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1. 发明申请

WO2015048329A3 MATRIX METALLOPROTEINASE SUBSTRATES AND OTHER CLEAVABLE MOIETIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：基质金属蛋白酶基质和其他可清除的动物及其使用方法
公开(公告)号：WO2015048329A3
公开(公告)日：2015-06-04
申请号：PCT/US2014057523
申请日：2014-09-25
申请人： CYTOMX THERAPEUTICS INC
发明人： MOORE STEPHEN JAMES , NGUYEN MARGARET THY LUU , HOSTETTER DANIEL R , VASILJEVA OLGA , FLANDEZ JEANNE GRACE
IPC分类号： A61K39/395 , C07K16/18 , C07K16/46
CPC分类号： C07K16/2866 , C07K7/06 , C07K16/2863 , C07K16/44 , C07K2317/73 , C07K2319/50
摘要： The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.
摘要翻译：本发明一般涉及包含可切割部分的多肽，其是至少一种基质金属蛋白酶（MMP）的底物，可激活的抗体和其它较大的分子，其包括作为至少一种MMP蛋白酶的底物的可切割部分，以及制备和使用这些多肽的方法，其包括在多种治疗，诊断和预防指征中作为至少一种MMP蛋白酶的底物的可切割部分。

2. 发明专利

CA2925106A1 MATRIX METALLOPROTEINASE SUBSTRATES AND OTHER CLEAVABLE MOIETIES AND METHODS OF USE THEREOF 未知
公开(公告)号：CA2925106A1
公开(公告)日：2015-04-02
申请号：CA2925106
申请日：2014-09-25
申请人： CYTOMX THERAPEUTICS INC
发明人： MOORE STEPHEN JAMES , NGUYEN MARGARET THY LUU , HOSTETTER DANIEL R , VASILJEVA OLGA , FLANDEZ JEANNE GRACE
IPC分类号： A61K39/395 , C07K16/18 , C07K16/46
摘要： The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.

3. 发明专利

AR113446A1 ANTICUERPOS, ANTICUERPOS ACTIVABLES, ANTICUERPOS BIESPECÍFICOS, Y ANTICUERPOS ACTIVABLES BIESPECÍFICOS, Y MÉTODOS DE USO DE LOS MISMOS 未知
公开(公告)号：AR113446A1
公开(公告)日：2020-05-06
申请号：ARP180102968
申请日：2018-10-12
申请人： CYTOMX THERAPEUTICS INC
发明人： FLANDEZ JEANNE GRACE , IRVING BRYAN A , LA PORTE SHERRY L , BOUSTANY LEILA MARIE
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N5/10 , C12N15/62 , C12N15/85
摘要： En la presente se proveen anticuerpos, anticuerpos activables (AA), anticuerpos biespecíficos, y anticuerpos activables biespecíficos (BAA). También se proveen métodos para preparar y usar estos anticuerpos, AA, anticuerpos biespecíficos, y BAA. Reivindicación 1: Un anticuerpo activable biespecífico (BAA), donde dicho BAA, cuando se activa, se une específicamente a dos blancos; dicho anticuerpo activable biespecífico caracterizado porque comprende la siguiente estructura: a) un anticuerpo IgG (AB1) que se une específicamente a un primer blanco, donde el AB1 comprende dos cadenas pesadas (AB1 HCs) y dos cadenas livianas (AB1 LCs); y donde el AB1 se une a un primer resto de enmascaramiento (MM1) unido a un primer resto escindible (CM1) para formar un constructo de MM1-CM1, donde el extremo carboxilo terminal de un constructo de MM1-CM1 se une a cada extremo amino terminal de cada cadena liviana del AB1, donde: el MM1 inhibe la unión del AB1 a su blanco; y el CM1 es un polipéptido que funciona como un sustrato para una primera proteasa, b) dos scFv (cada uno un AB2) que se unen específicamente a un segundo blanco, donde cada AB2 comprende una región variable de la cadena liviana unida a una región variable de la cadena pesada, donde el extremo carboxilo terminal de cada AB2 se une al extremo amino terminal de cada una de las cadenas pesadas de AB1; y donde cada AB2 se une a un segundo resto de enmascaramiento (MM2) unido a un segundo resto escindible (CM2) para formar un constructo de MM2-CM2, donde el extremo carboxilo terminal de cada constructo de MM2-CM2 se une al extremo amino terminal de cada AB2 donde: el MM2 inhibe la unión del AB2 a su blanco; y el CM2 es un polipéptido que funciona como un sustrato para una segunda proteasa, y donde el BAA tiene al menos una de las siguientes características: i) MM2 comprende la secuencia de aminoácidos de la SEQ ID Nº 12; ii) MM1 comprende una secuencia de aminoácidos seleccionada del grupo que consiste en las secuencias presentadas en la Tabla 7; iii) AB2 comprende un dominio variable de la cadena pesada como se expone en la SEQ ID Nº 2 o SEQ ID Nº 3 o un dominio variable de la cadena liviana como se expone en la SEQ ID Nº 1 o SEQ ID Nº 4; y iv) AB1 comprende una región Fc que comprende una sustitución de aminoácidos en al menos una de posiciones de aminoácidos L234, L235, N297, y P331, numerada por el índice EU como se expone en Kabat, de modo que el BAA tiene función efectora reducida.

