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1. 发明申请

WO2012034544A2 METHOD OF PREPARATION OF HIGHLY SUBSTITUTED HYALURONIC ACID AMIDES 审中-公开
标题翻译：制备高选择性羟丙酸的方法
公开(公告)号：WO2012034544A2
公开(公告)日：2012-03-22
申请号：PCT/CZ2011/000089
申请日：2011-09-08
申请人： CONTIPRO BIOTECH S R.O. , HUERTA-ANGELES, Gloria , CHLADKOVA, Drahomira , SMEJKALOVA, Daniela , BUFFA, Radovan , VELEBNY, Vladimir
发明人： HUERTA-ANGELES, Gloria , CHLADKOVA, Drahomira , SMEJKALOVA, Daniela , BUFFA, Radovan , VELEBNY, Vladimir
IPC分类号： C08B37/00
CPC分类号： C08B37/0072
摘要： The invention relates to the method of preparation of highly substituted hyaluronic acid amides with a controllable degree of substitution, which are prepared in a polar aprotic environment from an acidic form of hyaluronic acid in the presence of ethylchloroformiate, by means of a primary amine.
摘要翻译：本发明涉及制备具有可控制取代度的高度取代的透明质酸酰胺的方法，其在极性非质子环境中由酸性形式的透明质酸在氯甲酸乙酯存在下，通过伯胺制备。

2. 发明申请

WO2012146218A1 AMPHOTERIC MATERIALS BASED ON CROSSLINKED HYALURONIC ACID, METHOD OF PREPARATION THEREOF, MATERIALS CONTAINING ENTRAPPED ACTIVE AGENTS, METHOD OF PREPARATION THEREOF, AND USE OF SAID MATERIALS 审中-公开
标题翻译：基于交联的羟丙酸的农药材料，其制备方法，含有活化剂的材料，其制备方法和使用的材料
公开(公告)号：WO2012146218A1
公开(公告)日：2012-11-01
申请号：PCT/CZ2012/000035
申请日：2012-04-19
申请人： CONTIPRO BIOTECH S.R.O. , HUERTA-ANGELES, Gloria , CHLADKOVA, Drahomira , BUFFA, Radovan , KETTOU, Sofiane , VELEBNY, Vladimir
发明人： HUERTA-ANGELES, Gloria , CHLADKOVA, Drahomira , BUFFA, Radovan , KETTOU, Sofiane , VELEBNY, Vladimir
IPC分类号： C08B37/00 , A61K9/20 , A61K47/36
CPC分类号： A61K47/36 , A61K9/06 , A61K31/416 , A61K31/704 , A61K35/32 , C08B37/0072
摘要： The present invention describes novel amphoteric materials based on crosslinked hyaluronic acid, according to the general formula (I), and a method of preparation of said materials. Further, the invention relates to the material containing entrapped active agents (e.g. drugs, growth factors etc.) and a method of preparation thereof. Moreover, the present invention relates to the use of said materials for controlled release systems, in tissue engineering, wound dressing or tissue regeneration.
摘要翻译：本发明描述了根据通式（I）的基于交联透明质酸的新型两性材料及其制备方法。此外，本发明涉及包含截留的活性剂（例如药物，生长因子等）的材料及其制备方法。此外，本发明涉及所述材料用于控释系统，组织工程，伤口敷料或组织再生中的用途。

3. 发明申请

WO2011069475A2 A METHOD OF PREPARATION OF AN OXIDIZED DERIVATIVE OF HYALURONIC ACID AND A METHOD OF MODIFICATION THEREOF 审中-公开
标题翻译：制备羟丙酸的氧化衍生物的方法及其改性方法
公开(公告)号：WO2011069475A2
公开(公告)日：2011-06-16
申请号：PCT/CZ2010/000129
申请日：2010-12-10
申请人： CONTIPRO C A.S. , BUFFA, Radovan , KETTOU, Sofiane , POSPIŠILOVÁ Lucie , HUERTA-ANGELES, Gloria , CHLÁDKOVÁ Drahomira , VELEBNY, Vladimir
发明人： BUFFA, Radovan , KETTOU, Sofiane , POSPIŠILOVÁ Lucie , HUERTA-ANGELES, Gloria , CHLÁDKOVÁ Drahomira , VELEBNY, Vladimir
IPC分类号： C08B37/00
CPC分类号： C08B37/0072
摘要： The invention relates to a new method of preparation of a hyaluronan derivative with an aldehydic group in the position (6) of the polysaccharide glucosamine part. The hyaluronic acid oxidation can be performed by means of TEMPO/NaCIO or TEMPO/TCC systems in a protic environment with or without the presence of anorganic salts. Thus prepared aldehyde can be used for binding amines, diamines, amino acids, peptides and other compounds containing an amino group, e.g. by means of the reductive amination with NaBH 3 CN in water or in a water-organic solvent system. When a diamine or compounds containing three or more amino groups are used, cross-linked hyaluronan derivatives can be prepared. Cross-linked derivatives can be also prepared by a reaction of the aldehyde with a hyaluronan substituted by an amino-alkyl group HA-alkyl-NH 2 .
摘要翻译：本发明涉及在多糖葡糖胺部位（6）中制备具有醛基的透明质酸衍生物的新方法。在具有或不存在无机盐的质子环境中，透明质酸氧化可以通过TEMPO / NaCIO或TEMPO / TCC系统进行。如此制备的醛可用于结合胺，二胺，氨基酸，肽和其它含有氨基的化合物，例如。通过用NaBH 3 CN在水中或在水 - 有机溶剂体系中还原胺化。当使用二胺或含有三个或多个氨基的化合物时，可以制备交联的透明质酸衍生物。交联衍生物也可以通过醛与由氨基 - 烷基氨基烷基-NH 2取代的透明质酸的反应来制备。

