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1. 发明申请

WO9933515A3 APPARATUS FOR SUPPLYING RADIOACTIVE GAS TO A DELIVERY DEVICE 审中-公开
标题翻译：将放射性气体供应给送货装置的装置
公开(公告)号：WO9933515A3
公开(公告)日：1999-09-16
申请号：PCT/US9825129
申请日：1998-12-01
申请人： COOK INC , MED INST INC , APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
发明人： APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
IPC分类号： A61M36/04 , A61F2/958 , A61M36/12 , A61N5/10 , A61M36/06
CPC分类号： A61M25/10182 , A61M25/10185 , A61N5/1002 , A61N2005/1021
摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).
摘要翻译：公开了一种填充有诸如惰性放射性气体的辐射载体材料用于治疗血管成形术后的再狭窄的导管装置和恶性肿瘤。膨胀的导管包括单个单元或者可替换地，用于运输放射性载体材料的多个离散室，并且血液可以在用规定的辐射治疗期间继续流动。当放射性载体是诸如氙133的气体时，可以使用注射装置（1400），其允许使用可装载到放射源小瓶外壳或室（1403）中的标准放射性气体源小瓶（1401）。用于封闭小瓶（1404）的装置还可以用作推动机构（1442），以将源小瓶（1401）推向一个或多个允许将放射性气体输送到导管的刺穿套管（1406,1454）。在一系列实施例中，放射性气体通过诸如多位置阀的选择器装置（1409）被抽出到诸如注射器的气密可变容积腔室（1411）中，然后将其放置以将气体输送到导管。在处理之后，将气体取出到注射器中并返回到源小瓶（1401）。在另一系列实施例中，使用填充有液体的注射器将气体直接置换到输送导管（1422）中，或者进入将气体注射到输送导管（1422）的第二注射器中。

2. 发明专利

CA2303193A1 MEDICAL RADIATION TREATMENT DELIVERY APPARATUS 未知
公开(公告)号：CA2303193A1
公开(公告)日：1999-03-18
申请号：CA2303193
申请日：1998-09-11
申请人： COOK INC , APPLE MARC G , MED INST INC
发明人： APPLE MARC G , DEFORD JOHN A , BATES BRIAN L , FEARNOT NEAL E
IPC分类号： A61B1/00 , A61F2/958 , A61M36/04 , A61N5/10 , A61N5/00
摘要： A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons travelling toward the lumen wall. A radiation dosimetry unit indicator (21) is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.

3. 发明专利

JP2009050716A Cannula stent 有权
标题翻译：肛门支架
公开(公告)号：JP2009050716A
公开(公告)日：2009-03-12
申请号：JP2008272437
申请日：2008-10-22
申请人： Cook Inc , Med Inst Inc , William Cook Europe Aps , ウィリアムクックユーロープアーペーエス , エムイーディインスチィチュートインクMed Institute Incorporated , クックインコーポレイテッド
发明人： BATES BRIAN L , BERRY DALE T , FEARNOT NEAL E , HANSEN PALLE M , HERALD COY N , THYREGOD JESPER
IPC分类号： A61F2/91 , A61F2/915
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054
摘要： PROBLEM TO BE SOLVED: To provide a stent having a high strength and flexibility in the radial direction which endures pulsatile expansion/contraction. SOLUTION: The stent is formed from a cannula and has flexible segments 11 and high hoop strength segments 12 alternately. Axial tie bars interconnect the segments, and length reduction upon expansion is minimized. In the unexpanded condition, struts in the high hoop strength segment are parallel while struts in the flexible segment extend from a bent part and converge at the other end. In one embodiment, certain adjacent struts in the hoop segment are spaced apart by a large gap while other struts are spaced apart by a small gap. In another embodiment, struts in the hoop segment are spaced apart uniformly by a medium gap. By this, the occurrence of metal fatigue of high-stress sites is minimized upon expansion/contraction cycles from continuous pulsatile events. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种具有高径向强度和柔韧性的支架，其支持脉动扩张/收缩。解决方案：支架由插管形成，并且具有交替的柔性段11和高箍强度段12。轴向连接杆互连片段，并且在膨胀时减小长度被最小化。在未膨胀的条件下，高箍筋段中的支柱平行，而柔性段中的支柱从弯曲部分延伸并在另一端收敛。在一个实施例中，环箍段中的某些相邻的支柱间隔开大间隙，而其他支柱间隔开一小间隙。在另一个实施例中，环形段中的支柱通过介质间隙均匀间隔开。由此，在连续脉动事件的膨胀/收缩循环中，高应力部位的金属疲劳的发生被最小化。版权所有（C）2009，JPO＆INPIT

