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1. 发明申请

WO2009020455A1 COMPOSITIONS AND METHODS FOR MICROBE STORAGE AND DELIVERY 审中-公开
标题翻译： MICROBE存储和交付的组合物和方法
公开(公告)号：WO2009020455A1
公开(公告)日：2009-02-12
申请号：PCT/US2007/019520
申请日：2007-09-07
申请人： CONJUGON, INC. , SUZUKI, Hideki , BRAICO, Salvatore
发明人： SUZUKI, Hideki , BRAICO, Salvatore
IPC分类号： A61K39/108
CPC分类号： A61K35/744 , A61K9/19 , A61K35/74 , A61K35/741 , A61L29/085 , A61L29/16 , A61L2420/06 , Y02A50/402 , Y02A50/473
摘要： The present invention relates to the field of bacteriology. In particular, the invention relates to compositions of probiotic microbes and methods for making and using such compositions, e.g. in the treatment and prevention of catheter associated urinary tract infections.
摘要翻译：本发明涉及细菌学领域。特别地，本发明涉及益生菌微生物的组合物及其制备和使用方法。在治疗和预防导尿管相关泌尿道感染。

2. 发明申请

WO2005072092A2 SYSTEMS FOR TIGHTLY REGULATED GENE EXPRESSION 审中-公开
标题翻译：用于轻度调控基因表达的系统
公开(公告)号：WO2005072092A2
公开(公告)日：2005-08-11
申请号：PCT/US2004/041601
申请日：2004-12-13
申请人： CONJUGON, INC. , ANTHONY, Larry , FILUTOWICZ, Marcin , SUZUKI, Hideki
发明人： ANTHONY, Larry , FILUTOWICZ, Marcin , SUZUKI, Hideki
IPC分类号： C07H21/04 , C12N1/21 , C12N15/11 , C12N15/63 , C12N15/70 , C12N15/74 , C12P21/02 , C12P21/06 , C12Q1/68
CPC分类号： C12N15/70
摘要： The present invention relates to bacterial expression vectors. In particular, the present invention provides tightly-regulated bacterial expression vectors designed for the cloning and expression of toxic proteins, RNA, and metabolites in vivo. The present invention thus provides methods of expressing protein and RNAs that were previously not able to be expressed.
摘要翻译：本发明涉及细菌表达载体。特别地，本发明提供了设计用于在体内克隆和表达毒性蛋白质，RNA和代谢物的紧密调节的细菌表达载体。因此，本发明提供了表达以前不能表达的蛋白质和RNA的方法。

3. 发明申请

WO2006128089A2 COMPOSITIONS AND METHODS FOR TREATING TISSUE 审中-公开
标题翻译：用于治疗组织的组合物和方法
公开(公告)号：WO2006128089A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/020653
申请日：2006-05-26
申请人： CONJUGON, INC. , FILUTOWICZ, Marcin , SUZUKI, Hideki
发明人： FILUTOWICZ, Marcin , SUZUKI, Hideki
IPC分类号： C12N15/74 , C12N1/21 , C12N5/06
CPC分类号： C07K14/245 , A61K38/164 , A61K48/005 , C12N2800/101 , Y02A50/402 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481
摘要： The present invention relates to the field of bacteriology. In particular, the invention relates to novel compositions and methods for altering (e.g., inhibiting) the growth and virulence of populations of pathogenic microorganisms.
摘要翻译：本发明涉及细菌学领域。特别地，本发明涉及用于改变（例如抑制）致病微生物群体的生长和毒力的新型组合物和方法。

4. 发明申请

WO2006128044A2 COMPOSITIONS AND METHODS FOR ALTERING CELLULAR FUNCTIONS 审中-公开
标题翻译：用于改变细胞功能的组合物和方法
公开(公告)号：WO2006128044A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/020582
申请日：2006-05-26
申请人： CONJUGON, INC. , SUZUKI, Hideki , BATES, Donna, M.
发明人： SUZUKI, Hideki , BATES, Donna, M.
IPC分类号： C12N15/74 , C12N1/21
CPC分类号： C12N15/74
摘要： The present invention relates to the field of bacteriology. In particular, the invention relates to novel compositions and methods for altering (e.g., inhibiting) the growth and virulence of populations of pathogenic microorganisms.
摘要翻译：本发明涉及细菌学领域。特别地，本发明涉及用于改变（例如抑制）致病微生物群体的生长和毒力的新型组合物和方法。

