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2. 发明公开

EP0862615A4 IMMUNITY AGAINST PASTEURELLA HAEMOLYTICA LEUKOTOXIN 失效
标题翻译：免疫抗溶血巴斯德白细胞毒素
公开(公告)号：EP0862615A4
公开(公告)日：2000-01-12
申请号：EP96934209
申请日：1996-11-01
申请人： COMMW SCIENT IND RES ORG , UNIV NEW ENGLAND , STATE OF NEW SOUTH WALES , QUEENSLAND STATE
发明人： PRIDEAUX CHRISTOPHER THOMAS , HODGSON ADRIAN LESLIE MARK
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K48/00 , A61P31/00 , C07K14/285 , C12N1/21 , C12N15/31 , C12P21/02 , A61K39/08 , A61K39/10
CPC分类号： C07K14/285 , A61K39/00

3. 发明专利

CA2236700C IMMUNITY AGAINST PASTEURELLA HAEMOLYTICA LEUKOTOXIN 未知
公开(公告)号：CA2236700C
公开(公告)日：2010-06-29
申请号：CA2236700
申请日：1996-11-01
申请人： COMMW SCIENT IND RES ORG , STATE QUEENSLAND PRIMARY IND , STATE OF NEW SOUTH WALES THROU , UNIV NEW ENGLAND
发明人： PRIDEAUX CHRISTOPHER THOMAS , HODGSON ADRIAN LESLIE MARK
IPC分类号： C12N15/09 , C12N15/31 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/102 , A61K39/12 , A61K48/00 , A61P31/00 , C07K14/285 , C12N1/21 , C12N1/36 , C12N15/74 , C12P21/02
摘要： Bovine respiratory disease (BRD) complex, shipping fever, or pneumomic pasteurellosis, is a multifactorial disease whereby a combination of viral infection, adverse environment and poor immune status may combine to predispose animals to bacterial infections. The exotoxin, or leukotoxin (Lkt), may contribute to pathogenesis by impairing the primary lung defenses and subsequent immune responses or by causing inflammations as a result of leukocyte lysis. The present invention provides a modified microorganism which produces an Lkt toxin, wherein said Lkt toxin is partially or fully inactivated. In a further embodiment of the present invention, there is provided a modified microorganism wherein an Lkt toxin operon including an Lkt structural gene and/or a post translational activator of the organism is partially or fully inactivated. The present applicants have found that a precursor of Lkt toxin has reduced toxic activity. Surprisingly, the Lkt toxin precursor is capable of inducing an immune response in an animal that offers cross protection against heterologous challenge with a microorganism which produces the Lkt toxin. A microorganism which naturally produces an Lkt toxin may be engineered to produce an inactive Lkt toxin precursor by eliminating the post-translational activator of the precursor product. Accordingly, in a preferred embodiment the microorganism is unable to produce a post-translational activator of the Lkt toxin precursor or produces an inactivated post-translational activator of the Lkt toxin precursor. The post-translational activator may be a product of the Lkt C gene.

