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1. 发明申请

WO2005117963A1 MEDICAL USES OF CARRIER CONJUGATES OF NON-HUMAN TNF-PEPTIDES 审中-公开
标题翻译：非人TNF-α载体结合的医学用途
公开(公告)号：WO2005117963A1
公开(公告)日：2005-12-15
申请号：PCT/EP2005/005935
申请日：2005-06-02
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin, F. , MAURER, Patrik , SPOHN, Gunther
发明人： BACHMANN, Martin, F. , MAURER, Patrik , SPOHN, Gunther
IPC分类号： A61K39/385
CPC分类号： A61K39/0005 , A61K39/0008 , A61K39/385 , A61K47/6901 , A61K2039/5258 , A61K2039/6031 , A61K2039/6075 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K14/70575 , C12N7/00 , C12N2795/18122 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising- a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto for use in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了一种修饰的病毒样颗粒（VLP），其包含VLP和源自与其连接的TNF-超家族的多肽的特定肽，用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗，以及以有效地诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

2. 发明申请

WO2005117983A2 CARRIER CONJUGATES OF TNF-PEPTIDES 审中-公开
标题翻译：携带者TNF-PEPTIDES的结合
公开(公告)号：WO2005117983A2
公开(公告)日：2005-12-15
申请号：PCT/EP2005/005936
申请日：2005-06-02
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin, F. , MAURER, Patrik , SPOHN, Gunther
发明人： BACHMANN, Martin, F. , MAURER, Patrik , SPOHN, Gunther
IPC分类号： A61K47/48
CPC分类号： C12N7/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C07K14/525 , C07K2319/00 , C12N2710/00023 , C12N2730/10123 , C12N2795/00023
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含VLP和源自与其连接的TNF-超家族的多肽的特定肽的修饰的病毒样颗粒（VLP）。本发明还提供了制备修饰的VLP的方法。本发明的经修饰的VLP可用于生产用于治疗自身免疫性疾病和骨相关疾病并有效诱导免疫应答，特别是抗体应答的疫苗。此外，本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫应答。

3. 发明申请

WO2003039225A2 ANTIGEN ARRAYS FOR TREATMENT OF BONE DISEASE 审中-公开
标题翻译：用于治疗骨质疏松症的抗原阵列
公开(公告)号：WO2003039225A2
公开(公告)日：2003-05-15
申请号：PCT/EP2002/012449
申请日：2002-11-07
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , MAURER, Patrik , SPOHN, Gunther
发明人： BACHMANN, Martin , MAURER, Patrik , SPOHN, Gunther
IPC分类号： A61K39/12 , A61K38/11 , A61K38/19 , A61K39/00 , A61K39/02 , A61K39/165 , A61K39/21 , A61K39/29 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/48 , A61P1/02 , A61P19/00 , A61P19/08 , A61P25/28 , A61P35/00 , C07K14/02 , C07K14/08 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/08 , C07K16/22 , C07K16/28 , C07K16/40 , C07K16/42 , C12N7/01
CPC分类号： A61K39/35 , A61K38/00 , A61K39/0007 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2710/20022 , C12N2730/10122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

4. 发明申请

WO2011029870A1 USE OF INTERLEUKIN-1 BETA MUTEIN CONJUGATES IN THE TREATMENT OF DIABETES 审中-公开
标题翻译：在治疗糖尿病中使用白细胞介素-1β蛋白偶联物
公开(公告)号：WO2011029870A1
公开(公告)日：2011-03-17
申请号：PCT/EP2010/063237
申请日：2010-09-09
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SPOHN, Gunther , MAURER, Patrik
发明人： BACHMANN, Martin , SPOHN, Gunther , MAURER, Patrik
IPC分类号： A61K47/48 , A61K38/20 , A61K39/385 , C07K14/545 , A61P3/10
CPC分类号： A61K39/385 , A61K39/0005 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C07K14/545
摘要： The present invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and / or prophylaxis of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a virus-like particle of an RNA bacteriophage and an antigen, wherein said antigen comprises an interleukin-1 beta (IL-1β) mutein. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1β. Thus, the invention provides methods of treating, ameliorating or preventing type II diabetes by way of active immunization against IL-1β.
摘要翻译：本发明提供用于治疗，改善和/或预防II型糖尿病的组合物，药物组合物和疫苗。本发明的组合物，药物组合物和疫苗包含RNA噬菌体和抗原的病毒样颗粒，其中所述抗原包含白细胞介素-1β（IL-1β）突变蛋白。当施用于动物，优选给人时，所述组合物，药物组合物和疫苗诱导有效的免疫应答，特别是抗体应答，其中通常且优选所述抗体应答针对IL-1β。因此，本发明提供了通过对IL-1β的主动免疫来治疗，改善或预防II型糖尿病的方法。

5. 发明申请

WO2003039225A3 ANTIGEN ARRAYS COMPRISING RANKL FOR TREATMENT OF BONE DISEASE 审中-公开
公开(公告)号：WO2003039225A3
公开(公告)日：2003-05-15
申请号：PCT/EP2002/012449
申请日：2002-11-07
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , MAURER, Patrik , SPOHN, Gunther
发明人： BACHMANN, Martin , MAURER, Patrik , SPOHN, Gunther
IPC分类号： A61K39/39
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

