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1. 发明申请

WO2007092284A3 LOW DOSE NO DONOR-CONTAINING TRANSDERMAL PATCH 审中-公开
标题翻译：低剂量不含复合透皮贴片
公开(公告)号：WO2007092284A3
公开(公告)日：2008-07-03
申请号：PCT/US2007002835
申请日：2007-02-02
申请人： CURE THERAPEUCTICS INC , ANG ROBERT , JACOBSON SVEN , WEIMANN LUDWIG
发明人： ANG ROBERT , JACOBSON SVEN , WEIMANN LUDWIG
IPC分类号： A61F13/02 , A61F13/00
CPC分类号： A61K9/7061 , A61K31/21 , A61K47/10
摘要： The present invention is drawn to a transdermal patch for the delivery of a nitroglycerin or other NO donor. The patch can comprise a backing layer, and a nitroglycerin-containing composition or other NO donor-containing composition which is supported at least in part by the backing layer. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 µg/hour to about 70 µg/hour. In one embodiment, the transdermal patch can provide a delivery rate at the drug delivery zone of from about 1 µg/cm2/day to about 600 µg/cm2/day. In another embodiment, the transdermal patch can contain from 6 wt% to 18 wt% of the nitric oxide donor, e.g., nitroglycerin. In each embodiment, the patch can contain at least 450 µg/cm2 of nitroglycerin.
摘要翻译：本发明涉及用于递送硝酸甘油或其他NO供体的透皮贴片。贴剂可以包含背衬层和含硝酸甘油的组合物或至少部分由背衬层支撑的含NO供体的组合物。透皮贴剂可以具有由组合物接触完整的人皮肤部位的区域限定的药物递送区，并且透皮贴剂可以配制成以约5μg/小时至约约1μg/小时递送一氧化氮供体，例如硝酸甘油 70μg/小时。在一个实施方案中，透皮贴剂可以在药物递送区域提供约1μg/ cm 2 /天至约600μg/ cm 2 /天的递送速率。在另一个实施方案中，透皮贴剂可含有6重量％至18重量％的一氧化氮供体，例如硝酸甘油。在每个实施方案中，贴剂可含有至少450μg/ cm 2的硝酸甘油。

2. 发明申请

WO2007143185A3 TRANSDERMAL TREATMENT OF TENDINOPATHY USING GLYCERYL TRINITRITE 审中-公开
标题翻译：使用谷氨酸TRINITRITE的TENDINOPATHY的透皮治疗
公开(公告)号：WO2007143185A3
公开(公告)日：2008-06-26
申请号：PCT/US2007013117
申请日：2007-06-01
申请人： CURE THERAPEUTICS INC , MURRELL GEORGY ANTHONY CALVERT , ANG ROBERT , WEIMANN LUDWIG , JACOBSON SVEN
发明人： MURRELL GEORGY ANTHONY CALVERT , ANG ROBERT , WEIMANN LUDWIG , JACOBSON SVEN
IPC分类号： A61F13/00 , A61K31/21
CPC分类号： A61K9/0014 , A61K9/7023 , A61K31/21
摘要： The present invention provides methods for treating tendinopathy providing a durability of effect by administering nitroglycerin. Such methods include methods for relieving pain associated with such tendinopathies. The use of a transdermal patch configured to deliver glyceryl trinitrate at a rate of 5 mcg/hr to about 85 mcg/hr.
摘要翻译：本发明提供通过施用硝酸甘油来治疗提供耐久性的腱鞘的方法。这些方法包括减轻与这种腱病相关的疼痛的方法。使用透皮贴片，其配置为以5mcg / hr的速率将硝酸甘油酯输送至约85mcg / hr。

