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1. 发明申请

WO03085124A8 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
公开(公告)号：WO03085124A8
公开(公告)日：2004-02-19
申请号：PCT/US0309775
申请日：2003-04-01
申请人： CURAGEN CORP , ALSOBROOK JOHN P II , BENTO PATRICIA , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J
发明人： ALSOBROOK JOHN P II , BENTO PATRICIA , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J
IPC分类号： A61K38/00 , A61K38/17 , C07H21/04 , C07K14/00 , C07K14/47 , C07K16/18 , C12N15/12 , C12P21/02 , C12Q20060101 , C12Q1/68 , G01N33/53 , C12Q
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

2. 发明申请

WO02068652A9 PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：蛋白质和核酸编码相同
公开(公告)号：WO02068652A9
公开(公告)日：2002-11-28
申请号：PCT/US0205910
申请日：2002-02-26
申请人： CURAGEN CORP , ALSOBROOK JOHN P II , ANDERSON DAVID W , BALLINGER ROBERT A , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , ELLERMAN KAREN E , GANGOLLI ESHA A , GERLACH VALERIE L
发明人： ALSOBROOK JOHN P II , ANDERSON DAVID W , BALLINGER ROBERT A , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , ELLERMAN KAREN E , GANGOLLI ESHA A , GERLACH VALERIE L
IPC分类号： A61K38/00 , A61P3/00 , A61P3/10 , A61P21/00 , C07K14/47 , C12N15/12 , A61K38/17 , A61K39/395 , C07K16/18 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体，以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

4. 发明申请

WO03102155A2 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗性多肽，编码其的核酸及其使用方法
公开(公告)号：WO03102155A2
公开(公告)日：2003-12-11
申请号：PCT/US0317430
申请日：2003-06-03
申请人： CURAGEN CORP , ALSOBROOK JOHN P II , ALVAREZ ENRIQUE , ANDERSON DAVID W , BOLDOG FERENC L , CASMAN STACIE J , CATTERTON ELINA , CHAPOVAL ANDREI , CRABTREE-BOKOR JULIE R , EDINGER SHLOMIT R , ELLERMAN KAREN
发明人： ALSOBROOK JOHN P II , ALVAREZ ENRIQUE , ANDERSON DAVID W , BOLDOG FERENC L , CASMAN STACIE J , CATTERTON ELINA , CHAPOVAL ANDREI , CRABTREE-BOKOR JULIE R , EDINGER SHLOMIT R , ELLERMAN KAREN
IPC分类号： C12N20060101 , C12N1/00 , C12N15/12 , C12N
CPC分类号： C12N1/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法也包括在内。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

5. 发明申请

WO0246409A3 PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：蛋白质和核酸编码相同
公开(公告)号：WO0246409A3
公开(公告)日：2003-07-10
申请号：PCT/US0146586
申请日：2001-12-06
申请人： CURAGEN CORP , GUO XIAOJIA , LI LI , PATTURAJAN MEERA , SHIMKETS RICHARD A , CASMAN STACIE J , MALYANKAR URIEL M , TCHERNEV VELIZAR T , VERNET CORINNE A M , SPYTEK KIMBERLY A , SHENOY SURESH G , ALSOBROOK JOHN P II , EDINGER SCHLOMIT , PEYMAN JOHN A , STONE DAVID J , ELLERMAN KAREN , GANGOLLI ESHA A , BOLDOG FERENC L , COLMAN STEVEN D , EISEN ANDREW J , LIU XIAOHONG , PADIGARU MURALIDHARA , SPADERNA STEVEN K , ZERHUSEN BRYAN D
发明人： GUO XIAOJIA , LI LI , PATTURAJAN MEERA , SHIMKETS RICHARD A , CASMAN STACIE J , MALYANKAR URIEL M , TCHERNEV VELIZAR T , VERNET CORINNE A M , SPYTEK KIMBERLY A , SHENOY SURESH G , ALSOBROOK JOHN P II , EDINGER SCHLOMIT , PEYMAN JOHN A , STONE DAVID J , ELLERMAN KAREN , GANGOLLI ESHA A , BOLDOG FERENC L , COLMAN STEVEN D , EISEN ANDREW J , LIU XIAOHONG , PADIGARU MURALIDHARA , SPADERNA STEVEN K , ZERHUSEN BRYAN D
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K39/395 , A61P1/00 , A61P1/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P5/14 , A61P7/06 , A61P9/10 , A61P13/08 , A61P13/12 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K38/17 , A61K48/00 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
摘要翻译：公开了编码它们的多肽和核酸。还公开了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

6. 发明申请

WO0190187A3 G-PROTEIN COUPLED OLFACTORY RECEPTORS 审中-公开
标题翻译： G蛋白联合OLFACTORY受体
公开(公告)号：WO0190187A3
公开(公告)日：2003-03-13
申请号：PCT/US0117114
申请日：2001-05-24
申请人： CURAGEN CORP , PADIGARU MURALIDHARA , SPYTEK KIMBERLY A , MAJUMDER KUMUD , TCHERNEV VELIZAR T , GROSSE WILLIAM M , SZERKERES EDWARD D , ALSOBROOK JOHN P II , BURGESS CATHERINE E , SHIMKETS RICHARD A , TAUPIER RAYMOND J , CASMAN STACIE J , GANGOLLI ESHA A , MACDOUGALL JOHN R , STONE DAVID J , SMITHSON GLENNDA
发明人： PADIGARU MURALIDHARA , SPYTEK KIMBERLY A , MAJUMDER KUMUD , TCHERNEV VELIZAR T , GROSSE WILLIAM M , SZERKERES EDWARD D , ALSOBROOK JOHN P II , BURGESS CATHERINE E , SHIMKETS RICHARD A , TAUPIER RAYMOND J , CASMAN STACIE J , GANGOLLI ESHA A , MACDOUGALL JOHN R , STONE DAVID J , SMITHSON GLENNDA
IPC分类号： C07K14/705 , C12N15/12 , C07K14/72 , C07K16/28 , C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

