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1. 发明申请

WO2004075944A2 AN ASSEMBLY FOR THE PREPARATION OF A MEDICAL DEVICE HAVING A COATING COMPRISING HYDROGEN PEROXIDE 审中-公开
标题翻译：用于制备包含过氧化氢的涂层的医疗装置的组件
公开(公告)号：WO2004075944A2
公开(公告)日：2004-09-10
申请号：PCT/DK2004/000129
申请日：2004-02-26
申请人： COLOPLAST A/S , NIELSEN, Bo Rud , KRISTIANSEN, Søren , BRUUN, Bo Kjellman , SIDENIUS, Martin
发明人： NIELSEN, Bo Rud , KRISTIANSEN, Søren , BRUUN, Bo Kjellman , SIDENIUS, Martin
IPC分类号： A61M
CPC分类号： A61M25/0017 , A61K33/40 , A61L29/085 , A61L29/16 , A61L2300/404 , A61M25/002 , A61M25/0045 , A61M2025/0056 , C08L39/06
摘要： The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other implants, extra corporeal blood conduits, membranes e.g. for dialysis, blood filters, devices for circulatory assistance, dressings for wound care, and ostomy bags. The coating is in particular a hydrophilic coating formed from cross-linked polyvinylpyrrolidone. In one embodiment, the assembly holds a dry catheter element in one compartment of a package and an aqueous hydrogen peroxide solution in another compartment. The solution may also comprise stabilizers, e.g. chelators, and osmolality increasing agents. The catheter for insertion in the urethra is useful for the treatment, alleviation or prophylaxis of microbial infections such as urinary tract infections (UTI).
摘要翻译：本发明提供了一种用于制备具有包含过氧化氢的多孔涂层的医疗装置的组件。特别有趣的医疗设备是导管（例如导尿管），内窥镜，喉镜，用于进食的管，排水管，导丝，避孕套，尿囊，屏障涂层等。手套，支架和其他植入物，额外的体液血管，膜例如。用于透析，血液过滤器，循环辅助装置，伤口护理敷料和造口袋。涂层特别是由交联聚乙烯吡咯烷酮形成的亲水涂层。在一个实施例中，组件将干燥的导管元件保持在包装的一个隔室中，并且在另一隔室中保持过氧化氢水溶液。溶液也可以包括稳定剂，例如螯合剂和渗透压增加剂。用于插入尿道的导管可用于治疗，缓解或预防微生物感染如尿路感染（UTI）。

2. 发明申请

WO2006069579A2 A DEVICE HAVING A HYDROPHILIC COATING COMPRISING P-TOLUENE-SULFONAMIDE AND A METHOD FOR THE PREPARATION THEREOF 审中-公开
标题翻译：具有包含对 - 苯磺酰胺的疏水性涂料的装置及其制备方法
公开(公告)号：WO2006069579A2
公开(公告)日：2006-07-06
申请号：PCT/DK2005/000830
申请日：2005-12-23
申请人： COLOPLAST A/S , NIELSEN, Bo Rud , MADSEN, Niels, Joergen
发明人： NIELSEN, Bo Rud , MADSEN, Niels, Joergen
CPC分类号： A61L31/141 , A61L29/085 , A61L29/141 , A61L31/10 , C08J7/047 , C08J2375/04 , C08J2439/00 , C08K5/435 , C08L2203/02 , C09D139/06 , C08L39/06
摘要： The present invention provides a medical device having a substrate polymer surface carrying thereon a hydrophilic coating comprising a cross-linked hydrophilic polymer and ptoluenesfulfonamide, and a method for the preparation thereof.
摘要翻译：本发明提供了一种具有基材聚合物表面的医疗装置及其制备方法，所述基材聚合物表面上带有包含交联的亲水性聚合物和对甲苯磺酰脲的亲水涂层。

3. 发明申请

WO2013170859A2 NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS 审中-公开
标题翻译：新型聚合物光敏元件和光电元件
公开(公告)号：WO2013170859A2
公开(公告)日：2013-11-21
申请号：PCT/DK2013/050145
申请日：2013-05-14
申请人： COLOPLAST A/S
发明人： MADSEN, Niels Jørgen , SEHNAL, Petr , ANDERSON, David George , NIELSEN, Bo Rud
IPC分类号： C07C49/84 , C08F4/00 , C08G83/00 , C07C49/786 , C07D335/16 , C08F2/50 , C07C219/14 , C07C225/16 , C08F220/18 , C08G18/32 , C07D295/088 , C07C217/22
CPC分类号： C08G18/6674 , C07C217/54 , C08F2/50 , C08F120/18 , C08G18/3215 , C08G18/4833 , C08G18/72 , C08G18/73 , C08J3/24 , C08J3/28 , C08J2375/08
摘要： The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as the photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure.
摘要翻译：本发明提供了聚合物光引发剂，其是光引发剂单体和至少一种另外的单体的共聚物，以及光引发剂单体是制备这种聚合物光引发剂的中间体。此外，提供了在这种聚合物光引发剂的存在下通过至少一种丙烯酸酯单体（Ac）的自由基聚合获得的聚丙烯酸酯。在光引发剂单体和聚合物光引发剂中，将光引发剂部分和叔胺引入光引发剂结构中。

