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1. 发明申请

WO1997009970A1 POLYURETHANE HYDROGEL DRUG RESERVOIRS FOR USE IN TRANSDERMAL DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：聚氨酯水凝胶药物储存库用于转运药物输送系统
公开(公告)号：WO1997009970A1
公开(公告)日：1997-03-20
申请号：PCT/US1996014739
申请日：1996-09-13
申请人： CYGNUS, INC. , CHEN, Tung-Fen , CHIANG, Chia-Ming , JONA, Janan , JOSHI, Priti , RAMDAS, Asha
发明人： CYGNUS, INC.
IPC分类号： A61K09/70
CPC分类号： A61K9/7084
摘要： High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are hydrogels formulated from polyurethanes crosslinked with diisocyanate crosslinking agents or cured with radiation in the presence of a photoinitiator. Drug loading as high as 65 to 70 wt.% or higher can be achieved by absorbing drug formulation into the reservoir after hydrogel synthesis. Methods for making and using transdermal systems containing such reservoirs are provided as well.
摘要翻译：提供高容量药物储存器用于并入透皮药物递送系统。药物储存器是由与二异氰酸酯交联剂交联的聚氨酯配制的水凝胶或在光引发剂存在下用辐射固化的水凝胶。通过在水凝胶合成后将药物制剂吸收到储存器中可以实现高达65至70重量％或更高的药物负载。还提供了制备和使用含有这种储存器的透皮系统的方法。

2. 发明申请

WO1997009971A2 HIGH CAPACITY, SUPERABSORBENT DRUG RESERVOIRS FOR USE IN TRANSDERMAL DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：高容量，超吸收药物储存用于转运药物输送系统
公开(公告)号：WO1997009971A2
公开(公告)日：1997-03-20
申请号：PCT/US1996014784
申请日：1996-09-13
申请人： CYGNUS, INC. , CHEN, Tung-Fen , CHIANG, Chia-Ming , JONA, Janan , JOSHI, Priti , RAMDAS, Asha
发明人： CYGNUS, INC.
IPC分类号： A61K09/70
CPC分类号： A61K9/703 , A61K9/7084
摘要： High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are comprised of a superabsorbent material, typically a cross-linked polymer, which is capable of absorbing an amount of drug formulation corresponding to at least 15 grams formulation per gram of material. Methods for making and using transdermal systems containing such reservoirs are provided as well.
摘要翻译：提供高容量药物储存器用于并入透皮药物递送系统。药物储存器由超吸收材料（通常为交联聚合物）组成，其能够吸收对应于每克材料至少15克制剂的一定量的药物制剂。还提供了制备和使用含有这种储存器的透皮系统的方法。

3. 发明申请

WO1996022084A2 POLYMER ADHESIVE FORMULATION CONTAINING SORBENT PARTICLES 审中-公开
标题翻译：含聚合物颗粒的聚合物胶粘剂配方
公开(公告)号：WO1996022084A2
公开(公告)日：1996-07-25
申请号：PCT/US1996000740
申请日：1996-01-19
申请人： CYGNUS, INC. , BESTE, Russell, D. , CHIANG, Chia-Ming , XIA, Jun
发明人： CYGNUS, INC.
IPC分类号： A61K09/70
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7069
摘要： The cold flow properties of layers of transdermal or transmucosal patches composed of drug/excipient-plasticized polymer adhesives lacking functional groups are maintained at acceptable levels by including a sorptive material in the adhesive-drug/excipient mixture that sorbs a portion of the drug/excipient and thereby prevents the drug/excipient from unduly impairing the cold flow properties of the adhesive.
摘要翻译：通过在药物/赋形剂增塑聚合物粘合剂组成的透皮或经粘膜片的层的冷流动性质通过在吸附一部分药物/赋形剂的粘合剂 - 药物/赋形剂混合物中包含吸附材料而保持在可接受的水平从而防止药物/赋形剂过度损害粘合剂的冷流动性。

4. 发明申请

WO1997011696A1 TRANSDERMAL ADMINISTRATION OF ROPINIROLE AND ANALOGS THEREOF 审中-公开
标题翻译：。LE。。。。。。。。。。。。。。。。。。。。
公开(公告)号：WO1997011696A1
公开(公告)日：1997-04-03
申请号：PCT/US1996014278
申请日：1996-09-06
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , CHEN, Tung-Fen , CHIANG, Chia-Ming
IPC分类号： A61K31/40
CPC分类号： A61K9/7069 , A61K9/7084 , A61K31/4015
摘要： Transdermal administration of certain indolone derivatives which are dopamine D2 agonists is described. The method involves treating an individual afflicted with Parkinson's disease by administering an indolone derivative, e.g., ropinirole base or a pharmaceutically acceptable ropinirole salt, through the skin or mucosal tissue, for a time period and at an administration rate effective to alleviate the symptoms of the disease. Pharmaceutical formulations and drug delivery systems for administering the drugs are provided as well.
摘要翻译：描述了作为多巴胺D2激动剂的某些吲哚酮衍生物的透皮给药。该方法包括通过皮肤或粘膜组织施用吲哚酮衍生物（例如罗哌尼尔碱或药学上可接受的罗哌卡罗盐）治疗患有帕金森病的个体，并且以有效缓解其症状的给药速率疾病。还提供了用于施用药物的药物制剂和药物递送系统。