5. 发明申请

WO2006083315A2 NON-DIVIDING DONOR CELLS FOR GENE TRANSFER 审中-公开
标题翻译：用于基因转移的非分泌型细胞
公开(公告)号：WO2006083315A2
公开(公告)日：2006-08-10
申请号：PCT/US2005/023288
申请日：2005-06-29
申请人： CONJUGON, INC. , SUZUKI, Hideki , FILUTOWICZ, Marcin , ANTHONY, Larry
发明人： SUZUKI, Hideki , FILUTOWICZ, Marcin , ANTHONY, Larry
IPC分类号： C12N1/21 , C12N15/74
CPC分类号： C12N15/87 , C12N1/04 , C12N1/20
摘要： The present invention relates to compositions comprising conjugation-competent non-dividing cells for delivery of genes to bacteriel cells by conjugation. The present invention also relates to methods of making, using and storing such conjugation competent non-dividing cells.
摘要翻译：本发明涉及包含用于通过缀合将基因递送至细菌细胞的共轭感受态非分裂细胞的组合物。本发明还涉及制备，使用和储存这种具有共轭能力的非分裂细胞的方法。

6. 发明申请

WO2007013380A1 HIGH STRENGTH ALUMINUM ALLOY FIN MATERIAL AND METHOD OF PRODUCTION OF SAME 审中-公开
标题翻译：高强度铝合金材料及其生产方法
公开(公告)号：WO2007013380A1
公开(公告)日：2007-02-01
申请号：PCT/JP2006/314534
申请日：2006-07-18
申请人： Nippon Light Metal Company, Ltd. , SUZUKI, Hideki , OKI, Yoshito , SASAKI, Tomohiro , NAGASAWA, Masae
发明人： SUZUKI, Hideki , OKI, Yoshito , SASAKI, Tomohiro , NAGASAWA, Masae
IPC分类号： C22C21/00 , C22F1/04 , F28F21/08
CPC分类号： F28F21/084
摘要： A heat exchanger use high strength aluminum alloy fin material having a high strength and excellent in thermal conductivity, erosion resistance, sag resistance, sacrificial anodization effect, and self corrosion resistance, characterized by containing Si: 0.8 to 1.4 wt%, Fe: 0.15 to 0.7 wt%, Mn: 1.5 to 3.0 wt%, and Zn: 0.5 to 2.5 wt%, limiting the Mg as an impurity to 0.05 wt% or less, and having a balance of ordinary impurities and Al in chemical composition, having a metal structure before brazing of a fibrous crystal grain structure, a tensile strength before brazing of not more than 240 MPa, a tensile strength after brazing of not less than 150 MPa, and a recrystallized grain size after brazing of 500 μm or more.
摘要翻译：热交换器使用具有高强度和优异导热性，耐侵蚀性，抗流挂性，牺牲阳极氧化效果和自腐蚀性的高强度铝合金翅片材料，其特征在于，含有Si：0.8〜1.4重量％，Fe：0.15〜 0.7重量％，Mn：1.5〜3.0重量％，Zn：0.5〜2.5重量％，将Mg作为杂质限制在0.05重量％以下，其余为普通杂质和化学组成的Al，具有金属纤维状晶粒结构钎焊之前的结构，钎焊前的拉伸强度不大于240MPa，钎焊后的拉伸强度不低于150MPa，钎焊后的再结晶粒径为500μm以上。

