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1. 发明申请

WO2004012856A1 HYBRID CHIP FOR THE MINIATURIZATION OF CHEMICAL, BIOMEDICAL, AND BIOLOGICAL PROCESSES AND METHOD OF APPLICATION 审中-公开
标题翻译：用于化学，生物医学和生物过程的微型化的混合芯片及其应用方法
公开(公告)号：WO2004012856A1
公开(公告)日：2004-02-12
申请号：PCT/HU2003/000063
申请日：2003-07-30
申请人： COMGENEX RT. , DARVAS, Ferenc , ÜRGE, László , DORMÁN, György , KARANCSI, Tamás , GÖDÖRHÁZY, Lajos , SZALAY, Dániel
发明人： DARVAS, Ferenc , ÜRGE, László , DORMÁN, György , KARANCSI, Tamás , GÖDÖRHÁZY, Lajos , SZALAY, Dániel
IPC分类号： B01J19/00
CPC分类号： C40B50/08 , B01J19/0093 , B01J2219/00418 , B01J2219/00599 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/0072 , B01J2219/00822 , B01J2219/00871 , B01J2219/00986 , B01L3/5027 , B01L2200/14 , B01L2300/02 , C40B30/10 , C40B60/14
摘要： This invention involves a small hybrid sheet (chip), used to miniaturize chemical, biochemical, and biological processes, characterized by that it consists of mono or multilayer sheet (chip) comprising the following directly connected units: a) a unit used for synthesis and work-up of compounds and the transport of raw materials, reagents, and final products; b) a unit used for the analysis of compounds and transport of raw materials, reagents, and final products; c) a unit used for execution of biological assays of compounds and the transport of raw materials, reagents, and final products; and d) preferably an electronic unit, more preferably a semi conductor chip into which the following have been burnt: (i) the software source code of at least one computer program for the realization of a function algorithm between biological activity and the chemical structure of compounds; whose input is the chemical structure and biological activity of one or more compounds, and whose output is the chemical structure(s) of one or more further compounds likely to display the desired degree of biological activity, (ii) the software source code of a synthesis program whose input is the chemical formula(e) of one or more compounds obtained as the output of part (i), and whose output provides the laboratory synthesis protocols for these compounds (iii) the software source code of a control program whose input is the one or more laboratory synthesis protocols obtained as the output of the previous step (ii), and whose output provides the control program for the unit described in subsection a). (iv) and finally, preferably the software source code of a control program that controls the operation of the units described under subsections (a) through (d), including launch, shut down, and optimization of these units, preferably the software source code of a control program that controls the biological assay by means of a threshold to be attained during the assay. The small hybrid sheet (chip) may be applied to the production, analysis, and assay of biologically active compounds, and to the measurement of their metabolism, toxicity, and other adaptable biological interactions.
摘要翻译：本发明涉及用于使化学，生化和生物过程小型化的小型混合片（芯片），其特征在于它由包括以下直接连接的单元的单层或多层板（芯片）组成：a）用于合成和化合物的处理以及原材料，试剂和最终产品的运输; b）用于分析化合物和原料，试剂和最终产品运输的单位; c）用于执行化合物的生物测定的单位和原料，试剂和最终产品的运输; 以及d）优选地，用于分析和控制的软件源代码已被烧录的电子单元。小型杂交片（芯片）可用于生物活性化合物的生产，分析和测定，以及其代谢，毒性和其他适应性相互作用的测量。

