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1. 发明专利

JP2010004896A Polypeptide and biosynthetic pathway 有权
标题翻译：多肽和生物路径
公开(公告)号：JP2010004896A
公开(公告)日：2010-01-14
申请号：JP2009237596
申请日：2009-10-14
申请人： Cargill Inc , カーギル,インコーポレイティド
发明人： ABRAHAM TIMOTHY W , CAMERON DOUGLAS C , DALLUGE JOSEPH , HICKS PAULA M , HOBSON RUSSELL J , MCFARLAN SARA C , MILLIS JIM , ROSAZZA JOHN , ZHAO LISHAN , WEINER DAVID P
IPC分类号： C12N15/09 , C07D209/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12P13/04 , C12P17/10
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12P17/10
摘要： PROBLEM TO BE SOLVED: To provide a new polypeptide and a biosynthetic pathway. SOLUTION: There are provided the methods and compositions that can be used to produce monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid. Methods are also disclosed for producing indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供新的多肽和生物合成途径。提供了可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）丙酸生成莫纳甜的方法和组合物， -4-酮戊二酸。还公开了用于制备吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子，多肽，化学结构和细胞。方法包括体外和体内过程，体外方法包括化学反应。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2011250806A Polypeptide and biosynthetic pathway 有权
标题翻译：多肽和生物路径
公开(公告)号：JP2011250806A
公开(公告)日：2011-12-15
申请号：JP2011204605
申请日：2011-09-20
申请人： Cargill Inc , カーギル,インコーポレイティド
发明人： ABRAHAM TIMOTHY W , CAMERON DOUGLAS C , DALLUGE JOSEPH , HICKS PAULA M , HOBSON RUSSELL J , MCFARLAN SARA C , MILLIS JIM , ROSAZZA JOHN , ZHAO LISHAN , WEINER DAVID P
IPC分类号： C12N15/09 , C12P17/18 , C07D209/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12P13/04 , C12P17/10
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12P17/10
摘要： PROBLEM TO BE SOLVED: To provide a new polypeptide and a biosynthetic pathway.SOLUTION: Methods and compositions are provided that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(iridol-3-ylmethyl)-4-keto glutaric acid. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. The provided compositions include nucleic acid molecules, polypeptides, chemical structures, and cells. The methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译：要解决的问题：提供新的多肽和生物合成途径。提供了可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（环烯酚-3-基甲基）-4制备莫纳甜的方法和组合物 - 戊二酸。还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。所提供的组合物包括核酸分子，多肽，化学结构和细胞。该方法包括体外和体内过程，体外方法包括化学反应。版权所有（C）2012，JPO＆INPIT

3. 发明专利

AU2010201699A1 Polypeptides and biosynthetic pathways 未知
公开(公告)号：AU2010201699A1
公开(公告)日：2010-05-20
申请号：AU2010201699
申请日：2010-04-28
申请人： CARGILL INC
发明人： CAMERON DOUGLAS C , MILLIS JIM , ROSAZZA JOHN , DALLUGE JOSEPH , HICKS PAULA M , HOBSON RUSSELL J , MCFARLAN SARA C , ABRAHAM TIMOTHY W
IPC分类号： C12N15/09 , C07D209/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12P13/04 , C12P17/10
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(iridol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.

4. 发明专利

AU2003263097A1 POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS 未知
公开(公告)号：AU2003263097A1
公开(公告)日：2003-11-10
申请号：AU2003263097
申请日：2003-04-23
申请人： CARGILL INC
发明人： ROSAZZA JOHN , ABRAHAM TIMOTHY W , CAMERON DOUGLAS C , DALLUGE JOSEPH , HICKS PAULA M , HOBSON RUSSELL J , MCFARLAN SARA C , MILLIS JIM
IPC分类号： C12N15/09 , C07D209/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12P13/04 , C12P17/10
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(iridol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.