6. 发明申请

WO2009109643A2 USE OF INTERLEUKIN-1 CONJUGATES IN THE TREATMENT OF DIABETES 审中-公开
标题翻译：在治疗糖尿病中使用白介素-1结合蛋白
公开(公告)号：WO2009109643A2
公开(公告)日：2009-09-11
申请号：PCT/EP2009/052639
申请日：2009-03-05
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SPOHN, Gunther
发明人： BACHMANN, Martin , SPOHN, Gunther
IPC分类号： A61K38/20 , C07K14/545 , A61K39/12 , A61P3/10
CPC分类号： C07K14/545 , A61K38/2006 , A61K2039/5258 , C12N2795/18123
摘要： The invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and / or prophylaxis of diabetes, preferably of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a core particle and an antigen, wherein said antigen comprises an interleukin-1 (IL-I) molecule. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-I. Thus, the invention provides methods of treating, ameliorating or preventing diabetes, preferably type II diabetes, by way of active immunization against IL-I.
摘要翻译：本发明提供用于治疗，改善和/或预防糖尿病，优选II型糖尿病的组合物，药物组合物和疫苗。本发明的组合物，药物组合物和疫苗包含核心颗粒和抗原，其中所述抗原包含白细胞介素-1（IL-1）分子。当施用于动物，优选给人时，所述组合物，药物组合物和疫苗诱导有效的免疫应答，特别是抗体应答，其中通常且优选地所述抗体应答针对IL-1。因此，本发明提供了通过对IL-1的主动免疫来治疗，改善或预防糖尿病，优选II型糖尿病的方法。

7. 发明申请

WO2008037504A1 INTERLEUKIN-1 MUTEINS LINKED TO VIRUS-LIKE PARTICLES TO TREAT IL-1 ASSOCIATED DISEASES 审中-公开
标题翻译：与IL-1相关疾病相关的病毒颗粒连接的白细胞介素-1
公开(公告)号：WO2008037504A1
公开(公告)日：2008-04-03
申请号：PCT/EP2007/053007
申请日：2007-03-29
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SPOHN, Gunther , TISSOT, Alain
发明人： BACHMANN, Martin , SPOHN, Gunther , TISSOT, Alain
IPC分类号： A61K39/385 , C12N7/04 , C07K14/545
CPC分类号： C07K14/545 , A61K39/0005 , A61K2039/5258 , C12N7/00 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 mutein. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 mutein linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序重复抗原阵列的组合物，其中抗原是IL-1突变蛋白。更具体地，本发明提供了包含病毒样颗粒和与其连接的至少一种IL-1突变蛋白的组合物。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产用于治疗炎性疾病，慢性自身免疫性疾病，遗传性疾病和心血管疾病的疫苗。本发明的组合物有效地诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

8. 发明申请

WO2007039552A1 INTERLEUKIN-1 CONJUGATES AND USES THEREOF 审中-公开
标题翻译：白细胞介素-1结合物及其用途
公开(公告)号：WO2007039552A1
公开(公告)日：2007-04-12
申请号：PCT/EP2006/066866
申请日：2006-09-28
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SPOHN, Gunther
发明人： BACHMANN, Martin , SPOHN, Gunther
IPC分类号： A61K39/385 , C12N7/04 , C07K14/545
CPC分类号： C07K14/545 , A61K38/00 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2795/18122 , C12N2795/18123
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序重复抗原阵列的组合物，其中抗原是IL-1蛋白，IL-1突变蛋白或IL-1片段。更具体地，本发明提供了包含病毒样颗粒和至少一种IL-1蛋白，IL-1突变蛋白或与其连接的至少一个IL-1片段的组合物。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产用于治疗炎性疾病，慢性自身免疫性疾病，遗传性疾病和心血管疾病的疫苗。本发明的组合物有效地诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

9. 发明公开

EP2265281A2 USE OF INTERLEUKIN-1 CONJUGATES IN THE TREATMENT OF DIABETES 审中-公开
标题翻译：白细胞介素1的缀合物在糖尿病的治疗中使用
公开(公告)号：EP2265281A2
公开(公告)日：2010-12-29
申请号：EP09717553.3
申请日：2009-03-05
申请人： Cytos Biotechnology AG
发明人： BACHMANN, Martin , SPOHN, Gunther
IPC分类号： A61K38/20 , C07K14/545 , A61K39/12 , A61P3/10
CPC分类号： C07K14/545 , A61K38/2006 , A61K2039/5258 , C12N2795/18123
摘要： The invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and / or prophylaxis of diabetes, preferably of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a core particle and an antigen, wherein said antigen comprises an interleukin-1 (IL-I) molecule. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-I. Thus, the invention provides methods of treating, ameliorating or preventing diabetes, preferably type II diabetes, by way of active immunization against IL-I.

10. 发明授权

EP1441764B1 ANTIGEN ARRAYS COMPRISING RANKL FOR TREATMENT OF BONE DISEASE 有权
标题翻译：抗原GRID含RANKL用于治疗骨病CHINESE。
公开(公告)号：EP1441764B1
公开(公告)日：2008-10-29
申请号：EP02779538.4
申请日：2002-11-07
申请人： Cytos Biotechnology AG
发明人： BACHMANN, Martin , MAURER, Patrik , SPOHN, Gunther
IPC分类号： A61K39/39
CPC分类号： A61K39/35 , A61K38/00 , A61K39/0007 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2710/20022 , C12N2730/10122

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