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1. 发明申请

US20060014680A1 Peptides and compounds that bind to the IL-5 receptor 审中-公开
标题翻译：结合IL-5受体的肽和化合物
公开(公告)号：US20060014680A1
公开(公告)日：2006-01-19
申请号：US10890546
申请日：2004-07-13
申请人： Caiding Xu , Lydie Yang , Ashok Bhandari , Chris Holmes , Min-Jia Chen , Peter Schatz , Palani Balu
发明人： Caiding Xu , Lydie Yang , Ashok Bhandari , Chris Holmes , Min-Jia Chen , Peter Schatz , Palani Balu
IPC分类号： A61K38/16 , A61K38/08 , A61K38/10 , C07K7/64 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00
摘要： New IL-5 receptor antagonists and methods of use are described, e.g., in the treatment of IL-5 receptor mediated disorders. The compounds include both monomers and dimers that were identified using one or more of alanine scans, lysine scans, other residue substitutions, and C- and N-terminal truncations and additions vis a vis the core sequence Val Asp Glu Cys Trp Arg Ile Ile Ala Ser His Thr Trp Phe Cys Ala Glu Glu-AF17121 (SEQ ID NO: 1) and shorter sequences and derivatives thereof.
摘要翻译：描述了新的IL-5受体拮抗剂和使用方法，例如在治疗IL-5受体介导的病症中。化合物包括使用一个或多个丙氨酸扫描，赖氨酸扫描，其他残基取代和C-和N-末端截短并相对于核心序列添加的两种单体和二聚体Val Asp Glu Cys Trp Arg Ile Ile Ala Ser His Thr Trp Phe Cys Ala Glu Glu-AF17121（SEQ ID NO：1）及其较短的序列和衍生物。

2. 发明申请

US20050277588A1 Compounds having affinity for the granulocyte-colony stimulating factor receptor (G-CSFR) and associated uses 审中-公开
公开(公告)号：US20050277588A1
公开(公告)日：2005-12-15
申请号：US10929988
申请日：2004-08-30
申请人： Steven Cwirla , Palani Balu , David Duffin , Sunila Piplani , Barbara McEowen Merrill , Peter Schatz
发明人： Steven Cwirla , Palani Balu , David Duffin , Sunila Piplani , Barbara McEowen Merrill , Peter Schatz
IPC分类号： A61K38/00 , A61K38/08 , A61K38/10 , C07K7/06 , C07K7/08 , C07K14/53 , C07K14/535
CPC分类号： C07K14/53 , A61K38/00 , C07K14/535
摘要： Novel compounds are provided that bind to G-CSFR. The novel compounds have a peptide chain approximately 6 to 40 amino acids in length that binds to G-CSFR. The compounds are useful as probes for affinity screening. In addition, the compounds have demonstrated agonist or antagonist activity for the G-CSFR, and are therefore useful in treatment of diseases including patients who suffer from a low white blood cell titer. Pharmaceutical compositions and methods of use are provided as well.

3. 发明申请

US20050037959A1 Compounds having affinity for the granulocyte-colony stimulating factor receptor (G-CSFR) and associated uses 审中-公开
标题翻译：对粒细胞集落刺激因子受体（G-CSFR）具有亲和性的化合物及其相关用途
公开(公告)号：US20050037959A1
公开(公告)日：2005-02-17
申请号：US10659207
申请日：2003-09-09
申请人： Steven Cwirla , Palani Balu , David Duffin , Sunila Piplani , Barbara McEowen Merrill , Peter Schatz
发明人： Steven Cwirla , Palani Balu , David Duffin , Sunila Piplani , Barbara McEowen Merrill , Peter Schatz
IPC分类号： A61K38/00 , A61K38/08 , A61K38/10 , C07K7/06 , C07K7/08 , C07K14/53 , C07K14/535 , A61K38/17 , C07K14/47
CPC分类号： C07K14/53 , A61K38/00 , C07K14/535
摘要： Novel compounds are provided that bind to G-CSFR. The novel compounds have a peptide chain approximately 6 to 40 amino acids in length that binds to G-CSFR. The compounds are useful as probes for affinity screening. In addition, the compounds have demonstrated agonist or antagonist activity for the G-CSFR, and are therefore useful in treatment of diseases including patients who suffer from a low white blood cell titer. Pharmaceutical compositions and methods of use are provided as well.
摘要翻译：提供结合G-CSFR的新型化合物。新化合物具有长度约6至40个氨基酸的肽链，其结合G-CSFR。该化合物可用作亲和筛选的探针。此外，化合物已经证明了G-CSFR的激动剂或拮抗剂活性，因此可用于治疗疾病，包括患有低白细胞滴度的患者。也提供药物组合物和使用方法。