5. 发明申请

WO03091396A2 POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS 审中-公开
标题翻译：多肽和生物路径
公开(公告)号：WO03091396A2
公开(公告)日：2003-11-06
申请号：PCT/US0312588
申请日：2003-04-23
申请人： CARGILL INC
发明人： ABRAHAM TIMOTHY W , CAMERON DOUGLAS C , DALLUGE JOSEPH , HICKS PAULA M , HOBSON RUSSELL J , MCFARLAN SARA C , MILLIS JIM , ROSAZZA JOHN
IPC分类号： C12N15/09 , C07D209/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12P13/04 , C12P17/10 , C12N
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12P17/10
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(iridol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for produding the indole-3-pyruvate and 2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译：提供了可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（环烯醇-3-基甲基）-4-酮戊二酸制备莫纳甜的方法和组合物。还公开了用于生产吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子，多肽，化学结构和细胞。方法包括体外和体内过程，体外方法包括化学反应。

6. 发明专利

CA2483126C POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF MONATIN 未知
公开(公告)号：CA2483126C
公开(公告)日：2014-05-20
申请号：CA2483126
申请日：2003-04-23
申请人： CARGILL INC
发明人： ABRAHAM TIMOTHY W , CAMERON DOUGLAS C , DALLUGE JOSEPH , HICKS PAULA M , HOBSON RUSSELL J , MCFARLAN SARA C , MILLIS JIM , ROSAZZA JOHN , ZHAO LISHAN , WEINER DAVID P
IPC分类号： C12N15/09 , C12N15/54 , C07D209/18 , C07D209/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/08 , C12N9/10 , C12N9/88 , C12P13/04 , C12P17/10
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(iridol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for produding the indole-3-pyruvate and 2-hydroxy 2-(indol-3~ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.

7. 发明专利

ES2356132T3 POLIPEPTIDOS Y RUTAS BIOSINTETICAS. 未知
公开(公告)号：ES2356132T3
公开(公告)日：2011-04-05
申请号：ES03747304
申请日：2003-04-23
申请人： CARGILL INC
发明人： ABRAHAM TIMOTHY , CAMERON DOUGLAS , DALLUGE JOSEPH , HICKS PAULA , HOBSON RUSSELL , MCFARLAN SARA , MILLIS JIM , ROSAZZA JOHN , WEINER DAVID P , ZHAO LISHAN
IPC分类号： C12N15/09 , C12P17/10 , C07D209/18 , C07D209/20 , C12N1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12N15/52 , C12N15/63 , C12P13/04
摘要： Procedimiento de producción de monatina, que comprende convertir el triptófano y/o el ácido indol-3láctico en monatina, en el que el procedimiento comprende: (a) poner en contacto el triptófano o el ácido indol-3-láctico con un primer polipéptido, en el que, cuando el triptófano está en contacto con el primer polipéptido, el primer polipéptido se selecciona de entre triptófano aminotransferasa (CE 2.6.1.27), triptófano deshidrogenasa (CE 1.4.1.19), tirosina aminotransferasa (aromática) (CE 2.6.1.5), triptofan-fenilpiruvato transaminasa (CE 2.6.1.28), sustrato múltiple aminotransferasa (CE 2.6.1.-), aspartato aminotransferasa (CE 2.6.1.1), triptófano oxidasa, L-aminoácido oxidasa (CE 1.4.3.2), D-aminoácido deshidrogenasa (CE 1.4.99.1), D-aminoácido oxidasa (CE 1.4.3.3), D- triptófano aminotransferasa, D-alanina aminotransferasa (CE 2.6.1.21), glutamato deshidrogenasa (CE 1.4.1.2-4), fenilalanina deshidrogenasa (CE 1.4.1.20), o una combinación de las mismas, en el que, cuando el ácido indol-3-láctico se pone en contacto con el primer polipéptido, el primer polipéptido se selecciona de entre indol-lactato deshidrogenasa (CE 1.1.1.110), R-4 hidroxifenil-lactato deshidrogenasa (CE 1.1.1.222), 3-(4)-hidroxifenilpiruvato reductasa (CE 1.1.1.237), lactato deshidrogenasa (CE 1.1.1.27, 1.1.1.28, 1.1.2.3), (3-imidazol-5-il) lactato deshidrogenasa (CE 1.1.1.111), y lactato oxidasa (CE 1.1.3.-), o una combinación de las mismas, en el que el primer polipéptido convierte el triptófano o el ácido indol-3láctico en indol-3-piruvato; (b) poner en contacto el indol-3-piruvato con un segundo polipéptido y una fuente de carbono C3, en el que el segundo polipéptido es una enzima CE 4.1.2 o CE 4.1.3., en el que el segundo polipéptido convierte el indol-3-piruvato y la fuente de carbono C3 en 2-hidroxiácido 2-(indol-3-ilmetil)-4-cetoglutárico; y (c) poner en contacto el 2-hidroxiácido 2-(indol-3-ilmetil)-4-cetoglutárico con un tercer polipéptido, en el que el tercer polipéptido se selecciona de entre tirosina aminotransferasa (aromática) (CE 2.6.1.5), triptófano deshidrogenasa (CE 1.4.1.19), triptófano-fenilpiruvato transaminasa (CE 2.6.1.28), triptófano aminotransferasa (CE 2.6.1.27), aspartato aminotransferasa (CE 2.6.1.1), D-alanina aminotransferasa (CE 2.6.1.21), D-triptófano aminotransferasa, glutamato deshidrogenasa (CE 1.4.1.2-4), fenilalanina deshidrogenasa (CE 1.4.1.20), sustrato múltiple aminotransferasa (CE 2.6.1.-), D-aminoácido deshidrogenasa (CE 1.4.99.1), una lisina épsilon aminotransferasa, o una combinación de las mismas, en el que el tercer polipéptido convierte el 2-hidroxiácido 2-(indol-3ilmetil)-4-cetoglutárico en monatina.

