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1. 发明申请

WO2004043435A3 SYSTEMIC DELIVERY OF ANTIVIRAL AGENTS 审中-公开
标题翻译：系统地递送抗病毒剂
公开(公告)号：WO2004043435A3
公开(公告)日：2004-07-08
申请号：PCT/US0336637
申请日：2003-11-13
申请人： CONTROL DELIVERY SYS INC , ASHTON PAUL , CHEN JIANBING , SMITH THOMAS J
发明人： ASHTON PAUL , CHEN JIANBING , SMITH THOMAS J
IPC分类号： A61K9/00 , A61K9/28 , A61P31/12
CPC分类号： A61K9/0024 , A61K9/0004 , A61K9/2886
摘要： The systems and methods disclosed herein provide sustained delivery of a therapeutic agent for treating a patient, e.g., human, to obtain a desired local or systemic physiological or pharmacological effect. Method includes positioning the sustained released drug delivery system at an area wherein release of the agent is desired and allowing the agent to pass through the device to the desired area of treatment. In some embodiments, the method is for treating or reducing the risk of retroviral or lentiviral infection. In certain embodiments, the method is for preventing or reducing the risk of mother-to-child transmission of HIV, wherein the therapeutic agent is an antiviral agent.
摘要翻译：本文公开的系统和方法提供用于治疗患者例如人的治疗剂的持续递送以获得期望的局部或全身生理或药理作用。方法包括将持续释放的药物递送系统定位在需要药剂释放并允许药剂通过该装置至所需治疗区域的区域。在一些实施方案中，该方法用于治疗或降低逆转录病毒或慢病毒感染的风险。在某些实施方案中，该方法用于预防或降低HIV母婴传播的风险，其中治疗剂是抗病毒剂。

2. 发明申请

WO03049804A3 TREATMENT OF GENITOURINARY TRACT DISORDERS 审中-公开
标题翻译：治疗遗传性痉挛性疾病
公开(公告)号：WO03049804A3
公开(公告)日：2003-10-09
申请号：PCT/US0239597
申请日：2002-12-10
申请人： CONTROL DELIVERY SYS INC , ASHTON PAUL , CYNKOWSKA GRAZYNA , CYNKOWSKI TADEUSZ , SMITH THOMAS J
发明人： ASHTON PAUL , CYNKOWSKA GRAZYNA , CYNKOWSKI TADEUSZ , SMITH THOMAS J
IPC分类号： A61K9/00 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/513 , A61K31/58 , A61K31/616 , A61K45/00 , A61K47/32 , A61K47/48 , A61K51/00 , A61K51/12 , A61M37/00 , A61P1/00 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/08 , A61P15/10 , A61P35/00 , A61P43/00 , A61M36/14
CPC分类号： A61K51/1282 , A61K47/55 , A61K47/6957
摘要： Genitourinary system disorders are treated with therapeutic agents, and optionally further with radiation treatments.
摘要翻译：用治疗剂治疗泌尿生殖系统疾病，并任选进一步用放射治疗。

3. 发明申请

WO2005009480A3 IMPLANTS CONTAINING CODRUGS 审中-公开
标题翻译：含有植物的植物
公开(公告)号：WO2005009480A3
公开(公告)日：2005-07-14
申请号：PCT/US2004018455
申请日：2004-06-09
申请人： CONTROL DELIVERY SYS INC , ASHTON PAUL , CYNKOWSKA GRAZYNA , CYNKOWSKI TADEUSZ , SMITH THOMAS J
发明人： ASHTON PAUL , CYNKOWSKA GRAZYNA , CYNKOWSKI TADEUSZ , SMITH THOMAS J
IPC分类号： A61K47/48 , A61K51/12 , A61P5/24 , A61P13/00 , A61P15/00 , A61P21/02 , A61P23/00 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/02 , A61P41/00 , A61P43/00
CPC分类号： A61K51/1282 , A61K47/55 , A61K47/6957
摘要： Genitourinary system disorders are treated with therapeutic agents, and optionally further with radiation treatments. One aspect of the invention provides a drug delivery device comprising a codrug or a pharmaceutically acceptable salt or prodrug thereof, for administration of at least one biologically active moiety, which codrug comprises: a) at least two constituent moieties, each moiety being a residue of a biologically active compound or a product thereof, including a first constituent moiety and a second constituent moiety; and b) a linkage covalently linking said at least two constituent moieties to form said codrug, said linkage is cleaved under physiological conditions to regenerate said constituent moieties; wherein the device is dimensioned to position two radiation seeds a predetermined distance apart. Another aspect of the invention provides a drug delivery device comprising a codrug or a pharmaceutically acceptable salt or prodrug thereof, for administration of at least one biologically active moiety, which codrug comprises: a) at least two constituent moieties, each moiety being a residue of a biologically active compound or a product thereof, including a first constituent moiety and a second constituent moiety; and b) a linkage covalently linking said at least two constituent moieties to form said codrug, said linkage is cleaved under physiological conditions to regenerate said constituent moieties.
摘要翻译：用治疗剂治疗泌尿生殖系统疾病，任选地进一步用放射治疗。本发明的一个方面提供了包含其药物或其药学上可接受的盐或前药的药物递送装置，用于施用至少一种生物活性部分，所述药物包含：a）至少两个组成部分，每个部分是包括第一组成部分和第二组成部分的生物活性化合物或其产物; 和b）共价连接所述至少两个组成部分以形成所述代谢物的连接，所述连接在生理条件下被切割以再生所述组成部分; 其中所述装置的尺寸被设计成将两个辐射种子定位成预定距离。本发明的另一方面提供了一种药物递送装置，其包含用于施用至少一种生物活性部分的副产物或其药学上可接受的盐或前药，所述药物包含：a）至少两个组成部分，每个部分是包括第一组成部分和第二组成部分的生物活性化合物或其产物; 和b）共价连接所述至少两个组成部分以形成所述代谢物的连接，所述连接在生理条件下切割以再生所述组成部分。