7. 发明申请

WO0206345A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白和核酸编码相同
公开(公告)号：WO0206345A2
公开(公告)日：2002-01-24
申请号：PCT/US0122637
申请日：2001-07-18
申请人： CURAGEN CORP , ZERHUSEN BRYAN , PADIGARU MURALIDHARA , LI LI , BURGESS CATHERINE E , CASMAN STACIE J , SPYTEK KIMBERLY A , MISHRA VISHNU , TAYLOR SARAH , SHENOY SURESH , VERNET CORINE , GERLACH VALERIE , ELLERMAN KAREN , MACDOUGALL JOHN R , STONE DAVID , SMITHSON GLENNDA , GROSSE WILLIAM M , ALSOBROOK JOHN P II , LEPLEY DENISE M , TCHERNEV VELIZAR T , TAILLON BRUCE
发明人： ZERHUSEN BRYAN , PADIGARU MURALIDHARA , LI LI , BURGESS CATHERINE E , CASMAN STACIE J , SPYTEK KIMBERLY A , MISHRA VISHNU , TAYLOR SARAH , SHENOY SURESH , VERNET CORINE , GERLACH VALERIE , ELLERMAN KAREN , MACDOUGALL JOHN R , STONE DAVID , SMITHSON GLENNDA , GROSSE WILLIAM M , ALSOBROOK JOHN P II , LEPLEY DENISE M , TCHERNEV VELIZAR T , TAILLON BRUCE
IPC分类号： C07K14/705 , C12N15/12
CPC分类号： C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospeficically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human acids and proteins.
摘要翻译：本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及与多肽免疫表面结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人酸和蛋白质中的任何一种相关的病症的治疗，诊断和研究方法。

8. 发明申请

WO0181378A3 G-PROTEIN COUPLED RECEPTORS 审中-公开
标题翻译： G蛋白偶联受体
公开(公告)号：WO0181378A3
公开(公告)日：2003-05-08
申请号：PCT/US0113680
申请日：2001-04-27
申请人： CURAGEN CORP , PADIGARU MURALIDHARA , MISHRA VISHNU , SPYTEK KIMBERLY A , GROSSE WILLIAM M , SZEKERES EDWARD S JR , ALSOBROOK JOHN P II , BURGESS CATHERINE E , CASMAN STACIE J , LEPLEY DENISE M , GANGOLLI ESHA A , MACDOUGALL JOHN R , SMITHSON GLENNDA
发明人： PADIGARU MURALIDHARA , MISHRA VISHNU , SPYTEK KIMBERLY A , GROSSE WILLIAM M , SZEKERES EDWARD S JR , ALSOBROOK JOHN P II , BURGESS CATHERINE E , CASMAN STACIE J , LEPLEY DENISE M , GANGOLLI ESHA A , MACDOUGALL JOHN R , SMITHSON GLENNDA
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C07K14/72 , C07K16/28 , C12N5/10 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invension further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。该进一步公开了用于诊断，治疗和预防涉及这些新型人核酸和蛋白质中的任何一种的病症的治疗，诊断和研究方法。

9. 发明申请

WO03004687A8 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白质和编码相同的核酸
公开(公告)号：WO03004687A8
公开(公告)日：2003-05-08
申请号：PCT/US0221361
申请日：2002-07-03
申请人： CURAGEN CORP , ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , CATTERTON ELINA
发明人： ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , CATTERTON ELINA
IPC分类号： C07K14/47 , C12Q
CPC分类号： C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态。更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。本发明还公开了与疾病相关的治疗性小分子。本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

10. 发明申请

WO0212343A3 PROTEINS AND NUCLEIC ACIDS ENCODING G-PROTEIN COUPLED RECEPTORS 审中-公开
标题翻译：蛋白和核酸编码G蛋白偶联受体
公开(公告)号：WO0212343A3
公开(公告)日：2003-06-19
申请号：PCT/US0124787
申请日：2001-08-07
申请人： CURAGEN CORP , SPYTEK KIMBERLY A , PADIGARU MURALIDHARA , ZERHUSEN BRYAN D , BAUMGARTNER JASON C , LI LI , CASMAN STACIE J , VERNET CORINE A M , BALLINGER ROBERT A , SHENOY SURESH G , KEKUDA RAMESH , BURGESS CATHERINE E , MEZES PETER S , GROSSE WILLIAM M , ALSOBROOK JOHN P II , GORMAN LINDA , LAROCHELLE WILLIAM J , TAUPIER RAYMOND J JR , COLMAN STEVEN D , SZEKERES EDWARD S JR
发明人： SPYTEK KIMBERLY A , PADIGARU MURALIDHARA , ZERHUSEN BRYAN D , BAUMGARTNER JASON C , LI LI , CASMAN STACIE J , VERNET CORINE A M , BALLINGER ROBERT A , SHENOY SURESH G , KEKUDA RAMESH , BURGESS CATHERINE E , MEZES PETER S , GROSSE WILLIAM M , ALSOBROOK JOHN P II , GORMAN LINDA , LAROCHELLE WILLIAM J , TAUPIER RAYMOND J JR , COLMAN STEVEN D , SZEKERES EDWARD S JR
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , A61K38/17 , C07K16/28 , C12N5/10 , C12Q1/68 , G01N33/566 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/022
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and reserch methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码G偶联的蛋白质 - 受体相关多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防涉及这些新型人核酸和蛋白质中的任何一种的病症的治疗，诊断和储备方法。

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