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1. 发明申请

WO2007113646B1 A PHARMACEUTICAL COMPOSITION USEFUL AS AN IMMUNOMODULATING AGENT AND A PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：作为免疫调节剂有用的药物组合物及其制备方法
公开(公告)号：WO2007113646B1
公开(公告)日：2008-09-12
申请号：PCT/IB2007000856
申请日：2007-04-03
申请人： COUNCIL SCIENT IND RES , SANGWAN RAJENDER SINGH , CHAURASIYA NARAYAN DAS , MISRA LAXMI NARAIN , LAL PAYARE , UNIYAL GIRISH CHANDRA , SANGWAN NEELAM SINGH , SRIVASTAVA AVDHESH KUMAR , SURI KRISHAN AVTAR , QAZI GHULAM NABI , TULI RAKESH
发明人： SANGWAN RAJENDER SINGH , CHAURASIYA NARAYAN DAS , MISRA LAXMI NARAIN , LAL PAYARE , UNIYAL GIRISH CHANDRA , SANGWAN NEELAM SINGH , SRIVASTAVA AVDHESH KUMAR , SURI KRISHAN AVTAR , QAZI GHULAM NABI , TULI RAKESH
IPC分类号： A61K36/896 , A61K125/00 , A61P37/02
CPC分类号： A61K36/896
摘要： The present invention is directed towards immunity enhancing activity in Chlorophytum (Safed Musli) due to a novel gel ' forming aqueous extract of Chlorophytum (Safed Musli) or its partially or completely purified carbohydrate (polysaccharide), and thereby Chlorophytum or its aqueous extract or gel or carbohydrates form useful and safe health promoting substances that can be consumed alone or as additive in food, food products etc. or as functional food, dietary substances and nutraceutical. Further, the bioactive substance compositions comprising novel carbohydrates particularly but not limited to Chlorophytum or Musli glucomannan (MGM) discovered herein from the plant. Thus the plant, plant aqueous extract, partially purified or completely purified carbohydrate products and its associated processes, properties, uses and applications in any mode form the components of this invention. The novel bioactive polysaccharide/ heteroglycan of the plant invented herein preparations are positive biomodulators for mammalian physiology to jack-up its immune defence in normal as well as diseased and ailing individuals. These compositions if consumed orally or otherwise would improve the well being of mammals suffering from or susceptible to a variety of bodily inefficient functions or disorders in general and immune system related ones in particular. The invention allows alternate designation of Chlorophytum as Indian Konjac.
摘要翻译：本发明涉及绿藻（Safed Musli）中的免疫增强活性，因为新型凝胶形成的Chlorophytum（Safed Musli）的水提取物或其部分或完全纯化的碳水化合物（多糖），因此Chlorophyum或其水提取物或凝胶或碳水化合物形成有用和安全的健康促进物质，其可以单独消耗或作为食品，食品等中的添加剂或作为功能食品，膳食物质和营养品。此外，生物活性物质组合物包含新颖的碳水化合物，特别但不限于本文从植物中发现的Chlorophytum或Musli葡甘露聚糖（MGM）。因此，植物，植物水提取物，部分纯化或完全纯化的碳水化合物产物及其相关的方法，性质，用途和应用以任何方式形成本发明的组分。本文发明的植物的新型生物活性多糖/异源聚糖制剂是用于哺乳动物生理学的阳性生物调节剂，以在正常的以及患病和衰弱的个体中起到其免疫防御作用。这些组合物如果以口服或其他方式食用，则会改善患有或易患各种身体无效的功能或疾病，特别是与免疫系统相关的哺乳动物的健康。本发明允许替代命名为Chlorophyum作为印度魔芋。