3. 发明申请

WO2007100910A2 TRANSDERMAL PATCHES CONTAINING A NITRIC OXIDE-DONOR AND A SECOND ACTIVE AGENT AND ASSOCIATED METHODS 审中-公开
标题翻译：含有氮氧化物和第二活性剂及其相关方法的透皮胶条
公开(公告)号：WO2007100910A2
公开(公告)日：2007-09-07
申请号：PCT/US2007005395
申请日：2007-02-28
申请人： CURE THERAPEUTICS INC , ANG ROBERT , JACOBSON SVEN , WEIMMAN LUDWIG , MURRELL GEORGE ANTHONY CALVERT , GELIEBTER DAVID
发明人： ANG ROBERT , JACOBSON SVEN , WEIMMAN LUDWIG , MURRELL GEORGE ANTHONY CALVERT , GELIEBTER DAVID
IPC分类号： A61K31/21
CPC分类号： A61K9/7061 , A61K33/00 , A61K45/06
摘要： The present invention is drawn to a transdermal patch for the delivery of a nitric oxide-donor and a second active agent. The patch can comprise a backing layer and an active agent-containing composition which is supported at least in part by the backing layer. The active agent-containing composition can include an amount of a nitric oxide-donor and an amount of a second active agent. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 µg/hour to about 85 µg/hour. The second active agent can be selected from a number of agents including NSAIDS, opioids, local anesthetics, menthol, salicylic acid, salicylic acid derivatives, vanilloid receptor- 1 activators, corticosteroids, vasoconstrictors, and combinations thereof.
摘要翻译：本发明涉及用于递送一氧化氮给体和第二活性剂的透皮贴片。贴剂可以包括背衬层和至少部分由背衬层支撑的含活性剂的组合物。含活性剂的组合物可以包括一定量的一氧化氮供体和一定量的第二活性剂。透皮贴剂可以具有由组合物接触完整的人皮肤部位的区域限定的药物递送区，并且透皮贴剂可以配制成以约5μg/小时至约约1μg/小时递送一氧化氮供体，例如硝酸甘油 85微克/小时。第二活性剂可以选自许多试剂，包括NSAIDS，阿片样物质，局部麻醉剂，薄荷醇，水杨酸，水杨酸衍生物，香草素受体-1激活剂，皮质类固醇，血管收缩剂及其组合。

4. 发明申请

WO2007103190A3 TRANSDERMAL TREATMENT OF TENDINOP ATHY USING NO DONOR 审中-公开
标题翻译： TENDINOP ATHY使用无捐助物的转基因治疗
公开(公告)号：WO2007103190A3
公开(公告)日：2008-08-14
申请号：PCT/US2007005394
申请日：2007-02-28
申请人： CURE THERAPEUTICS INC , MURRELL GEORGE ANTHONY CALVERT , ANG ROBERT , WEIMMAN LUDWIG , JACOBSON SVEN
发明人： MURRELL GEORGE ANTHONY CALVERT , ANG ROBERT , WEIMMAN LUDWIG , JACOBSON SVEN
IPC分类号： A61F13/00 , A61K31/21
CPC分类号： A61K9/7023 , A61K31/21
摘要： The present invention provides methods for treating tendinopathy in the absence of inflammation by the transdermal administration of nitroglycerin. Such methods include methods for relieving pain associated with such tendinopathies. and the use of a transdermal patch configured to deliver glyceryl trinitrate at a rate of 5 mcg/hr to about 85 mcg/hr.
摘要翻译：本发明提供通过透皮给药硝酸甘油来治疗不存在炎症的腱鞘炎的方法。这些方法包括减轻与这种腱病相关的疼痛的方法。以及使用透皮贴片，其被配置成以5mcg / hr的速率递送硝酸甘油酯至约85mcg / hr。

5. 发明申请

WO2007127749A3 PREDICTING MORTALITY AND DETECTING SEVERE DISEASE 审中-公开
标题翻译：预防死亡和检测严重疾病
公开(公告)号：WO2007127749A3
公开(公告)日：2008-03-20
申请号：PCT/US2007067333
申请日：2007-04-24
申请人： CRITICAL CARE DIAGNOSTICS INC , SNIDER JAMES V , JACOBSON SVEN
发明人： SNIDER JAMES V , JACOBSON SVEN
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , C12Q1/6883 , G01N33/564 , G01N33/6869 , G01N2333/54 , G01N2333/7155 , G01N2800/12 , G01N2800/325 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： Measurement of circulating ST2 and/or IL-33 concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, and the detection of severe disease.
摘要翻译：循环ST2和/或IL-33浓度的测量对于受试者的预后评估是有用的，特别是用于预测不良临床结果，例如死亡率和严重疾病的检测。

