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1. 发明申请

WO2005072777A2 INTERVENTIONS FOR THE PREVENTION AND/OR TREATMENT OF AMYLOID-RELATED DISEASES 审中-公开
标题翻译：预防和/或治疗与艾滋病有关的疾病的干预措施
公开(公告)号：WO2005072777A2
公开(公告)日：2005-08-11
申请号：PCT/DK2005/000067
申请日：2005-01-28
申请人： CURIX APS , OLESEN, Ole, Frilev , BIRKELUND ANDERSEN, Svend , HOLM, Arne, Valdemar
发明人： OLESEN, Ole, Frilev , BIRKELUND ANDERSEN, Svend , HOLM, Arne, Valdemar
IPC分类号： A61K47/48
CPC分类号： C07K16/18 , A61K47/6415 , A61K47/643 , A61K47/646
摘要： New conjugates comprising fragments of amyloid proteins, which may be used in vaccines for the treatment, prevention and/or amelioration of diseases associated with deposition of amyloid proteins, such as, e.g. Alzheimers disease. Methods for treating, preventing and/or ameliorating amyloid-related diseases, by administering a conjugate comprising fragments of an amyloid protein to a subject in need thereof, thereby enabling the production of antibodies in the subject. Antibodies-being capable of interacting with pathological regions within an amyloid protein, and thereby preventing e.g. the formation of amyloid fibríls, plaques and/or deposits, and methods for passive immunization wherein an antibody as described above is administered to a subject in need thereof. Furthermore is provided specific fragments of the C-terminal part of amyloid beta (142), that when administered to a mammal generates antibodies, which specifically targets the soluble form of the highly amyloidogenic amyloid beta (1-42).
摘要翻译：包含淀粉样蛋白片段的新结合物，其可用于疫苗中用于治疗，预防和/或改善与淀粉样蛋白沉积相关的疾病，例如淀粉样蛋白。阿尔茨海默氏病。通过向有需要的受试者施用包含淀粉样蛋白的片段的缀合物来治疗，预防和/或改善淀粉样蛋白相关疾病的方法，从而能够在受试者中产生抗体。抗体能够与淀粉样蛋白质内的病理区域相互作用，从而防止例如淀粉样蛋白，斑块和/或沉积物的形成，以及被动免疫的方法，其中将上述抗体施用于有需要的受试者。此外提供了淀粉样蛋白β（142）的C-末端部分的特异性片段，当向哺乳动物施用时产生抗体，其特异性靶向高度淀粉样变性淀粉样蛋白β（1-42）的可溶形式。

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