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1. 发明申请

WO2012115851A1 ULTRA-HIGH SENSITIVE MONITORING OF EARLY TRANSPLANTATION FAILURE 审中-公开
标题翻译：超高灵敏度监测早期移植失败
公开(公告)号：WO2012115851A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/025393
申请日：2012-02-16
申请人： CITY OF HOPE , YEN, Yun , LIU, Qiang
发明人： YEN, Yun , LIU, Qiang
IPC分类号： G01N33/48
CPC分类号： C12Q1/6883 , C12Q2600/156 , G01N2510/00
摘要： The present invention provides a method for detecting transplantation failure of a transplanted organ or cells which comprises detecting a donor-positive but recipient-negative DNA marker in the recipient's plasma using pyrophosphorolysis activated polymerization. Because of the high sensitivity, specificity and selectivity of pyrophosphorolysis activated polymerization, transplantation failure can be detected at early stages and treatment can be initiate earlier.
摘要翻译：本发明提供一种检测移植器官或细胞的移植失败的方法，其包括使用焦磷酸裂解活化聚合检测受体血浆中的供体阳性但受体阴性的DNA标记。由于焦磷酸活化聚合的高灵敏度，特异性和选择性，早期可以检测到移植失败，早期可以开始治疗。

2. 发明申请

WO2011034954A1 TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症
公开(公告)号：WO2011034954A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/048973
申请日：2010-09-15
申请人： CERULEAN PHARMA INC. , CALANDO PHARMACEUTICALS, INC. , CITY OF HOPE , YEN, Yun , SCHLUEP, Thomas , RYAN, John
发明人： YEN, Yun , SCHLUEP, Thomas , RYAN, John
IPC分类号： C07D471/00
CPC分类号： A61K47/6851 , A61K39/3955 , A61K45/06 , A61K47/61 , C07D491/22
摘要： Provided are methods relating to compositions that include a CDP- topoisomerase inhibitor, e.g., a CDP-camptothecin or camptothecin derivative conjugate, e.g., CRLX101.
摘要翻译：提供了涉及包括CDP-拓扑异构酶抑制剂，例如CDP-喜树碱或喜树碱衍生物缀合物例如CRLX101的组合物的方法。

3. 发明申请

WO2015148839A1 TREATMENT OF BRCA1-DEFECTIVE CANCER OR RESISTANT CANCERS 审中-公开
标题翻译：治疗BRCA1缺陷性癌或耐药性癌
公开(公告)号：WO2015148839A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/022809
申请日：2015-03-26
申请人： CITY OF HOPE
发明人： YEN, Yun
IPC分类号： A01N43/78 , A01N43/50 , C07D277/00 , C07D233/00
CPC分类号： A61K31/426 , A61K31/337 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods of treating cancer in a subject, by administering COH29 ((N-(4- (3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide)). The methods of treating include treating a BRCA1 -defective subject, a PARP1 inhibitor-resistant subject or a DNA-damaging anti-cancer agent resistant subject. The methods include treating cancer by administering COH29 and a DNA-damaging anti-cancer agent in a combined synergistic amount.
摘要翻译：本文提供了通过给予COH29（（（N-（4-（3,4-二羟基苯基）-5-苯基噻唑-2-基）-3,4-二羟基苯甲酰胺））来治疗受试者的癌症的方法。治疗方法包括治疗BRCA1-鉴别受试者，PARP1抑制剂抗性受试者或抗DNA抗性剂抗性受试者。所述方法包括通过以组合的协同量施用COH29和DNA损伤性抗癌剂来治疗癌症。

