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2. 发明申请

WO2003008562A2 METHODS FOR DETECTING GENES ASSOCIATED WITH BONE PROPERTIES, HEIGHT, AND/OR BODY MASS PROPERTIES 审中-公开
标题翻译：用于检测与骨性质，身高和/或身体质量特性相关的基因的方法
公开(公告)号：WO2003008562A2
公开(公告)日：2003-01-30
申请号：PCT/US2002/023293
申请日：2002-07-22
申请人： CREIGHTON UNIVERSITY
发明人： RECKER, Robert, R. , DENG, Hong-Wen
IPC分类号： C12N
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Disclosed are methods for detecting the presence in a subject of a polymorphism linked to a gene associated with one or more bone properties, such as spine bone mineral density, hip bone mineral density, wrist bone mineral density, spine bone size, hip bone size, and wrist bone size. The method includes analyzing at least a portion of the subject's genome and detecting the presence of a polymorphism which is located in or near various specified regions of the subject's genome and which is linked to the gene associated with the bone property of interest. The presence of the polymorphism is indicative of the subject having or being susceptible to having aberrant bone properties. Also disclosed are methods for detecting the presence in a subject of a polymorphism linked to a gene associates with height or with one or more body mass properties, such as body mass index, percentage fat mass, fat mass, and lean mass. The methods can be used, for example, to screen for a subject's having or being susceptible to conditions such as osteoporosis and obesity.
摘要翻译：公开了用于检测受试者中存在与一种或多种骨性质相关的基因的多态性的方法，例如脊骨矿物质密度，髋骨矿物质密度，腕骨矿物质密度，脊骨尺寸，髋骨尺寸，和腕骨尺寸。该方法包括分析受试者的基因组的至少一部分并检测多态性的存在，所述多态性位于受试者的基因组的各个指定区域内或附近，并且与与感兴趣的骨性质相关的基因连接。多态性的存在表明受试者具有或易于具有异常骨性质。还公开了用于检测受试者中存在与高度相关的基因或与一种或多种身体质量特性（诸如身体质量指数，脂肪百分比，脂肪量和瘦体重）相关联的多态性的检测方法。例如，可以使用这些方法筛选具有或易受诸如骨质疏松症和肥胖症的受试者的受试者。

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