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1. 发明申请

US20220404350A1 METHOD FOR DETERMINATION OF AGGREGATES 有权
公开(公告)号：US20220404350A1
公开(公告)日：2022-12-22
申请号：US17776200
申请日：2020-12-03
申请人： Cytiva Sweden AB
发明人： Tomas Dalmo
IPC分类号： G01N33/543 , G01N21/552
摘要： The present disclosure provides a method for determining of aggregates comprising one or more macromolecules, in a first sample potentially comprising aggregates of the macromolecule(s), comprising the steps of (a) contacting a first sample with a sensing surface of an interaction analysis sensor, said sensing surface having immobilised thereon a ligand comprising a hydrophobic group, which is capable of increased binding interaction with aggregates of macromolecule(s) compared to non-aggregated macromolecule(s); (b) determining at least one parameter for the interaction of the first sample with the sensing surface; (c) Performing at least one of steps (i) and (ii): (i) Comparing the at least one parameter determined in step (b) with the corresponding parameter(s) determined for at least one additional sample potentially comprising aggregates of the macromolecule(s); (ii) determining at least one parameter related to aggregate(s) of the macromolecule(s); and (d) determining the presence, fraction, concentration, and/or amount of macromolecule(s) in the form of aggregate(s) in the first sample. The present disclosure also relates to uses of said method and an interaction analysis sensor for use in said method, as well as an interaction analysis sensor and a method for determining of the stability of a macromolecule.

2. 发明公开

US20240150697A1 RECONFIGURABLE BIOPROCESSING SYSTEMS 审中-公开
公开(公告)号：US20240150697A1
公开(公告)日：2024-05-09
申请号：US18550075
申请日：2022-04-25
申请人： CYTIVA SWEDEN AB
发明人： Klaus Gebauer , Tim Francois , Andreas Lundin , Bjorn Markus Olovsson , Kerstin Erickson , Tomas Dalmo
IPC分类号： C12M1/00 , C12M1/36 , C12M3/00
CPC分类号： C12M23/40 , C12M23/28 , C12M23/44 , C12M29/04 , C12M29/06 , C12M41/48
摘要： The present invention relates to a reconfigurable bioprocessing system (80) operable to perform a predetermined set of bioprocessing operations therein. The reconfigurable bioprocessing system (80) comprises a base unit (60) comprising a plurality of valve actuators (102). At least one of the plurality of valve actuators (102) is operable to releasably engage with at least part of a pinch valve cassette (103, 203) to control fluid flow through the pinch valve cassette (103, 203). At least part of the pinch valve cassette (103, 203) is removably attachable to the base unit (60) and the pinch valve cassette (103, 203) is provided adjacent to said plurality of valve actuators (102). The reconfigurable bioprocessing system (80) also includes a control system operable to selectively actuate respective of said plurality of valve actuators (102) to provide a valve configuration within the pinch valve cassette (103, 203) to enable the base unit (60) and the pinch valve cassette (103, 203) together to perform one of the predetermined set of bioprocessing operations. A flow kit (107) for use in reconfigurable bioprocessing systems (80) and various methods (1000) for reconfiguring bioprocessing systems (80) (e.g. automatically) are also disclosed.

3. 发明授权

US10996220B2 Methods for preparing a dilution series 有权
公开(公告)号：US10996220B2
公开(公告)日：2021-05-04
申请号：US15938903
申请日：2018-03-28
申请人： CYTIVA SWEDEN AB
发明人： Johan Dan Johansson , Tomas Dalmo
IPC分类号： G01N33/543 , G01N1/38 , G01N21/552 , G01N33/531 , G01N35/00
摘要： Methods for preparing a dilution series for use in forming calibration curves, preferably in the field of surface plasmon resonance, are provided. In one example, a dilution series is prepared by using receptacles such as tubes of a micro well plate in which samples of the dilution series are mixed. In another example, a dilution series is prepared by using a convection mix in a receptacle for achieving a concentration gradient in the sample. A biosensor system arranged to perform steps of methods disclosed are provided. A data processing apparatus and a software for performing steps of methods disclosed, and a computer readable medium for storing the software are also provided.

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