专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009036404A8 KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES 审中-公开
标题翻译：用于减少乙炔的KETOREDUCTASE POLYPEPTIDES
公开(公告)号：WO2009036404A8
公开(公告)日：2010-05-06
申请号：PCT/US2008076333
申请日：2008-09-13
申请人： CODEXIS INC , LIANG JACK , JENNE STEPHANE J , MUNDORFF EMILY , CHING CHARLENE , GRUBER JOHN M , KREBBER ANKE , HUISMAN GJALT W
发明人： LIANG JACK , JENNE STEPHANE J , MUNDORFF EMILY , CHING CHARLENE , GRUBER JOHN M , KREBBER ANKE , HUISMAN GJALT W
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12P7/22 , C12Y101/01 , C12Y101/01184 , Y02E50/17 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。

2. 发明申请

WO2009036404A3 KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES 审中-公开
标题翻译：酮缩酶多肽对ACETOPHONONES的抑制作用
公开(公告)号：WO2009036404A3
公开(公告)日：2009-07-16
申请号：PCT/US2008076333
申请日：2008-09-13
申请人： CODEXIS INC , LIANG JACK , JENNE STEPHANE J , MUNDORFF EMILY , CHING CHARLENE , GRUBER JOHN M , KREBBER ANKE , HUISMAN GJALT W
发明人： LIANG JACK , JENNE STEPHANE J , MUNDORFF EMILY , CHING CHARLENE , GRUBER JOHN M , KREBBER ANKE , HUISMAN GJALT W
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12P7/22 , C12Y101/01 , C12Y101/01184 , Y02E50/17 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译：本公开提供了与天然存在的野生型酮还原酶相比具有改善的性质的工程酮还原酶。还提供了编码工程酮还原酶的多核苷酸，能够表达工程酮还原酶的宿主细胞，以及使用工程酮还原酶合成各种手性化合物的方法。

3. 发明申请

WO2010025238A2 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE 审中-公开
标题翻译：用于生产3-亚氨基-3-羟基丙酰胺的3-氨基-3-羟基丙酰胺的热解聚醚多糖
公开(公告)号：WO2010025238A2
公开(公告)日：2010-03-04
申请号：PCT/US2009055175
申请日：2009-08-27
申请人： CODEXIS INC , SAVILE CHRISTOPHER , GRUBER JOHN M , MUNDORFF EMILY , HUISMAN GJALT W , COLLIER STEVEN J
发明人： SAVILE CHRISTOPHER , GRUBER JOHN M , MUNDORFF EMILY , HUISMAN GJALT W , COLLIER STEVEN J
IPC分类号： C12N9/02 , C12N15/53 , C12P7/00
CPC分类号： C12N9/0006 , C12P13/001 , C12P17/00 , C12P41/002
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。优化了工程化酮还原酶多肽，用于催化N，N-二甲基-3-酮-3-（2-噻吩基）-1-酮基丙胺转化为（S）-N，N-二甲基-3-羟基-3-（ 2-噻吩基）-1-丙胺。

4. 发明申请

WO2010025287A9 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE 审中-公开
标题翻译：用于制备3-亚氨基-3-羟基丙酰胺的3-氨基-3-羟基丙酰胺的高聚糖多糖
公开(公告)号：WO2010025287A9
公开(公告)日：2010-05-27
申请号：PCT/US2009055239
申请日：2009-08-27
申请人： CODEXIS INC , SAVILE CHRISTOPHER , GRUBER JOHN M , MUNDORFF EMILY , HUISMAN GJALT W , COLLIER STEVEN J
发明人： SAVILE CHRISTOPHER , GRUBER JOHN M , MUNDORFF EMILY , HUISMAN GJALT W , COLLIER STEVEN J
IPC分类号： C12N9/02 , C12N15/53 , C12P7/00
CPC分类号： C12P17/00 , C12N9/0006 , C12P13/001 , C12Y101/01164 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.

