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1. 发明申请

WO9601614A2 RNA COMPONENT OF TELOMERASE 审中-公开
标题翻译： RNA组分的TELOMERASE
公开(公告)号：WO9601614A2
公开(公告)日：1996-01-25
申请号：PCT/US9508620
申请日：1995-07-07
申请人： COLD SPRING HARBOR LAB , GERON CORP , ANDREWS WILLIAM H , AVILLON ARIEL ATHENA , FENG JUNLI , FUNK WALTER , GREIDER CAROL , MARHUENDA MARIA ANTONIA BLASCO , VILLEPONTEAU BRYANT
发明人： ANDREWS WILLIAM H , AVILLON ARIEL ATHENA , FENG JUNLI , FUNK WALTER , GREIDER CAROL , MARHUENDA MARIA ANTONIA BLASCO , VILLEPONTEAU BRYANT
IPC分类号： C12N15/09 , A61K31/70 , A61K48/00 , A61P31/12 , A61P35/00 , C12N5/10 , C12N9/12 , C12N15/00 , C12N15/11 , C12N15/113 , C12Q1/68 , C12R1/91 , A61K35/12
CPC分类号： C12N9/1241 , A01K2217/05 , C12N15/11 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Q2600/158 , C12Y207/07049 , C12N2310/3521
摘要： Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译：包含哺乳动物端粒酶的RNA组分的核酸可用作药物，治疗和诊断试剂。

2. 发明申请

WO9814592A3 TELOMERASE REVERSE TRANSCRIPTASE 审中-公开
标题翻译： TELOMERASE逆向转录
公开(公告)号：WO9814592A3
公开(公告)日：1999-04-01
申请号：PCT/US9717618
申请日：1997-10-01
申请人： GERON CORP , UNIV TECHNOLOGY CORP , CECH THOMAS R , LINGNER JOACHIM , NAKAMURA TORU , CHAPMAN KAREN B , MORIN GREGG B , HARLEY CALVIN B , ANDREWS WILLIAM H
发明人： CECH THOMAS R , LINGNER JOACHIM , NAKAMURA TORU , CHAPMAN KAREN B , MORIN GREGG B , HARLEY CALVIN B , ANDREWS WILLIAM H
IPC分类号： A01K67/027 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K38/45 , A61K38/55 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C07K5/10 , C07K5/107 , C07K5/117 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/113 , C12N15/12 , C12N15/54 , C12N15/85 , C12P21/08 , C12Q1/02 , C12Q1/48 , C12Q1/68 , C12R1/19 , C12R1/84 , C12R1/91 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/573 , C12N15/11
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Y207/07049 , Y10S530/827 , Y10S530/828
摘要： The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus, and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.
摘要翻译：本发明涉及新型端粒酶核酸和氨基酸。特别地，本发明涉及编码各种端粒酶蛋白亚基和基序的核酸和氨基酸序列，包括Euplotes aediculatus的123kDa和43kDa端粒酶蛋白亚基，以及来自粟酒裂殖酵母，酵母属序列和人端粒酶的相关序列。本发明还涉及包含这些端粒酶蛋白亚基的多肽，以及含有这些亚单位的功能性多肽和核糖核蛋白。

3. 发明申请

WO9814593A9 HUMAN TELOMERASE CATALYTIC SUBUNIT 审中-公开
标题翻译：人类TELOMERASE催化亚基
公开(公告)号：WO9814593A9
公开(公告)日：1999-05-14
申请号：PCT/US9717885
申请日：1997-10-01
申请人： GERON CORP , UNIV TECHNOLOGY CORP , CECH THOMAS R , LINGNER JOACHIM , NAKAMURA TORU , CHAPMAN KAREN B , MORIN GREGG B , HARLEY CALVIN B , ANDREWS WILLIAM H
发明人： CECH THOMAS R , LINGNER JOACHIM , NAKAMURA TORU , CHAPMAN KAREN B , MORIN GREGG B , HARLEY CALVIN B , ANDREWS WILLIAM H
IPC分类号： A01K67/027 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K38/45 , A61K38/55 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C07K5/10 , C07K5/107 , C07K5/117 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/113 , C12N15/12 , C12N15/54 , C12N15/85 , C12P21/08 , C12Q1/02 , C12Q1/48 , C12Q1/68 , C12R1/19 , C12R1/84 , C12R1/91 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/573 , C12N15/11
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Y207/07049 , Y10S530/827 , Y10S530/828
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译：本发明提供与人端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。