2. 发明申请

WO2007113646A3 A PHARMACEUTICAL COMPOSITION USEFUL AS AN IMMUNOMODULATING AGENT AND A PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：用作免疫调节剂的药物组合物及其制备方法
公开(公告)号：WO2007113646A3
公开(公告)日：2008-07-03
申请号：PCT/IB2007000856
申请日：2007-04-03
申请人： COUNCIL SCIENT IND RES , SANGWAN RAJENDER SINGH , CHAURASIYA NARAYAN DAS , MISRA LAXMI NARAIN , LAL PAYARE , UNIYAL GIRISH CHANDRA , SANGWAN NEELAM SINGH , SRIVASTAVA AVDHESH KUMAR , SURI KRISHAN AVTAR , QAZI GHULAM NABI , TULI RAKESH
发明人： SANGWAN RAJENDER SINGH , CHAURASIYA NARAYAN DAS , MISRA LAXMI NARAIN , LAL PAYARE , UNIYAL GIRISH CHANDRA , SANGWAN NEELAM SINGH , SRIVASTAVA AVDHESH KUMAR , SURI KRISHAN AVTAR , QAZI GHULAM NABI , TULI RAKESH
IPC分类号： A61K36/896 , A61K125/00 , A61P37/02
CPC分类号： A61K36/896
摘要： The present invention is directed towards immunity enhancing activity in Chlorophytum (Safed Musli) due to a novel gel ' forming aqueous extract of Chlorophytum (Safed Musli) or its partially or completely purified carbohydrate (polysaccharide), and thereby Chlorophytum or its aqueous extract or gel or carbohydrates form useful and safe health promoting substances that can be consumed alone or as additive in food, food products etc. or as functional food, dietary substances and nutraceutical. Further, the bioactive substance compositions comprising novel carbohydrates particularly but not limited to Chlorophytum or Musli glucomannan (MGM) discovered herein from the plant. Thus the plant, plant aqueous extract, partially purified or completely purified carbohydrate products and its associated processes, properties, uses and applications in any mode form the components of this invention. The novel bioactive polysaccharide/ heteroglycan of the plant invented herein preparations are positive biomodulators for mammalian physiology to jack-up its immune defence in normal as well as diseased and ailing individuals. These compositions if consumed orally or otherwise would improve the well being of mammals suffering from or susceptible to a variety of bodily inefficient functions or disorders in general and immune system related ones in particular. The invention allows alternate designation of Chlorophytum as Indian Konjac.
摘要翻译：本发明涉及由于新型凝胶形成的Chlorophytum（Safed Musli）水性提取物或其部分或完全纯化的碳水化合物（多糖）以及因此吊兰或其水提取物或凝胶而导致的吊兰（Safed Musli）中免疫增强活性或碳水化合物形成有用且安全的促进健康的物质，其可以单独食用或者作为食品，食品等中的添加剂或作为功能性食品，膳食物质和营养食品。此外，生物活性物质组合物包含新的碳水化合物，特别是但不限于本文从植物中发现的吊兰或甘蓝葡糖甘露聚糖（MGM）。因此，植物，植物含水提取物，部分纯化或完全纯化的碳水化合物产物及其相关工艺，性能，用途和以任何方式应用形成本发明的组分。本发明所述植物的新型生物活性多糖/杂聚糖是用于哺乳动物生理学的阳性生物调节剂，用于在正常以及患病和患病个体中提高其免疫防御能力。如果这些组合物口服或以其他方式消费，将改善哺乳动物的健康状况，所述哺乳动物特别是患有或易患各种身体低效功能或疾病的哺乳动物的健康状况，特别是与免疫系统有关的疾病。本发明允许将Chlorophytum替代称为印度魔芋。

