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1. 发明申请

WO2016162564A1 METHOD AND DEVICE FOR DETECTING A CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE 审中-公开
标题翻译：用于检测产生胆碱酯酶的生产方法和装置
公开(公告)号：WO2016162564A1
公开(公告)日：2016-10-13
申请号：PCT/EP2016/057927
申请日：2016-04-11
申请人： CORIS BIOCONCEPT SPRL
发明人： BOGAERTS, Pierre , GLUPCZYNSKI, Gerald , HUANG, Te-Din , MERTENS, Pascal , OTE, Isabelle , LECLIPTEUX, Thierry
IPC分类号： C12Q1/04 , G01N33/573 , C07K16/40 , C07K16/12
CPC分类号： G01N33/573 , C12Q1/04 , G01N2333/986 , Y02A50/451
摘要： The present invention is related to a method for the detection of one or several carbapenemases from a Carbapenemase-producing Enterobacteriaceae (CPE) possibly present in a biological sample, the method comprising the steps of providing a support, immobilizing on the support one or several capture reagents interacting with one or several epitope regions of one or several carbapenemases, providing one or several detection reagents interacting with one or several epitope regions of the one or several carbapenemases, the detection reagent or reagents being linked, directly or indirectly, to a label to form one or several detection conjugates, providing a sample to be tested comprising, or not, one or several carbapenemases to detect, bringing the sample into contact with the capture reagent or reagents, revealing a specific binding between one or several carbapenemases present in the sample using the detection reagent or reagents. The invention relates also to an immunochromatographic detection device to implement the method according to the invention.
摘要翻译：本发明涉及一种用于检测可能存在于生物样品中的来自产生碳青霉烯酶的肠杆菌科（CPE）的一种或几种碳青霉烯酶的方法，所述方法包括以下步骤：提供载体，固定在载体上一个或多个捕获与一种或几种碳青霉烯酶的一个或几个表位区域相互作用的试剂，提供与一种或几种碳青霉烯类酶的一个或几个表位区域相互作用的一种或几种检测试剂，所述检测试剂或试剂直接或间接连接到标记物形成一个或几个检测共轭物，提供待测试的样品包含或不包含一个或几个碳青霉烯酶以检测，使样品与捕获试剂或试剂接触，揭示样品中存在的一种或几种氨基甲酸酯酶之间的特异性结合使用检测试剂或试剂。本发明还涉及实现本发明方法的免疫色谱检测装置。

2. 发明申请

WO2014005969A1 PROCEDE ET DISPOSITIF POUR LA DETECTION RAPIDE DE SEQUENCES NUCLEOTIDIQUES AMPLIFIEES 审中-公开
标题翻译：用于快速检测放大核苷酸序列的方法和装置
公开(公告)号：WO2014005969A1
公开(公告)日：2014-01-09
申请号：PCT/EP2013/063777
申请日：2013-07-01
申请人： CORIS BIOCONCEPT SPRL
发明人： LECLIPTEUX, Thierry , MERTENS, Pascal , AVRAIN, Laetitia , OTE, Isabelle , SMEKENS, Valérie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L7/525 , B01L2200/10 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0825 , B01L2300/088 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2400/0481 , G01N2021/6439 , C12Q2537/143 , C12Q2565/625 , C12Q2565/629
摘要： La présente invention se rapporte à un procédé et un dispositif d'amplification et de détection rapide de séquences nucléotidiques cibles éventuellement présentes dans un échantillon combinant une amplification par PCR sous flux continu à une détection oligochromatographique par capillarité sur tigette.
摘要翻译：本发明涉及用于扩增和快速检测样本中可能存在的靶核苷酸序列的方法和装置，其通过毛细血管作用在测试条上组合连续流PCR扩增与寡色谱检测。

