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    • 5. 发明申请
    • COSMETIC PREPARATIONS CONTAINING PTH FRAGMENTS
    • 包含PTH片的化妆品制剂
    • WO2005120554A1
    • 2005-12-22
    • PCT/EP2005/006261
    • 2005-06-06
    • COGNIS FRANCE S.A.S.MOUSSOU, PhilippeDANOUX, LouisBARDEY, VincentJEANMAIRE, ChristinePAULY, Gilles
    • MOUSSOU, PhilippeDANOUX, LouisBARDEY, VincentJEANMAIRE, ChristinePAULY, Gilles
    • A61K38/29
    • A61K38/29A61K8/64A61K38/07A61Q7/00A61Q19/06A61Q19/08
    • It is proposed to use peptide fragments and/or derivatives and/or salts of peptide fragments of parathyroid hormone which comply with the structure: R1-NH-AA-R2 where R1 is selected from the group which is formed by -H, the linear saturated or unsaturated acyl group or branched saturated or unsaturated acyl group having from 1 to 24 carbon atoms, which can be functionalised with an -OH, -SH, -COOH or -CONH2 group, or a sterol group which is bonded by a functional group, such as a diacid with the peptide; where R2 = -OH, or the OH is functionalised by a linear saturated or unsaturated alkyl group or branched saturated or unsaturated alkyl group having from 1 to 24 carbon atoms or a sterol group; where AA corresponds completely or partially to the sequence of amino acids according to SEQ ID No. 1 corresponding to the PTH (28 to 34) region; in order to produce a cosmetic preparation and/or pharmaceutical preparation or for treating, in cosmetic terms, the skin and human hair against intrinsic or extrinsic cutaneous deterioration, and for preventing the appearance of deterioration. Furthermore, there are proposed cosmetic preparations which contain a derivative of peptide fragments of parathyroid hormone which comply with the structure R1-NH-AA-R2 where R1 is selected from the group which is formed by -H, by a linear saturated or unsaturated acyl group or branched saturated or unsaturated acyl group having from 1 to 24 carbon atoms, which can be functionalised with an -OH, -SH, -COOH or -CONH2 group, or a sterol group which is bonded by a functional group, such as a diacid with the peptide; where R2 = -OH, or the OH group is functionalised by a linear saturated or unsaturated alkyl group or branched saturated or unsaturated alkyl group having from 1 to 24 carbon atoms or a sterol group, where AA corresponds completely or partially to the amino acid sequence according to SEQ ID NO : 1 of the PTH (28-34) region, with the provision that R1 then corresponds to H only when R2 is different from -OH, or that R1 is different from H when R2 corresponds to OH.
    • 提出使用符合以下结构的甲状旁腺激素的肽片段的肽片段和/或衍生物和/或盐:R1-NH-AA-R2,其中R1选自-H形成的基团,线性 饱和或不饱和的酰基或具有1至24个碳原子的支链饱和或不饱和酰基,其可以被-OH,-SH,-COOH或-CONH 2基团官能化,或通过官能团键合的固醇基团 ,例如具有肽的二酸; 其中R 2 = -OH,或OH由具有1至24个碳原子的直链饱和或不饱和烷基或支链饱和或不饱和烷基或甾醇基官能化; 其中AA对应于与PTH(28至34)区域相对应的SEQ ID No.1的氨基酸序列完全或部分对应; 为了生产化妆品制剂和/或药物制剂,或者在化妆品方面,治疗皮肤和人的毛发抵抗固有的或外在的皮肤恶化,以及防止出现恶化。 此外,提出了含有甲状旁腺激素的肽片段的衍生物的化妆品制剂,其符合R1-NH-AA-R2的结构,其中R1选自-H形成的基团,通过线性饱和或不饱和酰基 可以用-OH,-SH,-COOH或-CONH 2基团官能化的具有1至24个碳原子的基团或支链饱和或不饱和酰基,或通过官能团键合的甾醇基,例如 二酸与肽; 其中R2 = -OH,或OH基团由具有1至24个碳原子的直链饱和或不饱和烷基或支链饱和或不饱和烷基或固醇基团官能化,其中AA对应于氨基酸序列的完全或部分 根据PTH(28-34)区域的SEQ ID NO:1,其条件是当R 2不同于-OH时,R1仅对应于H,或者当R 2对应于OH时,R 1不同于H。