4. 发明申请

WO2015074632A1 NANOFIBERS CONTAINING PHOTOCURABLE ESTER DERIVATIVE OF HYALURONIC ACID OR ITS SALT, PHOTOCURED NANOFIBERS, METHOD OF SYNTHESIS THEREOF, PREPARATION CONTAINING PHOTOCURED NANOFIBERS AND USE THEREOF 审中-公开
标题翻译：含有盐酸或其盐的光催化酯衍生物的纳米纤维，光催化剂的纳米纤维，其合成方法，含有光催化的纳米纤维的制备及其用途
公开(公告)号：WO2015074632A1
公开(公告)日：2015-05-28
申请号：PCT/CZ2014/000138
申请日：2014-11-21
申请人： CONTIPRO BIOTECH S R.O.
发明人： HUERTA-ANGELES, Gloria , BOBEK, Martin , PRIKOPOVA, Eva , RUZICKOVA, Jana , MORAVCOVA, Martina , BRANDEJSOVA, Martina , VELEBNY, Vladimir
IPC分类号： C08B37/08 , A61K8/00 , C08L5/08
CPC分类号： D01F6/94 , A61K8/0208 , A61K8/027 , A61K8/735 , A61K8/8129 , A61K8/8176 , A61K8/86 , A61K8/91 , A61K9/70 , A61K31/785 , A61K31/787 , A61K31/795 , A61K47/10 , A61K47/32 , A61K2800/413 , A61K2800/594 , A61K2800/81 , A61Q19/00 , A61Q19/08 , C08B37/0072 , C08F251/00 , C08J3/24 , C08J3/28 , C08J2329/04 , C08J2339/06 , C08J2371/02 , C08J2451/02 , C08K7/02 , C08L5/08 , C08L71/02 , C08L2203/02 , C08L2205/16 , D01F6/50 , D01F6/56 , D10B2321/08 , D10B2331/06 , D10B2509/00 , D10B2509/022 , C08L29/04 , C08L33/02 , C08L39/06
摘要： The invention relates to nanofibers containing photocurable ester derivatives of hyaluronic acid or its salt, the method of preparation thereof, and the photocured preparation made from the nanofibers by light irradiation and the use thereof
摘要翻译：本发明涉及含有透明质酸或其盐的光固化性酯衍生物的纳米纤维，其制备方法以及通过光照射从纳米纤维制得的光固化剂及其用途

5. 发明申请

WO2012122956A1 ANTIMICROBIAL MIXTURE AND A COVERING SUPPORTING WOUND HEALING, HAVING AN ANTIMICROBIAL ACTIVITY 审中-公开
标题翻译：抗微生物混合物和覆盖性支持治疗，具有抗微生物活性
公开(公告)号：WO2012122956A1
公开(公告)日：2012-09-20
申请号：PCT/CZ2012/000021
申请日：2012-03-01
申请人： CONTIPRO PHARMA A.S. , VALENTOVA, Zuzana , DUSKOVA, Sarka , ZAVADIL, Michal , HEKRLOVA, Veronika , VELEBNY, Vladimir , SOBOTKA, Lubos
发明人： VALENTOVA, Zuzana , DUSKOVA, Sarka , ZAVADIL, Michal , HEKRLOVA, Veronika , VELEBNY, Vladimir , SOBOTKA, Lubos
IPC分类号： A61L15/22 , A61L15/28 , A61L15/44
CPC分类号： A61L15/46 , A61L15/225 , A61L15/28 , A61L2300/206 , A61L2300/208 , A61L2300/404 , C08L5/08
摘要： The invention relates to an antimicrobial mixture for healing of superficial wounds based on a physiologically acceptable hyaluronic acid salt, optionally with one or more other polysaccharides, and a compound having an antimicrobial activity, which can be used for healing of superficial wounds, especially chronic wounds, for example varicose ulcers, and to a covering which contains said mixture.
摘要翻译：本发明涉及一种抗生素混合物，用于基于生理上可接受的透明质酸盐，任选地与一种或多种其它多糖和具有抗微生物活性的化合物来治愈浅表伤，其可用于表面伤口，特别是慢性伤口的愈合，例如静脉曲张溃疡，以及包含所述混合物的覆盖物。