3. 发明申请

WO2004099438A1 ONE STEP OLIGOCHROMATOGRAPHIC DEVICE AND METHOD OF USE 审中-公开
标题翻译：一步式光刻设备及其使用方法
公开(公告)号：WO2004099438A1
公开(公告)日：2004-11-18
申请号：PCT/BE2004/000061
申请日：2004-04-30
申请人： CORIS BIOCONCEPT SPRL , RENUART, Ismaelle , MERTENS, Pascal , LECLIPTEUX, Thierry
发明人： RENUART, Ismaelle , MERTENS, Pascal , LECLIPTEUX, Thierry
IPC分类号： C12Q1/68
CPC分类号： G01N33/54386 , C12Q1/6834 , G01N30/90 , G01N30/92 , G01N33/558 , C12Q2565/625 , C12Q2565/137 , C12Q2545/101 , C12Q2563/131 , C12Q2537/125
摘要： The present invention relates to methods and devices for detecting one or more analytes in a biological sample, preferably a clean liquid sample. This invention in particular relates to improved rapid tests such as "dipsticks", "lateral flow" devices and "flow-through" devices. The invention in particular relates to oligochromatographic devices (1) that make use of a peptide- or hapten-coupled oligonucleotide and a reagent (5) specifically recognizing said hapten or peptide (8) and a conjugated probe (6) that hybridizes specifically to a target sequence (7). It allows to detect specifically the presence of a polynucleotides directly or after molecular amplification steps with the use of a specific genuine internal control and a chromatographic control.
摘要翻译：本发明涉及用于检测生物样品中一种或多种分析物，优选清洁液体样品的方法和装置。本发明特别涉及改进的快速测试，例如“骰子”，“横向流动”装置和“流通”装置。本发明特别涉及利用肽或半抗原偶联的寡核苷酸的寡色谱装置（1）和特异性识别所述半抗原或肽（8）的试剂（5）和与目标序列（7）。它允许通过使用特定的真正的内部对照和色谱控制来直接或在分子扩增步骤之后具体检测多核苷酸的存在。

4. 发明公开

EP3280815A1 METHOD AND DEVICE FOR DETECTING A CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE 有权
标题翻译：用于检测产生卡巴肽酶的肠杆菌科的方法和装置
公开(公告)号：EP3280815A1
公开(公告)日：2018-02-14
申请号：EP16717589.2
申请日：2016-04-11
申请人： Coris Bioconcept SPRL
发明人： BOGAERTS, Pierre , GLUPCZYNSKI, Gerald , HUANG, Te-Din , MERTENS, Pascal , OTE, Isabelle , LECLIPTEUX, Thierry
IPC分类号： C12Q1/04 , G01N33/573 , C07K16/40 , C07K16/12
CPC分类号： G01N33/573 , C12Q1/04 , G01N2333/986 , Y02A50/451
摘要： The present invention is related to a method for the detection of one or several carbapenemases from a Carbapenemase-producing Enterobacteriaceae (CPE) possibly present in a biological sample, the method comprising the steps of providing a support, immobilizing on the support one or several capture reagents interacting with one or several epitope regions of one or several carbapenemases, providing one or several detection reagents interacting with one or several epitope regions of the one or several carbapenemases, the detection reagent or reagents being linked, directly or indirectly, to a label to form one or several detection conjugates, providing a sample to be tested comprising, or not, one or several carbapenemases to detect, bringing the sample into contact with the capture reagent or reagents, revealing a specific binding between one or several carbapenemases present in the sample using the detection reagent or reagents. The invention relates also to an immunochromatographic detection device to implement the method according to the invention.

5. 发明公开

EP2870260A1 PROCEDE ET DISPOSITIF POUR LA DETECTION RAPIDE DE SEQUENCES NUCLEOTIDIQUES AMPLIFIEES 有权
标题翻译： VERFAHREN UND VORRICHTUNG ZUM SCHNELLEN NACHWEIS VON AMPLIFIZIERTEN NUKLEOTIDSEQUENZEN
公开(公告)号：EP2870260A1
公开(公告)日：2015-05-13
申请号：EP13734714.2
申请日：2013-07-01
申请人： Coris Bioconcept SPRL
发明人： LECLIPTEUX, Thierry , MERTENS, Pascal , AVRAIN, Laetitia , OTE, Isabelle , SMEKENS, Valérie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L7/525 , B01L2200/10 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0825 , B01L2300/088 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2400/0481 , G01N2021/6439 , C12Q2537/143 , C12Q2565/625 , C12Q2565/629
摘要： The present invention relates to a method and a device for amplification and rapid detection of target nucleotide sequences possibly present in a sample, combining continuous-flow PCR amplification with oligochromatography detection by capillary action on a test strip.
摘要翻译：用于快速扩增和检测样品中可能存在的靶核苷酸序列的方法和装置，优选将PCR扩增与通过测试条上的毛细作用的低色谱检测结合。

6. 发明授权

EP1957984B1 TEST DEVICE FOR RAPID DIAGNOSTICS 有权
标题翻译：试验装置进行快速诊断
公开(公告)号：EP1957984B1
公开(公告)日：2011-10-05
申请号：EP06829403.2
申请日：2006-12-08
申请人： Coris Bioconcept SPRL
发明人： MERTENS, Pascal , DENORME, Laurence , LECLIPTEUX, Thierry
IPC分类号： G01N33/558 , G01N33/543
CPC分类号： G01N33/558 , G01N33/54386 , G01N33/569
摘要： This invention relates to devices for detecting analytes or analogues thereof in a biological sample comprising: a solid support, whereon is provided several juxtaposed zones, whereby the sample is able to migrate from a sample receiving zone towards a detection zone, whereby the analyte if present is detected, whereby both zones comprises material allowing a capillary flow of the sample through said zones, characterized in that in between said zones an intermediate zone of transport of the sample is provided which is free from any capillary material, allowing the sample to migrate by gravitational forces on the support laid in a vertical position. This invention also relates to methods for detecting analytes or analogues thereof in a biological sample.

