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1. 发明申请

WO2008030344A2 APPARATUS FOR ENDOLYMPHATIC DRUG DELIVERY 审中-公开
标题翻译：装置用于内分泌药物输送
公开(公告)号：WO2008030344A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/018631
申请日：2007-08-23
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan , KRAMER, Andrew, P. , BAYNHAM, Tamara, Colette , CAWTHRA, James , BROOKE, M., Jason
发明人： SHUROS, Allan , KRAMER, Andrew, P. , BAYNHAM, Tamara, Colette , CAWTHRA, James , BROOKE, M., Jason
IPC分类号： A61M5/142 , A61N1/05 , A61M25/10
CPC分类号： A61M5/14276 , A61M1/3613 , A61M25/1011 , A61M2025/0057 , A61M2025/0063 , A61M2202/0405 , A61N1/056 , A61N1/36135
摘要： Described herein are a method and apparatus for introducing instrumentation into the lymphatic system that can be used for physiological monitoring and/or delivery of therapy. Such instrumentation, for example, may include one or more sensors for measuring physiological variables and/or one or more instruments for delivering therapy that is adapted to be disposed within a lymphatic vessel.
摘要翻译：本文描述了用于将仪器引入淋巴系统中的方法和装置，其可用于治疗的生理监测和/或递送。例如，这种仪器可以包括用于测量生理变量的一个或多个传感器和/或用于递送适于布置在淋巴管内的治疗的一个或多个仪器。

2. 发明申请

WO2007073455A1 CARDIAC RHYTHM MANAGEMENT SYSTEM WITH NON-INVASIVE HEMODYNAMIC SENSOR 审中-公开
标题翻译： CARDIAC RHYTHM管理系统与非入侵的HEMODYMO传感器
公开(公告)号：WO2007073455A1
公开(公告)日：2007-06-28
申请号：PCT/US2006/044160
申请日：2006-11-14
申请人： CARDIAC PACEMAKERS, INC. , KRAMER, Andrew, P. , PASTORE, Joseph M. , STAHMANN, Jeffrey E. , SALO, Rodney W. , HARTLEY, Jesse W.
发明人： KRAMER, Andrew, P. , PASTORE, Joseph M. , STAHMANN, Jeffrey E. , SALO, Rodney W. , HARTLEY, Jesse W.
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36557 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61N1/36114 , A61N1/36564
摘要： A cardiac rhythm management (CRM) system includes a non-invasive hemodynamic sensing device and an implantable medical device to sense a hemodynamic signal and derive one or more cardiac performance parameters from the hemodynamic signal. The non-invasive hemodynamic sensing device includes at least a portion configured for external attachment to a body in which the implantable medical device is implanted. The one or more cardiac performance parameters are used for various diagnostic, monitoring, and therapy control purposes.
摘要翻译：心律管理（CRM）系统包括非侵入性血液动力学感测装置和可植入医疗装置，用于感测血液动力学信号并从血流动力学信号导出一个或多个心脏性能参数。非侵入式血流动力学检测装置包括至少一部分，其构造成用于外部附接到其中植入可植入医疗装置的主体。一个或多个心脏性能参数用于各种诊断，监测和治疗控制目的。

3. 发明申请

WO2007002888A1 SYSTEM FOR CONTROLLING CARDIAC THERAPY BASED ON ELECTROMECHANICAL TIMING 审中-公开
标题翻译：基于机电时间控制心脏治疗的系统
公开(公告)号：WO2007002888A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/025524
申请日：2006-06-28
申请人： CARDIAC PACEMAKERS, INC.
发明人： SALO, Rodney , PASTORE, Joseph, M. , KRAMER, Andrew, P. , STAHMANN, Jeffrey, E. , HARTLEY, Jesse, W.
IPC分类号： A61N1/362 , A61N1/365 , A61B5/0215 , A61B5/053 , A61B7/00 , A61B5/0402 , A61N1/36 , A61N1/39 , A61N1/37
CPC分类号： A61N1/3627 , A61M5/14276 , A61N1/36521 , A61N1/36585 , A61N1/3756
摘要： Devices for therapy control based on electromechanical timing provide for detecting electrical activation of a patient's heart, and detecting mechanical cardiac activity resulting from the electrical activation. A timing relationship is determined between the electrical activation and the mechanical activity. A therapy is controlled based on the timing relationship. The therapy may improve intraventricular dyssynchrony of the patient's heart, or treat at least one of diastolic and systolic dysfunction and/or dyssynchrony of the patient's heart, for example. Electrical activation may be detected by sensing delivery of an electrical stimulation pulse to the heart or sensing intrinsic depolarization of the patient's heart. Mechanical activity may be detected by sensing heart sounds, a change in one or more of left ventricular impedance, ventricular pressure, right ventricular pressure, left atrial pressure, right atrial pressure, systemic arterial pressure and pulmonary artery pressure.
摘要翻译：基于机电定时的用于治疗控制的装置提供用于检测患者心脏的电激活，以及检测由电激活引起的机械心脏活动。在电激活和机械活动之间确定时序关系。基于时间关系控制治疗。该治疗可以改善患者心脏的心室内不同步，或治疗患者心脏的舒张期和收缩功能障碍和/或不同步中的至少一种。可以通过感测向心脏传递电刺激脉冲或感测患者心脏的固有去极化来检测电激活。可以通过感测心脏声音，左心室阻抗，心室压力，右心室压力，左心房压力，右心房压力，全身动脉压力和肺动脉压力中的一个或多个的变化来检测机械活动。