4. 发明申请

WO2013170858A1 NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS 审中-公开
标题翻译：新型聚合物光敏元件和光电元件
公开(公告)号：WO2013170858A1
公开(公告)日：2013-11-21
申请号：PCT/DK2013/050144
申请日：2013-05-14
申请人： COLOPLAST A/S
发明人： MADSEN, Niels Jørgen , SEHNAL, Petr , ANDERSON, David George , NIELSEN, Bo Rud
IPC分类号： C08F2/50
CPC分类号： C08F2/50 , C07C49/84 , C07C69/738 , C08G18/3215 , C08G18/4833 , C08G18/6674 , C08G18/73 , C08G63/00 , G03F7/0384
摘要： The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety, a hydrolytic stable linker and two polymerisable functional groups are incorporated into the photoinitiator structure.
摘要翻译：本发明提供了作为光引发剂单体和至少一种其它单体的共聚物的聚合物光引发剂，以及光引发剂单体是制备这种聚合物光引发剂的中间体。此外，提供了在这种聚合物光引发剂存在下通过至少一种丙烯酸酯单体（Ac）的自由基聚合获得的聚丙烯酸酯。在光引发剂单体和聚合光引发剂中，光引发剂部分，水解稳定的连接体和两个可聚合的官能团引入光引发剂结构中。

5. 发明公开

EP2726140A1 A CATHETER WITH A BALLOON 有权转让
标题翻译：加德满都麻醉师EINEM BALLON
公开(公告)号：EP2726140A1
公开(公告)日：2014-05-07
申请号：EP12732780.7
申请日：2012-06-29
申请人： Coloplast A/S
发明人： NIELSEN, Bo Rud
IPC分类号： A61M25/10 , A61M25/00
CPC分类号： A61M27/00 , A61M25/0017 , A61M25/0043 , A61M25/10 , A61M2025/006
摘要： A catheter with a balloon element is provided with ribs under the balloon element so as to prevent the balloon from being attached to the shaft of the catheter to an extent where the balloon is difficult to inflate. The number of ribs can be any number above 3, but 6 to16 ribs are preferred.
摘要翻译：具有球囊元件的导管在球囊元件下方设置有肋，以便防止气囊附着到导管的轴上至气囊难以膨胀的程度。肋的数量可以是3以上的任何数，但优选6至16个肋。

6. 发明公开

EP2850112A2 NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS 有权转让
标题翻译：中性聚合物成分化合物
公开(公告)号：EP2850112A2
公开(公告)日：2015-03-25
申请号：EP13724725.0
申请日：2013-05-14
申请人： Coloplast A/S
发明人： MADSEN, Niels Jørgen , SEHNAL, Petr , ANDERSON, David George , NIELSEN, Bo Rud
IPC分类号： C08F2/50 , C08G71/00
CPC分类号： C08G18/6674 , C07C217/54 , C08F2/50 , C08F120/18 , C08G18/3215 , C08G18/4833 , C08G18/72 , C08G18/73 , C08J3/24 , C08J3/28 , C08J2375/08
摘要： The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as the photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure.
摘要翻译：本发明提供聚合物光引发剂，其是光引发剂单体和至少一种其它单体的共聚物，以及光引发剂单体是制备这种聚合物光引发剂的中间体。此外，提供了在这种聚合物光引发剂的存在下通过至少一种丙烯酸酯单体（Ac）的自由基聚合获得的聚丙烯酸酯。在光引发剂单体和聚合光引发剂中，光引发剂部分和叔胺被引入光引发剂结构中。

7. 发明授权

EP1599248B1 A MEDICAL DEVICE HAVING A COATING COMPRISING HYDROGEN PEROXIDE AND PACKAGE THEREFOR 失效
标题翻译：有氢含硅涂层和包装作为医生的产品
公开(公告)号：EP1599248B1
公开(公告)日：2010-06-02
申请号：EP04714725.1
申请日：2004-02-26
申请人： Coloplast A/S
发明人： NIELSEN, Bo Rud , KRISTIANSEN, Soren , BRUUN, Bo Kjellman , SIDENIUS, Martin
IPC分类号： A61M25/00
CPC分类号： A61M25/0017 , A61K33/40 , A61L29/085 , A61L29/16 , A61L2300/404 , A61M25/002 , A61M25/0045 , A61M2025/0056 , C08L39/06
摘要： The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other implants, extra corporeal blood conduits, membranes e.g. for dialysis, blood filters, devices for circulatory assistance, dressings for wound care, and ostomy bags. The coating is in particular a hydrophilic coating formed from cross-linked polyvinylpyrrolidone. In one embodiment, the assembly holds a dry catheter element in one compartment of a package and an aqueous hydrogen peroxide solution in another compartment. The solution may also comprise stabilizers, e.g. chelators, and osmolality increasing agents. The catheter for insertion in the urethra is useful for the treatment, alleviation or prophylaxis of microbial infections such as urinary tract infections (UTI).
摘要翻译：对本发明的组件提供了具有多孔涂层，其包含过氧化氢的医疗装置的制备。特别有趣的医疗装置是导管（：如导尿管），内窥镜，喉镜，管喂养，管的排水，导丝，避孕套，urisheaths，阻挡涂层E.G. 手套，支架和其他植入物，额外的体外血液导管，膜E.G. 透析，血液过滤器，用于循环辅助设备，敷料伤口护理和造瘘袋。该涂层特别是从交联的聚乙烯吡咯烷酮而形成的亲水性涂层。在一个中，实施例组件保持在封装中的一个隔室的干燥导管元件和wässrige在另一隔室的过氧化氢溶液。因此，该溶液可包含稳定剂，E.G. 螯合剂，以及渗透压增加剂。用于插入尿道导管为微生物感染的治疗，缓解或预防是有用的：如尿路感染（UTI）。

