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1. 发明申请

WO2007114860A8 ELECTRODE STRUCTURES HAVING ANTI-INFLAMMATORY PROPERTIES AND METHODS OF USE 审中-公开
标题翻译：具有抗炎功能的电极结构和使用方法
公开(公告)号：WO2007114860A8
公开(公告)日：2008-08-07
申请号：PCT/US2006061256
申请日：2006-11-27
申请人： CVRX INC , ROSSING MARTIN A , KIEVAL ROBERT S , COLE MARY L
发明人： ROSSING MARTIN A , KIEVAL ROBERT S , COLE MARY L
IPC分类号： A61B5/04
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/056 , A61N1/306
摘要： Electrode structures for implantation include an electrode, an elastic backing attached to the electrode, and a sequestered drug on the backing or the electrode which is released to control and/or limit the growth of scar tissue. The elastic backing includes a tissue contacting side which contacts a tissue structure, and an exposed side away from the tissue contacting side. The electrode structure can be used to activate baroreceptors, and the backing is elastic and can stretch and retract with the tissue structure, for example the carotid sinus. The electrode and the sequestered drug can be positioned on the tissue contacting side so the drug is released near the electrode. The backing can be made from an insulating material and limit diffusion of the drug toward the exposed side, permitting scar tissue to grow near the exposed side to maintain positioning of the electrode.
摘要翻译：用于植入的电极结构包括电极，附着到电极的弹性背衬和背衬或电极上的螯合药物，其被释放以控制和/或限制瘢痕组织的生长。弹性背衬包括接触组织结构的组织接触侧和远离组织接触侧的暴露侧。电极结构可用于激活压力感受器，并且背衬是弹性的并且可以与组织结构例如颈动脉窦一起伸展和缩回。电极和螯合药物可以定位在组织接触侧，因此药物在电极附近释放。背衬可以由绝缘材料制成并且限制药物朝向暴露侧的扩散，允许瘢痕组织在暴露侧附近生长以保持电极的定位。

2. 发明申请

WO2007114860A3 ELECTRODE STRUCTURES HAVING ANTI-INFLAMMATORY PROPERTIES AND METHODS OF USE 审中-公开
标题翻译：具有抗炎功能的电极结构和使用方法
公开(公告)号：WO2007114860A3
公开(公告)日：2009-04-09
申请号：PCT/US2006061256
申请日：2006-11-27
申请人： CVRX INC , ROSSING MARTIN A , KIEVAL ROBERT S , COLE MARY L
发明人： ROSSING MARTIN A , KIEVAL ROBERT S , COLE MARY L
IPC分类号： A61B5/04
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/056 , A61N1/306
摘要： Electrode structures for implantation include an electrode, an elastic backing attached to the electrode, and a sequestered drug on the backing or the electrode which is released to control and/or limit the growth of scar tissue. The elastic backing includes a tissue contacting side which contacts a tissue structure, and an exposed side away from the tissue contacting side. The electrode structure can be used to activate baroreceptors, and the backing is elastic and can stretch and retract with the tissue structure, for example the carotid sinus. The electrode and the sequestered drug can be positioned on the tissue contacting side so the drug is released near the electrode. The backing can be made from an insulating material and limit diffusion of the drug toward the exposed side, permitting scar tissue to grow near the exposed side to maintain positioning of the electrode.
摘要翻译：用于植入的电极结构包括电极，附着到电极的弹性背衬和背衬或电极上的螯合药物，其被释放以控制和/或限制瘢痕组织的生长。弹性背衬包括接触组织结构的组织接触侧和远离组织接触侧的暴露侧。电极结构可用于激活压力感受器，并且背衬是弹性的并且可以与组织结构例如颈动脉窦一起伸展和缩回。电极和螯合药物可以定位在组织接触侧，因此药物在电极附近释放。背衬可以由绝缘材料制成并且限制药物朝向暴露侧的扩散，允许瘢痕组织在暴露侧附近生长以保持电极的定位。

