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1. 发明申请

WO2002079126A1 CROSS-METATHESIS REACTION OF FUNCTIONALIZED AND SUBSTITUTED OLEFINS USING GROUP 8 TRANSITION METAL CARBENE COMPLEXES AS METATHESIS CATALYSTS 审中-公开
标题翻译：使用第8组过渡金属碳复合物作为元素催化剂的官能化和取代的烯烃的跨金属反应
公开(公告)号：WO2002079126A1
公开(公告)日：2002-10-10
申请号：PCT/US2002/010196
申请日：2002-04-01
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , GRUBBS, Robert, H. , CHATTERJEE, Arnab, K. , CHOI, Tae-Lim , GOLDBERG, Steven, D. , LOVE, Jennifer, A. , MORGAN, John, P. , SANDERS, Daniel, P. , SCHOLL, Matthias , TOSTE, F., Dean , TRNKA, Tina, M.
发明人： GRUBBS, Robert, H. , CHATTERJEE, Arnab, K. , CHOI, Tae-Lim , GOLDBERG, Steven, D. , LOVE, Jennifer, A. , MORGAN, John, P. , SANDERS, Daniel, P. , SCHOLL, Matthias , TOSTE, F., Dean , TRNKA, Tina, M.
IPC分类号： C07C6/02
CPC分类号： C07F9/40 , C07C6/04 , C07C17/275 , C07C29/40 , C07C29/46 , C07C41/14 , C07C45/69 , C07C67/293 , C07C67/297 , C07C67/343 , C07C67/475 , C07C201/12 , C07C319/20 , C07C2531/22 , C07C2601/14 , C07C2601/16 , C07C2603/74 , C07D263/14 , C07D317/12 , C07D317/20 , C07D317/24 , C07F7/1892 , C07F9/4015 , C07F15/0046 , C07C25/13 , C07C47/21 , C07C69/007 , C07C69/78 , C07C69/732 , C07C69/56 , C07C321/14 , C07C69/16 , C07C69/533 , C07C69/145 , C07C69/157 , C07C69/18 , C07C205/06 , C07C33/483
摘要： The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which mayor may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.
摘要翻译：本发明涉及第8族过渡金属卡宾配合物用作烯烃交叉复分解反应的催化剂。特别地，用N-杂环卡宾配体取代的钌和锇亚烷基配合物用于催化交叉复分解反应以提供各种取代和官能化的烯烃，包括膦酸酯取代的烯烃，直接卤代烯烃，三取代烯烃和季烯丙烯烯烃。本发明还提供了一种使用上述配合物来催化第一种烯属反应物（其可能不被官能团取代）的交叉复分解反应与多种不同的烯属反应物中的每一种的交叉复分解反应的方法，其可以或可能不被官能团取代，得到多个结构不同的烯属产物。本发明的方法还可用于促进顺式构型中1,2-二取代的烯烃的立体选择性合成。

2. 发明申请

WO2003087167A3 CROSS-METATHESIS OF OLEFINS DIRECTLY SUBSTITUTED WITH AN ELECTRON-WITHDRAWING GROUP USING TRANSITION METAL CARBENE CATALYSTS 审中-公开
公开(公告)号：WO2003087167A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/010694
申请日：2003-04-07
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： GRUBBS, Robert, H. , MORGAN, John, P. , LOVE, Jennifer, A. , TRNKA, Tina, M.
IPC分类号： C07F9/00
摘要： The invention pertains to the use of Group 8 transition metal alkylidene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand and at least one electron donor ligand in the form of a heterocyclic group are used to catalyze cross-metathesis reactions to provide a olefin products that are directly substituted with an electron-withdrawing group.

