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1. 发明申请

WO2012134253A3 CORYNEBACTERIUM SP. TRANSFORMED WITH A FRUCTOKINASE GENE DERIVED FROM ESCHERICHIA SP. AND PROCESS FOR PREPARING L-AMINO ACID USING THE SAME 审中-公开
标题翻译：红霉素用来自ESCHERICHIA SP的FRUCTOKINASE基因转化。和使用该方法制备L-氨基酸的方法和方法
公开(公告)号：WO2012134253A3
公开(公告)日：2012-12-27
申请号：PCT/KR2012002474
申请日：2012-04-02
申请人： CJ CHEILJEDANG CORP , BAE HYUN WON , KIM HYUNG JOON , MOON JUN OK , JANG JAE WOO , KIM JONG CHUL , KIM TAE HAN , SUNG JIN SUCK , LEE KYUNG HAN , KIM DAE CHEOL , KIM HYO JIN , BAE HYUN AE , LIM SANG JO
发明人： BAE HYUN WON , KIM HYUNG JOON , MOON JUN OK , JANG JAE WOO , KIM JONG CHUL , KIM TAE HAN , SUNG JIN SUCK , LEE KYUNG HAN , KIM DAE CHEOL , KIM HYO JIN , BAE HYUN AE , LIM SANG JO
IPC分类号： C12N1/21 , C12N15/31 , C12N15/77 , C12P13/04
CPC分类号： C12P13/14 , C12N9/1205 , C12P13/04 , C12P13/08 , C12Y207/01004
摘要： The present invention relates to Corynebacterium sp. that is transformed with an Escherichia sp.-derived fructokinase gene to express fructokinase showing a sufficient activity of converting fructose into fructose-6-phosphate, thereby preventing unnecessary energy consumption, and a method for producing L-amino acids using the strain. The transformed Corynebacterium sp. of the present invention is able to express fructokinase from the Escherichia-derived fructokinase gene to prevent unnecessary energy consumption during fructose metabolism, leading to more cost-effective production of L-amino acids. Therefore, it can be widely used for the effective production of L-amino acids.
摘要翻译：本发明涉及棒状杆菌属用Escherichia sp.衍生的果糖激酶基因转化以表达果糖激酶，其显示出将果糖转化为果糖-6-磷酸的足够活性，从而防止不必要的能量消耗，以及使用该菌株产生L-氨基酸的方法。转化的棒状杆菌属本发明能够从来自大肠杆菌的果糖激酶基因中表达果糖激酶，以防止在果糖代谢期间不必要的能量消耗，导致L-氨基酸的更具成本效益的生产。因此，可广泛用于L-氨基酸的有效生产。

2. 发明专利

AT443725T 未知
公开(公告)号：AT443725T
公开(公告)日：2009-10-15
申请号：AT05804498
申请日：2005-11-02
申请人： KIM JUNG MOON , KIM JUNG KOOK , KIM TAE HAN , LEE JONG SUK
发明人： KIM JUNG MOON , KIM JUNG KOOK , KIM TAE HAN , LEE JONG SUK , YOOK JONG IN
IPC分类号： C07K19/00 , C07K14/51
摘要： Non-activated tissue-regeneration polypeptides (TRPs) and their preparation methods are disclosed. The TRPs include: a protein transduction domain (PTD) making the polypeptides to permeate a cell membrane without cell membrane receptors; a furin activation domain (FAD) which has at least one proprotein convertase cleavage site and which can be cleaved by the proprotein convertase and activate a tissue regeneration domain (TRD) in cells; and a tissue regeneration domain (TRD) which can be activated by the proprotein convertase cleavage of the FAD to stimulate the growth or formation of tissues or to induce the regeneration of tissues. The TRPs can be mass-produced by cultured bacteria, such as recombinant E. coli, are in a non-activated state before in vivo administration, and their separation, purification, handling, storage and administration are simple and convenient. The in vivo administration of the TRPs is useful to stimulate the formation or regeneration of tissues, such as bones or cartilages, or to improve the fibrosis and cirrhosis of organs, such as kidneys, liver, lungs and heart by pharmacological mechanisms completely different from those of prior rhBMPs or TGF-&bgr; proteins.