5. 发明申请

WO2008103248A1 KETOREDUCTASES AND USES THEREOF 审中-公开
标题翻译：甜味剂及其用途
公开(公告)号：WO2008103248A1
公开(公告)日：2008-08-28
申请号：PCT/US2008001683
申请日：2008-02-08
申请人： CODEXIS INC , CHING CHARLENE , GRUBER JOHN M , HUISMAN GJALT W , MUNDORRF EMILY , NEWMAN LISA M
发明人： CHING CHARLENE , GRUBER JOHN M , HUISMAN GJALT W , MUNDORRF EMILY , NEWMAN LISA M
IPC分类号： C12N9/04 , C12N15/53
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/70 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。

6. 发明申请

WO2004015132A3 ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES 审中-公开
标题翻译：用于生产4-取代的3-羟基丁酸衍生物的酶法
公开(公告)号：WO2004015132A3
公开(公告)日：2005-04-14
申请号：PCT/US0325263
申请日：2003-08-11
申请人： CODEXIS INC , DAVIS S CHRISTOPHER , GRATE JOHN H , GRAY DAVID R , GRUBER JOHN M , HUISMAN GJALT W , MA STEVEN K , NEWMAN LISA M , SHELDON ROGER , WANG LI A
发明人： DAVIS S CHRISTOPHER , GRATE JOHN H , GRAY DAVID R , GRUBER JOHN M , HUISMAN GJALT W , MA STEVEN K , NEWMAN LISA M , SHELDON ROGER , WANG LI A
IPC分类号： C12N9/14 , C12P13/00 , C12P13/02
CPC分类号： C12P13/002 , C12N9/14 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives.
摘要翻译：本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化制备4-取代的3-羟基丁酸衍生物的方法和组合物。本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物制备4-卤代-3-羟基丁酸衍生物的方法和组合物。

7. 发明申请

WO2005018579A2 ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES AND VICINAL CYANO, HYDROXY SUBSTITUTED CARBOXYLIC ACID ESTERS 审中-公开
标题翻译：用于生产4-取代的3-羟基丁酸衍生物和邻氰基的羟基取代的羧酸酯的酶法
公开(公告)号：WO2005018579A2
公开(公告)日：2005-03-03
申请号：PCT/US2004004819
申请日：2004-02-18
申请人： CODEXIS INC , DAVIS S CHRISTOPHER , GRATE JOHN H , GRAY DAVID R , GRUBER JOHN M , HUISMAN GJALT W , MA STEVEN K , NEWMAN LISA M , SHELDON ROGER , WANG LI A
发明人： DAVIS S CHRISTOPHER , GRATE JOHN H , GRAY DAVID R , GRUBER JOHN M , HUISMAN GJALT W , MA STEVEN K , NEWMAN LISA M , SHELDON ROGER , WANG LI A
IPC分类号： A61K20060101 , C12N1/14 , C12N9/14 , C12P7/64 , C12P13/00 , A61K
CPC分类号： C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
摘要： The present invention provides methods and composition for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3ketobutyric acid derivatives. The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
摘要翻译：本发明提供了通过卤代醇脱卤素酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。本发明进一步提供了通过酮还原酶催化的4-卤代-3-酮丁酸衍生物的转化制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸酯的方法和组合物。

8. 发明申请

WO2010008828A3 BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS 审中-公开
标题翻译：用于制备主要立体纯化的双环脯氨酸化合物的生物催化过程
公开(公告)号：WO2010008828A3
公开(公告)日：2010-04-29
申请号：PCT/US2009048255
申请日：2009-06-23
申请人： CODEXIS INC , MIJTS BENJAMIN , MULEY SHEELA , LIANG JACK , NEWMAN LISA M , ZHANG XIYUN , LALONDE JAMES , CLAY MICHAEL D , ZHU JUN , GRUBER JOHN M , COLBECK JEFFREY , MUNGER JOHN D JR , MAVINHALLI JAGADEESH , SHELDON ROGER
发明人： MIJTS BENJAMIN , MULEY SHEELA , LIANG JACK , NEWMAN LISA M , ZHANG XIYUN , LALONDE JAMES , CLAY MICHAEL D , ZHU JUN , GRUBER JOHN M , COLBECK JEFFREY , MUNGER JOHN D JR , MAVINHALLI JAGADEESH , SHELDON ROGER
IPC分类号： C07D487/04 , C07D403/02 , C07D403/12 , C07D487/02
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially stereomerically pure fused bicyclic proline compounds of structural Formulae II to VII as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译：本公开提供如本文所述的结构式II至VII的基本上立体异构纯的稠合双环脯氨酸化合物，以及涉及其制备的生物催化方法，以及涉及那些方法中使用的酶。

