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    • 2. 发明申请
    • FLUID COCAMIDE MONOETHANOLAMIDE CONCENTRATES AND METHODS OF PREPARATION
    • 流体香草酸单乙酰胺浓度及其制备方法
    • WO2011110291A2
    • 2011-09-15
    • PCT/EP2011/000948
    • 2011-02-26
    • COGNIS IP MANAGEMENT GMBHHESSEL, John F.GROSS, Stephen, F.KVECHER, Anna
    • HESSEL, John F.GROSS, Stephen, F.KVECHER, Anna
    • A61K8/42A61K8/345A61Q19/00
    • The invention is drawn to fluid concentrate formulations of fatty acid monoethanolamides comprising (a) about 71-76% by weight of one or more C8- C22 fatty acid monoethanolamides, (b) about 15-17% by weight of water, and (c) about 10-12% by weight of one or more hydrotropes, based on the fluid formulation, wherein the fluid formulation is homogeneous, pumpable and color stable at a temperature of less than 55°C. A preferred embodiment is drawn to fluid concentrate formulations of cocamide monoethanolamide (CMEA) consisting of (a) about 71 -76% by weight of CMEA, (b) about 15-17% by weight of water, and (c) about 10-12% by weight of glycerol, based on the fluid formulation. Methods of preparing the fluid concentrate formulations are also disclosed. The fluid concentrate formulations of fatty acid monoethanolamides are useful in the preparation of cosmetic and pharmaceutical compositions.
    • 本发明涉及脂肪酸单乙醇酰胺的流体浓缩物制剂,其包含(a)约71-76重量%的一种或多种C 8 -C 22脂肪酸单乙醇酰胺,(b)约15-17%重量的水,和(c )约10-12重量%的一种或多种水溶助长剂,基于流体配方,其中流体配方在小于55℃的温度下是均匀的,可泵送的并且颜色稳定。 优选的实施方案被描述为由(a)约71-76重量%的CMEA,(b)约15-17重量%的水组成的椰油酰胺单乙醇酰胺(CMEA)的流体浓缩物制剂,和(c) 12%重量的甘油,基于流体配方。 还公开了制备流体浓缩物制剂的方法。 脂肪酸单乙醇酰胺的流体浓缩物制剂可用于制备化妆品和药物组合物。