7. 发明申请

WO2002022835A2 TARGETED GENETIC MANIPULATION USING MU BACTERIOPHAGE CLEAVED DONOR COMPLEX 审中-公开
标题翻译：使用MU BACTERIOPHAGE CLEAVED DONOR COMPLEX的目标遗传操作
公开(公告)号：WO2002022835A2
公开(公告)日：2002-03-21
申请号：PCT/US2001/028611
申请日：2001-09-14
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , SUZUKI, Hideki , LYZNIK, Leszek, Alexander
发明人： SUZUKI, Hideki , LYZNIK, Leszek, Alexander
IPC分类号： C12N15/70
CPC分类号： C12N15/8213 , A01K2217/05 , A01K2217/075 , C12N15/8202 , C12N15/8206 , C12N15/902
摘要： Compositions and methods for targeted genetic manipulation of an organism are provided. The compositions are novel integration vectors derived from the Mu bacteriophage comprising an active cleaved donor complex (CDC) and further comprising a targeting mechanism whereby integration of the Mu transposable cassette may be directed to a predetermined target site within a host organism's genome. These integration vectors comprise a Mu transposable cassette and one or more navigator elements that direct targeted insertion of the CDC. Methods of the invention utilize the integration vectors of the invention to insert the Mu transposable cassette into a target site of an organism's genome. The insertion occurs in the absence of the MuB accessory protein. The methods are useful for modulating activity of known genes and for targeting integration of nucleotide sequences of interest into a specific location of an organism's genome. Accordingly, the methods may also be used to create gene disruptions and knockouts.
摘要翻译：提供了一种用于有机体靶向遗传操作的组合物和方法。所述组合物是衍生自包含活性切割供体复合物（CDC）的Mu噬菌体的新型整合载体，并且还包含靶向机制，由此可将Mu转座盒的整合导向宿主生物体基因组内的预定靶位点。这些整合载体包含Mu转座盒和一个或多个引导CDC的目标插入的导航器元件。本发明的方法利用本发明的整合载体将Mu转座盒插入生物体基因组的靶位点。插入发生在没有MuB辅助蛋白的情况下。该方法可用于调节已知基因的活性并靶向将感兴趣的核苷酸序列整合到生物体基因组的特定位置。因此，该方法也可用于产生基因破坏和敲除。

8. 发明申请

WO2002022835A3 TARGETED GENETIC MANIPULATION USING MU BACTERIOPHAGE CLEAVED DONOR COMPLEX 审中-公开
公开(公告)号：WO2002022835A3
公开(公告)日：2002-03-21
申请号：PCT/US2001/028611
申请日：2001-09-14
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , SUZUKI, Hideki , LYZNIK, Leszek, Alexander
发明人： SUZUKI, Hideki , LYZNIK, Leszek, Alexander
IPC分类号： C12N15/70
摘要： Compositions and methods for targeted genetic manipulation of an organism are provided. The compositions are novel integration vectors derived from the Mu bacteriophage comprising an active cleaved donor complex (CDC) and further comprising a targeting mechanism whereby integration of the Mu transposable cassette may be directed to a predetermined target site within a host organism's genome. These integration vectors comprise a Mu transposable cassette and one or more navigator elements that direct targeted insertion of the CDC. Methods of the invention utilize the integration vectors of the invention to insert the Mu transposable cassette into a target site of an organism's genome. The insertion occurs in the absence of the MuB accessory protein. The methods are useful for modulating activity of known genes and for targeting integration of nucleotide sequences of interest into a specific location of an organism's genome. Accordingly, the methods may also be used to create gene disruptions and knockouts.

