专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010008828A2 BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS 审中-公开
标题翻译：用于制备主要纯度双熔体双酚化合物的生物化学方法
公开(公告)号：WO2010008828A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/048255
申请日：2009-06-23
申请人： CODEXIS, INC. , MIJTS, Benjamin , MULEY, Sheela , LIANG, Jack , NEWMAN, Lisa, M. , ZHANG, Xiyun , LALONDE, James , CLAY, Michael, D. , ZHU, Jun , GRUBER, John, M. , COLBECK, Jeffrey , MUNGER, John, D., Jr. , MAVINHALLI, Jagadeesh , SHELDON, Roger
发明人： MIJTS, Benjamin , MULEY, Sheela , LIANG, Jack , NEWMAN, Lisa, M. , ZHANG, Xiyun , LALONDE, James , CLAY, Michael, D. , ZHU, Jun , GRUBER, John, M. , COLBECK, Jeffrey , MUNGER, John, D., Jr. , MAVINHALLI, Jagadeesh , SHELDON, Roger
IPC分类号： C07D487/04 , C07D487/02 , C07D403/12 , C07D403/02
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially stereomerically pure fused bicyclic proline compounds of structural Formulae II to VII as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译：本公开提供了本文所述的基本上立体异构纯的结构式II至VII的稠合双环脯氨酸化合物，以及其制备的生物催化方法以及用于这些方法的酶。

2. 发明申请

WO2009036404A2 KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES 审中-公开
标题翻译：用于减少乙炔的KETOREDUCTASE POLYPEPTIDES
公开(公告)号：WO2009036404A2
公开(公告)日：2009-03-19
申请号：PCT/US2008/076333
申请日：2008-09-13
申请人： CODEXIS, INC. , LIANG, Jack , JENNE, Stephane, J. , MUNDORFF, Emily , CHING, Charlene , GRUBER, John, M. , KREBBER, Anke , HUISMAN, Gjalt, W.
发明人： LIANG, Jack , JENNE, Stephane, J. , MUNDORFF, Emily , CHING, Charlene , GRUBER, John, M. , KREBBER, Anke , HUISMAN, Gjalt, W.
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12P7/22 , C12Y101/01 , C12Y101/01184 , Y02E50/17 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。

3. 发明申请

WO2009042984A1 KETOREDUCTASE POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译： KETOREDUCTASE POLYPEPTIDES及其用途
公开(公告)号：WO2009042984A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/078046
申请日：2008-09-28
申请人： CODEXIS, INC. , LIANG, Jack , BORUP, Birthe , MITCHELL, Vesna , MUNDORFF, Emily , LALONDE, James , HUISMAN, Gjalt
发明人： LIANG, Jack , BORUP, Birthe , MITCHELL, Vesna , MUNDORFF, Emily , LALONDE, James , HUISMAN, Gjalt
IPC分类号： C12N9/04 , C12P7/42 , C12P7/66 , C12P41/00
CPC分类号： C12N9/0006 , C12P17/12
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。

4. 发明申请

WO2009029554A2 IMPROVED KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE 审中-公开
标题翻译：改进的用于立体选择性生产（R）-3-羟基乙烷的酮妥泰多肽
公开(公告)号：WO2009029554A2
公开(公告)日：2009-03-05
申请号：PCT/US2008/074135
申请日：2008-08-24
申请人： CODEXIS, INC. , LIANG, Jack , JENNE, Stephane, J. , MUNDORFF, Emily , VOLADRI, Rama , LALONDE, James , HUISMAN, Gjalt
发明人： LIANG, Jack , JENNE, Stephane, J. , MUNDORFF, Emily , VOLADRI, Rama , LALONDE, James , HUISMAN, Gjalt
IPC分类号： C12P17/16
CPC分类号： C12P17/00 , C12N9/0006 , C12P17/167 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
摘要翻译：与天然存在的野生型酮还原酶相比，本公开提供了具有改进性质的工程酮还原酶。还提供了编码工程酮还原酶的多核苷酸，能够表达工程酮还原酶的宿主细胞，以及使用工程酮还原酶合成手性化合物的方法。

6. 发明公开

EP2606139A2 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE 有权
标题翻译：生物催化剂和（1R，2R）-2-（3,4-二甲氧基苯氧基）环己胺合成方法
公开(公告)号：EP2606139A2
公开(公告)日：2013-06-26
申请号：EP11818555.2
申请日：2011-08-08
申请人： Codexis, Inc. , Cabirol, Fabien L. , Gohel, Anupam , Collier, Steven J. , Liang, Jack , Mock, Marissa , Mundorff, Emily , Novick, Scott , Limanto, John , Smith, Derek , Beutner, Gregory , Klapars, Artis , Ashley, Eric , Strotman, Hallena , Truppo, Matthew , Hughes, Gregory , Grau, Brendan , Janey, Jacob
发明人： CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
IPC分类号： C12P13/00 , C12P7/00
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译：本公开提供了能够以至少2:1非对映异构体将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽相对于顺式非对映异构体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺的比例。本公开还提供了用于制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的多核苷酸，载体，宿主细胞和方法，进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。

