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1. 发明申请

WO2009073767A1 TAPERED LOADING SYSTEM FOR IMPLANTABLE MEDICAL DEVICES. 审中-公开
标题翻译：用于可植入医疗器械的切割加载系统。
公开(公告)号：WO2009073767A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085495
申请日：2008-12-04
申请人： COOK INCORPORATED , MELSHEIMER, Jeffrey, S. , CHAMBERS, Sean , VALAIE, Arman , PAUL, Ram
发明人： MELSHEIMER, Jeffrey, S. , CHAMBERS, Sean , VALAIE, Arman , PAUL, Ram
IPC分类号： A61F2/00 , A61F2/84
CPC分类号： A61F2/0095 , A61F2/95 , A61F2002/9522 , Y10T29/53
摘要： Loading systems for compressing and loading an implantable medical device into a device chamber of a medical device delivery system are described. The loading systems include an elongate holding chamber within which the intraluminal medical device is disposed. A plunger has one or more attached pushers adapted to axially advance the intraluminal medical device through an intermediate portion of the holding chamber that has a tapered surface, which compresses the intraluminal medical device over a dilator of a medical device delivery system that has been introduced through the distal end of the elongate holding chamber. The elongate holding chamber can be placed within an outer storage container with an appropriate seal to for storage of the intraluminal medical device within the loading system. Methods of preparing an intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
摘要翻译：描述了用于将可植入医疗装置压缩和装载到医疗装置输送系统的装置室中的装载系统。装载系统包括细长的保持室，其中设置管腔内医疗装置。柱塞具有一个或多个附接的推动器，其适于轴向前进管腔内医疗装置通过具有锥形表面的保持室的中间部分，该锥形表面压缩管腔内医疗装置通过已经被引入的医疗装置输送系统的扩张器细长保持室的远端。细长保持室可以放置在具有适当密封件的外部存储容器内，以便将管腔内医疗装置储存在装载系统内。还描述了制备用于植入患者的管腔内医疗装置的方法和用于这些方法的试剂盒。

2. 发明申请

WO2009073774A1 STORAGE AND LOADING SYSTEM FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械的储存和装载系统
公开(公告)号：WO2009073774A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085510
申请日：2008-12-04
申请人： COOK INCORPORATED , CHAMBERS, Sean , PAUL, Ram
发明人： CHAMBERS, Sean , PAUL, Ram
IPC分类号： A61F2/00 , A61F2/24 , A61F2/84
CPC分类号： A61F2/0095 , A61F2/2427 , A61F2/95 , A61F2002/9522 , A61F2002/9528
摘要： Storage and loading systems (100) for expandable intraluminal medical devices (112) are described. The systems include a container (110) that defines an opening (156) that tapers from a relatively large first diameter to a relatively small second diameter. A neck region (122) includes structure adapted to engage an outer sheath of a delivery system such that an intraluminal medical device within the chamber of the container can be advanced through the tapered opening to effect compression of the intraluminal medical device and, ultimately, loading of the device into the delivery system. Methods of preparing and intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
摘要翻译：描述了用于可扩展管腔内医疗装置（112）的存储和装载系统（100）。该系统包括限定从相对大的第一直径逐渐变细到相对小的第二直径的开口（156）的容器（110）。颈部区域（122）包括适于接合输送系统的外护套的结构，使得容器腔室内的管腔内医疗装置可以推进通过锥形开口以实现腔内医疗装置的压缩，并且最终加载的设备进入传送系统。还描述了用于植入患者的制备方法和管腔内医疗装置以及在这些方法中有用的试剂盒。

