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1. 发明专利

ES2330833T3 DISPOSITIVOS PARA EL CONTROL REFLEJO CARDIOVASCULAR. 未知
公开(公告)号：ES2330833T3
公开(公告)日：2009-12-16
申请号：ES01975479
申请日：2001-09-27
申请人： CVRX INC
发明人： KIEVAL ROBERT S , PERSSON BRUCE J , SERDAR DAVID J , KEITH PETER T , IRWIN ERIC D , HEKTNER THOMAS R
IPC分类号： A61N1/05 , A61N1/36 , A61F2/82 , A61N1/08
摘要： Un dispositivo de activación de barorreceptores para conectar a un seno carótido humano (20) en la bifurcación de una arteria carótida común (14) y la arteria carótida interna (19) y la arteria carótida externa (18) comprendiendo el dispositivo: una base (306) capaz de envolverse alrededor de una arteria carótida interna (19); una pluralidad de electrodos (302) conectados a la base para activar los barorreceptores en dicha pared vascular; y un ancla (312) para envolver alrededor de la arteria carótida común (14) y conectarse a la base (306) por cable (304) o un cable multicanal (304), estando dichos cables o cable conectados a la pluralidad de electrodos actuando como un téter suelto.

2. 发明专利

AU2003220574A8 Electrode structures and methods for their use in cardiovascular reflex control 未知
公开(公告)号：AU2003220574A8
公开(公告)日：2003-10-13
申请号：AU2003220574
申请日：2003-03-27
申请人： CVRX INC
发明人： IRWIN ERIC D , SERDAR DAVID J , KIEVAL ROBERT S , BOLEA STEPHEN L , ROSSING MARTIN A , PERSSON BRUCE J , KEITH PETER T
IPC分类号： A61N1/05 , A61B20060101 , A61N20060101 , A61N1/08 , A61N1/36

3. 发明专利

DE60138902D1 未知
公开(公告)号：DE60138902D1
公开(公告)日：2009-07-16
申请号：DE60138902
申请日：2001-09-27
申请人： CVRX INC
发明人： KIEVAL ROBERT S , PERSSON BRUCE J , SERDAR DAVID J , KEITH PETER T , IRWIN ERIC D , HEKTNER THOMAS R , BURNS MATTHEW M , HANSEN GINA L
IPC分类号： A61N1/05 , A61N1/36 , A61F2/82 , A61N1/08
摘要： A baroreceptor activation device (70) is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system (60) may be used to modulate the baroreceptor activation device (70). The control system (60) may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. A mapping method permits the baroreceptor activation device (70) to be precisely located to maximize therapeutic efficacy. The baroreceptor activation device (70) may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue simulation.

4. 发明专利

AU2003220599A1 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL VIA COUPLED ELECTRODES 未知
公开(公告)号：AU2003220599A1
公开(公告)日：2003-10-13
申请号：AU2003220599
申请日：2003-03-27
申请人： CVRX INC
发明人： KIEVAL ROBERT S , PERSSON BRUCE J , SERDAR DAVID J , KEITH PETER T , ROSSING MARTIN A
IPC分类号： A61N1/05 , A61B20060101 , A61N20060101 , A61N1/08 , A61N1/36

5. 发明专利

AU2003220599A8 Devices and methods for cardiovascular reflex control via coupled electrodes 未知
公开(公告)号：AU2003220599A8
公开(公告)日：2003-10-13
申请号：AU2003220599
申请日：2003-03-27
申请人： CVRX INC
发明人： PERSSON BRUCE J , KEITH PETER T , ROSSING MARTIN A , KIEVAL ROBERT S , SERDAR DAVID J
IPC分类号： A61N1/05 , A61B20060101 , A61N20060101 , A61N1/08 , A61N1/36

6. 发明专利

AU2003220574A1 ELECTRODE STRUCTURES AND METHODS FOR THEIR USE IN CARDIOVASCULAR REFLEX CONTROL 未知
公开(公告)号：AU2003220574A1
公开(公告)日：2003-10-13
申请号：AU2003220574
申请日：2003-03-27
申请人： CVRX INC
发明人： BOLEA STEPHEN L , KIEVAL ROBERT S , PERSSON BRUCE J , SERDAR DAVID J , KEITH PETER T , IRWIN ERIC D , ROSSING MARTIN A
IPC分类号： A61N1/05 , A61B20060101 , A61N20060101 , A61N1/08 , A61N1/36