5. 发明申请

WO1997024059A1 CONTINUOUS MONITORING OF PHYSIOLOGICAL ANALYTE 审中-公开
标题翻译：生理分析的连续监测
公开(公告)号：WO1997024059A1
公开(公告)日：1997-07-10
申请号：PCT/US1996020591
申请日：1996-12-20
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , KURNIK, Ronald, T. , TAMADA, Janet , TIERNEY, Michael , POTTS, Russell, Owen
IPC分类号： A61B05/00
CPC分类号： A61B5/14532
摘要： A method for continual monitoring of a physiologic analyte in a subject includes steps of contacting the subject with a collection reservoir such that the analyte can move from the subject into the collection reservoir, the contents of the collection reservoir being in operative communication with a detector, collecting the analyte in the collection reservoir, using the detector to detect the analyte in the collection reservoir, and, once the analyte has been detected, rendering the analyte undetectable by the detector. Also, apparatus for continual monitoring of a physiologic analyte in a subject includes a collection reservoir for receiving the analyte from the subject, the contents of the collection reservoir being in operative relationship with a detector that detects the analyte in the reservoir, and means for rendering the analyte, once detected, undetectable by the reservoir.
摘要翻译：用于连续监测受试者中的生理分析物的方法包括以下步骤：使受试者与收集储存器接触，使得分析物可以从受试者移动到收集容器中，收集储存器的内容物与检测器操作性地通信，收集储存器中的分析物，使用检测器检测收集储存器中的分析物，一旦检测到分析物，就使检测器不能检测到分析物。此外，用于连续监测受试者中的生理分析物的装置包括用于从受试者接收分析物的收集储存器，收集储存器的内容物与检测储存器中的分析物的检测器处于操作关系，以及用于渲染的装置被检测到的分析物，不能被储存器检测到。

6. 发明申请

WO1996040087A2 PRESSURE SENSITIVE ACRYLATE ADHESIVE COMPOSITION CROSS-LINKED WITH ALUMINUM ACETYLACETONATE AND CONTAINING A DRUG HAVING A REACTIVE AROMATIC HYDROXYL GROUP 审中-公开
标题翻译：与乙酸乙烯酯交联并含有具有反应性芳族羟基的药物的压力敏感性丙烯酸酯胶粘剂组合物
公开(公告)号：WO1996040087A2
公开(公告)日：1996-12-19
申请号：PCT/US1996008492
申请日：1996-06-03
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , LI, Chunhua , SCHONFELD, Edward , CHU, Tara , CHIANG, Chia-Ming
IPC分类号： A61K09/70
CPC分类号： A61K9/7061
摘要： Non-yellowing organic solvent based pressure sensitive acrylate adhesives that have good cohesive strength and cold flow properties and are useful in fabricating transdermal drug delivery patches are made from an organic solvent based pressure sensitive acrylate adhesive cross-linked with aluminum acetylacetonate and combined with a drug, such as estradiol, that has a reactive aromatic hydroxyl group.
摘要翻译：具有良好内聚强度和冷流动性的非黄变有机溶剂型压敏丙烯酸酯粘合剂可用于制造透皮药物递送贴片，由与乙酰丙酮铝交联并与药物组合的有机溶剂型压敏丙烯酸酯粘合剂，如雌二醇，其具有反应性芳族羟基。

7. 发明申请

WO1996040355A1 TRANSDERMAL PATCH AND METHOD FOR ADMINISTERING 17-DEACETYL NORGESTIMATE ALONE OR IN COMBINATION WITH AN ESTROGEN 审中-公开
标题翻译：用于管理17-DEACETYY NORGESTIMATE或者与雌激素组合的透皮贴剂和方法
公开(公告)号：WO1996040355A1
公开(公告)日：1996-12-19
申请号：PCT/US1996009396
申请日：1996-06-06
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , JONA, Janan , AUDETT, Jay , SINGH, Noel
IPC分类号： A61M37/00
CPC分类号： A61K31/569 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/565 , A61K31/567 , A61K31/575 , Y10S514/947 , A61K2300/00
摘要： Compositions and methods for preventing ovulation in a woman are provided, as well as compositions and methods for female hormone replacement therapy. The compositions can be administered by the use of a transdermal patch. The patch will administer 17-deacetyl norgestimate alone or in combination with an estrogen such as ethinyl estradiol to women.
摘要翻译：提供了防止女性排卵的组合物和方法，以及用于女性激素替代疗法的组合物和方法。组合物可以通过使用透皮贴剂来施用。该补丁将单独或与雌激素如乙炔雌二醇组合施用17-脱乙酰诺孕酯。

