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    • 5. 发明专利
    • Enzyme-containing composition, method for producing the same and use thereof
    • 含酶的组合物,其生产方法及其用途
    • JP2010090164A
    • 2010-04-22
    • JP2009294987
    • 2009-12-25
    • 3M Espe Agスリーエム エスペ アーゲー
    • HAEBERLEIN INGOGUGGENBERGER RAINERWEINMANN WOLFGANGKAPPLER OLIVER
    • A61K8/19A61K8/66A61K8/73A61K38/48A61P1/02A61Q11/00
    • A61K38/47A61K38/482A61K38/488A61K38/4886A61K2300/00
    • PROBLEM TO BE SOLVED: To cope with problems requiring a composition for removal of tooth tissue infected with caries by daily practice with a simple and painless method, further a composition for removal of caries without affecting, damaging or at least avoiding healthy tooth materials valuable to be preserved, and further a composition for removal of caries essentially securing no remaining of bacterial residue after treatment of caries, and further requiring a method for treating caries with simple and painless manner. SOLUTION: The composition includes at least one of each of biologically active protease and glycosidase with their activity ratio of 1,000,000:1 to 1:1,000,000 and at least 2 U/mL of the total enzymic activity. The method further relates to the method for production of the composition including such enzymes and a method of removing caries. In addition, the composition relates to use of the composition including one or more enzymes to produce a therapeutic agent for the removal of caries. COPYRIGHT: (C)2010,JPO&INPIT
    • 要解决的问题:为了解决需要通过简单和无痛方法通过日常实践去除感染龋齿的牙齿组织的组合物的问题,还提供了用于去除龋齿而不影响,损伤或至少避免健康牙齿的组合物 有待保存的材料,以及进一步用于除去龋齿的组合物,基本上确保了龋齿处理后没有残留的细菌残留物,并且还需要一种以简单且无痛的方式治疗龋齿的方法。 解决方案:组合物包含生物活性蛋白酶和糖苷酶各自中的至少一种,其活性比为1,000,000:1-1,000,000,总酶活性为至少2U / mL。 该方法还涉及包含这些酶的组合物的生产方法以及去除龋齿的方法。 此外,该组合物涉及包含一种或多种酶的组合物的使用以产生用于去除龋齿的治疗剂。 版权所有(C)2010,JPO&INPIT
    • 7. 发明申请
    • CATIONICALLY CURABLE DENTAL MATERIALS
    • 阳离子固化牙科材料
    • WO02055028A2
    • 2002-07-18
    • PCT/EP0200101
    • 2002-01-08
    • 3M ESPE AGHOESCHELER STEFANWEINMANN WOLFGANGSTIPPSCHILD ANDREAWEGNER SUSANNE
    • HOESCHELER STEFANWEINMANN WOLFGANGSTIPPSCHILD ANDREAWEGNER SUSANNE
    • A61K6/087
    • A61K6/005A61K6/09C08L83/12
    • The invention relates to a polymerizable dental material containing: (a) 3 to 80 wt. % of one or more cationically curable monomers; (b) 3 to 90 wt. % of one or more radio-opaque fillers; (c) 0.01 to 25 wt. % of initiators, retarders and/or accelerators, and; (d) 0 to 25 wt. % of auxiliary agents, whereby the cited percentages each refer to the total weight of the material. Filler (b) is produced by means of a melting method and is selected so that it has a refractive index of nD = 1.49 1.54, so that the viscosity of the polymerizable dental material, after a period of at least 9 months during which it was stored at a temperature ranging from 20 to 25 DEG C, has a value of +/- 50 % of the initial value measured 24 hours after the polymerizable dental material was produced, and so that the polymerizable dental material has a reactivity of the type that, once polymerization is initiated, the amount of the maximum heat flux generated by the dental material equals at least 0.8 mW/mg, and this maximum heat flux is attained within a period of no longer than 60 s.
    • 本发明涉及可聚合的牙科用组合物包括(a)3至80重量重量%的一种或多种阳离子固化的单体,(B)3至90重量%的一种或多种不透X射线的填料%,(C)0.01至25 .-%的引发剂,阻滞剂和/或促进剂,(D)0至25级重量%的助剂,在每种情况下所述百分比基于组合物的总重量,并且其中,所述填料(b)通过熔融法制造,并以这样的方式被选择 它具有ND的折射率= 1.49 - 1.54有,并且所述可聚合牙科用材料的Visikosität具有在20的存储温度的初始值的+/- 50%至25℃至少9个月的值,测得的 制备可聚合的牙科材料的24个小时后,和可聚合的牙科材料具有反应性的,使得,在聚合开始后,由牙科材料产生,至少为0的最大热通量的量, 为8毫瓦/ mg和该最大热通量至多60秒内完成。