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1. 发明申请

WO2010036541A1 CATHETER SYSTEM HAVING VARIABLE STIFFNESS 审中-公开
标题翻译：具有可变刚度的导管系统
公开(公告)号：WO2010036541A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/057075
申请日：2009-09-16
申请人： COOK INCORPORATED , MCINTOSH, Charles, L. , ELSESSER, James, C. , WEEKS, Aaron
发明人： MCINTOSH, Charles, L. , ELSESSER, James, C. , WEEKS, Aaron
IPC分类号： A61M25/00 , A61M25/01
CPC分类号： A61M25/00 , A61M25/0043 , A61M25/0071 , A61M25/0102 , A61M2025/0063
摘要： A catheter system a method and a kit for cannulating an occlusion in a body lumen are provided. The catheter system includes an elongate sheath having a proximal portion, a distal portion, a first lumen extending at least partially through the elongate sheath and a second lumen extending at least partially through the sheath. The sheath further includes an opening at the distal portion of the sheath, the opening is connected to the first lumen and positioned proximal to a distal end of the second lumen. The system also includes a stiffening elongate member slidably and removably positionable within the second lumen and distally extendable within the second lumen so that a distal end of the stiffening elongate member is positional distal to the opening. The stiffening member has a first stiffness.
摘要翻译：提供导管系统用于将闭塞插入体腔内的方法和试剂盒。导管系统包括细长护套，其具有近端部分，远端部分，至少部分延伸穿过细长护套的第一内腔和至少部分延伸穿过护套的第二内腔。护套还包括在护套的远端部分处的开口，该开口连接到第一内腔并且定位在第二内腔的远端附近。该系统还包括加强的细长构件，其可滑动地和可移除地定位在第二内腔内并且在第二腔内可远端延伸，使得加强细长构件的远端位于开口的远侧。加强构件具有第一刚度。

2. 发明申请

WO2010099209A1 LOW PROFILE SUPPORT FRAME AND RELATED INTRALUMINAL MEDICAL DEVICES 审中-公开
标题翻译：低配置支持框架和相关的内科医疗设备
公开(公告)号：WO2010099209A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/025245
申请日：2010-02-24
申请人： COOK INCORPORATED , PAUL, Ram, H. , CHAMBERS, Sean, D. , MCINTOSH, Charles, L. , AGNEW, Charles, W.
发明人： PAUL, Ram, H. , CHAMBERS, Sean, D. , MCINTOSH, Charles, L. , AGNEW, Charles, W.
IPC分类号： A61F2/24 , A61F2/86
CPC分类号： A61F2/2418 , A61F2/01 , A61F2/2412 , A61F2/2475 , A61F2/848 , A61F2/86 , A61F2/88 , A61F2002/016 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2230/0013 , A61F2230/0021
摘要： A low profile support frame (10) for use as an or in an expandable intraluminal medical device includes first (12) and second (14) wire members that define arcuate paths having opposing curves. Connectors (20,22) join the wire members, and barbs can be disposed on the connectors. The support frame has radially compressed and radially expanded configurations. When the support frame is in the radially expanded configuration, substantially no portion of the support frame is disposed on a first transverse axis of the frame opposite one end of the frame and substantially no portion of the frame is disposed on a second transverse axis of the frame opposite the other end of the frame. The support frame can be used as an intraluminal medical device by itself or as a component in a medical device that includes other components, such as a stent, prosthetic valve, occluder, or filter.
摘要翻译：用作可扩展管腔内医疗装置中的或在可扩展的管腔内医疗装置中的低调支撑框架（10）包括限定具有相对曲线的弓形路径的第一（12）和第二（14）线构件。连接器（20,22）连接线构件，倒钩可以设置在连接器上。支撑框架具有径向压缩和径向扩张的构造。当支撑框架处于径向展开构型时，支撑框架的基本上没有部分设置在与框架的一端相对的框架的第一横向轴线上，并且基本上没有框架的任何部分设置在框架的第二横向轴线上框架与框架的另一端相对。支撑框架可以作为管腔内医疗装置本身或作为包括其它部件（例如支架，假体瓣膜，封堵器或过滤器）的医疗装置中的部件使用。

3. 发明申请

WO2008103336A1 METHODS FOR INTRAVASCULAR ENGRAFTMENT IN HEART 审中-公开
标题翻译：心脏内腔内积累的方法
公开(公告)号：WO2008103336A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/002152
申请日：2008-02-19
申请人： COOK INCORPORATED , MCINTOSH, Charles, L.
发明人： MCINTOSH, Charles, L.
IPC分类号： A61K35/34 , A61P9/10
CPC分类号： A61K35/34 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K2300/00
摘要： The invention relates to a method of engrafting donor cells into injured myocardium. The method includes delivering donor cells to a delivery site adjacent to and downstream of a chronic total occlusion and treating the chronic total occlusion. The delivery device may be a catheter with a wireguide that may be provided by a retrograde approach via an un- occluded artery or antegrade approach through the chronic total occlusion. The invention also relates to a method of treating injured myocardium and cell compositions for treatment of injured myocardium.
摘要翻译：本发明涉及将供体细胞移植到损伤心肌中的方法。该方法包括将供体细胞递送至慢性全闭塞附近和下游的递送部位并治疗慢性完全闭塞。递送装置可以是具有导线的导管，其可以通过经由未闭塞动脉的逆行进近或通过慢性全闭塞的顺行方法提供。本发明还涉及一种治疗受伤心肌的方法和用于治疗受伤心肌的细胞组合物。

4. 发明公开

EP2405863A1 LOW PROFILE SUPPORT FRAME AND RELATED INTRALUMINAL MEDICAL DEVICES 有权转让
标题翻译： STÜTZRAHMENMIT NIEDRIGEM PROFIL UND RELEVANTE INTRALUMINALE MEDIZINPRODUKTE
公开(公告)号：EP2405863A1
公开(公告)日：2012-01-18
申请号：EP10706443.8
申请日：2010-02-24
申请人： Cook Incorporated
发明人： PAUL, Ram, H. , CHAMBERS, Sean, D. , MCINTOSH, Charles, L. , AGNEW, Charles, W.
IPC分类号： A61F2/24 , A61F2/86
摘要： A low profile support frame for use as an or in an expandable intraluminal medical device includes first and second wire members that define arcuate paths having opposing curves. Connectors join the wire members, and barbs can be disposed on the connectors. The support frame has radially compressed and radially expanded configurations. When the support frame is in the radially expanded configuration, substantially no portion of the support frame is disposed on a first transverse axis of the frame opposite one end of the frame and substantially no portion of the frame is disposed on a second transverse axis of the frame opposite the other end of the frame. The support frame can be used as an intraluminal medical device by itself or as a component in a medical device that includes other components, such as a stent, prosthetic valve, occluder, or filter.
摘要翻译：用作可扩展管腔内医疗装置中的或在可扩展的管腔内医疗装置中的低调支撑框架包括限定具有相对曲线的弓形路径的第一和第二线构件。连接器连接线构件，倒钩可以设置在连接器上。支撑框架具有径向压缩和径向扩张的构造。当支撑框架处于径向扩张构型时，基本上不支撑框架的任何部分都布置在与框架的一端相对的框架的第一横向轴线上，并且基本上没有框架的任何部分设置在框架的第二横向轴线上框架与框架另一端相对。支撑框架可以单独使用或作为医疗装置中的部件用作管腔内医疗装置，医疗装置包括其他部件，例如支架，假体瓣膜，封堵器或过滤器。

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