3. 发明申请

WO2003087167A2 CROSS-METATHESIS OF OLEFINS DIRECTLY SUBSTITUTED WITH AN ELECTRON-WITHDRAWING GROUP USING TRANSITION METAL CARBENE CATALYSTS 审中-公开
标题翻译：使用过渡金属碳纳米管催化剂直接取代电子取材组的烯烃交联
公开(公告)号：WO2003087167A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/010694
申请日：2003-04-07
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： GRUBBS, Robert, H. , MORGAN, John, P. , LOVE, Jennifer, A. , TRNKA, Tina, M.
IPC分类号： C08F
CPC分类号： C07C253/30 , C07C255/15 , C07C255/34
摘要： The invention pertains to the use of Group 8 transition metal alkylidene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand and at least one electron donor ligand in the form of a heterocyclic group are used to catalyze cross-metathesis reactions to provide a olefin products that are directly substituted with an electron-withdrawing group.
摘要翻译：本发明涉及使用第8族过渡金属亚烷基络合物作为烯烃交叉复分解反应的催化剂。特别地，用N-杂环卡宾配体取代的钌和锇亚烷基络合物和至少一种杂环基形式的电子给体配体被用于催化交叉复分解反应以提供直接被电子取代的烯烃产物牵引组。

4. 发明申请

WO2003011455A1 HEXACOORDINATED RUTHENIUM OR OSMIUM METAL CARBENE METATHESIS CATALYSTS 审中-公开
标题翻译：异丁烯酸丁酯或奥氏体金属碳酸盐METATHESIS催化剂
公开(公告)号：WO2003011455A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/019167
申请日：2002-06-14
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： GRUBBS, Robert, H. , SANFORD, Melanie, S. , MOORE, Jason, L. , LOVE, Jennifer, A. , TRNKA, Tina, M.
IPC分类号： B01J31/00
CPC分类号： C07C6/04 , B01J23/462 , B01J23/466 , B01J31/181 , B01J31/1815 , B01J31/183 , B01J31/2273 , B01J31/28 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C6/06 , C07C2531/22 , C07F15/002 , C07F15/0046 , C08G61/06
摘要： The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula wherein: M is ruthenium or osmium; X and XI are the same or different and are each independently an anionic ligand; L, L 1' and L 2 are the same or different and are each independently a neutral electron donor ligand; and, R and R 1 are each independently hydrogen or a substituent selected from the group consisting of C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, aryl, C 1 -C 20 carboxylate, C 1 -C 20 alkoxy, C 2 -C 20 alkenyloxy, C 2 -C 20 alkynyloxy, aryloxy, C 2 -C¿20 ? alkoxycarbonyl, C 1 -C 20 alkylthio, C 1 -C 20 alkylsulfonyl and C 1 -C 20 alkylsulfinyl and silyl. Optionally, each of the R or R 1 substituent group may be substituted with one or more moieties selected from the group consisting of C 1 -C 10 alkyl, C 1 -C 10 alkoxy, and aryl which in turn may each be further substituted with one or more groups selected from a halogen, a C 1 -C 5 alkyl, C 1 -C 5 alkoxy, and phenyl. Moreover, any of the catalyst ligands may further include one or more functional groups. Examples of suitable functional groups include but are not limited to: hydroxyl, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, halogen, alcohol, sulfonic acid, phosphine, imide, acetal, ketal, boronate, cyano, cyanohydrin, hydrazine, enamine, sulfone, sulfide, and sulfenyl. In certain embodiments, at least one of L, L l' and L 2 is an N-heterocyclic carbene ligand.
摘要翻译：本发明涉及新型六配位复分解催化剂及其制备和使用方法。本发明的催化剂具有下式：其中：M是钌或锇; X和XI相同或不同，各自独立地为阴离子配体; L，L 1和L 2相同或不同，各自独立地为中性给电子体配体; 和R 1和R 2各自独立地是氢或选自C 1 -C 20烷基，C 2 -C 20烯基，C 2 -C 20炔基，芳基，C 1 -C 20羧酸酯，C 1 -C 20烷氧基，C 2 -C 20 烯氧基，C 2 -C 20炔氧基，芳氧基，C 2 -C 20烷氧基羰基，C 1 -C 20烷硫基，C 1 -C 20烷基磺酰基和C 1 -C 20烷基亚磺酰基和甲硅烷基。任选地，R或R 1取代基中的每一个可以被一个或多个选自C 1 -C 10烷基，C 1 -C 10烷氧基和芳基的部分取代，所述基团可以进一步被一个或多个更多选自卤素，C 1 -C 5烷基，C 1 -C 5烷氧基和苯基的基团。此外，任何催化剂配体还可以包括一个或多个官能团。合适的官能团的实例包括但不限于：羟基，硫醇，硫醚，酮，醛，酯，醚，胺，亚胺，酰胺，硝基，羧酸，二硫化物，碳酸酯，异氰酸酯，碳二亚胺，碳烷氧基，氨基甲酸酯，卤素醇，磺酸，膦，酰亚胺，缩醛，缩酮，硼酸酯，氰基，氰醇，肼，烯胺，砜，硫化物和亚磺酰基。在某些实施方案中，L，L'和L 2中的至少一个是N-杂环卡宾配体。

