052 , A61K31/397
CPC分类号： A61K31/7052 , A61K31/397 , A61K45/06 , A61K2300/00
摘要： A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent. An article of manufacture is also provided which comprises a container, instructions, and a composition, wherein the composition comprises a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe or its phenolic glucuronide, and the instructions are for the administration of the composition for the prevention or treatment of a cholesterol-associated tumor.
摘要翻译：提供了预防或治疗胆固醇相关肿瘤的方法，其包括施用治疗有效量的基于氮杂环丁酮的胆固醇吸收抑制剂，优选依泽替米贝（SCH 58235）和/或其酚醛葡糖苷酸，或至少一种依泽替米贝类似物，例如SCH 48461和SCH 58053，其中患者处于发展为胆固醇相关肿瘤或已经表现出胆固醇相关肿瘤的风险。还提供了依泽替米贝的制剂用于预防或治疗进一步包含至少一种其它抗癌剂的胆固醇相关肿瘤。还提供了一种制品，其包括容器，说明书和组合物，其中所述组合物包含治疗有效量的基于氮杂环丁酮的胆固醇吸收抑制剂，优选依泽替米贝或其酚醛葡糖苷酸，并且所述说明书用于给予用于预防或治疗胆固醇相关肿瘤的组合物。

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