4. 发明申请

WO9814593A2 HUMAN TELOMERASE CATALYTIC SUBUNIT 审中-公开
标题翻译：人类TELOMERASE催化亚基
公开(公告)号：WO9814593A2
公开(公告)日：1998-04-09
申请号：PCT/US9717885
申请日：1997-10-01
申请人： GERON CORP , UNIV TECHNOLOGY CORP , CECH THOMAS R , LINGNER JOACHIM , NAKAMURA TORU , CHAPMAN KAREN B , MORIN GREGG B , HARLEY CALVIN B , ANDREWS WILLIAM H
发明人： CECH THOMAS R , LINGNER JOACHIM , NAKAMURA TORU , CHAPMAN KAREN B , MORIN GREGG B , HARLEY CALVIN B , ANDREWS WILLIAM H
IPC分类号： A01K67/027 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K38/45 , A61K38/55 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C07K5/10 , C07K5/107 , C07K5/117 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/113 , C12N15/12 , C12N15/54 , C12N15/85 , C12P21/08 , C12Q1/02 , C12Q1/48 , C12Q1/68 , C12R1/19 , C12R1/84 , C12R1/91 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/573 , C12N15/11
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Y207/07049 , Y10S530/827 , Y10S530/828
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译：本发明提供与人端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。

5. 发明申请

WO03016474A3 METHODS AND COMPOSITIONS FOR USE IN SELECTIVELY PRODUCING A PROTEIN IN TELOMERASE EXPRESSING CELLS 审中-公开
标题翻译：用于在端粒酶表达细胞中选择性产生蛋白质的方法和组合物
公开(公告)号：WO03016474A3
公开(公告)日：2003-08-21
申请号：PCT/US0225759
申请日：2002-08-13
申请人： SIERRA SCIENCES INC , ANDREWS WILLIAM H , FYLSTRA DANIEL , FOSTER CHRISTOPHER A , FRASER STEPHANIE , MOHAMMADPOUR HAMID
发明人： ANDREWS WILLIAM H , FYLSTRA DANIEL , FOSTER CHRISTOPHER A , FRASER STEPHANIE , MOHAMMADPOUR HAMID
IPC分类号： C12N9/12 , C12N15/63 , C12Q1/68 , A61K38/17 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/00
CPC分类号： C12N9/1241 , C12N15/635
摘要： Methods and compositions for use in selectively expressing a protein in a telomerase expressing cell are provided. In the subject methods, an expression cassette comprising a Site C repressor site and a coding sequence for the protein is introduced into the target telomerase expressing cell, e.g., by administering the expression cassette to a host that includes the target cell. The protein may be a therapeutic or diagnostic protein. The subject methods find use in a variety of different applications, and are particularly suited for use in diagnostic and therapeutic applications, e.g., of cellular proliferative disease conditions.
摘要翻译：提供了用于在端粒酶表达细胞中选择性表达蛋白质的方法和组合物。在主题方法中，例如通过将表达盒施用于包含靶细胞的宿主，将包含位点C阻遏物位点和蛋白质的编码序列的表达盒引入目标端粒酶表达细胞。蛋白质可以是治疗性或诊断性蛋白质。主题方法可用于各种不同的应用，并且特别适用于诊断和治疗应用，例如细胞增殖性疾病状况。