3. 发明申请

WO2016051424A4 A FORMULATION USEFUL FOR DELIVERY OF NEURO PROTECTING AGENT 审中-公开
标题翻译：用于输送神经保护剂的配方
公开(公告)号：WO2016051424A4
公开(公告)日：2016-05-19
申请号：PCT/IN2015050124
申请日：2015-09-29
申请人： COUNCIL SCIENT IND RES
发明人： DWIVEDI ANIL KUMAR , AHMAD HAFSA , KHANDELWAL KIRAN , SANGWAN RAJENDER SINGH , SANGWAN NEELAM SINGH , GAYEN JIAUR RAHAMAN , SARIKA , BHADUARIA SMRATI , GAUR SURESH PRATAP SINGH , BHOSALE VIVEK VIDYADHAR , RATH SRIKANTA KUMAR , SHARMA SHARAD , SHUKLA RAKESH
IPC分类号： A61K9/127 , A61K9/20 , A61K9/48 , A61K36/81 , A61P9/10
CPC分类号： A61K9/127 , A61K9/2009 , A61K9/485 , A61K36/81
摘要： The present invention relates to a formulation useful for delivery of neuro protecting agent. It also demonstrates and discloses a novel delivery system for an extract of a new chemotype of Withania sonmifera (NMITLI118RT+) for neuro- protection against cerebral stroke (signifies concentrated aqueous ethanolic extract of roots of NMITLI-118, a new chemotype of Withania somnifera, a variety of Ashwagandha, which is unique in having high root yield, possessing a uniform crop canopy and uniform composition with respect to its secondary metabolites- withanolides. It is phytochemically characterized by particular abundance of two withanolides i.e. withanone and/or withanolide A, specimens of which are kept in the herbarium of CSIR-CIMAP, Lucknow, India) (Chaurasiya ND, Sangwan RS, Mishra L N, Tuli R, Sangwan N S, Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, Isoenzyme, polypeptide and withanolide profile diversity-Fitoterapia 2009, 80 (8) 496-505) for neuro- protection against cerebral stroke. Broadly, the invention discloses potent and prudent therapeutic potential of a new formulation using standardized fraction NMITLI118RT+ of a new variety of Withania somnifera (Ashwagandha) for brain function restoration and protection from neurological failures. Particularly the present invention further relates to the process for the preparation of the said formulation containing Standardized NMITLI118RT+ extract, its pharmaceutical compositions, for the management of cerebral stroke. The present invention also relates to a method of treatment of cerebral stroke and comprising of administering the formulation in a predetermined doses and period.
摘要翻译：本发明涉及可用于递送神经保护剂的制剂。它还展示并公开了用于神经保护脑卒中的新型化学型（NMITLI118RT +）的提取物的新型递送系统（意指NMITLI-118的根的浓缩含水乙醇提取物，一种新的With new new new new，各种Ashwagandha，其具有高根系的独特性，具有均匀的作物冠层和相对于其次级代谢产物 - 均匀化合物的均匀组成，其植物化学特征在于特别丰富的两种己内酯，即与酮和/或内酯A，（Chaurasiya ND，Sangwan RS，Mishra LN，Tuli R，Sangwan NS），通过DNA，同工酶，多肽和印度人参的核心收集的印度人参的隐性聚集体的代谢聚类（CSR-CIMAP，对于大脑中风的神经保护作用，其具有多种多样性 - Fitoterapia 2009,80（8）496-505）。概括地说，本发明公开了一种使用标准化部分NMITLI118RT +的新型制剂的有效且审慎的治疗潜力，其用于大脑功能恢复和保护免受神经功能障碍的新型多巴胺虫（Ashwagandha）。特别地，本发明还涉及制备含有用于管理脑中风的标准化NMITLI118RT +提取物及其药物组合物的制剂的方法。本发明还涉及一种治疗脑卒中的方法，包括以预定的剂量和时期施用该制剂。

4. 发明专利

ZA200407702B Protein profiling of hyper acidic plants. 未知
公开(公告)号：ZA200407702B
公开(公告)日：2006-02-22
申请号：ZA200407702
申请日：2004-09-23
申请人： COUNCIL SCIENT IND RES
发明人： SANGWAN RAJENDER SINGH , SANGWAN NEELAM SINGH , TYAGI BALI RAM , SRIVASTAVA AVDHESH KUMAR , YADAV USHA
IPC分类号： G01N , A01H

5. 发明专利

AU2015326378A1 A formulation useful for delivery of neuro protecting agent 未知
公开(公告)号：AU2015326378A1
公开(公告)日：2016-08-18
申请号：AU2015326378
申请日：2015-09-29
申请人： COUNCIL SCIENT IND RES
发明人： DWIVEDI ANIL KUMAR , AHMAD HAFSA , KHANDELWAL KIRAN , SANGWAN RAJENDER SINGH , SANGWAN NEELAM SINGH , GAYEN JIAUR RAHAMAN , SARIKA , BHADUARIA SMRATI , GAUR SURESH PRATAP SINGH , BHOSALE VIVEK VIDYADHAR , RATH SRIKANTA KUMAR , SHARMA SHARAD , SHUKLA RAKESH
IPC分类号： A61K9/127 , A61K9/20 , A61K9/48 , A61K36/81 , A61P9/10
摘要： The present invention relates to a formulation useful for delivery of neuro protecting agent. It also demonstrates and discloses a novel delivery system for an extract of a new chemotype of Withania sonmifera (NMITLI118RT+) for neuro- protection against cerebral stroke (signifies concentrated aqueous ethanolic extract of roots of NMITLI-118, a new chemotype of Withania somnifera, a variety of Ashwagandha, which is unique in having high root yield, possessing a uniform crop canopy and uniform composition with respect to its secondary metabolites- withanolides. It is phytochemically characterized by particular abundance of two withanolides i.e. withanone and/or withanolide A, specimens of which are kept in the herbarium of CSIR-CIMAP, Lucknow, India) (Chaurasiya ND, Sangwan RS, Mishra L N, Tuli R, Sangwan N S, Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, Isoenzyme, polypeptide and withanolide profile diversity-Fitoterapia 2009, 80 (8) 496-505) for neuro- protection against cerebral stroke. Broadly, the invention discloses potent and prudent therapeutic potential of a new formulation using standardized fraction NMITLI118RT+ of a new variety of Withania somnifera (Ashwagandha) for brain function restoration and protection from neurological failures. Particularly the present invention further relates to the process for the preparation of the said formulation containing Standardized NMITLI118RT+ extract, its pharmaceutical compositions, for the management of cerebral stroke. The present invention also relates to a method of treatment of cerebral stroke and comprising of administering the formulation in a predetermined doses and period.

