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1. 发明申请

WO2014153107A1 HYDRODYNAMIC FOCUSING APPARATUS AND METHODS 审中-公开
标题翻译：水动力聚焦装置和方法
公开(公告)号：WO2014153107A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/029090
申请日：2014-03-14
申请人： CYTONOME/ST, LLC
发明人： KOKSAL, Erin , SHARPE, Johnathan, Charles , BUCHANAN, Kristopher, Scott , MORAD, Blair, D.
IPC分类号： G01N15/14
CPC分类号： B01L3/502776 , B01F13/0062 , B01L2200/0636 , F17D1/08 , F17D5/00 , G01N15/1404 , G01N2015/1409 , G01N2015/1411 , G01N2015/1413 , Y10T137/8359
摘要： A microfluidic chip having a micro channel for processing a sample is provided. The micro channel may focus the sample by using focusing fluid and a core stream forming geometry. The core stream forming geometry may include a lateral fluid focusing component and one or more vertical fluid focusing components. A microfluidic chip may include a plurality micro channels operating in parallel on a microfluidic chip.
摘要翻译：提供了具有用于处理样品的微通道的微流控芯片。微通道可以通过使用聚焦流体和形成核心流的几何形状来聚焦样品。核心流形成几何形状可以包括侧向流体聚焦部件和一个或多个垂直流体聚焦部件。微流控芯片可以包括在微流体芯片上并行操作的多个微通道。

2. 发明申请

WO2014152048A2 ASSEMBLIES AND METHODS FOR REDUCING OPTICAL CROSSTALK IN PARTICLE PROCESSING SYSTEMS 审中-公开
标题翻译：用于减少粒子处理系统中光学串扰的组件和方法
公开(公告)号：WO2014152048A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/026877
申请日：2014-03-13
申请人： CYTONOME/ST, LLC
发明人： SHARPE, Johnathan, Charles , PERRAULT, Donald, Frances, Jr. , MACHADO, Emanuel Tito, Mendes , MORAD, Blair, D.
IPC分类号： G01N15/14
CPC分类号： G01N15/1434 , G01N15/10 , G01N15/14 , G01N15/1429
摘要： The present disclosure relates to optical crosstalk reduction in particle processing (e.g., cytometry including flow cytometry using microfluidic based sorters, drop formation based sorters, and/or cell purification) systems and methods in order to improve performance. More particularly, the present disclosure relates to assemblies, systems and methods for minimizing optical crosstalk during the analyzing, sorting, and/or processing (e.g., purifying, measuring, isolating, detecting, monitoring and/or enriching) of particles (e.g., cells, microscopic particles, etc.). The exemplary systems and methods for crosstalk reduction in particle processing systems (e.g., cell purification systems) may be particularly useful in the area of cellular medicine or the like. The systems and methods may be modular and used singly or in combination to optimize cell purification based on the crosstalk environment and specific requirements of the operator and/or system.
摘要翻译：本公开涉及粒子加工中的光学串扰减少（例如，包括使用基于微流体分选器的流式细胞术的流式细胞仪，基于液滴形成的分选器和/或细胞纯化）系统和方法以改善性能。更具体地说，本公开涉及用于在分析，分选和/或处理颗粒（例如，细胞）的过程（例如纯化，测量，分离，检测，监测和/或富集）期间最小化光学串扰的组件，系统和方法。，微观颗粒等）。用于在粒子处理系统（例如细胞纯化系统）中减少串扰的示例性系统和方法可能在细胞医学等领域特别有用。该系统和方法可以是模块化的并且可以单独使用或组合使用，以基于串扰环境和操作员和/或系统的特定要求来优化细胞净化。