6. 发明申请

WO02090571A2 METHODS AND COMPOSITIONS FOR MODULATING TELOMERASE REVERSE TRANSCRIPTASE (TERT) EXPRESSION 审中-公开
标题翻译：调节TELOMERASE逆转录酶（TERT）表达的方法和组合
公开(公告)号：WO02090571A2
公开(公告)日：2002-11-14
申请号：PCT/US0214740
申请日：2002-05-07
申请人： SIERRA SCIENCES INC , ANDREWS WILLIAM H , FOSTER CHRISTOPHER A , FRASER STEPHANIE , MOHAMMADPOUR HAMID
发明人： ANDREWS WILLIAM H , FOSTER CHRISTOPHER A , FRASER STEPHANIE , MOHAMMADPOUR HAMID
IPC分类号： A61K38/00 , C12N9/12 , C12Q
CPC分类号： C12N9/1241 , A61K38/00 , C12Y207/07049 , Y10T436/143333
摘要： Nucleic acid compositions comprising a region and a TERT minimal promoter activator binding site that acts to activate transcription of the telomerase reverse transcriptase (TERT) coding sequence, as well as vectors and constructs including the same, are provided. Also provided are methods of modulating, e.g., inhibiting, the TERT transcription activation activity of the subject TERT activator binding site regions in order to regulate, e.g., repress, telomerase expression, which methods find use in a variety of different applications, including the therapeutic applications and the like. In addition, methods of screening for agents that modulate the TERT transcription activating activity of the subject TERT activator sites are provided. The subject invention finds use in, among other applications, the regulation of TERT expression.
摘要翻译：提供了包含作用于激活端粒酶逆转录酶（TERT）编码序列的转录的区域和TERT最小启动子激活物结合位点的核酸组合，以及包含其的载体和构建体。还提供了调节，例如抑制受试者TERT激活物结合位点区域的TERT转录活化活性以调节例如抑制端粒酶表达的方法，该方法可用于多种不同应用，包括治疗应用程序等。此外，提供筛选调节受试者TERT激活剂位点的TERT转录激活活性的试剂的方法。除了其他应用之外，本发明可用于调节TERT表达。

7. 发明申请

WO02090570A2 METHODS AND COMPOSITIONS FOR MODULATING TELOMERASE REVERSE TRANSCRIPTASE (TERT) EXPRESSION 审中-公开
标题翻译：调节TELOMERASE逆转录酶（TERT）表达的方法和组合
公开(公告)号：WO02090570A2
公开(公告)日：2002-11-14
申请号：PCT/US0214720
申请日：2002-05-07
申请人： SIERRA SCIENCES INC , ANDREWS WILLIAM H
发明人： ANDREWS WILLIAM H
IPC分类号： C07K16/00 , C12N9/12 , C12N15/63 , C12P19/34 , C12P21/06 , C12Q
CPC分类号： C07K16/00 , C12N9/1276 , C12N15/635
摘要： Nucleic acid compositions comprising a TF-13 or TF-8 repressor binding site that acts to repress transcription of the telomerase reverse transcriptase (TERT) coding sequence, as well as vectors and constructs including the same, are provided. Also provide are methods of modulating, e.g., inhibiting, the TERT transcription repressing activity of the subject TF-8 and TF-13 repressor binding site regions in order to regulate, e.g., enhance, telomerase expression, which methods find use in a variety of different applications, including the production of reagents for use in life science research, therapeutic applications and the like. In addition, methods of screening for agents that modulate the TERT transcription repressing activity of the subject TF-8 and TF-13 sites are provided. The subject invention finds use in, among other applications, the regulation of TERT expression.
摘要翻译：提供了包含用于抑制端粒酶逆转录酶（TERT）编码序列的转录的TF-13或TF-8阻遏物结合位点的核酸组合，以及包含其的载体和构建体。还提供了调节，例如抑制受试者TF-8和TF-13阻遏物结合位点区域的TERT转录抑制活性以调节例如增强端粒酶表达的方法，该方法可用于各种不同的应用，包括生产用于生命科学研究的试剂，治疗应用等。此外，提供了筛选调节受试者TF-8和TF-13位点的TERT转录抑制活性的试剂的方法。除了其他应用之外，本发明可用于调节TERT表达。

8. 发明专利

CA170973A FLUID RECEPTACLE 未知
公开(公告)号：CA170973A
公开(公告)日：1916-07-25
申请号：CA170973D
申请日：1915-11-04
申请人： CARROLL JOHN E , WIZARD TIRE INFLATOR AND FIRE EXTINGUISHER COMPANY , ANDREWS WILLIAM H
发明人： CARROLL JOHN E , ANDREWS WILLIAM H

9. 发明授权

US650665A Vehicle-axle. 失效
公开(公告)号：US650665A
公开(公告)日：1900-05-29
申请号：US1900010667
申请日：1900-03-29
申请人： S J KENNERLY , A D MADDOX , F W SCHOPMEYER , E G BAILEY , ANDREWS WILLIAM H
发明人： ANDREWS WILLIAM H
CPC分类号： B60B2310/305

10. 发明授权

US1093097A Fruit-picker. 失效
公开(公告)号：US1093097A
公开(公告)日：1914-04-14
申请号：US1912705602
申请日：1912-06-24
申请人： ANDREWS WILLIAM H
发明人： ANDREWS WILLIAM H
CPC分类号： A01D46/247

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