2. 发明申请

WO2006000840A1 CHROMATOGRAPHY PURIFICATION SYSTEM 审中-公开
标题翻译：色谱纯化系统
公开(公告)号：WO2006000840A1
公开(公告)日：2006-01-05
申请号：PCT/HU2005/000068
申请日：2005-06-27
申请人： COMGENEX RT. , DARVAS, Ferenc , GÖDÖRHÁZY, Lajos , KARANCSI, Tamás , SZALAY, Dániel , ÜRGE, László
发明人： DARVAS, Ferenc , GÖDÖRHÁZY, Lajos , KARANCSI, Tamás , SZALAY, Dániel , ÜRGE, László
IPC分类号： B01D15/08
CPC分类号： G01N30/82
摘要： The chromatography purification system (10) for automated chromatography separation of a plurality of different components in a sample and collection the fraction of at least one target component comprises a fluid streaming unit (11), a chromatography column (12) for receiving a sample and separating the components of the sample, a sample injection valve (18) for injecting the sample, a detector (14) coupled to the chromatography column (12) for receiving the sample and outputting a signal indicating the presence of at least one component in the sample flowing through it, a waste reservoir (17), a fraction collector (16) for dispensing the collected fractions into fraction containers and a system controller (20) for controlling the operation of the fluid streaming unit (11) and the fraction collector (16). The system further comprises a selector (22) for receiving the sample from the detector (14), selecting a predetermined number of target components with a predetermined property from the at least one component of the sample, directing the fraction of the at least one selected target component to the fraction collector (16) and discharging the remaining part of the sample into the waste reservoir (17).
摘要翻译：用于自动色谱分离样品中多种不同组分并收集至少一种目标组分的级分的色谱纯化系统（10）包括流体流动单元（11），用于接收样品的色谱柱（12）和分离样品的组分，用于注射样品的样品注入阀（18），耦合到色谱柱（12）的检测器（14），用于接收样品并输出指示存在至少一种组分的信号流经其的样品，废液储存器（17），用于将收集的馏分分配到馏分容器中的馏分收集器（16）和用于控制流体流动单元（11）和馏分收集器 16）。所述系统还包括用于从所述检测器（14）接收样品的选择器（22），从所述样品的所述至少一个组分中选择具有预定特性的预定数量的目标成分，引导所述至少一个选定的将目标组分加入到馏分收集器（16）中并将剩余部分的样品排放到废物储存器（17）中。

3. 发明申请

WO2004008151A3 NEW COMBINATORIAL PEPTIDE LIBRARIES CONTAINING MARKERS AND METHODS FOR THEIR PREPARATION AND UTILIZATION 审中-公开
公开(公告)号：WO2004008151A3
公开(公告)日：2004-01-22
申请号：PCT/HU2003/000056
申请日：2003-07-09
申请人： COMGENEX RT. , DARVAS, Ferenc , ÜRGE, László , DORMÁN, György , KRAJCSI, Péter , SZALAY, Dániel , BÉRES, Mariann , BUCSAI, Ágota , NAGY, Tamás , KÁLMÁN, Ferenc
发明人： DARVAS, Ferenc , ÜRGE, László , DORMÁN, György , KRAJCSI, Péter , SZALAY, Dániel , BÉRES, Mariann , BUCSAI, Ágota , NAGY, Tamás , KÁLMÁN, Ferenc
IPC分类号： G01N33/68
摘要： The invention consists substantially of combinatorial, protein-marker molecule libraries, having groups that may be chemically and photochemically activated, with or without reporter groups, connected in different diversity points or spatial arrangements via side chains around a common molecular core. The invention consists furthermore of combinatorial libraries of marker units having chemically or photochemically reactive marker groups, reporter groups, and various other types of side chains attached variably to a common molecular, preferably lysine-based, structural core. The invention consists furthermore of a method for combinatorial chemical tethering, where a side chain having a terminal functional group, preferably an amino group, and to which a marker group is optionally attached, is introduced in optimal position ensuring structural diversity and protein binding effectiveness. The invention contributes to simplifying complexity of proteome in different tissues and to the identification of protein markers for diagnosis by alternating different labeling pattern in healthy and diseased tissues.