3. 发明专利

DE602005016847D1 未知
公开(公告)号：DE602005016847D1
公开(公告)日：2009-11-05
申请号：DE602005016847
申请日：2005-11-02
申请人： KIM JUNG KOOK , KIM JUNG MOON , KIM TAE HAN , LEE JONG SUK
发明人： KIM JUNG MOON , KIM JUNG KOOK , KIM TAE HAN , LEE JONG SUK , YOOK JONG IN
IPC分类号： C07K19/00 , C07K14/51
摘要： Non-activated tissue-regeneration polypeptides (TRPs) and their preparation methods are disclosed. The TRPs include: a protein transduction domain (PTD) making the polypeptides to permeate a cell membrane without cell membrane receptors; a furin activation domain (FAD) which has at least one proprotein convertase cleavage site and which can be cleaved by the proprotein convertase and activate a tissue regeneration domain (TRD) in cells; and a tissue regeneration domain (TRD) which can be activated by the proprotein convertase cleavage of the FAD to stimulate the growth or formation of tissues or to induce the regeneration of tissues. The TRPs can be mass-produced by cultured bacteria, such as recombinant E. coli, are in a non-activated state before in vivo administration, and their separation, purification, handling, storage and administration are simple and convenient. The in vivo administration of the TRPs is useful to stimulate the formation or regeneration of tissues, such as bones or cartilages, or to improve the fibrosis and cirrhosis of organs, such as kidneys, liver, lungs and heart by pharmacological mechanisms completely different from those of prior rhBMPs or TGF-&bgr; proteins.

4. 发明公开

EP1951752A4 NON-ACTIVATED WNT INHIBITION POLYPEPTIDES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译： NOT ACTIVATED WNT抑制多肽及其制备方法
公开(公告)号：EP1951752A4
公开(公告)日：2008-12-31
申请号：EP06823842
申请日：2006-11-30
申请人： KIM JUNG MOON , KIM JUNG KOOK , KIM TAE HAN , LEE JONG SUK
发明人： KIM JUNG MOON , KIM JUNG KOOK , KIM TAE HAN , LEE JONG SUK , YOOK JONG IN
IPC分类号： C07K14/705 , C12N15/62
CPC分类号： C07K14/475 , C07K14/4703

5. 发明公开

EP1863850A4 NON-ACTIVATED POLYPEPTIDES HAVING A FUNCTION OF TISSUE REGENERATION AND METHOD FOR PREPARING THE SAME 失效转让
标题翻译：随着对生产组织再生函数和方法的不活化多肽
公开(公告)号：EP1863850A4
公开(公告)日：2008-10-08
申请号：EP05804498
申请日：2005-11-02
申请人： KIM JUNG MOON , KIM JUNG KOOK , KIM TAE HAN , LEE JONG SUK
发明人： KIM JUNG MOON , KIM JUNG KOOK , KIM TAE HAN , LEE JONG SUK , YOOK JONG IN
IPC分类号： C07K19/00 , C07K14/51
CPC分类号： C07K14/51
摘要： Non-activated tissue-regeneration polypeptides (TRPs) and the preparation methods thereof are disclosed. The TRPs contain: a protein transduction domain (PTD) making the polypeptides to permeate a cell membrane without cell membrane receptors; a furin activation domain (FAD) which has at least one proprotein convertase cleavage site and which can be cleaved by the proprotein convertase and activate a tissue regeneration domain (TRD) in cells; and a tissue regeneration domain (TRD) which can be activated by the proprotein convertase cleavage of the FAD to stimulate the growth or formation of tissues or to induce the regeneration of tissues. The TRPs can be practically mass-produced by the culture of bacteria, such as recombinant E. coli, and are in a non-activated state before in vivo administration. Thus, their production cost is only a few tenths of the prior active proteins having uses similar thereto, and processes for their separation, purification, handling, storage and administration are significantly simple and convenient. The in vivo administration of the TRPs can stimulate the formation or regeneration of tissues, such as bones or cartilages, or improve the fibrosis and cirrhosis of organs, such as kidneys, liver, lungs and heart by pharmacological mechanisims completely different from those of prior rhBMPs or TGF-ß proteins. Accordingly, the TRPs will be useful as drugs having new mechanisms.