4. 发明申请

US20070148091A1 PEPTIDES AND COMPOUNDS THAT BIND TO A RECEPTOR 有权
标题翻译：与受体结合的肽和化合物
公开(公告)号：US20070148091A1
公开(公告)日：2007-06-28
申请号：US11610226
申请日：2006-12-13
申请人： William Dower , Ronald Barrett , Steven Cwirla , David Duffin , Christian Gates , Sherril Haselden , Larry Mattheakis , Peter Schatz , Christopher Wagstrom , Nicholas Wrighton
发明人： William Dower , Ronald Barrett , Steven Cwirla , David Duffin , Christian Gates , Sherril Haselden , Larry Mattheakis , Peter Schatz , Christopher Wagstrom , Nicholas Wrighton
IPC分类号： A61K51/00 , C07K7/64
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译：描述了结合并激活血小板生成素受体的肽和肽模拟物。这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。

5. 发明申请

US20060058240A1 Peptides and compounds that bind to a receptor 审中-公开
公开(公告)号：US20060058240A1
公开(公告)日：2006-03-16
申请号：US11254419
申请日：2005-10-20
申请人： William Dower , Ronald Barrett , Steven Cwirla , David Duffin , Christian Gates , Sherril Haselden , Larry Mattheakis , Peter Schatz , Christopher Wagstrom , Nicholas Wrighton
发明人： William Dower , Ronald Barrett , Steven Cwirla , David Duffin , Christian Gates , Sherril Haselden , Larry Mattheakis , Peter Schatz , Christopher Wagstrom , Nicholas Wrighton
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

6. 发明申请

US20070027074A1 Novel peptides that bind to the erythropoietin receptor 有权
标题翻译：结合促红细胞生成素受体的新型肽
公开(公告)号：US20070027074A1
公开(公告)日：2007-02-01
申请号：US10555868
申请日：2004-05-12
申请人： Christopher Holmes , Qun Yin , Guy Lalonde , Peter Schatz , David Tumelty , Balu Palani , Genet Zemede
发明人： Christopher Holmes , Qun Yin , Guy Lalonde , Peter Schatz , David Tumelty , Balu Palani , Genet Zemede
IPC分类号： A61K38/16 , A61K38/10 , C07K14/47
CPC分类号： C07K14/001 , A61K38/00 , A61K38/10 , A61K38/16 , C07K7/08 , C07K14/505
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译：本发明涉及作为促红细胞生成素受体（EPO-R）的激动剂的肽化合物。本发明还涉及使用这种肽化合物治疗与不充分或有缺陷的红细胞产生相关的疾病的治疗方法。还提供了包含本发明的肽化合物的药物组合物。

7. 发明授权

US07021577B2 Multi-roller crusher 有权
标题翻译：多辊破碎机
公开(公告)号：US07021577B2
公开(公告)日：2006-04-04
申请号：US10475076
申请日：2002-04-03
申请人： Detlef Papajewski , Peter Schatz
发明人： Detlef Papajewski , Peter Schatz
IPC分类号： B02C18/16
CPC分类号： B02C18/142 , B02C4/08 , B02C4/30 , B02C4/42
摘要： The invention relates to a multi-roller crusher for the comminuting of mineral mill-feed, whereby the crushing roll are provided with crushing teeth, extending in the circumferential and longitudinal axial directions. Viewed in plan, the crushing teeth are arranged on each crushing roller such that several serial crushing teeth groups are formed behind each other, the imagined connection lines of which run successively at an inclined angle to the plan (1′,2′) of each crushing roller outer edge in the direction of the crushing roller centre.
摘要翻译：本发明涉及一种用于粉碎矿物磨料进料的多辊破碎机，由此破碎辊设置有沿周向和纵向轴向延伸的破碎齿。在计划中看到，破碎齿布置在每个破碎辊上，使得几个连续的破碎齿组彼此相邻地形成，其想象的连接线与每个破碎辊的平面（1'，2'）倾斜地相对于每个破碎辊外缘沿破碎辊中心方向。