9. 发明专利

JP2010172348A Enzymatic process for production of 4-substituted 3-hydroxybutyric acid derivative 审中-公开
标题翻译：用于生产4-取代的3-羟基丁酸衍生物的酶法
公开(公告)号：JP2010172348A
公开(公告)日：2010-08-12
申请号：JP2010115827
申请日：2010-05-19
申请人： Codexis Inc , コデクシス, インコーポレイテッド
发明人： DAVIS S CHRISTOPHER , GRATE JOHN H , GRAY DAVID R , GRUBER JOHN M , HUISMAN GJALT W , MA STEVEN K , NEWMAN LISA M , SHELDON ROGER , WANG LI A
IPC分类号： C12P13/00 , C12N9/14 , C12N15/09 , C12P7/62 , C12P13/02 , C12P41/00
CPC分类号： C12P13/002 , C12N9/14 , C12P13/02
摘要： PROBLEM TO BE SOLVED: To provide methods for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives, and to provide a composition. SOLUTION: The invention provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives. The methods include a step of feeding a 4-halo-3-hydroxybutyric acid ester, and a step of contacting the 4-halo-3-hydroxybutyric acid ester with a halohydrin dehalogenase and a cyanide. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化制备4-取代的3-羟基丁酸衍生物的方法，并提供组合物。解决方案：本发明提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。所述方法包括进料4-卤代-3-羟基丁酸酯的步骤和使4-卤代-3-羟基丁酸酯与卤代醇脱卤素酶和氰化物接触的步骤。版权所有（C）2010，JPO＆INPIT

10. 发明申请

WO9903803A2 PROCESS FOR PREPARING AMINOARYLACETYLENES 审中-公开
标题翻译：制备氨基乙酰丙酮的方法
公开(公告)号：WO9903803A2
公开(公告)日：1999-01-28
申请号：PCT/US9814253
申请日：1998-07-08
申请人： CATALYTICA PHARMACEUTICALS INC , GRUBER JOHN M
发明人： GRUBER JOHN M
IPC分类号： B01J31/24 , B01J31/30 , C07B61/00 , C07C209/62 , C07C211/45 , C07C249/02 , C07C251/24 , C07C
CPC分类号： C07C249/02 , C07C251/24
摘要： This invention provides a process for preparing aminoarylacetylenes comprising reacting an N-arylmethylidene aminoarylhalide with a terminal acetylene in the presence of a base and a catalyst system comprising a palladium catalyst and a cuprous salt to produce a novel N-arylmethylidene aminoarylacetylene, and hydrolyzing the N-arylmethylidene aminoarylacetylene to the aminoarylacetylene. In one embodiment, the invention provides a process for preparing aminophenylacetylenes comprising reacting an N-benzylidene aminophenylhalide with a terminal acetylene in the presence of a base and the catalyst system to produce a novel N-benzylidene aminophenylacetylene, and hydrolyzing the N-benzylidene aminophenylacetylene to the aminophenylacetylene.
摘要翻译：本发明提供了一种制备氨基芳基乙炔的方法，该方法包括使N-芳基亚甲基氨基芳基卤化物与末端乙炔在碱和包含钯催化剂和亚铜盐的催化剂体系存在下反应以制备新的N-芳基亚甲基氨基芳基乙炔并将N - 芳基亚甲基氨基芳基乙炔转化为氨基芳基乙炔。在一个实施方案中，本发明提供了一种制备氨基苯基乙炔的方法，包括在碱和催化剂体系存在下使N-亚苄基氨基苯基卤与末端乙炔反应以制备新的N-亚苄基氨基苯基乙炔，并将N-亚苄基氨基苯基乙炔水解为氨基苯乙炔。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式