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1. 发明授权

US11577240B2 Liquid storage and controlled-release device and biological detection chip 有权
公开(公告)号：US11577240B2
公开(公告)日：2023-02-14
申请号：US17166546
申请日：2021-02-03
申请人： Capitalbio Corporation , West China Hospital of Sichuan University
发明人： Xinying Zhou , Lei Wang , Liang Bai , Tengfei Guo , Shuo Li , Baolian Li , Bin Zhuang , Xiang Chen , Hongju Guo , Xiaolei Zhao , Wanli Xing , Jing Cheng
IPC分类号： B01L3/00
摘要： A liquid storage and controlled-release device and a biological detection chip. The liquid storage and controlled-release device comprises a liquid storage capsule with a liquid storage body which is deformable under a pressure, and a sealing layer for sealing the liquid storage body. A support platform is provided right below the liquid storage capsule and tightly connected with the liquid storage capsule, wherein, a directional release chamber is provided at the middle of the support platform, and the directional release chamber is provided with a guiding chamber for collecting the liquid and a sharp edge for inducing break. Compared with the conventional technology, the opening for liquid release is at the end far away from the rotation center, so that the liquid can be released completely by the centrifugal force, ensuring the quantitative release of stored liquid and reducing the influence on the accuracy of the subsequent detection.

2. 发明授权

US11565255B2 Valve system for driving fluid and method for using the same 有权
公开(公告)号：US11565255B2
公开(公告)日：2023-01-31
申请号：US17168763
申请日：2021-02-05
申请人： Capitalbio Corporation , West China Hospital of Sichuan University
发明人： Liang Bai , Tengfei Guo , Lei Wang , Xinying Zhou , Juan Xin , Baolian Li , Li Ma , Libing Dong , Jing Cheng
IPC分类号： B01L3/00 , F16K31/12 , F16K99/00
摘要： A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.

3. 发明申请

US20210322983A1 VALVE SYSTEM FOR DRIVING FLUID AND METHOD FOR USING THE SAME 有权
公开(公告)号：US20210322983A1
公开(公告)日：2021-10-21
申请号：US17168763
申请日：2021-02-05
申请人： Capitalbio Corporation , West China Hospital of Sichuan University
发明人： Liang Bai , Tengfei Guo , Lei Wang , Xinying Zhou , Juan Xin , Baolian Li , Li Ma , Libing Dong , Jing Cheng
IPC分类号： B01L3/00 , F16K31/12
摘要： A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.

4. 发明申请

US20210322979A1 LIQUID STORAGE AND CONTROLLED-RELEASE DEVICE AND BIOLOGICAL DETECTION CHIP 有权
公开(公告)号：US20210322979A1
公开(公告)日：2021-10-21
申请号：US17166546
申请日：2021-02-03
申请人： Capitalbio Corporation , West China Hospital of Sichuan University
发明人： Xinying Zhou , Lei Wang , Liang Bai , Tengfei Guo , Shuo Li , Baolian Li , Bin Zhuang , Xiang Chen , Hongju Guo , Xiaolei Zhao , Wanli Xing , Jing Cheng
IPC分类号： B01L3/00
摘要： A liquid storage and controlled-release device and a biological detection chip. The liquid storage and controlled-release device comprises a liquid storage capsule with a liquid storage body which is deformable under a pressure, and a sealing layer for sealing the liquid storage body. A support platform is provided right below the liquid storage capsule and tightly connected with the liquid storage capsule, wherein, a directional release chamber is provided at the middle of the support platform, and the directional release chamber is provided with a guiding chamber for collecting the liquid and a sharp edge for inducing break. Compared with the conventional technology, the opening for liquid release is at the end far away from the rotation center, so that the liquid can be released completely by the centrifugal force, ensuring the quantitative release of stored liquid and reducing the influence on the accuracy of the subsequent detection.