4. 发明申请

WO2006110882A3 HMGCOA REDUCTASE INHIBITOR CODRUGS AND USES THEREOF 审中-公开
标题翻译： HMGCOA还原酶抑制剂及其用途
公开(公告)号：WO2006110882A3
公开(公告)日：2007-07-19
申请号：PCT/US2006013907
申请日：2006-04-12
申请人： PSIVIDA INC , ASHTON PAUL , CYNKOWSKA GRAZYNA , CYNKOWSKI TADEUSZ , SMITH THOMAS J
发明人： ASHTON PAUL , CYNKOWSKA GRAZYNA , CYNKOWSKI TADEUSZ , SMITH THOMAS J
IPC分类号： A61K47/48
CPC分类号： A61K31/4178 , A61K31/22 , A61K31/366 , A61K31/401 , A61K47/55 , A61K47/60
摘要： The invention provides a compound comprising a first pharmacological moiety connected to at least a second pharmacological moiety through a physiologically labile linker, or a salt thereof. The invention also provides a method of reducing cardiovascular disease or cardiovascular disease-related conditions in an individual. The method involves administering to an individual with cardiovascular disease an effective amount of a compound, in which the compound has a first pharmacological moiety linked to a second pharmacological moiety, and the compound or either or both of the constituent pharmacological moieties acts to reduce, treat, or prevent cardiovascular disease. The compounds of the invention can be delivered in a drug delivery device.
摘要翻译：本发明提供一种化合物，其包含通过生理不稳定接头或其盐与至少第二药理学部分连接的第一药理学部分。本发明还提供减少个体心血管疾病或心血管疾病相关病症的方法。该方法包括向具有心血管疾病的个体施用有效量的化合物，其中该化合物具有与第二药理学部分连接的第一药理学部分，并且该化合物或组分药理学部分中的任一个或两者起作用以减少，治疗，或预防心血管疾病。本发明的化合物可以在药物递送装置中递送。

5. 发明公开

EP1461122A4 TREATMENT OF GENITOURINARY TRACT DISORDERS 审中-公开
标题翻译： BEHANDLUNG VON ERKRANKUNGEN DES UROGENITALSYSMSMS
公开(公告)号：EP1461122A4
公开(公告)日：2006-08-23
申请号：EP02795819
申请日：2002-12-10
申请人： CONTROL DELIVERY SYS INC
发明人： ASHTON PAUL , CYNKOWSKA GRAZYNA , CYNKOWSKI TADEUSZ , SMITH THOMAS J
IPC分类号： A61K9/00 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/513 , A61K31/58 , A61K31/616 , A61K45/00 , A61K47/32 , A61K47/48 , A61K51/00 , A61K51/12 , A61M37/00 , A61P1/00 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/08 , A61P15/10 , A61P35/00 , A61P43/00 , A61P5/24 , A61P21/02 , A61P23/00 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P37/02 , A61P41/00
CPC分类号： A61K51/1282 , A61K47/55 , A61K47/6957