8. 发明申请

WO1996022083A1 POLYISOBUTYLENE ADHESIVES CONTAINING HIGH Tg TACKIFIER FOR TRANSDERMAL DEVICES 审中-公开
标题翻译：含有高Tg热交换器的聚异丁烯胶粘剂
公开(公告)号：WO1996022083A1
公开(公告)日：1996-07-25
申请号：PCT/US1996000729
申请日：1996-01-19
申请人： CYGNUS, INC. , AUDETT, Jay , BESTE, Russell, D. , FARINAS, Kathleen , PUTNAM, Wendy
发明人： CYGNUS, INC.
IPC分类号： A61K09/70
CPC分类号： A61K9/7053
摘要： Polyisobutylene adhesive compositions in the form of the basal layer of a laminated composite transdermal or transmucosal patch and which contain sufficient nicotine to plasticize the polyisobutylene adhesive and a sufficient amount of a polyisobutylene compatible, high Tg, low molecular weight tackifier to increase the tackiness of the layer.
摘要翻译：聚异丁烯粘合剂组合物为叠层复合透皮或经粘膜贴片基底层的形式，并含有足够的尼古丁以增塑聚异丁烯粘合剂和足够量的聚异丁烯相容的高Tg低分子量增粘剂，以增加其粘度层。

9. 发明申请

WO1996021432A1 DELIVERY OF ACTIVE SUBSTANCES BY WAY OF MUCOSAL SURFACES OF PHARYNGEAL AND ESOPHAGEAL REGIONS 审中-公开
标题翻译：通过肉眼和食道区域的表面方式递送活性物质
公开(公告)号：WO1996021432A1
公开(公告)日：1996-07-18
申请号：PCT/US1996000566
申请日：1996-01-11
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , CLEARY, Gary, W. , VENKATRAMAN, Subbu , BIEGAJSKI, James, E. , SCOTT, Ann, M. , WATTS, Peter
IPC分类号： A61K09/50
CPC分类号： A61K9/5026 , A61K9/006 , A61K9/5047 , A61K9/5052
摘要： A method for delivering a therapeutically active substance to a subject includes contacting mucosal tissues of the subject's pharyngeal region and/or esophageal region with mucoadhesive particles containing a pharmaceutically effective amount of the active agent. Also, a composition for delivery of an active substance to a subject has the form of a preparation of particles containing the active substance, the particles adhering to mucosal surfaces of the pharyngeal or esophageal regions of the subject. Also, a method for treating "acid stomach" or reflux esophagitis in a subject includes administering to the subject a swallowable liquid composition including mucoadhesive particles containing a pharmaceutically effective amount of an antacid agent; and such a swallowable liquid composition.
摘要翻译：将治疗活性物质递送到受试者的方法包括使受试者的咽部区域和/或食道区域的粘膜组织与含有药学有效量的活性剂的粘膜粘附颗粒接触。此外，用于将活性物质递送到受试者的组合物具有制备包含活性物质的颗粒的形式，所述颗粒粘附到受试者的咽或食管区域的粘膜表面。此外，在受试者中治疗“酸性胃”或反流性食管炎的方法包括向受试者施用包含含有药学有效量的抗酸剂的粘膜粘附颗粒的可吞咽液体组合物; 和这样的吞咽液体组合物。

10. 发明申请

WO1997024148A1 SYSTEMS AND METHODS FOR THE TRANSDERMAL ADMINISTRATION OF ANDROGENIC AGENTS 审中-公开
标题翻译：用于远程管理并发原子的系统和方法
公开(公告)号：WO1997024148A1
公开(公告)日：1997-07-10
申请号：PCT/US1996020365
申请日：1996-12-27
申请人： CYGNUS, INC.
发明人： CYGNUS, INC. , CHEN, Tung-Fen , CHIANG, Chia-Ming , JONA, Janan , JOSHI, Priti , RAMDAS, Asha
IPC分类号： A61L15/44
CPC分类号： A61K9/7084
摘要： Drug delivery systems and methods for transdermally administering androgenic agents are provided. The systems are generally laminated composites containing a pharmaceutical formulation within a drug reservoir, wherein an androgenic agent is present in the formulation at or above saturation concentration. The composite is also provided with a means for adhering to the skin or mucosal tissue. The reservoirs are typically comprised of "high capacity" materials such as polyurethane hydrogels or superabsorbent materials. The androgenic agent will in most cases be testosterone or a pharmaceutically acceptable derivative thereof, administered alone or in combination with an estrogen and/or progestogen.
摘要翻译：提供用于经皮给药雄激素剂的药物递送系统和方法。该系统通常是在药物储存器内含有药物制剂的层压复合材料，其中雄激素剂以等于或高于饱和浓度存在于制剂中。复合材料还具有粘附于皮肤或粘膜组织的装置。储存器通常由“高容量”材料组成，例如聚氨酯水凝胶或超吸收材料。雄激素剂在大多数情况下是单独施用或与雌激素和/或孕激素组合施用的睾酮或其药学上可接受的衍生物。

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