6. 发明申请

WO2008128484A3 PREPARATION OF NANOFIBRES FROM POLYSACCHARIDES AND MIXTURES THEREOF WITH POLYVINYL ALCOHOL 审中-公开
公开(公告)号：WO2008128484A3
公开(公告)日：2008-10-30
申请号：PCT/CZ2008/000047
申请日：2008-04-22
申请人： CPN SPOL. S.R.O. , KNOTKOVA, Katerina , HRUBA, Jana , VELEBNY, Vladimir
发明人： KNOTKOVA, Katerina , HRUBA, Jana , VELEBNY, Vladimir
IPC分类号： D01D5/00 , D01F9/00 , D01F6/50 , D01F1/10
摘要： The invention relates to a method of preparation of nanomaterials-based nanofibres and scaffolds by means of an electrospinning method, made from polysaccharides and the mixtures thereof with polyvinyl alcohol in an aqueous solution or a water/ethanol solution in the presence of a surfactant.

7. 发明申请

WO2003059404A3 PREPARATION FOR WOUND HEALING AND PREVENTION OF BANDAGE ADHESION TO THE WOUND 审中-公开
公开(公告)号：WO2003059404A3
公开(公告)日：2003-07-24
申请号：PCT/CZ2003/000003
申请日：2003-01-15
申请人： CPN SPOL. S R.O. , VELEBNY, Vladimir , SOBOTKA, Lubos , PAVEK, Stanislav , RUZICKOVA, Jana
发明人： VELEBNY, Vladimir , SOBOTKA, Lubos , PAVEK, Stanislav , RUZICKOVA, Jana
IPC分类号： A61L15/28
摘要： Preparation for wound healing and prevention of adhesion to the wound containing a physiologically acceptable salt of hyaluronic acid, iodine and potassium iodine.

8. 发明申请

WO2012092908A1 MEDICAL PREPARATION GENERATING IODINE, METHOD OF PREPARATION THEREOF AND BANDAGE CONTAINING SAID PREPARATION 审中-公开
标题翻译：产生碘的药物制备方法及其制备方法
公开(公告)号：WO2012092908A1
公开(公告)日：2012-07-12
申请号：PCT/CZ2012/000002
申请日：2012-01-04
申请人： CONTIPRO PHARMA A.S. , ZAVADIL, Michal , VELEBNY, Vladimir , HEKRLOVA, Veronika
发明人： ZAVADIL, Michal , VELEBNY, Vladimir , HEKRLOVA, Veronika
IPC分类号： A61L15/28 , A61L15/44 , A61L26/00
CPC分类号： A61L26/0066 , A61L15/28 , A61L15/44 , A61L26/0023 , A61L2300/106 , C08L5/08
摘要： The invention relates to the preparation for healing of intracorporeal and/or surface wounds and burn injuries based on the physiologically acceptable salt of hyaluronic acid and compounds which are able to generate iodine in the presence of water and the initiating agent, wherein the preparation either contains one component or contains more components. The preparation comrpises the physiologically acceptable salt of hyaluronic acid, the source or the sources of iodine, the initiating agent and optionally one, or more adjuvants including for example auxiliary textiles. The preparation can be in the form of a liquid composition, gel, in a solid form or in a combination of these forms. Further, the invention relates to the method of production of the preparation consisting in the dissolution of the components in water to form one solution or gel or two separate solutions or gels that can be dried subsequently alone or on a support, or they can be extruded through a capillary into a solvent resulting in the precipitation of fibres. The invention also relates to a bandage containing the preparation:
摘要翻译：本发明涉及基于透明质酸的生理学上可接受的盐和能够在水和起始剂存在下产生碘的化合物来治疗体内和/或表面伤口和烧伤的制剂，其中制剂包含一个组件或包含更多组件。该制剂使透明质酸的生理学上可接受的盐，碘的来源或来源，起始剂和任选的一种或多种佐剂，包括例如辅助纺织品。制剂可以是液体组合物，凝胶，固体形式或这些形式的组合的形式。此外，本发明涉及制备该制剂的方法，该方法包括将组分溶解在水中以形成一种溶液或凝胶或两种单独的溶液或凝胶，其可以随后单独或在载体上干燥，或者它们可以挤出通过毛细管进入溶剂，导致纤维的沉淀。本发明还涉及含有该制剂的绷带：