4. 发明专利

AU9479898A Medical radiation treatment delivery apparatus 未知
公开(公告)号：AU9479898A
公开(公告)日：1999-03-29
申请号：AU9479898
申请日：1998-09-11
申请人： APPLE MARC G , COOK INC , MED INSTITUTE INC
发明人： APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E
IPC分类号： A61B1/00 , A61F2/958 , A61M36/04 , A61N5/10 , A61N5/00
摘要： A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall. A radiation dosimetry unit indicator (21) is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.

5. 发明申请

WO9915108A2 RADIALLY EXPANDABLE STENT 审中-公开
标题翻译：放射性可扩展的
公开(公告)号：WO9915108A2
公开(公告)日：1999-04-01
申请号：PCT/US9819990
申请日：1998-09-24
申请人： MED INST INC , COOK INC
发明人： BERRY DALE T , HERALD COY M , BATES BRIAN L , BOATMAN SCOTT E , HOFFA MICHAEL C , FEARNOT NEAL E , VOORHEES WILLIAM D III
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61F2/90 , A61L31/02 , A61L31/18
CPC分类号： A61F2/915 , A61F2/88 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/91583 , A61F2230/0054 , A61F2250/0036 , A61F2250/0098 , A61L31/022 , A61L31/18
摘要： A radially expandable stent (10) made from a cannula or sheet of biocompatible material that includes at least one longitudinal segment (14) comprised of a series of laterally interconnected closed cells (13). Each closed cell of a longitudinal segment is defined laterally by a pair of longitudinal struts (15, 16) that are interconnected at each end by a circumferentially adjustable member (19, 20). When the stent is expanded using a balloon (47), the opposing circumferentially adjustable members deform to allow circumferential expansion of the longitudinal segment, while the length of the segment, as defined by the longitudinal struts, is maintained. Self-expanding versions of the stent utilize a nickel-titanium alloy. Adjacent longitudinal segments are joined by flexible interconnection segments (21) that permit the stent to bend laterally. The flexible interconnection segment is comprised of curvvilinear struts (22, 23) that form a series of serpentine bends (81) that distribute lateral bending forces. In a preferred embodiment, a short strut interconnects a longitudinal segment and adjacent interconnection segment. Each interconnection strut attaches to the longitudinal segment within a region (27) at the end (17) of a longitudinal strut (15) dividing two adjacent closed cells.
摘要翻译：一种由包括生物相容性材料的套管或片材制成的径向可扩张的支架（10），其包括由一系列横向互连的闭孔（13）构成的至少一个纵向段（14）。纵向段的每个闭合单元由一对纵向支柱（15,16）侧向地限定，所述纵向支柱在每个端部由周向可调节构件（19,20）互连。当使用球囊（47）扩张支架时，相对的周向可调部件变形以允许纵向段的周向膨胀，而由纵向支柱限定的段的长度被维持。自扩张型支架采用镍钛合金。相邻的纵向段通过柔性互连段（21）连接，允许支架横向弯曲。柔性互连部分由弯曲的支柱（22,23）组成，其形成一系列分布横向弯曲力的蛇形弯曲部（81）。在优选实施例中，短支柱将纵向段和相邻互连段互连。每个互连支柱在分开两个相邻闭孔的纵向支柱（15）的端部（17）处的区域（27）内附接到纵向段。

6. 发明专利

DE69938058D1 未知
公开(公告)号：DE69938058D1
公开(公告)日：2008-03-13
申请号：DE69938058
申请日：1999-12-16
申请人： COOK INC , WILLIAM COOK EUROPE AS , MED INST INC
发明人： BATES BRIAN L , BERRY DALE T , FEARNOT NEAL E , HANSEN PALLE M , HERALD COY N , THYREGOD JESPER
IPC分类号： A61F2/91 , A61F2/915
摘要： A stent (10) formed from cannula and having flexible segments (11) and high hoop strength segments (12) alternating therealong. Axial tie bars (21, 22) interconnect the segments; minimal length reduction would occur upon expansion. In the high hoop strength segment (12), struts (16) are initially parallel in the unexpanded strut condition, while in the flexible segment (11), struts (14) extend from a respective bight (15) to converge at distal ends when unexpanded. In one embodiment, certain adjacent struts (16) of the hoop segment are spaced apart by a large gap (20) while others are spaced apart by a small gap (18). In another embodiment all the struts (16) of the hoop segment are spaced apart uniformly from each other (or from an axial tie bar) by a small gap (23), resulting in minimizing the occurrence of fatigue of high-stress sites upon expansion/contraction cycles from continuous pulsatile events.