4. 发明申请

WO2007072097A2 FLOW-TYPE LABORATORY OZONOLYSIS APPARATUS AND METHOD OF PERFORMING OZONOLYSIS REACTION 审中-公开
标题翻译：流动型实验室臭氧分解装置及进行臭氧分解反应的方法
公开(公告)号：WO2007072097A2
公开(公告)日：2007-06-28
申请号：PCT/HU2006/000125
申请日：2006-12-22
申请人： THALES NANOTECHNOLÓGIAI ZRT. , SZALAY, Dániel , VARGA, Norbert , BONCZ, Ferenc , DARVAS, Ferenc , KARANCSI, Tamás , GÖDÖRHÁZY, Lajos , ÜRGE, László
发明人： SZALAY, Dániel , VARGA, Norbert , BONCZ, Ferenc , DARVAS, Ferenc , KARANCSI, Tamás , GÖDÖRHÁZY, Lajos , ÜRGE, László
IPC分类号： B01J19/00 , B01L3/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0095 , B01J2219/00986 , C07C29/48 , C07C231/10 , C25B1/13 , C25B9/08 , C25B11/04 , C07C233/25 , C07C33/22 , C07C33/24
摘要： A flow-type laboratory scale ozonolysis apparatus (100) according to the invention comprises a reservoir (104), a feed pump (102), a mixing element (120) with two inlets and an outlet, a reactor unit (110) and a pressure-adjusting means (160), all connected into a flow path. The ozonolysis apparatus (100) further comprises an ozone source (110), as well as a dispensing valve (112) transmitting a gas stream only in a single direction and installed between the ozone source (110) and one of the inlets of the mixing element (120). The feed pump (102) of the ozonolysis apparatus (100) according to the invention is a liquid pump generating a constant volume rate, the reservoir (104) contains at least the substance, as a solute, to be subjected to the ozonolysis reaction and the reactor unit consists of first and second reactor zones differing in function from one another. In the flow path, the outlet of the first reactor zone is connected to the inlet of the second reactor zone. Furthermore, an inlet for feeding in substances is inserted into the flow path between the reactor zones, and the pressure-adjusting means (160) is installed into the flow path after the reactor unit and is provided with an electrically governed control.
摘要翻译：根据本发明的流式实验室规模的臭氧分解装置（100）包括储器（104），进料泵（102），具有两个入口和一个出口的混合元件（120）一个反应器单元（110）和一个压力调节装置（160），它们都连接到一个流动路径中。臭氧分解装置（100）还包括臭氧源（110）以及分配阀（112），该分配阀仅在单一方向上传送气流并且被安装在臭氧源（110）与混合的入口之一之间元素（120）。根据本发明的臭氧分解装置（100）的进料泵（102）是产生恒定体积流量的液体泵，所述容器（104）至少包含作为溶质的待经受臭氧分解反应的物质和反应器单元由彼此在功能上不同的第一和第二反应器区组成。在流动路径中，第一反应器区域的出口连接到第二反应器区域的入口。此外，在反应器区域之间的流动路径中插入用于供给物质的入口，并且压力调整装置（160）安装在反应器单元之后的流动路径中，并且提供有电控制的控制。

5. 发明申请

WO2006021822A1 A CARTRIDGE REACTOR FOR A FLOW-TYPE LABORATORY HYDROGENATION APPARATUS 审中-公开
标题翻译：流动型实验室加氢装置的卡特彼勒反应器
公开(公告)号：WO2006021822A1
公开(公告)日：2006-03-02
申请号：PCT/HU2005/000090
申请日：2005-08-23
申请人： THALES NANOTECHNOLÓGIAI RT. , DARVAS, Ferenc , GÖDÖRHÁZY, Lajos , KARANCSI, Tamás , SZALAY, Dániel , BONCZ, Ferenc , ÜRGE, László
发明人： DARVAS, Ferenc , GÖDÖRHÁZY, Lajos , KARANCSI, Tamás , SZALAY, Dániel , BONCZ, Ferenc , ÜRGE, László
IPC分类号： B01J8/02 , B01J8/00
CPC分类号： B01J8/0221 , B01J8/006 , B01J8/008 , B01J2208/00814 , B01J2208/00884 , B01J2219/00011
摘要： The invention relates to a cartridge reactor (10) for a flow-type hydrogenation apparatus. The cartridge reactor (10) has a casing equipped with an inlet (18), an outlet (20) and a closed expanded portion enclosing a reaction volume (16) spreading between the inlet (18) and the outlet (20). The cartridge reactor (10) according to the invention is prepared in a laboratory size and its reaction volume (16) is at most 10 cm 3 in size. The reaction volume (16) is filled with an immobilized packing medium (29) that increases flow resistance and facilitates mixing. The inlet (18) and the outlet (20) of the cartridge reactor (10) are formed with a structure enabling a detachable connection to the hydrogenation apparatus.
摘要翻译：本发明涉及一种用于流式加氢装置的筒式反应器（10）。滤筒式反应器（10）具有壳体，其配备有入口（18），出口（20）和封闭的膨胀部分，其封闭在入口（18）和出口（20）之间铺展的反应体积（16）。根据本发明的筒式反应器（10）以实验室尺寸制备，其反应体积（16）至多为10cm