9. 发明申请

WO2012089179A1 HYALURONAN FIBRES, METHOD OF PREPARATION THEREOF AND USE THEREOF 审中-公开
标题翻译： HYALURONAN FIBERS，其制备方法及其用途
公开(公告)号：WO2012089179A1
公开(公告)日：2012-07-05
申请号：PCT/CZ2011/000126
申请日：2011-12-28
申请人： CONTIPRO BIOTECH S.R.O. , BURGERT, Ladislav , HRDINA, Radim , MASEK, David , VELEBNY, Vladimir
发明人： BURGERT, Ladislav , HRDINA, Radim , MASEK, David , VELEBNY, Vladimir
IPC分类号： D01D5/06 , D01F9/00 , D03D15/00 , D04H3/00
CPC分类号： D01D5/06 , C08B37/0072 , D01F9/00 , D02G3/02 , Y10T428/298
摘要： The invention relates to the method of preparation of hyaluronic acid-based fibres, where first the spinning solution of hyaluronic acid and/or a metal compound thereof, optionally containing a metal salt or a hyaluronic acid compound and metal ions, is prepared, then the spinning solution is introduced into the coagulation bath comprising an acid, an alcohol and not more than 10 %wt. of water, and optionally a metal salt, resulting in forming a fibre which is preferably left in the coagulation bath and/or is drawn, then the fibre is washed with alcohol and dried. After washing of the fibre, metal ions may be introduced in the fibre by means of the metalization bath. Further, the invention relates to the fibres based on hyaluronic acid and/or a metal compound thereof, having the fibre (monofilament) diameter 4 μm to 1 mm, linear weight 0.1 to 30 g/1000 m (0.1 to 30 tex), tensile strength 0.5 to 3 cN.dtex -1 and loop strength 20 to 80 % of the tensile strength. The invention also relates to a silk tow that contains 2 to 50 primary fibres. Moreover, the invention relates to the use of the fibres for the production of woven and non- swoven fabrics.
摘要翻译：本发明涉及透明质酸类纤维的制备方法，其中首先制备透明质酸和/或其金属化合物的纺丝溶液，任选地含有金属盐或透明质酸化合物和金属离子，然后将纺丝溶液引入包含酸，醇的不超过10重量％的凝固浴中。的水和任选的金属盐，导致形成优选留在凝固浴中和/或拉伸的纤维，然后用醇洗涤纤维并干燥。洗涤纤维后，可以通过金属化浴将金属离子引入纤维中。此外，本发明涉及基于透明质酸和/或其金属化合物的纤维，其纤维（单丝）直径为4μm至1mm，线形重量为0.1至30g / 1000m（0.1至30tex），拉伸强度强度为0.5〜3cN.dtex-1，回弹强度为拉伸强度的20〜80％。本发明还涉及含有2至50个初级纤维的丝束。而且，本发明涉及纤维用于生产机织和非织造织物的用途。

10. 发明申请

WO2003059404A2 PREPARATION FOR WOUND HEALING AND PREVENTION OF BANDAGE ADHESION TO THE WOUND 审中-公开
标题翻译：创伤治疗的准备和防止绑扎的伤口
公开(公告)号：WO2003059404A2
公开(公告)日：2003-07-24
申请号：PCT/CZ2003/000003
申请日：2003-01-15
申请人： CPN SPOL. S R.O. , VELEBNY, Vladimir , SOBOTKA, Lubos , PAVEK, Stanislav , RUZICKOVA, Jana
发明人： VELEBNY, Vladimir , SOBOTKA, Lubos , PAVEK, Stanislav , RUZICKOVA, Jana
IPC分类号： A61L15/00
CPC分类号： A61L24/08 , A61L15/28 , A61L26/0023 , C08L5/08
摘要： Preparation for wound healing and prevention of adhesion to the wound containing a physiologically acceptable salt of hyaluronic acid, iodine and potassium iodine.
摘要翻译：制备伤口愈合并防止对包含透明质酸，碘和碘的生理学上可接受的盐的伤口的粘附。

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