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1. 发明授权

US09352028B2 Composition for treating lung cancer, particularly of non-small lung cancers (NSCLC) 有权
标题翻译：用于治疗肺癌，特别是非小细胞肺癌（NSCLC）的组合物
公开(公告)号：US09352028B2
公开(公告)日：2016-05-31
申请号：US13750664
申请日：2013-01-25
申请人： CUREVAC GMBH
发明人： Marijke Barner , Jochen Probst , Thomas Lander , Ingmar Hoerr
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/70
摘要： The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably a mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal. The invention furthermore relates to a vaccine comprising the active (immunostimulatory) composition, and to the use of the active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, particularly of non-small cell lung cancers (NSCLC), preferably selected from the three main sub-types squamous cell lung carcinoma, adenocarcinoma and large cell lung carcinoma, or of disorders related thereto. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.
摘要翻译：本发明涉及包含至少一种编码至少两种（优选不同的）抗原的RNA，优选mRNA的活性（免疫刺激）组合物，其能够在哺乳动物中引发（适应性的）免疫应答。本发明还涉及包含活性（免疫刺激）组合物以及使用活性（免疫刺激）组合物（用于制备疫苗）和/或用于引发（适应性）免疫应答的疫苗的疫苗，其用于治疗肺癌，特别是非小细胞肺癌（NSCLC），优选选自三种主要亚型鳞状细胞肺癌，腺癌和大细胞肺癌，或与其相关的疾病。最后，本发明涉及试剂盒，特别涉及含有活性（免疫刺激）组合物和/或疫苗的试剂盒。

2. 发明申请

US20130202645A1 COMPOSITION FOR TREATING LUNG CANCER, PARTICULARLY OF NON-SMALL LUNG CANCERS (NSCLC) 有权
标题翻译：用于治疗肺癌的组合物，特别是非小细胞肺癌（NSCLC）
公开(公告)号：US20130202645A1
公开(公告)日：2013-08-08
申请号：US13750664
申请日：2013-01-25
申请人： CUREVAC GMBH
发明人： Marijke Barner , Jochen Probst , Thomas Lander , Ingmar Hoerr
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/70
摘要： The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably a mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal. The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, particularly of non-small cell lung cancers (NSCLC), preferably selected from the three main sub-types squamous cell lung carcinoma, adenocarcinoma and large cell lung carcinoma, or of disorders related thereto. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.
摘要翻译：本发明涉及包含至少一种编码至少两种（优选不同的）抗原的RNA，优选mRNA的活性（免疫刺激）组合物，其能够在哺乳动物中引发（适应性的）免疫应答。本发明还涉及包含所述活性（免疫刺激）组合物的疫苗，以及所述活性（免疫刺激性）组合物（用于制备疫苗）和/或用于引发（适应性）免疫应答的疫苗的用途治疗肺癌，特别是非小细胞肺癌（NSCLC），优选选自三种主要亚型鳞状细胞肺癌，腺癌和大细胞肺癌，或与其相关的疾病。最后，本发明涉及试剂盒，特别涉及含有活性（免疫刺激）组合物和/或疫苗的试剂盒。

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