4. 发明申请

WO2006101749A1 SYSTEM TO PROVIDE MYOCARDIAL AND NEURAL STIMULATION 审中-公开
标题翻译：系统提供心肌和神经刺激
公开(公告)号：WO2006101749A1
公开(公告)日：2006-09-28
申请号：PCT/US2006/008314
申请日：2006-03-09
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , ZHU, Qingsheng , VANDERLINDE, Scott , KRAMER, Andrew, P. , GARG, Ankur , JAMES, Kristofer, J.
发明人： LIBBUS, Imad , ZHU, Qingsheng , VANDERLINDE, Scott , KRAMER, Andrew, P. , GARG, Ankur , JAMES, Kristofer, J.
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36057 , A61N1/36117 , A61N1/36128 , A61N1/3621 , A61N1/3627
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种方面提供可植入装置。在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到电极。刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。感测和刺激电路适用于执行CRM功能。该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。本文提供了其它方面和实施例。

5. 发明申请

WO2003053510A2 APPARATUS AND METHOD FOR MULTI-SITE ANTI-TACHYCARDIA PACING 审中-公开
标题翻译：用于多地表抗紫杉醇的装置和方法
公开(公告)号：WO2003053510A2
公开(公告)日：2003-07-03
申请号：PCT/US2002/040907
申请日：2002-12-19
申请人： CARDIAC PACEMAKERS, INC.
发明人： SPINELLI, Julio, C. , ZHU, Qingsheng , KRAMER, Andrew, P. , STAHMANN, Jeffrey, E.
IPC分类号： A61N
CPC分类号： A61N1/3622 , A61N1/3684
摘要： An apparatus and method for treating ventricular tachycardia in which paces are delivered to the ventricles at multiple pacing sites in accordance with an anti-tachycardia pacing protocol. Paces are delivered at a selected offset interval in a manner that both resynchronizes ventricular contractions and increases the probability of terminating the tachycardia.
摘要翻译：一种用于治疗室性心动过速的装置和方法，其中根据抗心动过速起搏方案，将步道在多个起搏部位输送到心室。以选择的偏移间隔以两者重新同步心室收缩并增加终止心动过速的可能性的方式递送步态。

6. 发明申请

WO2002087694A1 APPARATUS AND METHOD FOR REVERSAL OF MYOCARDIAL REMODELING WITH ELECTRICAL STIMULATION 审中-公开
标题翻译：装置和方法用于电刺激的肌肉重塑
公开(公告)号：WO2002087694A1
公开(公告)日：2002-11-07
申请号：PCT/US2002/012950
申请日：2002-04-25
申请人： CARDIAC PACEMAKERS, INC.
发明人： KRAMER, Andrew, P. , SALO, Rodney, W. , SPINELLI, Julio, C. , KENKNIGHT, Bruce, H.
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译：用电刺激治疗逆转心室重构的装置和方法。通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

7. 发明申请

WO2011130488A2 AUTONOMIC MODULATION USING TRANSIENT RESPONSE WITH INTERMITTENT NEURAL STIMULATION 审中-公开
标题翻译：使用瞬时响应与间歇性神经刺激的自动调制
公开(公告)号：WO2011130488A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/032450
申请日：2011-04-14
申请人： CARDIAC PACEMAKERS, INC. , KRAMER, Andrew, P. , HAMANN, Jason, J.
发明人： KRAMER, Andrew, P. , HAMANN, Jason, J.
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
摘要翻译：在用于操作可植入神经刺激器以将神经刺激疗法递送至自主神经靶标的各种方法实施例中，该方法包括使用可植入神经刺激器将神经刺激疗法递送至自主神经靶标，以及评估对神经元的诱发反应刺激爆发。神经刺激治疗包括多个神经刺激脉冲串，其中每个神经刺激脉冲串包括多个神经刺激脉冲，并且连续神经刺激脉冲串在没有神经刺激脉冲的情况下被分离一段时间。评估诱发反应包括感测对神经刺激突发的诱发反应，其中感测诱发反应包括感测受神经刺激突发影响的至少一个生理参数，将感测的诱发反应与基线进行比较，以及确定诱发反应是否基本上返回到神经刺激爆发之间的基线。