9. 发明申请

WO2012102861A1 POLYMER - ACTIVE AGENT CONJUGATES 审中-公开
标题翻译：聚合物 - 主动代理商
公开(公告)号：WO2012102861A1
公开(公告)日：2012-08-02
申请号：PCT/US2012/020959
申请日：2012-01-11
申请人： FLEX BIOMEDICAL , WATHIER, Michel , SUZUKI, Hideki
发明人： WATHIER, Michel , SUZUKI, Hideki
IPC分类号： A61K47/48 , A61P19/02
CPC分类号： A61K47/48176 , A61K47/58
摘要： A polymer includes at least one monomeric unit represented by Formula I, II, or III: where X is CH 2 or O; R 1 is H, COOR 2 , COCH 3 , CONHR 2 , OR 2 or SR 2 ; L is a bond or a linker group; AA is a group derived from an active agent; each R 2 is independently H, a cation, an alkyl, an alkenyl, an alkynyl, COCH 3 , CH 2 CH 2 OH, CH 2 CH 2 OR 3 , an amino acid, a small peptide, a large peptide, enzyme, protein, growth factor, cytokine, antibody, single chain antibody, antibody fragment, COCCH 3 =CH 2 , COCH=CH 2 , CH 2 CO 2 H, CH 2 CH 2 CO 2 H, CH 2 CH 2 SH, CH 2 CH 2 SR 3 or (CH 2 CH 2 O) n' R 4 ; n' is an integer from 1 to 2000; each R 3 is independently trityl, 4-methyltrityl or 2 pyridyl; each R 4 is independently H, an alkyl, an alkenyl, an alkynyl, COCCH 3 =CH 2 , COCH=CH 2 , CH 2 CHO, CH 2 CH 2 CHO, CO 2 H, CO 2 R 5 , CH 2 CO 2 H, CH 2 CH 2 CO 2 H, CH 2 NH 2 , CH 2 NHR 5 , CH 2 N(R 5 ) 2 , CH 2 CH 2 NH 2 , CH 2 CH 2 NHR, CH 2 CH 2 N(R 5 ) 2 , SH, CH 2 CO 2 R 5 , orCH 2 CH 2 CO 2 R 5 ; and each R 5 is independently maleimide, a cation, an amino acid, a small peptide, a large peptide, protein, enzyme, growth factor, cytokine, antibody, single chain antibody, phosphate, sulfate, choline, or an activated ester.
摘要翻译：聚合物包括由式I，II或III表示的至少一个单体单元：其中X是CH 2或O; R1是H，COOR2，COCH3，CONHR2，OR2或SR2; L是键或连接基; AA是一种衍生自活性剂的基团; 每个R 2独立地是H，阳离子，烷基，烯基，炔基，COCH 3，CH 2 CH 2 OH，CH 2 CH 2OR 3，氨基酸，小肽，大肽，酶，蛋白质，生长因子，细胞因子，抗体，单链抗体，抗体片段，COCCH3 = CH2，COCH = CH2，CH2CO2H，CH2CH2CO2H，CH2CH2SH，CH2CH2SR3或（CH2CH2O）n'R4; n'是从1到2000的整数; 每个R 3独立地是三苯甲基，4-甲基三苯甲基或2-吡啶基; 每个R 4独立地是H，烷基，烯基，炔基，COCCH 3 = CH 2，COCH = CH 2，CH 2 CHO，CH 2 CH 2 CHO，CO 2 H，CO 2 R 5，CH 2 CO 2 H，CH 2 CH 2 CO 2 H，CH 2 NH 2，CH 2 NHR 5，CH 2 N（R 5）2，CH 2 CH 2 NH 2，CH 2 CH 2 NHR，CH 2 CH 2 N （R5）2，SH，CH2CO2R5或CH2CH2CO2R5; 每个R 5独立地为马来酰亚胺，阳离子，氨基酸，小肽，大肽，蛋白质，酶，生长因子，细胞因子，抗体，单链抗体，磷酸盐，硫酸盐，胆碱或活化酯。

10. 发明申请

WO2012097078A3 VISCOSUPPLEMENTARY MATERIALS 审中-公开
公开(公告)号：WO2012097078A3
公开(公告)日：2012-07-19
申请号：PCT/US2012/020960
申请日：2012-01-11
申请人： FLEX BIOMEDICAL , WATHIER, Michel , SUZUKI, Hideki
发明人： WATHIER, Michel , SUZUKI, Hideki
IPC分类号： A61K31/00 , A61L31/00 , C08F24/00 , C08G61/08 , C08G61/12 , C08L5/00
摘要： A polymer includes at least one of the following repeat units (I), (II), (III): where R 1 and R 2 are either the same or different and are individually H, COOR 3 , COCH 3 , CONHR 4 , OR 4 or SR 4 ; wherein the polymer has a number average molecular weight from 1,500,000 g/mol to 2,500,000 g/mol; and with the proviso that both R 1 and R 2 are not H. Such polymers have a variety of uses including injection into a synovial joint for chondroprotection and as a viscosupplement.

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