4. 发明公开

EP3128842A1 TREATMENT OF BRCA1-DEFECTIVE CANCER OR RESISTANT CANCERS 有权
标题翻译： BEHANDLUNG VON BRCA1-DEFEKTEM KREBS ODER-RESISTENTEM KREBS
公开(公告)号：EP3128842A1
公开(公告)日：2017-02-15
申请号：EP15767925.9
申请日：2015-03-26
申请人： City of Hope
发明人： YEN, Yun
IPC分类号： A01N43/78 , A01N43/50 , C07D277/00 , C07D233/00
CPC分类号： A61K31/426 , A61K31/337 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods of treating cancer in a subject, by administering COH29 ((N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide)). The methods of treating include treating a BRCA1-defective subject, a PARP1 inhibitor-resistant subject or a DNA-damaging anti-cancer agent resistant subject. The methods include treating cancer by administering COH29 and a DNA-damaging anti-cancer agent in a combined synergistic amount.
摘要翻译：本文提供了通过给予COH29（（（N-（4-（3,4-二羟基苯基）-5-苯基噻唑-2-基）-3,4-二羟基苯甲酰胺））来治疗受试者的癌症的方法。治疗方法包括治疗BRCA1缺陷受试者，PARP1抑制剂抗性受试者或DNA损伤抗癌剂抗性受试者。所述方法包括通过以组合的协同量施用COH29和DNA损伤性抗癌剂来治疗癌症。

5. 发明公开

EP3324954A1 AMINONAPTHOQUINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR BLOCKING UBIQUITINATION-PROTEASOME SYSTEM IN DISEASES 有权转让
公开(公告)号：EP3324954A1
公开(公告)日：2018-05-30
申请号：EP15899099.4
申请日：2015-07-23
申请人： Taipei Medical University , Yen, Yun
发明人： YEN, Yun , LIOU, Jing-ping , PAN, Shiow-lin
IPC分类号： A61K31/18 , A61K31/166 , A61K31/167
CPC分类号： C07D213/75 , A61K31/166 , A61K31/167 , A61K31/337 , A61K31/4409 , A61K31/475 , A61K31/506 , A61K31/593 , A61K31/704 , A61K33/24 , A61K2300/00 , A61P3/10 , A61P25/28 , A61P35/02 , A61P37/00 , C07D209/04 , C07D213/74 , C07D213/76 , C07D215/40 , C07D215/42 , C07D231/38 , C07D235/30 , C07D239/42 , C07D241/04 , C07D241/20 , C07D277/42 , C07D471/04 , C07D487/04
摘要： The invention relates to new compounds with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.

6. 发明公开

EP3129373A1 HISTONE DEACETYLASE INHIBITORS 有权
标题翻译： HISTONDEACETYLASE-INHIBITOREN
公开(公告)号：EP3129373A1
公开(公告)日：2017-02-15
申请号：EP15776965.4
申请日：2015-04-09
申请人： Taipei Medical University , National Health Research Institutes , Yen, Yun
发明人： LIOU, Jing-Ping , CHANG, Jang-Yang , WANG, Jia-Yi , YEN, Yun
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , C07D209/08 , C07D231/56 , C07D487/04
摘要： Fused bicycle indol, indoline, azoindole, or azoindoline compounds of Formula (I) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same. Further disclosed is a method for treating cancer, e.g., glioma, prostate cancer, and colorectal cancer, with these compounds.
摘要翻译：本文所述的式（I）的熔融自行车吲哚，二氢吲哚，偶氮吲哚或偶氮二吲哚啉化合物。还公开了这些化合物的药学上可接受的盐和含有它们的药物组合物。进一步公开的是用这些化合物治疗癌症的方法，例如胶质瘤，前列腺癌和结肠直肠癌。

7. 发明申请

WO2010083203A2 NON-EMBRYONIC STEM CELLS AND USES THEREOF 审中-公开
标题翻译：非胚胎干细胞及其用途
公开(公告)号：WO2010083203A2
公开(公告)日：2010-07-22
申请号：PCT/US2010/020884
申请日：2010-01-13
申请人： STEMBIOS TECHNOLOGIES, INC. , WANG, James , YEN, Yun
发明人： WANG, James , YEN, Yun
IPC分类号： C12N5/074 , C12N5/02 , C12N15/12 , A61K35/12 , A61P25/16 , A61P35/00 , A61P37/00
CPC分类号： A61K35/545 , C12N5/0607 , G01N33/5073 , G01N2333/4712 , G01N2333/90203
摘要： Disclosed are novel stem cells of non-embryonic origins and the uses thereof.
摘要翻译：公开了非胚胎来源的新型干细胞及其用途。