8. 发明申请

WO2009035515A1 SYSTEMS FOR AVOIDING NEURAL STIMULATION HABITUATION 审中-公开
标题翻译：避免神经刺激症状的系统
公开(公告)号：WO2009035515A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/010324
申请日：2008-09-02
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , KRAMER, Andrew, P.
发明人： LIBBUS, Imad , KRAMER, Andrew, P.
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36057 , A61N1/36114 , A61N1/36167 , A61N1/37235
摘要： A neural stimulator embodiment includes a neural stimulation delivery system and a controller operationally connected to the neural stimulation delivery system. The neural stimulation delivery system is adapted to non-selectively stimulate both afferent axons and efferent axons in a vagus nerve. The controller includes a neural stimulation scheduler to control neural stimulation from the neural stimulation system according to a predetermined schedule. The predetermined schedule includes at least one parameter with a value selected to avoid physiological habituation to the neural stimulation. The parameter(s) include at least one parameter selected from the group of parameters consisting of a predetermined therapy duration parameter for a predetermined therapy period, and a predetermined intermittent neural stimulation parameter associated with on / off timing for the intermittent neural stimulation parameter.
摘要翻译：神经刺激器实施例包括神经刺激递送系统和可操作地连接到神经刺激递送系统的控制器。神经刺激递送系统适于非选择性地刺激迷走神经中的传入轴突和传出轴突。控制器包括神经刺激调度器，以根据预定时间表从神经刺激系统控制神经刺激。预定时间表包括至少一个参数，其具有被选择用于避免对神经刺激的生理习惯的值。该参数包括从由用于预定治疗期间的预定治疗持续时间参数组成的参数组中选择的至少一个参数以及与用于间歇神经刺激参数的开启/关闭定时相关联的预定间歇神经刺激参数。

9. 发明申请

WO2008079347A1 IMPLANTABLE DEVICE WITH MULTIPLE PARAMETER SETS 审中-公开
标题翻译：具有多个参数集的可植入设备
公开(公告)号：WO2008079347A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/026191
申请日：2007-12-21
申请人： CARDIAC PACEMAKERS, INC. , SATHAYE, Alok, S. , CAZARES, Shelley, M. , KRAMER, Andrew, P. , DONG, Yanting , WEI, Xuan , GARG, Ankur , NI, Quan
发明人： SATHAYE, Alok, S. , CAZARES, Shelley, M. , KRAMER, Andrew, P. , DONG, Yanting , WEI, Xuan , GARG, Ankur , NI, Quan
IPC分类号： A61N1/365 , A61N1/372 , G06F19/00 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3688 , A61N1/37282 , G06F19/00 , G06F19/3418
摘要： An implantable device including a programmable controller can be used to include a user-specifiable therapy control parameter set. The therapy control parameter set may then be configured to include at least one therapy control parameter that is user-configurable to automatically switch from a first parameter value to a second parameter value at a time that occurs between separate user programming sessions of the device. A remote external interface can be included that is configured to be communicatively coupled to the device. The remote external interface can be configured to perform an analysis of physiologic data received from the device in response to operation of the device using a plurality of therapy control parameter sets. The remote external interface can further be configured to select a particular therapy control parameter set using the analysis.
摘要翻译：包括可编程控制器的可植入装置可以用于包括用户可指定的治疗控制参数组。治疗控制参数集合然后可被配置为包括用户可配置的至少一个治疗控制参数，以便在设备的不同的用户编程会话之间发生的时刻自动地从第一参数值切换到第二参数值。可以包括配置为通信地耦合到设备的远程外部接口。远程外部接口可以被配置为响应于使用多个治疗控制参数组的设备的操作来执行从设备接收的生理数据的分析。远程外部接口还可以配置为使用分析来选择特定的治疗控制参数集。

10. 发明申请

WO2008063396A1 AUTOMATIC NEURAL STIMULATION MODULATION BASED ON ACTIVITY 审中-公开
标题翻译：基于活动的自动神经刺激调制
公开(公告)号：WO2008063396A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/023288
申请日：2007-11-05
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , KRAMER, Andrew, P.
发明人： LIBBUS, Imad , KRAMER, Andrew, P.
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/3601 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36135 , A61N1/3627 , A61N1/36535 , A61N1/36542 , A61N1/3655 , A61N1/36564 , A61N1/36571 , A61N1/37288
摘要： An embodiment senses activity, and automatically controls neural stimulation based on the sensed activity. An embodiment determines periods of rest and periods of exercise using the sensed activity, and applies neural stimulation during rest and withdrawing neural stimulation during exercise. Other embodiments are provided herein.
摘要翻译：实施例感测活动，并且基于感测的活动自动控制神经刺激。实施例使用感测到的活动来确定休息时间和运动周期，并且在休息期间应用神经刺激并且在运动期间抽出神经刺激。本文提供了其他实施例。

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