8. 发明申请

WO2013170857A1 NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS 审中-公开
标题翻译：新型聚合物光敏元件和光电元件
公开(公告)号：WO2013170857A1
公开(公告)日：2013-11-21
申请号：PCT/DK2013/050143
申请日：2013-05-14
申请人： COLOPLAST A/S
发明人： MADSEN, Niels Jørgen , SEHNAL, Petr , ANDERSON, David George , NIELSEN, Bo Rud
IPC分类号： C08F4/00 , C08G83/00 , C08F2/50
CPC分类号： C08G18/6688 , C07C217/54 , C07D335/16 , C08F2/48 , C08F2/50 , C08F4/04 , C08F20/18 , C08F22/105 , C08G18/0814 , C08G18/3275 , C08G18/4833 , C08G18/73 , C08G18/758 , C09D4/00 , C08F220/20
摘要： The present invention provides polymeric quaternary ammonium photoinitiators being co-polymers of photoinitiator monomers, as well as quaternary ammonium photoinitiator monomer being valuable intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided a polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety and a quaternary ammonium are incorporated into the photoinitiator structure.
摘要翻译：本发明提供聚合季铵光引发剂，其是光引发剂单体的共聚物，以及季铵光引发剂单体，作为制备这种聚合物光引发剂的有价值的中间体。另外，提供了在这种聚合物光引发剂的存在下通过至少一种丙烯酸酯单体（Ac）的自由基聚合获得的聚丙烯酸酯。在光引发剂单体和聚合光引发剂中，光引发剂部分和季铵加入到光引发剂结构中。

9. 发明申请

WO2013004236A1 A CATHETER WITH A BALLOON 审中-公开
标题翻译：带气球的导管
公开(公告)号：WO2013004236A1
公开(公告)日：2013-01-10
申请号：PCT/DK2012/050231
申请日：2012-06-29
申请人： COLOPLAST A/S , NIELSEN, Bo Rud
发明人： NIELSEN, Bo Rud
IPC分类号： A61M25/10 , A61M25/00
CPC分类号： A61M27/00 , A61M25/0017 , A61M25/0043 , A61M25/10 , A61M2025/006
摘要： A catheter with a balloon element is provided with ribs under the balloon element so as to prevent the balloon from being attached to the shaft of the catheter to an extent where the balloon is difficult to inflate. The number of ribs can be any number above 3, but 6 to16 ribs are preferred.
摘要翻译：具有球囊元件的导管在球囊元件下方设置有肋，以便防止气囊附着到导管的轴上至气囊难以膨胀的程度。肋的数量可以是3以上的任何数，但优选6至16个肋。

10. 发明申请

WO2011076217A1 WETTING MEDIA WITH LOW MOLECOLAR POLYOL AND BUFFER 审中-公开
标题翻译：低分子聚合物和缓冲剂的湿润介质
公开(公告)号：WO2011076217A1
公开(公告)日：2011-06-30
申请号：PCT/DK2010/050353
申请日：2010-12-21
申请人： COLOPLAST A/S , NIELSEN, Bo Rud , SCHOENFELDT, Lars , MADSEN, Niels Joergen
发明人： NIELSEN, Bo Rud , SCHOENFELDT, Lars , MADSEN, Niels Joergen
IPC分类号： A61L29/08 , A61L31/10 , A61L2/08
CPC分类号： A61L2/08 , A61L2/081 , A61L2/087 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/048 , A61L31/10 , C08L39/06
摘要： Medical device comprising a hydrophilic coating, sterilised while in contact with a swelling medium comprising a low molecular polyol; and a separate buffer selected from the group consisting of carboxylic acids, amino acids, aminosulphonic acids and inorganic acids. The swelling media provides a stable pH after sterilisation and maintain the low friction of the coating.
摘要翻译：包含亲水涂层的医疗装置，与包含低分子量多元醇的溶胀介质接触时灭菌; 和选自羧酸，氨基酸，氨基磺酸和无机酸的单独缓冲液。溶胀介质在灭菌后提供稳定的pH，并保持涂层的低摩擦。

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