8. 发明专利

DE60335361D1 POLYPEPTIDE UND BIOSYNTHETISCHE PFADE 未知
公开(公告)号：DE60335361D1
公开(公告)日：2011-01-27
申请号：DE60335361
申请日：2003-04-23
申请人： CARGILL INC
发明人： ABRAHAM TIMOTHY W , CAMERON DOUGLAS C , DALLUGE JOSEPH , HICKS PAULA M , HOBSON RUSSELL J , MCFARLAN SARA C , MILLIS JIM , ROSAZZA JOHN , WEINER DAVID P , ZHAO LISHAN
IPC分类号： C07D209/18 , C12N15/09 , C07D209/20 , C12N1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12N15/52 , C12N15/63 , C12P13/04 , C12P17/10

9. 发明专利

NO20045029A 未知
公开(公告)号：NO20045029A
公开(公告)日：2005-01-04
申请号：NO20045029
申请日：2004-11-19
申请人： CARGILL INC
发明人： ABRAHAM TIMOTHY W , CAMERON DOUGLAS C , DALLUGE JOSEPH , HICKS PAULA M , HOBSON RUSSELL J , MCFARLAN SARA C , MILLIS JIM , ROSAZZA JOHN , ZHAO LISHAN , WEINER DAVID P
IPC分类号： C12N15/09 , C07D209/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12P13/04 , C12P17/10 , C07D209/18
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12P17/10

10. 发明专利

SG146453A1 POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS 未知
公开(公告)号：SG146453A1
公开(公告)日：2008-10-30
申请号：SG2006074017
申请日：2003-04-23
申请人： CARGILL INC
发明人： ABRAHAM TIMOTHY W , CAMERON DOUGLAS C , DALLUGE JOSEPH , HICKS PAULA M , ROSAZZA JOHN , HOBSON RUSSELL J , ZHAO LISHAN , MCFARLAN SARA C , WEINER DAVID P , MILLIS JIM
IPC分类号： C12N15/09 , C07D209/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12P13/04 , C12P17/10 , C07D209/18 , C12N1/00 , C12N15/52 , C12N15/63
摘要： POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS "no figure"

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