6. 发明专利

AU2002246295A1 PROTEIN PROFILING OF HYPER ACIDIC PLANTS 未知
公开(公告)号：AU2002246295A1
公开(公告)日：2003-10-08
申请号：AU2002246295
申请日：2002-03-25
申请人： COUNCIL SCIENT IND RES
发明人： SANGWAN NEELAM SINGH , TYAGI BALI RAM , SRIVASTAVA AVDHESH KUMAR , YADAV USHA , SANGWAN RAJENDER SINGH
IPC分类号： A01H5/00 , C12Q1/44 , C12Q1/52 , G01N33/50 , G01N33/569 , G01N33/68

7. 发明专利

AU2015326378B2 A formulation useful for delivery of neuro protecting agent 未知
公开(公告)号：AU2015326378B2
公开(公告)日：2021-01-21
申请号：AU2015326378
申请日：2015-09-29
申请人： COUNCIL SCIENT IND RES
发明人： DWIVEDI ANIL KUMAR , AHMAD HAFSA , KHANDELWAL KIRAN , SANGWAN RAJENDER SINGH , SANGWAN NEELAM SINGH , GAYEN JIAUR RAHAMAN , SARIKA , BHADUARIA SMRATI , GAUR SURESH PRATAP SINGH , BHOSALE VIVEK VIDYADHAR , RATH SRIKANTA KUMAR , SHARMA SHARAD , SHUKLA RAKESH
IPC分类号： A61K9/127 , A61K9/20 , A61K9/48 , A61K36/81 , A61P9/10
摘要： The present invention relates to a formulation useful for delivery of neuro protecting agent. It also demonstrates and discloses a novel delivery system for an extract of a new chemotype of Withania sonmifera (NMITLI118RT+) for neuro- protection against cerebral stroke (signifies concentrated aqueous ethanolic extract of roots of NMITLI-118, a new chemotype of Withania somnifera, a variety of Ashwagandha, which is unique in having high root yield, possessing a uniform crop canopy and uniform composition with respect to its secondary metabolites- withanolides. It is phytochemically characterized by particular abundance of two withanolides i.e. withanone and/or withanolide A, specimens of which are kept in the herbarium of CSIR-CIMAP, Lucknow, India) (Chaurasiya ND, Sangwan RS, Mishra L N, Tuli R, Sangwan N S, Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, Isoenzyme, polypeptide and withanolide profile diversity-Fitoterapia 2009, 80 (8) 496-505) for neuro- protection against cerebral stroke. Broadly, the invention discloses potent and prudent therapeutic potential of a new formulation using standardized fraction NMITLI118RT+ of a new variety of Withania somnifera (Ashwagandha) for brain function restoration and protection from neurological failures. Particularly the present invention further relates to the process for the preparation of the said formulation containing Standardized NMITLI118RT+ extract, its pharmaceutical compositions, for the management of cerebral stroke. The present invention also relates to a method of treatment of cerebral stroke and comprising of administering the formulation in a predetermined doses and period.

8. 发明专利

BR0215659A 未知
公开(公告)号：BR0215659A
公开(公告)日：2005-01-25
申请号：BR0215659
申请日：2002-03-25
申请人： COUNCIL SCIENT IND RES
发明人： SANGWAN RAJENDER SINGH , SANGWAN NEELAM SINGH , TYAGI BALI RAM , SRIVASTAVA AVDHESH KUMAR , YADAV USHA
IPC分类号： A01H5/00 , C12Q1/44 , C12Q1/52 , G01N33/50 , G01N33/569 , G01N33/68

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