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    • 3. 发明专利
    • DE1618229A1
    • 1970-12-10
    • DE1618229
    • 1967-04-29
    • COLGATE PALMOLIVE CO
    • T SUH JOHNI JUDD CLAUDE
    • A61K31/295A61K33/26C07F17/02C09B1/34C07F15/02
    • 1,158,279. Haematinics. COLGATE-PALMOLIVE CO. 26 April, 1967 [12 May, 1966], No. 19155/67. Heading A5B. [Also in Divisions C2 and C5] Haematinics for the treatment of iron deficiencies in animals comprise carbocyclic ferrocenes I combined with pharmaceutical diluents, in which Y and Z each represent hydrogen or halogen atoms or trifluoromethyl or lower alkyl groups, i.e. 1 to 4 carbon atoms. A represents an alkylene group of 2 to 7 carbon atoms, R represents a hydrogen atom or a lower alkyl, aralkyl, aryl or heterocyclic group; R 1 represents a hydrogen atom or an hydroxy or lower alkyl group, and R 2 represents a hydrogen atom or an hydroxy, lower alkyl, aralkyl or aryl group, provided that either R or R 2 must be aryl except when R 1 is hydroxy. The above pharmaceutical composition can be formed into suitable oral or parenteral dosage forms such as capsules, tablets or solutions, and such dosage forms generally contain 5 to 500 mg. of the novel compounds.
    • 5. 发明专利
    • DE1568338A1
    • 1970-02-12
    • DE1568338
    • 1966-10-05
    • COLGATE PALMOLIVE CO
    • T SUH JOHN
    • A61K31/295A61K33/26C07F17/02C07C13/08
    • 1,143,796. Ferrocene cyclic ethers. COLGATE-PALMOLIVE CO. 6 Oct., 1966 [7 Oct., 1965], No. 44650/66. Heading C2J. [Also in Division A5] Ferrocene cyclic ethers, of formula are prepared by reacting the appropriate ferro cene diol with a concentrated liquid C 1 -C 3 aliphatic acid, followed by treatment with water. R' and R 2 in the general formula shown may represent hydrogen, a C 1 -C 6 alkyl, aryl, aralkyl, cycloalkyl, or cycloalkyl-lower alkyl. Suitable acids are formic, acetic, and propionic acids. Preparations of the ferrocene diols, ferrocene diacyls, ferrocene dicarboxylic acids and ferrocene itself are also described. The following reactions are performed. Examples 1-3: 1,1 1 -Diacetyl ferrocene # 1,1 1 -di-α- hydroxyethylferrocene # 1,1 1 -(α,α 1 -oxadiethyl) ferrocene. Examples 4-6: 1,1 1 - Dibenzoyl ferrocene -#1,1 1 -di-α-hydroxybenzoylferrocene -# 1,1 1 - (α,α 1 -oxadibenzyl)ferrocene. Examples 7-9: 1,1 1 -Dihexanoylferrocene -# 1, 1 1 -di-α- hydroxyhexylferrocene-#1,1 1 - (α,α 1 - oxadihexyl) ferrocene. Examples 10-12: 1-Acetyl- 1 1 - propionylferrocene-# 1 (α-hydroxyethyl)-1 1 - (α 1 - hydroxypropyl) ferrocene -# 1 - Ethyl - 1 1 - propyl - α,α 1 - oxaferrocene. Examples 13-15: 1 - Acetyl - 1 1 - benzoylferrocene -# 1 - (α - hydroxyethyl) - 1 1 - (α 1 - hydroxybenzyl) ferrocene -# 1 - Ethyl - 1 1 - benzyl - α,α 1 - oxaferrocene.