5. 发明授权

EP1497299B1 CROSS-METATHESIS OF OLEFINS DIRECTLY SUBSTITUTED WITH AN ELECTRON-WITHDRAWING GROUP USING TRANSITION METAL CARBENE CATALYSTS 有权
标题翻译： KREUZMETHATHESE直接向AN吸电子基团取代的烯烃USINGÜBERGANGSMETALLCARBENKATALYSATOREN
公开(公告)号：EP1497299B1
公开(公告)日：2012-06-27
申请号：EP03718252.4
申请日：2003-04-07
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： GRUBBS, Robert, H. , MORGAN, John, P. , LOVE, Jennifer, A. , TRNKA, Tina, M.
IPC分类号： C07F9/00 , C07F9/28 , C07F15/00
CPC分类号： C07C253/30 , C07C255/15 , C07C255/34
摘要： The invention pertains to the use of Group 8 transition metal alkylidene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand and at least one electron donor ligand in the form of a heterocyclic group are used to catalyze cross-metathesis reactions to provide a olefin products that are directly substituted with an electron-withdrawing group.

6. 发明授权

EP1423195B1 HEXACOORDINATED RUTHENIUM OR OSMIUM METAL CARBENE METATHESIS CATALYSTS 有权
标题翻译：六配位的钌或锇金属卡宾的复分解催化剂
公开(公告)号：EP1423195B1
公开(公告)日：2016-03-02
申请号：EP02791535.4
申请日：2002-06-14
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , Materia, Inc.
发明人： GRUBBS, Robert, H. , SANFORD, Melanie, S. , MOORE, Jason L. , LOVE, Jennifer, A. , TRNKA, Tina M.
IPC分类号： B01J31/00 , C07F15/00 , C08F4/80 , B01J31/22
CPC分类号： C07C6/04 , B01J23/462 , B01J23/466 , B01J31/181 , B01J31/1815 , B01J31/183 , B01J31/2273 , B01J31/28 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C6/06 , C07C2531/22 , C07F15/002 , C07F15/0046 , C08G61/06

7. 发明公开

EP1373170A1 CROSS-METATHESIS REACTION OF FUNCTIONALIZED AND SUBSTITUTED OLEFINS USING GROUP 8 TRANSITION METAL CARBENE COMPLEXES AS METATHESIS CATALYSTS 无效
标题翻译：功能化的交叉复分解和取代烯烃使用过渡金属集团8 CARBEN复杂的AS METHATESE催化剂
公开(公告)号：EP1373170A1
公开(公告)日：2004-01-02
申请号：EP02731215.6
申请日：2002-04-01
申请人： California Institute of Technology
发明人： GRUBBS, Robert, H. , CHATTERJEE, Arnab, K. , CHOI, Tae-Lim , GOLDBERG, Steven, D. , LOVE, Jennifer, A. , MORGAN, John, P. , SANDERS, Daniel, P. , SCHOLL, Matthias , TOSTE, F., Dean , TRNKA, Tina, M.
IPC分类号： C07C6/02 , C07C6/04 , C07C6/06
CPC分类号： C07F9/40 , C07C6/04 , C07C17/275 , C07C29/40 , C07C29/46 , C07C41/14 , C07C45/69 , C07C67/293 , C07C67/297 , C07C67/343 , C07C67/475 , C07C201/12 , C07C319/20 , C07C2531/22 , C07C2601/14 , C07C2601/16 , C07C2603/74 , C07D263/14 , C07D317/12 , C07D317/20 , C07D317/24 , C07F7/1892 , C07F9/4015 , C07F15/0046 , C07C25/13 , C07C47/21 , C07C69/007 , C07C69/78 , C07C69/732 , C07C69/56 , C07C321/14 , C07C69/16 , C07C69/533 , C07C69/145 , C07C69/157 , C07C69/18 , C07C205/06 , C07C33/483
摘要： The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which mayor may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.