6. 发明专利

CA2444894C SUSTAINED RELEASE DRUG DELIVERY SYSTEM CONTAINING CODRUGS 未知
公开(公告)号：CA2444894C
公开(公告)日：2013-06-25
申请号：CA2444894
申请日：2002-04-26
申请人： CONTROL DELIVERY SYS INC
发明人： CHEN JIANBING , ASHTON PAUL , SMITH THOMAS J
IPC分类号： A61K47/48 , A61F2/84 , A61K9/00 , A61K9/10 , A61K9/22 , A61K9/52 , A61K9/70 , A61K31/192 , A61K31/496 , A61K31/513 , A61K31/58 , A61K45/00 , A61K47/30 , A61K47/32 , A61K47/34 , A61L17/00 , A61L29/00 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/10 , A61P35/00 , A61P37/00 , A61P43/00 , C08K5/00 , C08L101/00
摘要： Disclosed is a sustained release system that includes a polymer and a prodrug having a solubility less than about 1 mg/ml dispersed in the polymer. Advantageously, the polymer is permeable to the prodrug and may be non-release rate limiting with respect to the rate of release of the prodrug from the polymer. This permits improved drug delivery within a body in the vicinity of a surgery via sustained release rate kinetics over a prolonged period of time, while not requiring complicated manufacturing processes.

7. 发明专利

BR0209198A 未知
公开(公告)号：BR0209198A
公开(公告)日：2004-06-08
申请号：BR0209198
申请日：2002-04-26
申请人： CONTROL DELIVERY SYS INC
发明人： CHEN JIANBING , ASHTON PAUL , SMITH THOMAS J
IPC分类号： A61K47/48 , A61F2/84 , A61K9/00 , A61K9/10 , A61K9/22 , A61K9/52 , A61K9/70 , A61K31/192 , A61K31/496 , A61K31/513 , A61K45/00 , A61K47/30 , A61K47/32 , A61K47/34 , A61L17/00 , A61L29/00 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/10 , A61P35/00 , A61P37/00 , A61P43/00 , C08K5/00 , C08L101/00
摘要： Disclosed is a sustained release system that includes a polymer and a prodrug having a solubility less than about 1 mg/ml dispersed in the polymer. Advantageously, the polymer is permeable to the prodrug and may be non-release rate limiting with respect to the rate of release of the prodrug from the polymer. This permits improved drug delivery within a body in the vicinity of a surgery via sustained release rate kinetics over a prolonged period of time, while not requiring complicated manufacturing processes.

8. 发明专利

NZ528994A Sustained release drug delivery system containing codrugs 未知
公开(公告)号：NZ528994A
公开(公告)日：2006-02-24
申请号：NZ52899402
申请日：2002-04-26
申请人： CONTROL DELIVERY SYS INC
发明人： CHEN JIANBING , ASHTON PAUL , SMITH THOMAS J
IPC分类号： A61K47/48 , A61F2/84 , A61K9/00 , A61K9/10 , A61K9/22 , A61K9/52 , A61K9/70 , A61K31/192 , A61K31/496 , A61K31/513 , A61K45/00 , A61K47/30 , A61K47/32 , A61K47/34 , A61L17/00 , A61L29/00 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/10 , A61P35/00 , A61P37/00 , A61P43/00 , C08K5/00 , C08L101/00
摘要： Disclosed is a sustained release coating formulation for a medical device, comprising a polymer matrix and a prodrug dispersed in the polymer, having the formula A-L-B or A :: B in which: -A is a drug moiety having a therapeutically active form for producing a clinical response in a patient, -L is a covalent linker, linking A and B to form a prodrug, the linker being cleaved under physiological conditions to generate the therapeutically active form of A, - :: represents a ionic bond between A and B that dissociates under physiological conditions to generate the therapeutically active form of A, and -B represents a moiety which, when linked to A, results in the prodrug having a lower solubility than the therapeutically active form of A, wherein the solubility of therapeutically active form of A in water is greater than 1 mg/mL and the solubility of the prodrug in water is less than 1 mg/mL.

9. 发明专利

AU2003287666A8 Systemic delivery of antiviral agents 未知
公开(公告)号：AU2003287666A8
公开(公告)日：2004-06-03
申请号：AU2003287666
申请日：2003-11-13
申请人： CONTROL DELIVERY SYS INC
发明人： CHEN JIANBING , ASHTON PAUL , SMITH THOMAS J
IPC分类号： A61K9/00 , A61K9/28 , A61P31/12

10. 发明专利

AU2002360555A1 TREATMENT OF GENITOURINARY TRACT DISORDERS 未知
公开(公告)号：AU2002360555A1
公开(公告)日：2003-06-23
申请号：AU2002360555
申请日：2002-12-10
申请人： CONTROL DELIVERY SYS INC
发明人： ASHTON PAUL , CYNKOWSKA GRAZYNA , CYNKOWSKI TADEUSZ , SMITH THOMAS J
IPC分类号： A61K9/00 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/513 , A61K31/58 , A61K31/616 , A61K45/00 , A61K47/32 , A61K47/48 , A61K51/00 , A61K51/12 , A61M37/00 , A61P1/00 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/08 , A61P15/10 , A61P35/00 , A61P43/00
摘要： Genitourinary system disorders are treated with therapeutic agents, and optionally further with radiation treatments.

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