6. 发明申请

WO2005107936A1 A FLOW-TYPE LABORATORY HYDROGENATION APPARATUS AND A LABORATORY HYDROGENATION PROCESS USING THE APPARATUS. 审中-公开
标题翻译：流动型实验室加氢装置和使用装置的实验室加氢方法。
公开(公告)号：WO2005107936A1
公开(公告)日：2005-11-17
申请号：PCT/HU2005/000046
申请日：2005-05-09
申请人： THALES NANOTECHNOLÓGIAI RT. , DARVAS, Ferenc , GÖDÖRHÁZY, Lajos , KARANCSI, Tamás , SZALAY, Dániel , BONCZ, Ferenc , ÜRGE, László
发明人： DARVAS, Ferenc , GÖDÖRHÁZY, Lajos , KARANCSI, Tamás , SZALAY, Dániel , BONCZ, Ferenc , ÜRGE, László
IPC分类号： B01J10/00
CPC分类号： B01J10/007 , B01J10/002 , B01J23/44 , B01J2208/00539 , B01J2208/00548 , B01J2219/00011 , B01J2219/0002 , B01J2219/00038 , B01L5/00
摘要： A flow-type laboratory hydrogenation apparatus (100) comprises a reservoir (104), a feed pump (102), a mixing element (108) with two inlets and an outlet, a hydrogenation reactor (110) and a pressure-adjusting unit (112), all connected into a flow path. The apparatus (100) also comprises a hydrogen source (126) and a one-way valve (120) arranged between the hydrogen source (126) and the second inlet of the mixing element (108). The feed pump (102) is realized by a pump providing a constant volume rate. The reservoir (104) contains at least the solvent, as base solution, of the sample to be hydrogenated. The hydrogenation reactor (110) is connected into the flow path by means of detachable connections and is formed as a replaceable cartridge which contains a packing which increases the flow resistance and facilitates mixing of the liquid and gaseous components. The pressure-adjusting unit (112) is connected into the flow path after the hydrogenation reactor (110) and is provided with a regulation controlled electrically.
摘要翻译：流式实验室加氢装置（100）包括储存器（104），进料泵（102），具有两个入口和出口的混合元件（108），氢化反应器（110）和压力调节单元 112），全部连接成流路。装置（100）还包括氢源（126）和布置在氢源（126）和混合元件（108）的第二入口之间的单向阀（120）。进料泵（102）由提供恒定体积速率的泵实现。储存器（104）至少含有待氢化的样品的溶剂作为碱溶液。氢化反应器（110）通过可拆卸的连接件连接到流动路径中，并且形成为可更换的筒，其包含增加流动阻力并促进液体和气体组分的混合的填料。压力调节单元（112）在氢化反应器（110）之后连接到流路中，并且具有电控调节。