7. 发明申请

WO2012024104A2 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE 审中-公开
标题翻译：生物催化剂和（1R，2R）-2-（3,4-二甲氧基苯氧基）环己胺合成方法
公开(公告)号：WO2012024104A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/046932
申请日：2011-08-08
申请人： CODEXIS, INC. , CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
发明人： CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译：本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽以相对于顺式非对映异构体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺至少2:1的非对映异构体比例。本公开还提供了用于制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的多核苷酸，载体，宿主细胞和方法，进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。

8. 发明申请

WO2010141494A3 SYNTHESIS OF EZETIMIBE 审中-公开
公开(公告)号：WO2010141494A3
公开(公告)日：2010-12-09
申请号：PCT/US2010/036938
申请日：2010-06-01
申请人： CODEXIS, INC. , COLLIER, Steven, J. , LIANG, Jack , FU FAN, Jasyln , WILSON, Robert, John
发明人： COLLIER, Steven, J. , LIANG, Jack , FU FAN, Jasyln , WILSON, Robert, John
IPC分类号： C07D205/08 , A61K31/397 , A61P9/10
摘要： The present disclosure relates to processes for the preparation of Ezetimibe (1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone) and related azetidine compounds.

9. 发明申请

WO2010117796A3 PROCESSES FOR THE PREPARATION OF ALPHA-CHLOROKETONES FROM CARBOXYLIC ACIDS 审中-公开
公开(公告)号：WO2010117796A3
公开(公告)日：2010-10-14
申请号：PCT/US2010/029222
申请日：2010-03-30
申请人： CODEXIS, INC. , COLLIER, Steven, J. , LIANG, Jack
发明人： COLLIER, Steven, J. , LIANG, Jack
IPC分类号： C07C45/72 , C07C49/16 , C07C67/10 , C07C69/96 , C07C271/16
摘要： The present disclosure provides compositions and methods for the preparation of ? chloroketones from carboxylic acids. In particular embodiments, the present disclosure provides procedures for the preparation of chiral ? chloroketone derivatives of amino acids.

10. 发明申请

WO2004037174A2 PROCESS FOR THE PREPARATION OF (S,S)-CIS-2-PHENYL-3-AMINOPIPERIDINE 审中-公开
标题翻译：（S，S） - 顺式-2-苯基-3-氨基哌啶的制备方法
公开(公告)号：WO2004037174A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/032620
申请日：2003-10-15
申请人： PFIZER PRODUCTS, INC. , DSM PHARMACEUTICALS, INC. , NUGENT, Thomas, C. , SEEMAYER, Robert , LIANG, Jack
发明人： NUGENT, Thomas, C. , SEEMAYER, Robert , LIANG, Jack
IPC分类号： A61K
CPC分类号： C07D211/56 , Y02P20/55
摘要： The present invention is directed to a process for preparing (S,S)-cis-2-phenyl-3-aminopiperidine which comprises: (a) reacting the amino acid, ornithine or salt having a protecting group on the amino groups on the α and δ carbons thereof, having the formula (I) with N-methoxy-N-methylamino or salt thereof under amide forming conditions to produce an amide of the formula in the S configuration (II) (b) adding said amide to an effective amount of a Grignard reagent of the formula Ph MgX to form a ketone of the formula in the S configuration (III) (c) selectively deprotecting the amino group on the δ carbon under conditions sufficient to cyclize said ketone to form a cyclic imine and reducing the resulting imine to form a product of the formula in the (S,S) configuration (IV) and (d) removing the amino protecting group on the α-carbon to form said (S,S)-cis-2-phenyl-3-aminopiperidine, wherein P 1 and P 2 are different amino protecting groups, which are removed under different reaction conditions and X is halide. When P 1 is t-butyloxycarbonyl the above process is also used to prepare (S,S)-cis-2-phenyl-3-tertbutoxycarbonylaminopiperidine.
摘要翻译：本发明涉及制备（S，S） - 顺式-2-苯基-3-氨基哌啶的方法，其包括：（a）使具有保护基的氨基酸，鸟氨酸或盐（I）与N-甲氧基-N-甲基氨基或其盐在酰胺形成条件下反应，生成式（II）的通式（II）的酰胺（b ）将所述酰胺加入到有效量的式PhMgX的格氏试剂中以形成S构型（III）中的式（III）的酮：（c）在足以环化所述酮的条件下选择性地将δ碳上的氨基脱保护（S，S）构型（IV）和（d）除去α-碳上的氨基保护基以形成所述（S，S）构型的产物， - 顺-2-苯基-3-氨基哌啶，其中P 1和P 2是不同的氨基保护基，其中a 在不同反应条件下重新除去，X是卤化物。当P 1为叔丁氧基羰基时，上述方法也用于制备（S，S） - 顺式-2-苯基-3-叔丁氧基羰基氨基哌啶。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式