5. 发明授权

US11666911B2 Sample extraction chip and biological reaction device 有权
公开(公告)号：US11666911B2
公开(公告)日：2023-06-06
申请号：US17121337
申请日：2020-12-14
申请人： Capitalbio Corporation
发明人： Longtang Zheng , Lei Wang , Liang Bai , Xinying Zhou , Fei Wen , Yanan Wang , Xiang Chen , Tengfei Guo , Baolian Li , Li Ma , Jing Cheng
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L2300/0803
摘要： A sample extraction chip and a biological reaction device are disclosed according to the present disclosure. The sample extraction chip includes a chip body and a sample extraction module provided on the chip body, the sample extraction module includes a sample-loading lysis unit, a liquid release-control unit, an extraction unit, a liquid switch-control unit, a liquid collection unit and a sample collection unit, which are connected through flow channels in a sequence of extraction. The liquid release-control unit is configured to store and release liquid reagents, and the liquid switch-control unit is configured to switch between communication of the liquid collection unit and the extraction unit and communication of the sample collection unit and the extraction unit. The sample collection unit includes a front collection portion and a rear collection portion which are both in communication with the liquid switch-control unit.

6. 发明授权

US10309977B2 Device for detecting and/or analyzing bio-chip 有权
公开(公告)号：US10309977B2
公开(公告)日：2019-06-04
申请号：US15511216
申请日：2015-09-25
申请人： CapitalBio Corporation
发明人： Yuan Xue , Guanbin Zhang , Cheng Chen , Kaijun Zhao , Yu Dong , Jing Cheng
IPC分类号： G01N35/00 , G01N21/25 , G01N21/15 , G01N21/78 , G01N1/10 , G01N21/88 , G01N35/02 , G01N15/14 , B01L3/00
摘要： In some aspects, the present disclosure provides a biochip detecting device that comprises a first shell (2) connect to a second shell (1), and a rotatable support frame (5) of biochip possessing a detecting zone that holds one or more biochips, and a detector (7).

7. 发明授权

US10300483B2 Multi-index detection microfluidic chip and methods of use 有权
公开(公告)号：US10300483B2
公开(公告)日：2019-05-28
申请号：US15123978
申请日：2015-03-06
申请人： CapitalBio Corporation , Tsinghua University
发明人： Lei Wang , Guohao Zhang , Xinying Zhou , Juan Xin , Yao Zhang , Mingxian Lin , Guoliang Huang , Can Wang , Wanli Xing , Jing Cheng
IPC分类号： B01L99/00 , B01L3/00 , C12Q1/6869
摘要： A multi-index detection microfluidic chip is provided. A bottom plate (1) and a cover plate (2) that matches the bottom plate (1) and seals it are provided in the microfluidic chip. The center of the microfluidic chip has a through-hole (3). The bottom plate (1) has one or more wave-shaped main channel(s) (4), one end of each of the main channel (4) connected to a sample injection hole (9) on the bottom plate (1), and the other end connected to an exhaust hole (10) on the bottom plate (1). The valley on the main channel (1) is distal to the through-hole (3), and the peak is proximal to the through-hole (3). Each valley of the main channel (1) is connected to a reaction chamber (6) by a linking channel (5). The linking channel (5) comprises one or more buffering chambers (7). The microfluidic chip can be used in detection by fluorescence, turbidity, color, detection equipment, and/or direct observation by the naked eyes. The detection is real-time as the reaction occurs or after the reaction.

8. 发明申请

US20210322982A1 SAMPLE EXTRACTION CHIP AND BIOLOGICAL REACTION DEVICE 有权
公开(公告)号：US20210322982A1
公开(公告)日：2021-10-21
申请号：US17121337
申请日：2020-12-14
申请人： Capitalbio Corporation
发明人： Longtang Zheng , Lei Wang , Liang Bai , Xinying Zhou , Fei Wen , Yanan Wang , Xiang Chen , Tengfei Guo , Baolian Li , Li Ma , Jing Cheng
IPC分类号： B01L3/00
摘要： A sample extraction chip and a biological reaction device are disclosed according to the present disclosure. The sample extraction chip includes a chip body and a sample extraction module provided on the chip body, the sample extraction module includes a sample-loading lysis unit, a liquid release-control unit, an extraction unit, a liquid switch-control unit, a liquid collection unit and a sample collection unit, which are connected through flow channels in a sequence of extraction. The liquid release-control unit is configured to store and release liquid reagents, and the liquid switch-control unit is configured to switch between communication of the liquid collection unit and the extraction unit and communication of the sample collection unit and the extraction unit. The sample collection unit includes a front collection portion and a rear collection portion which are both in communication with the liquid switch-control unit.