7. 发明申请

WO2003083477A3 ACTIVE SOLID SUPPORT AND METHOD FOR SURFACE IMMOBILIZATION OF COMBINATORIAL COMPOUNDS OR LIBRARIES 审中-公开
公开(公告)号：WO2003083477A3
公开(公告)日：2003-10-09
申请号：PCT/HU2003/000025
申请日：2003-03-28
申请人： COMGENEX RT. , MTA SZEGEDI BIOLÓGIAI KUTATÓKÖZPONT , DARVAS, Ferenc , ÜRGE, László , BUCSAI, Ágota , BÉRES, Mariann , DORMÁN, György , KRAJCSI, Péter , GÖDÖRHÁZY, Lajos , BÁGYI, István , PUSKÁS, László , HACKLER, László , ZVARA, Ágnes
发明人： DARVAS, Ferenc , ÜRGE, László , BUCSAI, Ágota , BÉRES, Mariann , DORMÁN, György , KRAJCSI, Péter , GÖDÖRHÁZY, Lajos , BÁGYI, István , PUSKÁS, László , HACKLER, László , ZVARA, Ágnes
IPC分类号： G01N33/543
摘要： The subject of the invention is a method for production of an active solid support suitable for anchoring drug molecules through covalent bonds, using the following methods a.) a solid support prepared in advance, preferably by pre-treatment in the presence of strong bases or acids, then reacted with a polyamine-functionalized alcoxy-silane derivative, preferably 3-[2-(2-aminoethylamino)ethylamino]propyl trimethoxy-silane, followed by washing and drying, b1) the solid support obtained in the procedure described above in Section a.) will be reacted with (I) where Z: = bond or a -CO or -CNR 1 group and group 121 is an alkyl, aralkyl or aryl group; B: = bond or a - (CH 2 ) n - or -(CH 2 ) n O-(CH 2 ) n or O - (CH 2 ) n - or -NH(CH 2 ) n - group; A: = a branched or unbranched alkyl or substituted aryl or aralkyl group containing 1-5 carbon atoms; D: = a halogen or -O-A group and n = 0, 1, 2, ... integer - with a bi-functional reagent, preferably reacted with acryloyl/chloride or 1,4-butanediol diacrylate in the presence of an organic or inorganic scavenger or b2) the support prepared using the method described in part (a) is reacted with a bi-functional reagent, preferably 1,4-butanediol diglicidyl-ether or epichlorohydrin, in the presence of an organic or inorganic scavenger containing terminal epoxy groups and an amino-group reactive functional subgroup. The invention also includes the active solid support produced using the several methods described above, as well as application of the active solid support described above for production of chemical microarrays and combinatorial chemical microarrays. The invention further comprises a method for immobilization of what have been termed organic molecules of low molecular weight, having a size less than 1500 Da, preferably between 250 and 750 Da. This is achieved by anchoring an unmodified drug or drug candidate molecule to the active solid support described above by adding the appropriate functional groups of the drug or drug candidate molecule, preferably executed using a micron-sized robotized binding technique.