3. 发明申请

WO2006125163A3 IMPLANTABLE ELECTRODE ASSEMBLY HAVING REVERSE ELECTRODE CONFIGURATION 审中-公开
标题翻译：具有反向电极配置的可植入电极组件
公开(公告)号：WO2006125163A3
公开(公告)日：2007-04-05
申请号：PCT/US2006019470
申请日：2006-05-18
申请人： CVRX INC , HAGEN JEFFREY J , COLE MARY L , ROSSING MARTIN A
发明人： HAGEN JEFFREY J , COLE MARY L , ROSSING MARTIN A
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0556 , A61N1/3956
摘要： Methods and apparatus for generating an electric field inside a patient include at least a first electrode and a second electrode on a common implantable substrate. Each of the electrodes has a respective proximal end and a respective distal end. Electrical energy can be applied that causes electrical current to flow simultaneously through the first and second electrodes preferentially from the proximal end of one electrode to the distal end of the other electrode.
摘要翻译：用于在患者体内产生电场的方法和装置包括在可共同植入的基底上的至少第一电极和第二电极。每个电极具有相应的近端和相应的远端。可以施加电能，其导致电流同时通过第一和第二电极从一个电极的近端到另一个电极的远端。

4. 发明申请

WO2007118090A3 IMPLANTABLE EXTRAVASCULAR ELECTROSTIMULATION SYSTEM HAVING A RESILIENT CUFF 审中-公开
标题翻译：具有弹性模量的可植入的超静电电化学系统
公开(公告)号：WO2007118090A3
公开(公告)日：2008-11-06
申请号：PCT/US2007065880
申请日：2007-04-03
申请人： CVRX INC , ROSSING MARTIN A , COLE MARY L , SOLTIS BRIAN
发明人： ROSSING MARTIN A , COLE MARY L , SOLTIS BRIAN
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0556
摘要： A method and device for providing stimulation to an artery for purposes of eliciting a physfalogic response. A cuff (100) having at least one electrode is provided, wherein the cuff is biased to conform to at least a portion of a vascular structure to maintain an intimate vascular structure-electrode interface. The device is selectively positioned proximate the effective position for providing stimulation to the vascular structure and the cuff is enabled to biasedly conform to at least a portion of the vascular structure. The cuff comprises includes resiliency enabling substantially normal pulsatile expansion of the artery while maintaining effective artery-electrode interface.
摘要翻译：为了引发生理反应的目的，为动脉提供刺激的方法和装置。提供具有至少一个电极的袖带（100），其中所述袖带被偏置以符合血管结构的至少一部分以维持紧密的血管结构 - 电极界面。选择性地将该装置定位在有效位置附近，以便向血管结构提供刺激，并且该袖带使得能够偏向地与至少一部分血管结构一致。袖带包括弹性，使得动脉实质上正常的脉动扩张同时保持有效的动脉 - 电极界面。

5. 发明公开

EP2001550A4 IMPLANTABLE EXTRAVASCULAR ELECTROSTIMULATION SYSTEM HAVING A RESILIENT CUFF 审中-公开
标题翻译：有弹性袖口植入血管外的电刺激系统
公开(公告)号：EP2001550A4
公开(公告)日：2009-06-17
申请号：EP07760041
申请日：2007-04-03
申请人： CVRX INC
发明人： ROSSING MARTIN A , COLE MARY L , SOLTIS BRIAN
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/05 , A61N1/0556
摘要： A method and device for providing stimulation to an artery for purposes of eliciting a physfalogic response. A cuff (100) having at least one electrode is provided, wherein the cuff is biased to conform to at least a portion of a vascular structure to maintain an intimate vascular structure-electrode interface. The device is selectively positioned proximate the effective position for providing stimulation to the vascular structure and the cuff is enabled to biasedly conform to at least a portion of the vascular structure. The cuff comprises includes resiliency enabling substantially normal pulsatile expansion of the artery while maintaining effective artery-electrode interface.

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