3. 发明申请

WO2011097591A2 PARTICLE PROCESSING SYSTEMS AND METHODS FOR NORMALIZATION/CALIBRATION OF SAME 审中-公开
标题翻译：颗粒加工系统及其正规化/校准方法
公开(公告)号：WO2011097591A2
公开(公告)日：2011-08-11
申请号：PCT/US2011/023945
申请日：2011-02-07
申请人： CYTONOME/ST, LLC , SHARPE, Johnathan, Charles , MACHADO, Emanuel, Tito Mendes , HULSPAS, Ruud
发明人： SHARPE, Johnathan, Charles , MACHADO, Emanuel, Tito Mendes , HULSPAS, Ruud
IPC分类号： G01N15/10 , G01N15/14
CPC分类号： G01N15/1484 , G01N15/1012 , G01N15/1056 , G01N15/1429 , G01N15/1459 , G01N21/53 , G01N21/64 , G01N2015/1018 , G01N2015/1075 , G01N2015/1402 , G01N2015/149
摘要： Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard.
摘要翻译：本文公开了系统，方法和非暂时性存储介质，用于调整表示在颗粒处理系统的流动路径中流动的颗粒的颗粒特性的颗粒检查系统的输出。更具体地，可以处理输出并生成校准的粒子特性的输出。在其它实施方案中，使用一种或多种校准颗粒。因此，可以相对于标准比较代表在粒子处理系统的流路中流动的一个或多个校准粒子的粒子特性的粒子检查系统的输出，并且可以基于将输出与标准进行比较。

4. 发明申请

WO2014152039A9 OPERATORLESS PARTICLE PROCESSING SYSTEMS AND METHODS 审中-公开
标题翻译：无需操作的粒子处理系统和方法
公开(公告)号：WO2014152039A9
公开(公告)日：2014-09-25
申请号：PCT/US2014/026858
申请日：2014-03-13
申请人： CYTONOME/ST, LLC
发明人： SHARPE, Johnathan, Charles , SEDOGLAVICH, Nemanya , SHAPIRO, Vladimir , EHRLICH, Stuart, R. , PERRAULT, Donald, Francis, Jr. , MORAD, Blair, D.
IPC分类号： G01N15/14 , G01N15/10
摘要： The present disclosure provides improved particle processing (e.g., cytometry and/or cell purification) systems and methods that can operate in an autonomous fashion. More particularly, the present disclosure provides for assemblies, systems and methods for analyzing, sorting, and/or processing (e.g., purifying, measuring, isolating, detecting and/or enriching) particles (e.g., cells, microscopic particles, etc.) where human intervention is not required and/or is minimized. The systems, assemblies and methods of the present disclosure advantageously improve run performance of particle processing systems (e.g., cell purification systems, cytometers) by significantly reducing and/or substantially eliminating the burden of operation for human intervention by automating numerous functions, features and/or steps of the disclosed systems and methods.
摘要翻译：本公开提供了可以自主方式操作的改进的颗粒加工（例如，细胞计数和/或细胞纯化）系统和方法。更具体地说，本公开提供了用于分析，分选和/或处理（例如纯化，测量，分离，检测和/或富集）颗粒（例如细胞，微观颗粒等）的组件，系统和方法，其中人为干预不是必需的和/或被最小化。本公开的系统，组件和方法通过显着地减少和/或基本消除用于人类干预的操作负担，通过使许多功能，特征和/或功能自动化而有利地改进了颗粒处理系统（例如，细胞净化系统，细胞计数仪）或所公开的系统和方法的步骤。