7. 发明公开

EP2694638A4 CORYNEBACTERIUM SP. TRANSFORMED WITH A FRUCTOKINASE GENE DERIVED FROM ESCHERICHIA SP. AND PROCESS FOR PREPARING L-AMINO ACID USING THE SAME 有权
标题翻译：棒状杆菌属WITH A大肠埃希氏SP改变。得到果糖激酶基因和方法是这样就产生L-氨基酸
公开(公告)号：EP2694638A4
公开(公告)日：2014-11-12
申请号：EP12764461
申请日：2012-04-02
申请人： CJ CHEILJEDANG CORP
发明人： BAE HYUN WON , KIM HYUNGJOON , MOON JUN OK , JANG JAE WOO , KIM JONG CHUL , KIM TAE HAN , SUNG JIN SUCK , LEE KYUNG HAN , KIM DAE CHEOL , KIM HYO JIN , BAE HYUN AE , LIM SANG JO
IPC分类号： C12N1/21 , C12N15/31 , C12N15/77 , C12P13/04
CPC分类号： C12P13/14 , C12N9/1205 , C12P13/04 , C12P13/08 , C12Y207/01004
摘要： The present invention relates to Corynebacterium sp. that is transformed with an Escherichia sp.-derived fructokinase gene to express fructokinase showing a sufficient activity of converting fructose into fructose-6-phosphate, thereby preventing unnecessary energy consumption, and a method for producing L-amino acids using the strain. The transformed Corynebacterium sp. of the present invention is able to express fructokinase from the Escherichia-derived fructokinase gene to prevent unnecessary energy consumption during fructose metabolism, leading to more cost-effective production of L-amino acids. Therefore, it can be widely used for the effective production of L-amino acids.
摘要翻译：本发明涉及棒状杆菌属。没有与在埃希氏菌属来源的果糖激酶基因转化以表达果糖激酶表示转换果糖转化为果糖-6-磷酸，从而防止不必要的能量消耗的足够的活性，以及使用该菌株的L-氨基酸的方法。转化的棒状杆菌属。本发明的能够表达来自大肠杆菌衍生的果糖激酶基因的果糖激酶，以防止果糖代谢期间不必要的能量消耗，从而导致更具成本效益的生产L-氨基酸。因此，它可以广泛地用于有效生产L-氨基酸。

8. 发明申请

WO2008156272A3 APPARATUS AND METHOD FOR PROVIDING CHILDCARE INFORMATION 审中-公开
标题翻译：提供儿童信息的装置和方法
公开(公告)号：WO2008156272A3
公开(公告)日：2009-02-12
申请号：PCT/KR2008003391
申请日：2008-06-16
申请人： KIM TAE HAN
发明人： KIM TAE HAN
IPC分类号： G06Q99/00 , G06Q10/00 , G06Q50/00
CPC分类号： G06Q50/22 , G06Q10/10 , Y02A90/22
摘要： Disclosed is an apparatus for providing childcare information, including: a sensor unit for detecting environmental information on a surrounding environment; a time information unit for generating time information; a memory for storing childcare information data including optimum childcare environmental information and a childcare schedule; a controller for generating current childcare environmental condition information by comparing the detected environmental information with the stored optimum childcare environmental information, and for searching current childcare schedule information from the stored childcare schedule based on the time information; and an output unit for outputting the generated childcare environmental condition information and the searched childcare schedule information.
摘要翻译：公开了一种用于提供托儿信息的装置，包括：用于检测周围环境的环境信息的传感器单元; 时间信息单元，用于产生时间信息; 用于存储儿童保育信息数据的记忆，包括最佳育儿环境信息和育儿计划; 通过将检测到的环境信息与所存储的最佳育儿环境信息进行比较来产生当前育儿环境状况信息的控制器，并且用于基于所述时间信息从所存储的托儿计划中搜索当前的托儿计划信息; 以及输出单元，用于输出所生成的育儿环境条件信息和所搜索的育儿计划信息。