6. 发明申请

WO2007131031A2 DIAGNOSIS OF PULMONARY AND/OR CARDIOVASCULAR DISEASE 审中-公开
标题翻译：肺动脉和/或心血管疾病诊断
公开(公告)号：WO2007131031A2
公开(公告)日：2007-11-15
申请号：PCT/US2007068024
申请日：2007-05-02
申请人： CRITICAL CARE DIAGNOSTICS INC , SNIDER JAMES V , JACOBSON SVEN
发明人： SNIDER JAMES V , JACOBSON SVEN
IPC分类号： G01N33/53
CPC分类号： G01N33/53 , C07K14/54 , C07K14/58 , C07K14/7155 , C12Q1/6883 , G01N33/6869 , G01N33/6893 , G01N33/74 , G01N2333/58 , G01N2800/12 , G01N2800/32 , Y10T436/143333
摘要： Described are methods and kits for determining the likelihood of the presence of cardiovascular disease (CVD) or pulmonary disease (PD) in a subject using ST2/Interleukin 1 Receptor Like 1 (IL1RL1) and/or Interleukin 33 (IL-33), and a biomarker for CVD, e.g., a natriuretic peptide, e.g., brain natriuretic peptide (BNP), prohormone BNP (proBNP), N-Terminal proBNP (NT-proBNP), atrial natriuretic peptide (ANP), proANP, or NT-proANP.
摘要翻译：描述了使用ST2 /白细胞介素1受体1（IL1RL1）和/或白细胞介素33（IL-33）在受试者中确定心血管疾病（CVD）或肺部疾病（PD）存在的可能性的方法和试剂盒，以及用于CVD的生物标志物，例如利钠肽，例如脑利钠肽（BNP），激素原BNP（proBNP），N-末端proBNP（NT-proBNP），心房钠尿肽（ANP），proANP或NT-proANP。

7. 发明授权

US863399A Stump-puller. 失效
公开(公告)号：US863399A
公开(公告)日：1907-08-13
申请号：US1907352378
申请日：1907-01-15
申请人： JACOBSON SVEN , SVENDSON SVEND E
发明人： JACOBSON SVEN , SVENDSON SVEND E
CPC分类号： F16G11/12 , B66D1/08

8. 发明专利

DE889707C 未知
公开(公告)号：DE889707C
公开(公告)日：1953-09-14
申请号：DEI0005351
申请日：1951-12-23
申请人： JACOBSON SVEN
发明人： JACOBSON SVEN

9. 发明专利

AT169948B 未知
公开(公告)号：AT169948B
公开(公告)日：1951-12-27
申请号：AT169948D
申请日：1947-05-27
申请人： JACOBSON SVEN
发明人： JACOBSON SVEN

10. 发明申请

WO2007130962A3 DIAGNOSIS OF CARDIOVASCULAR DISEASE 审中-公开
标题翻译：心血管疾病诊断
公开(公告)号：WO2007130962A3
公开(公告)日：2008-09-04
申请号：PCT/US2007067914
申请日：2007-05-01
申请人： CRITICAL CARE DIAGNOSTICS INC , SNIDER JAMES V , JACOBSON SVEN
发明人： SNIDER JAMES V , JACOBSON SVEN
IPC分类号： G01N33/53 , A61K38/12 , C07H21/02 , C07H21/04 , C07K16/00
CPC分类号： G01N33/6869 , G01N33/6893 , G01N2333/7155 , G01N2800/226 , G01N2800/32 , G01N2800/325 , G01N2800/52
摘要： This invention relates to methods for the detection of cardiovascular disease, e.g., acute coronary syndrome, heart failure and/or pulmonary embolism, in high body mass index (BMI) individuals, e.g., with a BMI of 25-29, or 30 or above, and those with impaired renal function.
摘要翻译：本发明涉及用于检测高体重指数（BMI）个体的心血管疾病例如急性冠状动脉综合征，心力衰竭和/或肺栓塞的方法，例如BMI为25-29或30或更高，肾功能受损者。

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