5. 发明申请

WO2014047206A1 FLOW CELL FOR PARTICLE SORTING 审中-公开
标题翻译：用于颗粒分级的流动池
公开(公告)号：WO2014047206A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060454
申请日：2013-09-18
申请人： CYTONOME/ST, LLC
发明人： SHARPE, Johnathan, Charles , HULSPAS, Rudolf , BUCHANAN, Kris, S.
IPC分类号： G01N15/14
CPC分类号： G01N15/1436 , G01N15/1404 , G01N15/1459 , G01N2015/149 , Y10T436/25375
摘要： A flow cell for particle processing such as particle sorting, may be operatively engaged to a particle processing apparatus. The fluid contact surfaces of the flow cell may be fully enclosed. Further, the flow cell may encapsulate all fluid contact surfaces in the particle processing apparatus. The enclosing or encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The flow cell may employ any suitable technique for processing particles. The flow cell may be disposable and suitable for use in droplet sorting. The flow cell may include an operatively sealed sort chamber having a particle stream focusing region, an orifice, an interrogation zone and a sorting region.
摘要翻译：用于颗粒处理的流动池例如颗粒分选可以可操作地接合到颗粒处理装置。流动池的流体接触表面可以是完全封闭的。此外，流动池可以将所有流体接触表面封装在颗粒处理装置中。流体接触表面的封闭或封装确保，改善或促进操作者隔离和/或产品隔离。流动池可以采用任何合适的处理颗粒的技术。流动池可以是一次性的并且适合用于液滴分选。流动池可以包括具有颗粒流聚焦区域，孔口，询问区域和分选区域的可操作地密封的分类室。

6. 发明申请

WO2012106645A1 FLUID STREAM IMAGING APPARATUS 审中-公开
标题翻译：流体流成像设备
公开(公告)号：WO2012106645A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023843
申请日：2012-02-03
申请人： CYTONOME/ST, LLC , SHARPE, Johnathan, Charles , PERRAULT, Donald, Francis , SEDOGLAVICH, Nemanya
发明人： SHARPE, Johnathan, Charles , PERRAULT, Donald, Francis , SEDOGLAVICH, Nemanya
IPC分类号： G01N15/14
CPC分类号： G01N15/14 , G01N1/08 , G01N15/1404 , G01N15/1434 , G01N2015/1406 , G01N2015/144 , G01N2015/149
摘要： A fluid stream imaging apparatus having either optics for manipulating the aspect ratio or sensing elements configured for manipulating the aspect ratio of an image of the fluid stream. This application may also relate to a system for acquiring images of a portion of a fluid stream at high speeds for image processing to measure and predict droplet delays for individual forming particles.
摘要翻译：流体流成像装置具有用于操纵纵横比的光学元件或被配置用于操纵流体流的图像的纵横比的感测元件。该应用还可以涉及用于以高速获取流体流的一部分图像以进行图像处理以测量和预测单个成形颗粒的液滴延迟的系统。

7. 发明申请

WO2011097032A1 MULTIPLE FLOW CHANNEL PARTICLE ANALYSIS SYSTEM 审中-公开
标题翻译：多通道流通粒子分析系统
公开(公告)号：WO2011097032A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/000211
申请日：2011-02-04
申请人： CYTONOME/ST, LLC , SHARPE, Johnathan, Charles , MACHADO, Emanuel, Tito Mendes , MORAD, Blair, David , HULSPAS, Rudolf , PERRAULT, Donald, Francis, Jr.
发明人： SHARPE, Johnathan, Charles , MACHADO, Emanuel, Tito Mendes , MORAD, Blair, David , HULSPAS, Rudolf , PERRAULT, Donald, Francis, Jr.
IPC分类号： C12Q1/04 , G01N21/47
CPC分类号： G01N15/1484 , G01N15/1012 , G01N15/1056 , G01N15/1429 , G01N15/1459 , G01N21/53 , G01N21/64 , G01N2015/1018 , G01N2015/1075 , G01N2015/1402 , G01N2015/149
摘要： A microfluidic multiple channel particle analysis system (1) which allows particles (2) from a plurality of particle sources (3) to be independently simultaneously entrained in a corresponding plurality of fluid streams (4) for analysis and sorting into particle subpopulations (5) based upon one or more particle characteristics (6).
摘要翻译：允许来自多个颗粒源（3）的颗粒（2）独立地同时夹带在相应的多个流体流（4）中用于分析和分选成颗粒子群体（5）的微流体多通道粒子分析系统（1）基于一个或多个颗粒特征（6）。