8. 发明申请

WO2003083477A2 NEW ACTIVE SOLID SUPPORT AND METHOD FOR SURFACE IMMOBILIZATION OF COMBINATORIAL COMPOUNDS OR LIBRARIES 审中-公开
标题翻译：新型活性固体支持和组合化合物或文库的表面固化方法
公开(公告)号：WO2003083477A2
公开(公告)日：2003-10-09
申请号：PCT/HU2003/000025
申请日：2003-03-28
申请人： COMGENEX RT. , MTA SZEGEDI BIOLÓGIAI KUTATÓKÖZPONT , DARVAS, Ferenc , ÜRGE, László , BUCSAI, Ágota , BÉRES, Mariann , DORMÁN, György , KRAJCSI, Péter , GÖDÖRHÁZY, Lajos , BÁGYI, István , PUSKÁS, László , HACKLER, László , ZVARA, Ágnes
发明人： DARVAS, Ferenc , ÜRGE, László , BUCSAI, Ágota , BÉRES, Mariann , DORMÁN, György , KRAJCSI, Péter , GÖDÖRHÁZY, Lajos , BÁGYI, István , PUSKÁS, László , HACKLER, László , ZVARA, Ágnes
IPC分类号： G01N33/543
CPC分类号： G01N33/54353
摘要： The subject of the invention is a method for production of an active solid support suitable for anchoring drug molecules through covalent bonds, using the following methods a.) a solid support prepared in advance, preferably by pre-treatment in the presence of strong bases or acids, then reacted with a polyamine-functionalized alcoxy-silane derivative, preferably 3-[2-(2-aminoethylamino)ethylamino]propyl trimethoxy-silane, followed by washing and drying, b1) the solid support obtained in the procedure described above in Section a.) will be reacted with (I) where Z: = bond or a -CO or -CNR 1 group and group 121 is an alkyl, aralkyl or aryl group; B: = bond or a - (CH 2 ) n - or -(CH 2 ) n O-(CH 2 ) n or O - (CH 2 ) n - or -NH(CH 2 ) n - group; A: = a branched or unbranched alkyl or substituted aryl or aralkyl group containing 1-5 carbon atoms; D: = a halogen or -O-A group and n = 0, 1, 2, ... integer - with a bi-functional reagent, preferably reacted with acryloyl/chloride or 1,4-butanediol diacrylate in the presence of an organic or inorganic scavenger or b2) the support prepared using the method described in part (a) is reacted with a bi-functional reagent, preferably 1,4-butanediol diglicidyl-ether or epichlorohydrin, in the presence of an organic or inorganic scavenger containing terminal epoxy groups and an amino-group reactive functional subgroup. The invention also includes the active solid support produced using the several methods described above, as well as application of the active solid support described above for production of chemical microarrays and combinatorial chemical microarrays. The invention further comprises a method for immobilization of what have been termed organic molecules of low molecular weight, having a size less than 1500 Da, preferably between 250 and 750 Da. This is achieved by anchoring an unmodified drug or drug candidate molecule to the active solid support described above by adding the appropriate functional groups of the drug or drug candidate molecule, preferably executed using a micron-sized robotized binding technique.
摘要翻译：本发明的主题是制备适用于通过共价键锚定药物分子的活性固体支持物的方法，使用以下方法a）预先制备的固体支持物，优选通过在强碱存在下预处理或然后与多胺官能化的烷氧基硅烷衍生物，优选3- [2-（2-氨基乙基氨基）乙基氨基]丙基三甲氧基硅烷反应，然后洗涤和干燥，b1）以上述方法获得的固体支持物部分a。）将与（I）反应，其中Z：=键或-CO或-CNR 1基团，基团121是烷基，芳烷基或芳基; B：=键或 - （CH 2）n - 或 - （CH 2）n O-（CH 2）n或O - （CH 2）n - 或-NH（CH 2）n - A：=含1-5个碳原子的支链或非支链烷基或取代的芳基或芳烷基; D：=卤素或-OA基团，n = 0,1,2，...整数 - 与双官能试剂反应，优选与丙烯酰氯/ 1,4-丁二醇二丙烯酸酯在有机或无机清除剂或b2）使用部分（a）中描述的方法制备的载体与双功能试剂，优选1,4-丁二醇二缩水甘油醚或表氯醇在含有末端环氧基的有机或无机清除剂存在下反应基团和氨基反应性功能亚组。本发明还包括使用上述几种方法制备的活性固体支持物，以及上述用于生产化学微阵列和组合化学微阵列的活性固体支持物的应用。本发明还包括一种固定所谓的低分子量有机分子的方法，其具有小于1500Da，优选250至750Da的尺寸。这是通过将未修饰的药物或药物候选分子锚定到上述活性固体支持物上，通过加入药物或药物候选分子的适当官能团，优选使用微米级的自动化装订技术进行的。

9. 发明申请

WO2007072098A2 OZONE GENERATING ELECTROLYSIS CELL 审中-公开
标题翻译：臭氧发生电解槽
公开(公告)号：WO2007072098A2
公开(公告)日：2007-06-28
申请号：PCT/HU2006/000126
申请日：2006-12-22
申请人： THALES NANOTECHNOLÓGIAI ZRT. , SZALAY, Dániel , VARGA, Norbert , BONCZ, Ferenc , DARVAS, Ferenc , KARANCSI, Tamás , GÖDÖRHÁZY, Lajos
发明人： SZALAY, Dániel , VARGA, Norbert , BONCZ, Ferenc , DARVAS, Ferenc , KARANCSI, Tamás , GÖDÖRHÁZY, Lajos
CPC分类号： C25B1/13 , C25B9/08 , C25B11/04
摘要： The ozone generating electrolysis cell (10) according to the invention has a negative electrode (13) and an ozone generating positive electrode (16) comprising a mixture of lead dioxide and polytetrafluoroethylene (PTFE). A proton conducting solid electrolytic membrane (15) is arranged between the negative and positive electrodes (13, 16). The ozone generating electrolysis cell (10) also comprises an electrically conducting, liquid and gas permeable first electrode support (17) in contact with a side of the positive electrode (16) located opposite to the membrane (15), wherein said side of the electrode support (17) has a surface covered with a platinum-containing layer. The positive electrode (16) is made of a mixture prepared by the high-pressure compression of lead dioxide grains of colloid size and PTFE filaments having a dimension of at most 1 mm. Furthermore, the negative electrode (13) is adjoined to a side of the membrane (15) located opposite to the positive electrode (16) by a given compressing force and is formed on a surface of a porous second electrode support (12).
摘要翻译：根据本发明的臭氧发生电解槽（10）具有负极（13）和包含二氧化铅和聚四氟乙烯（PTFE）的混合物的产生臭氧的正极（16）。质子传导固体电解质膜（15）设置在负极和正极（13,16）之间。臭氧发生电解槽（10）还包括与位于与膜（15）相对的正电极（16）的一侧接触的导电，液体和气体可透过的第一电极支撑件（17），其中电极支撑件（17）具有被含铂层覆盖的表面。正极（16）由通过高压压缩胶体尺寸的二氧化铅颗粒和尺寸至多为1mm的PTFE细丝制成的混合物制成。此外，负极（13）通过给定的压缩力与位于与正极（16）相对的膜（15）的一侧相邻，并形成在多孔第二电极支撑体（12）的表面上。