3. 发明申请

WO2011146729A2 DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 审中-公开
标题翻译：用于密封裸露开口的装置和方法
公开(公告)号：WO2011146729A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/037173
申请日：2011-05-19
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , PAUL, Ram, H. , STANLEY, Cleon , BATES, Brian, L. , OBERMILLER, F., Joseph , OSBORNE, Thomas, A. , CHAMBERS, Sean
发明人： PAUL, Ram, H. , STANLEY, Cleon , BATES, Brian, L. , OBERMILLER, F., Joseph , OSBORNE, Thomas, A. , CHAMBERS, Sean
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/3468 , A61B2017/00004 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
摘要翻译：除此之外，还公开了用于医疗密封容器或壁中的开口的装置和方法。例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。固定在细丝上的圆顶状密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。输送管被构造成使得其可以通过护套插入到容器中。在灯丝上保持张力以将密封件保持在管或鞘上。护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在容器内部的适当位置。

4. 发明申请

WO2010011878A2 VALVE DEVICE WITH BIASED LEAFLETS 审中-公开
标题翻译：具有偏心叶片的阀装置
公开(公告)号：WO2010011878A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051612
申请日：2009-07-24
申请人： COOK INCORPORATED , CHAMBERS, Sean , PAUL, Ram, H.
发明人： CHAMBERS, Sean , PAUL, Ram, H.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0067 , A61F2230/008
摘要： Valve devices useful in the treatment of various valve-related disorders and/or conditions are described. A valve device includes a leaflet and a means for biasing the leaflet in an open configuration. A method of making a valve device comprises the steps of determining a desired closing pressure; determining a desired opening pressure, selecting one or more valve leaflets; selecting an appropriate means for biasing the leaflet in an open configuration based on the determined closing and opening pressures; and attaching the one or more valve leaflets to the means for biasing the leaflet in an open configuration.
摘要翻译：描述了可用于治疗各种与瓣膜相关的疾病和/或病症的瓣膜装置。阀装置包括传单和用于将开口偏压在打开构型中的装置。制造阀装置的方法包括以下步骤：确定期望的关闭压力; 确定期望的打开压力，选择一个或多个瓣膜传单; 基于所确定的关闭和打开压力，选择适当的装置以将所述传单偏置在打开的构型中; 以及将所述一个或多个瓣膜小叶附接到用于将所述小叶偏压成打开构型的装置。

5. 发明申请

WO2009052340A1 IMPLANTABLE VALVE DEVICE 审中-公开
标题翻译：可植入阀装置
公开(公告)号：WO2009052340A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080249
申请日：2008-10-17
申请人： COOK INCORPORATED , CHAMBERS, Sean , PAUL, Ram , JAFFE, Norman
发明人： CHAMBERS, Sean , PAUL, Ram , JAFFE, Norman
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2240/001 , A61F2250/0098
摘要： Valve devices, methods of making valve devices, and methods of treating various venous-related conditions, disorders and/or diseases are described. In one embodiment, a valve device includes an expandable support frame and a bioprosthetic valve attached to the support frame. The bioprosthetic valve comprises a leaflet and a contiguous wall portion harvested from a multi-leaflet xenogeneic valve. The contiguous wall portion includes the attachment region where the leaflets attaches to the vessel wall and, in some embodiments, includes the natural margins of attachment between the leaflet and vessel wall.
摘要翻译：描述了阀装置，制造阀装置的方法以及治疗各种静脉相关病症，病症和/或疾病的方法。在一个实施例中，阀装置包括可扩展支撑框架和附接到支撑框架的生物假肢瓣膜。生物假肢瓣膜包括从多叶瓣异种瓣膜收获的小叶和邻接的壁部分。邻接的壁部分包括附件区域，其中小叶附着到血管壁，并且在一些实施例中包括叶片和血管壁之间的附着的天然边缘。