8. 发明公开

EP1497299A2 CROSS-METATHESIS OF OLEFINS DIRECTLY SUBSTITUTED WITH AN ELECTRON-WITHDRAWING GROUP USING TRANSITION METAL CARBENE CATALYSTS 有权
标题翻译：直接取代电子反应基团的烯烃交换型金属碳化物催化剂的交换行为
公开(公告)号：EP1497299A2
公开(公告)日：2005-01-19
申请号：EP03718252.4
申请日：2003-04-07
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： GRUBBS, Robert, H. , MORGAN, John, P. , LOVE, Jennifer, A. , TRNKA, Tina, M.
IPC分类号： C07F9/00 , C07F9/28 , C07F15/00
CPC分类号： C07C253/30 , C07C255/15 , C07C255/34
摘要： The invention pertains to the use of Group 8 transition metal alkylidene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand and at least one electron donor ligand in the form of a heterocyclic group are used to catalyze cross-metathesis reactions to provide a olefin products that are directly substituted with an electron-withdrawing group.
摘要翻译：本发明涉及使用第8族过渡金属亚烷基络合物作为烯烃交叉复分解反应的催化剂。具体而言，用N-杂环卡宾配体和至少一个杂环基形式的电子给体配体取代的钌和锇的亚烷基配合物用于催化交叉复分解反应，以提供直接被电子取代的烯烃产物 - 提款组。

9. 发明公开

EP1423195A1 HEXACOORDINATED RUTHENIUM OR OSMIUM METAL CARBENE METATHESIS CATALYSTS 有权
标题翻译：六配位的钌或锇金属卡宾的复分解催化剂
公开(公告)号：EP1423195A1
公开(公告)日：2004-06-02
申请号：EP02791535.4
申请日：2002-06-14
申请人： California Institute of Technology
发明人： GRUBBS, Robert, H. , SANFORD, Melanie, S. , MOORE, Jason L. , LOVE, Jennifer, A. , TRNKA, Tina M.
IPC分类号： B01J31/00 , C07F15/00 , C08F4/80
CPC分类号： C07C6/04 , B01J23/462 , B01J23/466 , B01J31/181 , B01J31/1815 , B01J31/183 , B01J31/2273 , B01J31/28 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C6/06 , C07C2531/22 , C07F15/002 , C07F15/0046 , C08G61/06
摘要： The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula wherein: M is ruthenium or osmium; X and XI are the same or different and are each independently an anionic ligand; L, L ?1' and L 2¿ are the same or different and are each independently a neutral electron donor ligand; and, R and R 1 are each independently hydrogen or a substituent selected from the group consisting of C¿1?-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl and silyl. Optionally, each of the R or R ?1¿ substituent group may be substituted with one or more moieties selected from the group consisting of C¿1?-C10 alkyl, C1-C10 alkoxy, and aryl which in turn may each be further substituted with one or more groups selected from a halogen, a C1-C5 alkyl, C1-C5 alkoxy, and phenyl. Moreover, any of the catalyst ligands may further include one or more functional groups. Examples of suitable functional groups include but are not limited to: hydroxyl, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, halogen, alcohol, sulfonic acid, phosphine, imide, acetal, ketal, boronate, cyano, cyanohydrin, hydrazine, enamine, sulfone, sulfide, and sulfenyl. In certain embodiments, at least one of L, L ?l' and L 2¿ is an N-heterocyclic carbene ligand.

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