10. 发明申请

WO2007072099A2 METHOD OF FORMING A SEALED CHANNEL OF A MICROFLUIDIC REACTOR AND A MICROFLUIDIC REACTOR COMPRISING SUCH CHANNEL 审中-公开
标题翻译：形成微流体反应器的密封通道的方法和包含这种通道的微流体反应器
公开(公告)号：WO2007072099A2
公开(公告)日：2007-06-28
申请号：PCT/HU2006/000127
申请日：2006-12-22
申请人： THALES NANOTECHNOLÓGIAI ZRT. , SZALAY, Dániel , VARGA, Norbert , BONCZ, Ferenc , DARVAS, Ferenc , KARANCSI, Tamás , GÖDÖRHÁZY, Lajos
发明人： SZALAY, Dániel , VARGA, Norbert , BONCZ, Ferenc , DARVAS, Ferenc , KARANCSI, Tamás , GÖDÖRHÁZY, Lajos
IPC分类号： B81C1/00
CPC分类号： B81C1/0046
摘要： In a method according to the invention for forming a sealed channel (125) in the surface of a sheet made of a material with certain extent of plasticity, the machining surface of a tool with a rolling machining surface is brought into contact with a first point of the channel (125) to be formed in the surface of the sheet constituting a reactor block. Next, said machining surface is pressed onto the surface of the sheet with a compressive force (F) required to achieve the depth of the channel (125) to be formed, whereby the plastic material is squeezed out and becomes raised from the sheet surface on the peripheries of the depression being formed. After this, while maintaining the compressive force (F), by displacing said machining surface along the centerline of the channel (125) over the sheet surface it is rolled from the first point of the channel (125) to be formed to a second point thereof, whereby the channel (125) is machined in the material of the sheet and sealing edges (127) are created on the peripheries of the channel (125) from the material squeezed out and become raised. After creating said sealing edges (127), a closing member bearing against the sealing edges (127) is arranged at the surface of the sheet provided with the channel (125) and the sealing edges (127), and then said closing member is pressed onto the sheet by a compressive force required to deform said sealing edges (127) and is fixed in the position obtained, whereby a sealed channel (125) running between the first and second points is formed within the reactor block.
摘要翻译：在根据本发明的用于在由具有一定塑性程度的材料制成的片材的表面中形成密封通道（125）的方法中，具有滚动加工表面的工具的加工表面与通道（125）的第一点接触以形成在构成反应器块的片材的表面中。接着，利用实现要形成的通道（125）的深度所需的压缩力（F）将所述加工表面压到片材的表面上，由此塑料材料被挤出并从片材表面升起凹陷的周边正在形成。之后，在保持压缩力（F）的同时，通过沿着通道（125）的中心线在片材表面上移动所述加工表面，它从要形成的通道（125）的第一点滚动到第二点由此通道（125）在片材的材料中被机械加工，并且在通道（125）的周边上由挤出并升高的材料形成密封边缘（127）。在形成所述密封边缘（127）之后，在设置有通道（125）和密封边缘（127）的片材的表面处布置抵靠密封边缘（127）的封闭构件，然后将所述封闭构件通过使所述密封边缘（127）变形所需的压缩力将所述密封通道（125）固定在所述位置上，由此在所述反应器块内形成在所述第一和第二点之间延伸的密封通道（125）。

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