4. 发明专利

NZ320025A A MODIFIED MICROORGANISM SUCH AS PASTEURELLA HAEMOLYTICA WHICH PRODUCES A LEUKOTOXIN (LKT TOXIN) THAT IS PARTIALLY OR FULLY INACTIVATED 未知
公开(公告)号：NZ320025A
公开(公告)日：1999-04-29
申请号：NZ32002596
申请日：1996-11-01
申请人： COMMW SCIENT IND RES ORG , STATE OF QUEENSLAND DEPARTMENT , UNIV NEW ENGLAND , STATE OF NEW SOUTH WALES DEPAR
发明人： PRIDEAUX CHRISTOPHER THOMAS , HODGSON ADRIAN LESLIE MARK
IPC分类号： A61K31/00 , A61K38/00 , A61K39/00 , C12N15/09 , A61K39/02 , A61K39/12 , A61K48/00 , A61P31/00 , C07K14/285 , C12N1/21 , C12N15/31 , C12P21/02 , A61K39/102
摘要： Bovine respiratory disease (BRD) complex, shipping fever, or pneumomic pasteurellosis, is a multifactorial disease whereby a combination of viral infection, adverse environment and poor immune status may combine to predispose animals to bacterial infections. The exotoxin, or leukotoxin (Lkt), may contribute to pathogenesis by impairing the primary lung defenses and subsequent immune responses or by causing inflammations as a result of leukocyte lysis. The present invention provides a modified microorganism which produces an Lkt toxin, wherein said Lkt toxin is partially or fully inactivated. In a further embodiment of the present invention, there is provided a modified microorganism wherein an Lkt toxin operon including an Lkt structural gene and/or a post transational activator of the organism is partially or fully inactivated. The present applicants have found that a precursor of Lkt toxin has reduced toxic activity. Surprisingly, the Lkt toxin precursor is capable of inducing an immune response in an animal that offers cross protection against heterologous challenge with a microorganism which produces the Lkt toxin. A microorganism which naturally produces an Lkt toxin may be engineered to produce an inactive Lkt toxin precursor by eliminating the post-translational activator of the precursor product. Accordingly, in a preferred embodiment the microorganism is unable to produce a post-translational activator of the Lkt toxin precursor or produces an inactivated post-translational activator of the Lkt toxin precursor. The post-translational activator may be a product of the Lkt C gene.

5. 发明专利

BR9610848A 未知
公开(公告)号：BR9610848A
公开(公告)日：2001-10-09
申请号：BR9610848
申请日：1996-11-01
申请人： COMMW SCIENT IND RES ORG , PIG RES AND DEV CORP
发明人： PRIDEAUX CHRISTOPHER THOMAS , HODGSON ADRIAN LESLIE MARK
IPC分类号： C12N15/00 , A61K31/00 , A61K38/00 , A61K39/02 , A61K39/08 , A61K39/10 , A61K39/102 , A61P39/00 , A61P39/02 , C07K14/285 , C12N1/21 , C12N15/31 , C12P21/02 , C12P21/04
摘要： Disclosed herein is a modified microorganism which produces an RTX toxin, wherein said RTX toxin is partially or fully inactivated. Also disclosed is a modified microorganism wherein an RTX toxin gene including an RTX structural gene and/or a post-translational activator of the organism is partially or full inactivated. As disclosed, the precursor of an RTX toxin has reduced toxic activity.

6. 发明专利

BR9611278A 未知
公开(公告)号：BR9611278A
公开(公告)日：1999-01-26
申请号：BR9611278
申请日：1996-11-01
申请人： COMMW SCIENT IND RES ORG , STATE OF NEW SOUTH WALES THROU , UNIV NEW ENGLAND
发明人： HODGSON ADRIAN LESLIE MARK , PRIDEAUX CHRISTOPHER THOMAS
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K48/00 , A61P31/00 , C07K14/285 , C12N1/21 , C12N15/31 , C12P21/02 , A61K39/10 , A61K39/08
摘要： Bovine respiratory disease (BRD) complex, shipping fever, or pneumomic pasteurellosis, is a multifactorial disease whereby a combination of viral infection, adverse environment and poor immune status may combine to predispose animals to bacterial infections. The exotoxin, or leukotoxin (Lkt), may contribute to pathogenesis by impairing the primary lung defenses and subsequent immune responses or by causing inflammations as a result of leukocyte lysis. The present invention provides a modified microorganism which produces an Lkt toxin, wherein said Lkt toxin is partially or fully inactivated. In a further embodiment of the present invention, there is provided a modified microorganism wherein an Lkt toxin operon including an Lkt structural gene and/or a post transational activator of the organism is partially or fully inactivated. The present applicants have found that a precursor of Lkt toxin has reduced toxic activity. Surprisingly, the Lkt toxin precursor is capable of inducing an immune response in an animal that offers cross protection against heterologous challenge with a microorganism which produces the Lkt toxin. A microorganism which naturally produces an Lkt toxin may be engineered to produce an inactive Lkt toxin precursor by eliminating the post-translational activator of the precursor product. Accordingly, in a preferred embodiment the microorganism is unable to produce a post-translational activator of the Lkt toxin precursor or produces an inactivated post-translational activator of the Lkt toxin precursor. The post-translational activator may be a product of the Lkt C gene.