7. 发明专利

AU6217800A Stent adapted for tangle-free deployment 未知
公开(公告)号：AU6217800A
公开(公告)日：2001-02-13
申请号：AU6217800
申请日：2000-07-17
申请人： MED INST INC , COOK INC
发明人： FEARNOT NEAL E , WANINGER MATTHEW S , CHOULES BRIAN , DEBRUYNE MICHAEL P
IPC分类号： A61F2/06 , A61F2/84
摘要： An expandable stent prosthesis is disclosed in which the apices of the bends located at at least one end of the stent are individually twisted at an angle to the circumference of the stent to form a fan blade-like arrangement when viewed from that end. The fan blade-like arrangement allows the stent to expand from the compressed condition during deployment such that likelihood of a strut or bend of the stent become entangled with a barb or adjacent strut or bend, is reduced. In one embodiment of the invention, the fan blade-like arrangement results from plastically deforming the individual apices, while in another embodiment, the apices are twisted into the fan blade-like arrangement during the loading process, such as by use of a suture thread to pull the apices into alignment.

8. 发明专利

AU4995997A Silver implantable medical device 未知
公开(公告)号：AU4995997A
公开(公告)日：1998-05-15
申请号：AU4995997
申请日：1997-10-23
申请人： COOK INC , MED INST INC
发明人： BATES BRIAN L , OSBORNE THOMAS A , ROBERTS JOSEPH W , FEARNOT NEAL E , KOZMA THOMAS G , RAGHEB ANTHONY O , VOORHEES WILLIAM D
IPC分类号： A61L27/00 , A61L29/00 , A61L31/00 , A61L33/00

9. 发明专利

CA2349256C CANNULA STENT 未知
公开(公告)号：CA2349256C
公开(公告)日：2009-04-14
申请号：CA2349256
申请日：1999-12-16
申请人： COOK WILLIAM EUROP , MED INST INC , COOK INC
发明人： HERALD COY N , HANSEN PALLE M , FEARNOT NEAL E , THYREGOD JESPER , BATES BRIAN L , BERRY DALE T
IPC分类号： A61F2/91 , A61F2/915 , A61L31/02
摘要： A stent (10) formed from cannula and having flexible segments (11) and high hoop strength segments (12) alternating therealong. Axial tie bars (21, 22) interconnect the segments; minimal length reduction would occur upon expansion. In the high hoop strength segment (12), struts (16) are initially parallel in the unexpanded strut condition, while in the flexible segment (11), struts (14) extend from a respective bight (15) to converge at distal ends when unexpanded. In one embodiment, certain adjacent struts (16) of the hoop segment are spaced apart by a large gap (20) while others are spaced apart by a small gap (18). In another embodiment all the struts (16) of the hoop segment are spaced apart uniformly from each other (or from an axial tie bar) by a small gap (23), resulting in minimizing the occurrence of fatigue of high-stress sites upon expansion/contraction cycles from continuous pulsatile events.

10. 发明专利

DE69623855T2 未知
公开(公告)号：DE69623855T2
公开(公告)日：2003-05-28
申请号：DE69623855
申请日：1996-06-04
申请人： MED INST INC , COOK INC
发明人： FEARNOT NEAL E , RAGHEB ANTHONY O , KOZMA THOMAS G , VOORHEES WILLIAM D , BATES BRAIN L
IPC分类号： A61B17/00 , A61F2/00 , A61K9/00 , A61K51/12 , A61L27/30 , A61L27/54 , A61L29/08 , A61L29/10 , A61L29/16 , A61L31/00 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/02 , A61M37/00 , A61N5/10 , A61L29/00 , A61L27/00 , A61L33/00
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. The invention is also directed to the method of manufacture of the device 10, as well as a method of using it in medical treatments.

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