6. 发明申请

WO2012051489A2 OCCLUSION DEVICE FOR BLOCKING FLUID FLOW THROUGH BODILY PASSAGES 审中-公开
标题翻译：堵塞流体流动通过身体通道的堵塞装置
公开(公告)号：WO2012051489A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/056278
申请日：2011-10-14
申请人： COOK MEDICAL TECHNOLOGIES LLC , BRAD, Shirley , RANDOLPH, J,.R. , DUSAN, Pavcnik , FREDERICK, Keller , THEOBALD, Elizabeth , CHAMBERS, Sean , PAUL, Ram , OREGON HEALTH & SCIENCE UNIVERSITY
发明人： BRAD, Shirley , RANDOLPH, J,.R. , DUSAN, Pavcnik , FREDERICK, Keller , THEOBALD, Elizabeth , CHAMBERS, Sean , PAUL, Ram
IPC分类号： A61B17/12
CPC分类号： A61B17/1214 , A61B17/0057 , A61B2017/00597
摘要： An occlusion device has a covering attached to a support frame that includes a disc-shaped member and a crossbar that extends across a central opening defined by the disc-shaped member. The occlusion device has a first, or deployed, configuration in which the crossbar defines a curve that extends from the disc-shaped member, and a second, or resting, configuration in which the discshaped member and the crossbar lie substantially in a single plane. Each of the disc-shaped member and the crossbar include a core wire that extends through a lumen of a coil multiple times.
摘要翻译：闭塞装置具有附接到支撑框架的覆盖物，所述支撑框架包括盘形构件和横跨由盘形构件限定的中央开口延伸的横杆。闭塞装置具有第一或部署的配置，其中横杆限定从盘形构件延伸的曲线，以及第二或静止的构造，其中盘形构件和横杆基本位于单个平面中。盘形构件和横杆中的每一个包括多次延伸穿过线圈的内腔的芯线。

7. 发明公开

EP2231059A1 TAPERED LOADING SYSTEM FOR IMPLANTABLE MEDICAL DEVICES 有权转让
标题翻译：锥形装系统植入式医疗设备
公开(公告)号：EP2231059A1
公开(公告)日：2010-09-29
申请号：EP08857612.9
申请日：2008-12-04
申请人： Cook Incorporated
发明人： MELSHEIMER, Jeffrey, S. , CHAMBERS, Sean , VALAIE, Arman , PAUL, Ram
IPC分类号： A61F2/00 , A61F2/84
CPC分类号： A61F2/0095 , A61F2/95 , A61F2002/9522 , Y10T29/53
摘要： Loading systems for compressing and loading an implantable medical device into a device chamber of a medical device delivery system are described. The loading systems include an elongate holding chamber within which the intraluminal medical device is disposed. A plunger has one or more attached pushers adapted to axially advance the intraluminal medical device through an intermediate portion of the holding chamber that has a tapered surface, which compresses the intraluminal medical device over a dilator of a medical device delivery system that has been introduced through the distal end of the elongate holding chamber. The elongate holding chamber can be placed within an outer storage container with an appropriate seal to for storage of the intraluminal medical device within the loading system. Methods of preparing an intraluminal medical device for implantation in a patient and kits useful in such methods are also described.

8. 发明公开

EP2209440A1 IMPLANTABLE VALVE DEVICE 有权转让
标题翻译： IMPLANTIERBARE KLAPPENVORRICHTUNG
公开(公告)号：EP2209440A1
公开(公告)日：2010-07-28
申请号：EP08839587.6
申请日：2008-10-17
申请人： Cook Incorporated
发明人： CHAMBERS, Sean , PAUL, Ram , JAFFE, Norman
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2240/001 , A61F2250/0098
摘要： Valve devices, methods of making valve devices, and methods of treating various venous-related conditions, disorders and/or diseases are described. In one embodiment, a valve device includes an expandable support frame and a bioprosthetic valve attached to the support frame. The bioprosthetic valve comprises a leaflet and a contiguous wall portion harvested from a multi-leaflet xenogeneic valve. The contiguous wall portion includes the attachment region where the leaflets attaches to the vessel wall and, in some embodiments, includes the natural margins of attachment between the leaflet and vessel wall.
摘要翻译：描述了阀装置，制造阀装置的方法以及治疗各种静脉相关病症，病症和/或疾病的方法。在一个实施例中，阀装置包括可扩展支撑框架和附接到支撑框架的生物假发阀。生物假体瓣膜包括从多叶异种瓣膜收获的小叶和连续的壁部分。邻接的壁部分包括附件区域，其中小叶附着到血管壁上，并且在一些实施例中包括叶片和血管壁之间的附着的天然边缘。

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