7. 发明专利

AU7268696A Immunity against actinobacillus pleuropneumoniae's RTX toxins APX 未知
公开(公告)号：AU7268696A
公开(公告)日：1997-05-22
申请号：AU7268696
申请日：1996-11-01
申请人： COMMW SCIENT IND RES ORG , PIG RES AND DEVELOPMENT CORPORATION
发明人： PRIDEAUX CHRISTOPHER THOMAS , HODGSON ADRIAN LESLIE MARK
IPC分类号： C12N15/00 , A61K31/00 , A61K38/00 , A61K39/02 , A61K39/08 , A61K39/10 , A61K39/102 , A61P39/00 , A61P39/02 , C07K14/285 , C12N1/21 , C12N15/31 , C12P21/02 , C12P21/04
摘要： Disclosed herein is a modified microorganism which produces an RTX toxin, wherein said RTX toxin is partially or fully inactivated. Also disclosed is a modified microorganism wherein an RTX toxin gene including an RTX structural gene and/or a post-translational activator of the organism is partially or full inactivated. As disclosed, the precursor of an RTX toxin has reduced toxic activity.

8. 发明专利

BR9610848B8 未知
公开(公告)号：BR9610848B8
公开(公告)日：2014-08-05
申请号：BR9610848
申请日：1996-11-01
申请人： COMMW SCIENT IND RES ORG , PIG RES AND DEV CORP
发明人： PRIDEAUX CHRISTOPHER THOMAS , HODGSON ADRIAN LESLIE MARK
IPC分类号： C12N1/21 , C12N15/00 , A61K31/00 , A61K38/00 , A61K39/02 , A61K39/08 , A61K39/10 , A61K39/102 , A61P39/00 , A61P39/02 , C07K14/285 , C12N15/31 , C12P21/02 , C12P21/04
摘要： Disclosed herein is a modified microorganism which produces an RTX toxin, wherein said RTX toxin is partially or fully inactivated. Also disclosed is a modified microorganism wherein an RTX toxin gene including an RTX structural gene and/or a post-translational activator of the organism is partially or full inactivated. As disclosed, the precursor of an RTX toxin has reduced toxic activity.

9. 发明专利

AU717773B2 Immunity against pasteurella haemolytica leukotoxin 未知
公开(公告)号：AU717773B2
公开(公告)日：2000-03-30
申请号：AU7268596
申请日：1996-11-01
申请人： COMMW SCIENT IND RES ORG , STATE QUEENSLAND PRIMARY IND , STATE OF NEW SOUTH WALES THROU , UNIV NEW ENGLAND
发明人： PRIDEAUX CHRISTOPHER THOMAS , HODGSON ADRIAN LESLIE MARK
IPC分类号： A61K39/02 , A61K39/08 , A61K39/10 , C12N1/21 , C12N15/31

10. 发明专利

AU717769B2 Immunity against actinobacillus pleuropneumoniae's RTX toxins APX 未知
公开(公告)号：AU717769B2
公开(公告)日：2000-03-30
申请号：AU7268696
申请日：1996-11-01
申请人： COMMW SCIENT IND RES ORG , PIG RESEARCH AND DEV CORP
发明人： PRIDEAUX CHRISTOPHER THOMAS , HODGSON ADRIAN LESLIE MARK
IPC分类号： C12N15/00 , A61K31/00 , A61K38/00 , A61K39/02 , A61K39/08 , A61K39/10 , A61K39/102 , A61P39/00 , A61P39/02 , C07K14/285 , C12N1/21 , C12N15/31 , C12P21/02 , C12P21/04
摘要： Disclosed herein is a modified microorganism which produces an RTX toxin, wherein said RTX toxin is partially or fully inactivated. Also disclosed is a modified microorganism wherein an RTX toxin gene including an RTX structural gene and/or a post-translational activator of the organism is partially or full inactivated. As disclosed, the precursor of an RTX toxin has reduced toxic activity.

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