8. 发明申请

US20060040858A1 Novel peptides that bind to the erythropoietin receptor 有权
标题翻译：结合促红细胞生成素受体的新型肽
公开(公告)号：US20060040858A1
公开(公告)日：2006-02-23
申请号：US11261157
申请日：2005-10-27
申请人： Christopher Holmes , Qun Yin , Guy Lalonde , Peter Schatz , David Tumelty , Balu Palani , Genet Zemede
发明人： Christopher Holmes , Qun Yin , Guy Lalonde , Peter Schatz , David Tumelty , Balu Palani , Genet Zemede
IPC分类号： A61K38/12 , C07K7/64
CPC分类号： C07K14/001 , A61K38/00 , A61K47/60 , C07K14/505 , C07K2319/00
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译：本发明涉及作为促红细胞生成素受体（EPO-R）的激动剂的肽化合物。本发明还涉及使用这种肽化合物治疗与不充分或有缺陷的红细胞产生相关的疾病的治疗方法。还提供了包含本发明的肽化合物的药物组合物。

9. 发明申请

US20050137329A1 Novel peptides that bind to the erythropoietin receptor 失效
标题翻译：结合促红细胞生成素受体的新型肽
公开(公告)号：US20050137329A1
公开(公告)日：2005-06-23
申请号：US10844968
申请日：2004-05-12
申请人： Christopher Holmes , Qun Yin , Guy Lalonde , Peter Schatz , David Tumelty , Balu Palani , Genet Zemede
发明人： Christopher Holmes , Qun Yin , Guy Lalonde , Peter Schatz , David Tumelty , Balu Palani , Genet Zemede
IPC分类号： A61K38/00 , A61K38/12 , A61K38/18 , C07K7/64 , C07K14/00 , C07K14/505 , C07K14/71 , C08G63/48 , C08G63/91
CPC分类号： C07K14/001 , A61K38/00 , A61K47/60 , C07K14/505 , C07K2319/00
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译：本发明涉及作为促红细胞生成素受体（EPO-R）的激动剂的肽化合物。本发明还涉及使用这种肽化合物治疗与不充分或有缺陷的红细胞产生相关的疾病的治疗方法。还提供了包含本发明的肽化合物的药物组合物。

10. 发明授权

US5277370A Vertical impact mill with coupled material classification 失效
标题翻译：垂直冲击磨机，配合材料分类
公开(公告)号：US5277370A
公开(公告)日：1994-01-11
申请号：US779005
申请日：1992-08-24
申请人： Peter Schatz
发明人： Peter Schatz
IPC分类号： B02C13/14 , B02C13/18 , B02C21/00 , B02C23/22 , B02C23/30 , B07B4/02 , B07B7/083 , B07B9/02 , B02C23/08
CPC分类号： B02C13/1835 , B02C23/22 , B07B4/025 , B07B7/083 , B07B9/02 , B02C2013/1885
摘要： A device for crushing and screening bulk materials consists of a vertical impact mill with associated feeder, an air-charged separator, a discharge device for the final product and a conveyor for returning the insufficiently crushed bulk materials fraction to the crushing region. The vertical impact mill and the separator are arranged on a divided drive shaft, which can be coupled if necessary. The separator is arranged below the vertical impact mill and is designed as a distributor plate, possibly with guide blades. The air is introduced laterally or tangentially below the distributor plate. The finished materials fraction is discharged laterally or tangentially above the distributor plate and conveyed to separator (cyclone) which may be connected downstream. The insufficiently crushed bulk materials fractions are discharged through an outlet below the distributor plate in the base region of the separator. The outlet co-operates with the conveying device which returns the bulk materials fractions to the region of the feeder.
摘要翻译： PCT No.PCT / EP91 / 00236 Sec。 371日期：1992年8月24日 102（e）日期1992年8月24日PCT 1991年2月8日PCT PCT。公开号WO91 / 12892 1991年9月5日。用于破碎和筛分散装材料的装置包括具有相关进料器的垂直冲击研磨机，充气分离器，用于最终产品的排出装置和用于将不充分破碎的散装材料部分返回到破碎区域。垂直冲击式磨机和分离器布置在分开的驱动轴上，如果需要可以联接。分离器布置在垂直冲击磨机的下方，并被设计为分配器板，可能具有导向叶片。空气横向或切向地分布在分配板下方。成品材料馏分横向或切向排出分配器板上方并输送到可以连接在下游的分离器（旋风分离器）。不充分破碎的散装材料部分通过分离器板下方的分离器底部区域中的出口排出。出口与输送装置配合，输送装置将散装材料部分返回到进料器的区域。

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