9. 发明申请

US20140285215A1 CELL-IMPEDANCE SENSORS 有权
标题翻译：电池阻抗传感器
公开(公告)号：US20140285215A1
公开(公告)日：2014-09-25
申请号：US14171757
申请日：2014-02-03
申请人： CAPITALBIO CORPORATION
发明人： Lei Wang , Keith Mitchelson , He Wang , Jing Cheng
IPC分类号： G01N27/06 , G01N33/487 , G01N27/22
CPC分类号： G01N27/06 , G01N27/221 , G01N33/48707 , G01N33/48728 , G01N33/5438
摘要： Systems, apparatus and methods for designing and operating a cell-electrode impedance sensor to detect chemical and biological samples, including biological cells. In one implementation, a method of designing a cell-electrode impedance sensor includes determining a cell free cell-electrode impedance and a cell covered cell-electrode impedance based on a design model for the cell-electrode impedance sensor, wherein the design model is based on one or more factors, the factors including properties and elements of a cell-electrode impedance measurement system, using the cell free cell-electrode impedance and the cell covered cell-electrode impedance to obtain a sensor sensitivity of the cell-electrode impedance measurement system, and choosing one or more design parameters of the cell-electrode impedance sensor in the cell-electrode impedance measurement system to maximize the sensor sensitivity.
摘要翻译：用于设计和操作细胞电极阻抗传感器以检测包括生物细胞在内的化学和生物样品的系统，装置和方法。在一个实施方式中，设计电池电极阻抗传感器的方法包括基于用于电池电极阻抗传感器的设计模型来确定无电池单元电极阻抗和电池覆盖的电池电极阻抗，其中设计模型基于关于一个或多个因素，包括电池电极阻抗测量系统的特性和元件的因素，使用无电池电池电阻和电池覆盖的电池 - 电极阻抗来获得电池电极阻抗测量系统的传感器灵敏度，并且在单元电极阻抗测量系统中选择电池电极阻抗传感器的一个或多个设计参数以最大化传感器灵敏度。

10. 发明授权

US10264965B2 Eye imaging device and method of use 有权
公开(公告)号：US10264965B2
公开(公告)日：2019-04-23
申请号：US15374818
申请日：2016-12-09
申请人： CAPITALBIO EHEALTH SCIENCE & TECHNOLOGY (BEIJING) CO., LTD. , CapitalBio Corporation , Tsinghua University
发明人： Guoliang Huang , Wenjun Wang , Hongmei Cao , Lili Zhang , Li Ma , Chengjin Zhang , Yimin Sun , Dong Wang , Jing Cheng
IPC分类号： A61B3/12 , A61B3/15 , G06F16/51 , G06F16/583 , G06T7/13 , A61B3/00 , G06K9/00 , G06K9/46 , G06T7/00
摘要： In one aspect, disclosed herein are devices, systems, and methods for assessing human health states based on non-shadow imaging of sclera, or whites, of one or both eyes. In one aspect, the device is an on-body device. In one aspect, the system comprises a positioning aperture, an illuminating apparatus, an imaging apparatus, and/or a processing apparatus. In one aspect, the process only takes a short period of time to take images of the sclera without any operation of splicing multiple images. In one aspect, the device or system improves the quality of images by avoiding the formation of reflection of the illuminating apparatus on the images of the sclera. In a further aspect, the system can utilize the sclera images to obtain information of eye diseases and to predict the physiological and pathological changes in the health status of subject or diagnostic results, which can provide helpful information for medical diagnosis.

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