9. 发明申请

WO2010036056A2 APPARATUS AND METHOD FOR INPUTTING ENGLISH CHARACTERS 审中-公开
标题翻译：用于输入英文字符的装置和方法
公开(公告)号：WO2010036056A2
公开(公告)日：2010-04-01
申请号：PCT/KR2009005494
申请日：2009-09-25
申请人： ANY FUTURE TECHNOLOGY CO LTD , JEONG YOUNG SEOK , CHUNG SEON HYE , KIM TAE HAN
发明人： JEONG YOUNG SEOK , CHUNG SEON HYE , KIM TAE HAN
IPC分类号： G06F3/02
CPC分类号： G06F3/0233
摘要： Disclosed are an apparatus and a method for inputting English characters using clone keys in a portable terminal, wherein English characters which are identical to the English characters arranged on the key most recently inputted by a user are allocated to the clone key. The apparatus for inputting English characters comprises: a data storage unit for storing a program for inputting English characters; a key input unit for sensing a key operation signal from the user to select an English character arranged on each key; and a memory unit for storing the arrangement information of the English characters on the key, which corresponds to the most recent key operation signal, to allocate the arrangement information to the clone key.
摘要翻译：公开了一种在便携式终端中使用克隆密钥输入英文字符的装置和方法，其中与由用户最近输入的密钥上排列的英文字符相同的英文字符被分配给克隆密钥。用于输入英文字符的装置包括：数据存储单元，用于存储用于输入英文字符的程序; 键输入单元，用于感测来自用户的键操作信号，以选择布置在每个键上的英文字符; 以及存储单元，用于存储与密钥操作信号对应的密钥上的英文字符的配置信息，以将配置信息分配给克隆密钥。

10. 发明申请

WO2006080630A8 PHARMACEUTICAL COMBINATION PREPARATION FOR ORAL DELIVERY FOR THE TREATMENT OF DIABETES MELLITUS 审中-公开
标题翻译：用于口服输送用于治疗糖尿病的药物组合制剂
公开(公告)号：WO2006080630A8
公开(公告)日：2006-12-14
申请号：PCT/KR2005003134
申请日：2005-09-22
申请人： HANDOK PHARMACEUTICALS CO LTD , WEON KWON YEON , KIM DONG WOOK , KIM TAE HAN , KIM JUNG HOON , KIM EUN JUNG
发明人： WEON KWON YEON , KIM DONG WOOK , KIM TAE HAN , KIM JUNG HOON , KIM EUN JUNG
IPC分类号： A61K9/28
CPC分类号： A61K9/2866 , A61K9/209
摘要： Disclosed are a combined pharmaceutical preparation for oral delivery for treatment of diabetes mellitus, comprising a) an inner layer comprising metformin or a pharmaceutically acceptable salt thereof, a swellable polymer and a pharmaceutically acceptable excipient, b) a drug-free intermediate layer comprising a water-soluble polymer, and c) an outer layer comprising glimepiride and a releasing controller; and a method for preparing the same.
摘要翻译：公开了用于治疗糖尿病的口服递送的组合药物制剂，其包含a）包含二甲双胍或其药学上可接受的盐，可溶胀聚合物和药学上可接受的赋形剂的内层，b）包含水的无药物中间层和c）包含格列美脲和释放控制剂的外层; 及其制备方法。

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