7. 发明授权

EP3280815B1 METHOD AND DEVICE FOR DETECTING A CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE 有权
公开(公告)号：EP3280815B1
公开(公告)日：2020-10-28
申请号：EP16717589.2
申请日：2016-04-11
申请人： Coris Bioconcept SPRL
发明人： BOGAERTS, Pierre , GLUPCZYNSKI, Gerald , HUANG, Te-Din , MERTENS, Pascal , OTE, Isabelle , LECLIPTEUX, Thierry
IPC分类号： C12Q1/04 , G01N33/573 , C07K16/40 , C07K16/12

8. 发明公开

EP1623042A1 ONE STEP OLIGOCHROMATOGRAPHIC DEVICE AND METHOD OF USE 有权
标题翻译：一步寡聚色谱装置和使用方法
公开(公告)号：EP1623042A1
公开(公告)日：2006-02-08
申请号：EP04730419.1
申请日：2004-04-30
申请人： Coris Bioconcept SPRL
发明人： RENUART, Ismaelle , MERTENS, Pascal , LECLIPTEUX, Thierry
IPC分类号： C12Q1/68 , G01N33/558
CPC分类号： G01N33/54386 , C12Q1/6834 , G01N30/90 , G01N30/92 , G01N33/558 , C12Q2565/625 , C12Q2565/137 , C12Q2545/101 , C12Q2563/131 , C12Q2537/125
摘要： The present invention relates to methods and devices for detecting one or more analytes in a biological sample, preferably a clean liquid sample. This invention in particular relates to improved rapid tests such as 'dipsticks', 'lateral flow' devices and 'flow-through' devices. The invention in particular relates to oligochromatographic devices (1) that make use of a peptide- or hapten-coupled oligonucleotide and a reagent (5) specifically recognizing said hapten or peptide (8) and a conjugated probe (6) that hybridizes specifically to a target sequence (7). It allows to detect specifically the presence of a polynucleotides directly or after molecular amplification steps with the use of a specific genuine internal control and a chromatographic control.
摘要翻译：本发明涉及用于检测生物样品中优选清洁液体样品中的一种或多种分析物的方法和装置。本发明尤其涉及改进的快速测试，例如“测试棒”，“横流”装置和“流通”装置。本发明尤其涉及利用肽或半抗原偶联的寡核苷酸和特异性识别所述半抗原或肽（8）的试剂（5）和特异性杂交至特异性结合的探针（6）的寡聚色谱装置（1）目标序列（7）。它允许直接或在分子扩增步骤之后使用特定的真正内部对照和色谱对照来特异性检测多核苷酸的存在。

9. 发明授权

EP3075451B1 DISPOSABLE FLOW CHIP DEVICE 有权
公开(公告)号：EP3075451B1
公开(公告)日：2020-05-13
申请号：EP15162040.8
申请日：2015-03-31
申请人： Coris Bioconcept SPRL
发明人： MERTENS, Pascal , OTE, Isabelle , LECLIPTEUX, Thierry , AUSSEMS, Eric
IPC分类号： B01L3/00

10. 发明授权

EP2870260B1 PROCEDE ET DISPOSITIF POUR LA DETECTION RAPIDE DE SEQUENCES NUCLEOTIDIQUES AMPLIFIEES 有权
标题翻译：程序和药物检测快速序列核苷酸序列扩增
公开(公告)号：EP2870260B1
公开(公告)日：2017-08-30
申请号：EP13734714.2
申请日：2013-07-01
申请人： Coris Bioconcept SPRL
发明人： LECLIPTEUX, Thierry , MERTENS, Pascal , AVRAIN, Laetitia , OTE, Isabelle , SMEKENS, Valérie
IPC分类号： B01L3/00 , B01L7/00 , G01N21/64 , C12Q1/68
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L7/525 , B01L2200/10 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0825 , B01L2300/088 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2400/0481 , G01N2021/6439 , C12Q2537/143 , C12Q2565/625 , C12Q2565/629

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