8. 发明公开

EP4134656A1 ASSEMBLIES AND METHODS FOR REDUCING OPTICAL CROSSTALK IN PARTICLE PROCESSING SYSTEMS 审中-实审
公开(公告)号：EP4134656A1
公开(公告)日：2023-02-15
申请号：EP22196397.8
申请日：2014-03-13
申请人： Cytonome/ST, LLC
发明人： SHARPE, Johnathan, Charles , PERRAULT, Donald, Frances, Jr. , MACHADO, Emanuel Tito, Mendes , MORAD, Blair, D.
IPC分类号： G01N15/14
摘要： The present disclosure relates to optical crosstalk reduction in particle processing (e.g., cytometry including flow cytometry using microfluidic based sorters, drop formation based sorters, and/or cell purification) systems and methods in order to improve performance. More particularly, the present disclosure relates to assemblies, systems and methods for minimizing optical crosstalk during the analyzing, sorting, and/or processing (e.g., purifying, measuring, isolating, detecting, monitoring and/or enriching) of particles (e.g., cells, microscopic particles, etc.). The exemplary systems and methods for crosstalk reduction in particle processing systems (e.g., cell purification systems) may be particularly useful in the area of cellular medicine or the like. The systems and methods may be modular and used singly or in combination to optimize cell purification based on the crosstalk environment and specific requirements of the operator and/or system.

9. 发明公开

EP2972206A2 OPERATORLESS PARTICLE PROCESSING SYSTEMS AND METHODS 有权转让
标题翻译： BEDIENERLOSE PARTIKELVERARBEITUNGSSYSTEME UND-FORFAHREN
公开(公告)号：EP2972206A2
公开(公告)日：2016-01-20
申请号：EP14720363.2
申请日：2014-03-13
申请人： Cytonome/ST, LLC
发明人： MORAD, Blair, D. , SHARPE, Johnathan, Charles , SEDOGLAVICH,Nemanya , SHAPIRO, Vladimir , EHRLICH, Stuart, R. , PERRAULT, Donald, Francis, Jr.
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G05D21/02 , G01N15/1404 , G01N15/1425 , G01N15/1484 , G01N2015/1006 , G01N2015/1406 , G01N2015/1452 , G01N2015/149
摘要： The present disclosure provides improved particle processing (e.g., cytometry and/or cell purification) systems and methods that can operate in an autonomous fashion. More particularly, the present disclosure provides for assemblies, systems and methods for analyzing, sorting, and/or processing (e.g., purifying, measuring, isolating, detecting and/or enriching) particles (e.g., cells, microscopic particles, etc.) where human intervention is not required and/or is minimized. The systems, assemblies and methods of the present disclosure advantageously improve run performance of particle processing systems (e.g., cell purification systems, cytometers) by significantly reducing and/or substantially eliminating the burden of operation for human intervention by automating numerous functions, features and/or steps of the disclosed systems and methods.
摘要翻译：本公开提供可以以自主的方式操作的改进的颗粒处理（例如，细胞计数和/或细胞纯化）系统和方法。更具体地，本公开提供了用于分析，分选和/或处理（例如，净化，测量，分离，检测和/或富集）颗粒（例如，细胞，微观颗粒等）的组件，系统和方法，其中不需要人力干预和/或被最小化。本公开的系统，组件和方法有利地通过自动化许多功能，特征和/或功能来显着地减少和/或基本上消除人为干预的操作负担来改善颗粒处理系统（例如细胞纯化系统，细胞计数器）的运行性能，或所公开的系统和方法的步骤。

10. 发明授权

EP2531832B1 PARTICLE PROCESSING SYSTEMS AND METHODS FOR NORMALIZATION/CALIBRATION OF SAME 有权转让
公开(公告)号：EP2531832B1
公开(公告)日：2020-05-27
申请号：EP11707946.7
申请日：2011-02-07
申请人： Cytonome/ST, LLC
发明人： SHARPE, Johnathan, Charles , MACHADO, Emanuel, Tito Mendes , HULSPAS, Ruud
IPC分类号： G01N15/10 , G01N15/14

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