7. 发明申请

WO2005097256A3 STIMULUS REGIMENS FOR CARDIOVASCULAR REFLEX CONTROL 审中-公开
标题翻译：用于心脏反射控制的刺激方案
公开(公告)号：WO2005097256A3
公开(公告)日：2006-11-23
申请号：PCT/US2005011501
申请日：2005-04-04
申请人： CVRX INC , ROSSING MARTIN A , KIEVAL ROBERT S , SERDAR DAVID J , PERSSON BRUCE J
发明人： ROSSING MARTIN A , KIEVAL ROBERT S , SERDAR DAVID J , PERSSON BRUCE J
IPC分类号： A61N1/36 , A61F2/82 , A61N1/05 , A61N1/08 , A61N1/18 , A61N1/32 , A61N1/365
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/3627 , A61N1/36514
摘要： Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.
摘要翻译：通过向压力反射激活装置提供合适的控制信号来实现巴罗反射激活。一种方法包括在治疗间隔内建立治疗间隔（可能在数分钟到数小时，或者可能是不确定的持续时间），建立多个剂量间隔，以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在至少一些剂量间隔的第一和第二部分之间不同。另一种方法包括在至少一些治疗间隔期间建立一系列治疗间隔部分，建立多个突发间隔（可能具有与心跳之间的间隔相当的持续时间），以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在治疗间隔的第一和第二部分之间不同，并且在至少一些突发间隔的第一和第二部分之间也不同。

8. 发明公开

EP1330288A4 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL 有权
标题翻译：装置和方法心血管反射控制
公开(公告)号：EP1330288A4
公开(公告)日：2005-12-28
申请号：EP01975479
申请日：2001-09-27
申请人： CVRX INC
发明人： KIEVAL ROBERT S , PERSSON BRUCE J , SERDAR DAVID J , KEITH PETER T , IRWIN ERIC D , HEKTNER THOMAS R , BURNS MATTHEW M , HANSEN GINA L
IPC分类号： A61N1/36 , A61F2/82 , A61N1/05 , A61N1/08
CPC分类号： A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117
摘要： Devices, systems and methods by which the blood pressure, nervous system activity and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device (70) is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system (60) may be used to modulate the baroreceptor activation device (70). The control system (60) may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. A mapping method permits the baroreceptor activation device (70) to be precisely located to maximize therapeutic efficacy. The baroreceptor activation device (70) may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

9. 发明公开

EP1487536A4 DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL VIA COUPLED ELECTRODES 审中-公开
标题翻译：装置和方法心血管反射控制耦合电极
公开(公告)号：EP1487536A4
公开(公告)日：2009-12-02
申请号：EP03716913
申请日：2003-03-27
申请人： CVRX INC
发明人： KIEVAL ROBERT S , PERSSON BRUCE J , SERDAR DAVID J , KEITH PETER T , ROSSING MARTIN A
IPC分类号： A61N1/05 , A61N1/36 , A61B20060101 , A61N20060101 , A61N1/08 , A61N1/372
CPC分类号： A61N1/0556 , A61N1/36117 , A61N1/37205 , A61N1/37223

10. 发明公开

EP1740264A4 STIMULUS REGIMENS FOR CARDIOVASCULAR REFLEX CONTROL 审中-公开
标题翻译： STIMULUS政权KARDIOVASKUKÄRE反射控制
公开(公告)号：EP1740264A4
公开(公告)日：2010-02-24
申请号：EP05737549
申请日：2005-04-04
申请人： CVRX INC
发明人： ROSSING MARTIN A , KIEVAL ROBERT S , SERDAR DAVID J , PERSSON BRUCE J
IPC分类号： A61N1/36 , A61F2/82 , A61N1/05 , A61N1/08 , A61N1/18 , A61N1/32 , A61N1/365
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/3627 , A61N1/36514
摘要： Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.

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