4. 发明专利

SG11202002384VA ANTIBODIES, ACTIVATABLE ANTIBODIES, BISPECIFIC ANTIBODIES, AND BISPECIFIC ACTIVATABLE ANTIBODIES AND METHODS OF USE THEREOF 未知
公开(公告)号：SG11202002384VA
公开(公告)日：2020-04-29
申请号：SG11202002384V
申请日：2018-10-12
申请人： CYTOMX THERAPEUTICS INC
发明人： BOUSTANY LEILA MARIE , LA PORTE SHERRY L , IRVING BRYAN A , FLANDEZ JEANNE GRACE
IPC分类号： C07K16/28
摘要： Provided herein antibodies, activatable antibodies (AAs), bispecific antibodies, and bispecific activatable antibodies (BAAs). Also provided herein are methods of making and methods of use of these antibodies, AAs, bispecific antibodies, and BAAs.

5. 发明专利

AU2014324884A1 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof 未知
公开(公告)号：AU2014324884A1
公开(公告)日：2016-04-21
申请号：AU2014324884
申请日：2014-09-25
申请人： CYTOMX THERAPEUTICS INC
发明人： MOORE STEPHEN JAMES , NGUYEN MARGARET THY LUU , HOSTETTER DANIEL R , VASILJEVA OLGA , FLANDEZ JEANNE GRACE
IPC分类号： C07K16/18 , A61K39/395 , C07K16/46
摘要： The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.

6. 发明专利

AU2018347607A1 Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof 未知
公开(公告)号：AU2018347607A1
公开(公告)日：2020-03-26
申请号：AU2018347607
申请日：2018-10-12
申请人： CYTOMX THERAPEUTICS INC
发明人： BOUSTANY LEILA MARIE , LA PORTE SHERRY L , IRVING BRYAN A , FLANDEZ JEANNE GRACE
IPC分类号： C07K16/28
摘要： Provided herein antibodies, activatable antibodies (AAs), bispecific antibodies, and bispecific activatable antibodies (BAAs). Also provided herein are methods of making and methods of use of these antibodies, AAs, bispecific antibodies, and BAAs.

7. 发明专利

AU2014324884B2 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof 未知
公开(公告)号：AU2014324884B2
公开(公告)日：2020-03-26
申请号：AU2014324884
申请日：2014-09-25
申请人： CYTOMX THERAPEUTICS INC
发明人： MOORE STEPHEN JAMES , NGUYEN MARGARET THY LUU , HOSTETTER DANIEL R , VASILJEVA OLGA , FLANDEZ JEANNE GRACE
IPC分类号： C07K16/18 , A61K39/395 , C07K16/46
摘要： The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.

8. 发明专利

CA3078911A1 ANTIBODIES, ACTIVATABLE ANTIBODIES, BISPECIFIC ANTIBODIES, AND BISPECIFIC ACTIVATABLE ANTIBODIES AND METHODS OF USE THEREOF 未知
公开(公告)号：CA3078911A1
公开(公告)日：2019-04-18
申请号：CA3078911
申请日：2018-10-12
申请人： CYTOMX THERAPEUTICS INC
发明人： BOUSTANY LEILA MARIE , LA PORTE SHERRY L , IRVING BRYAN A , FLANDEZ JEANNE GRACE
IPC分类号： C07K16/28
摘要： Provided herein antibodies, activatable antibodies (AAs), bispecific antibodies, and bispecific activatable antibodies (BAAs). Also provided herein are methods of making and methods of use of these antibodies, AAs, bispecific antibodies, and BAAs.

9. 发明专利

AU2020203910A1 Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof 未知
公开(公告)号：AU2020203910A1
公开(公告)日：2020-07-02
申请号：AU2020203910
申请日：2020-06-12
申请人： CYTOMX THERAPEUTICS INC
发明人： MOORE STEPHEN JAMES , NGUYEN MARGARET THY LUU , HOSTETTER DANIEL R , VASILJEVA OLGA , FLANDEZ JEANNE GRACE
IPC分类号： C07K16/18 , A61K39/395 , C07K16/46
摘要： Abstract The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.

10. 发明申请

WO2014052462A3 ACTIVATABLE ANTIBODIES THAT BIND INTERLEUKIN-6 RECEPTOR AND METHODS OF USE THEREOF 审中-公开
标题翻译：结合白细胞介素-6受体的活性抗体及其使用方法
公开(公告)号：WO2014052462A3
公开(公告)日：2015-07-16
申请号：PCT/US2013061694
申请日：2013-09-25
申请人： CYTOMX THERAPEUTICS INC
发明人： WEST JAMES WILLIAM , SAGERT JASON GARY , HOSTETTER DANIEL R , FLANDEZ JEANNE GRACE , MOORE STEPHEN JAMES , NGUYEN MARGARET THY LUU , VASILJEVA OLGA
IPC分类号： C12P21/08 , C07K16/00 , C12P21/04
CPC分类号： C07K16/2866 , A61K47/48338 , A61K47/65 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/50
摘要： Activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to interleukin-6 receptor (IL-6R), and methods of making and using these anti-IL-6R activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications are provided. Further provided are sequences of MM and CM that are suitable for making these anti-IL-6R activatable antibodies.
摘要翻译：包括特异性结合白细胞介素-6受体（IL-6R）的掩蔽部分（MM），可切割部分（CM）和抗体（AB）的可活化抗体以及制备和使用这些抗IL-6R 提供了各种治疗，诊断和预防指征中的可激活抗体。还提供了适于制备这些抗IL-6R可活化抗体的MM和CM的序列。

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