8. 发明申请

WO2005094485A2 DRUG SCREENING 审中-公开
标题翻译：药物筛选
公开(公告)号：WO2005094485A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/009639
申请日：2005-03-23
申请人： YEN, Yun
发明人： YEN, Yun
IPC分类号： C07H21/04 , C12N9/02 , C12N9/06 , C12N15/09 , C12Q1/68
CPC分类号： C12N9/0093 , C12Q1/6886 , C12Q2600/136
摘要： An isolated polypeptide containing (i) an immunogenic fragment of an RNR subunit (SEQ ID NO: 1 or 15) spanning Y162 or Y369 of SEQ ID NO: 1, or Y124 or Y331 of SEQ ID NO: 15, or (ii) a mutant fragment of SEQ ID NO: 1 or 15 in which at least one of the aforementioned Y residues is replaced by a non-tyrosine residue. Disclosed are related nucleic acids, expression vectors, host cells, reconstituted RNR enzymes, preparation methods, and compound screening methods. Also disclosed are RNAi agents for inhibiting expression of a gene encoding SEQ ID NO: 1 or 15. Within the scope of this invention are methods of treating a cell proliferation-associated disorder.
摘要翻译：一种分离的多肽，其包含（i）跨越SEQ ID NO：1的Y162或Y369或SEQ ID NO：15的Y124或Y331的RNR亚基（SEQ ID NO：1或15）的免疫原性片段，或（ii） SEQ ID NO：1或15的突变体片段，其中至少一个上述Y残基被非酪氨酸残基替代。公开了相关的核酸，表达载体，宿主细胞，重建的RNR酶，制备方法和化合物筛选方法。还公开了用于抑制编码SEQ ID NO：1或15的基因表达的RNAi剂。在本发明的范围内，是治疗细胞增殖相关病症的方法。

9. 发明申请

WO2017123809A1 COMPOUNDS FOR INHIBITING CANCER AND VIRUS 审中-公开
标题翻译：抑制癌症和病毒的化合物
公开(公告)号：WO2017123809A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/013253
申请日：2017-01-12
申请人： TAIPEI MEDICAL UNIVERSITY , YEN, Yun
发明人： YEN, Yun , LIOU, Jing-Ping , LIU, Yun-Ru
IPC分类号： C07H15/207 , C07C235/84 , C07D213/81 , C07D401/04 , A61K31/381 , A61K31/4453 , A61K31/7034
CPC分类号： A61K31/381 , A61K31/4453 , A61K31/7034 , C07C235/64 , C07D211/58 , C07H15/203
摘要： The invention relates to compounds for inhibiting a cancer cell or a virus. Particularly, the invention provides compounds for inhibiting, treating and/or preventing cancer and Zika virus.
摘要翻译：本发明涉及用于抑制癌细胞或病毒的化合物。特别地，本发明提供了用于抑制，治疗和/或预防癌症和寨卡病毒的化合物。

10. 发明申请

WO2017020030A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITION ASSOCIATED WITH UBIQUITINATION-PROTEASOME SYSTEM 审中-公开
标题翻译：与UBIQUITINATION-PROTEASOME SYSTEM相关的化合物和药物组合物
公开(公告)号：WO2017020030A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/044932
申请日：2016-07-30
申请人： TAIPEI MEDICAL UNIVERSITY , YEN, Yun
发明人： YEN, Yun , LIOU, Jing-ping , PAN, Shiow-lin
IPC分类号： A61K31/122 , C07C50/12
CPC分类号： A61K31/122 , C07C225/30 , C07C235/56 , C07C237/34 , C07C255/58 , C07C311/29 , C07D209/08 , C07D209/44 , C07D213/40 , C07D215/38 , C07D215/40 , C07D295/13 , C07D295/135
摘要： The invention relates to new compounds with low cytotoxicity for blocking ubiquitination- proteasome system in diseases. Accordingly, these compounds can be used in treatment of treating disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders and autoimmune disorders and metabolic disorders.
摘要翻译：本发明涉及在疾病中阻断泛素化蛋白酶体系的细胞毒性低的新化合物。因此，这些化合物可用于治疗疾病的治疗，包括但不限于癌症，神经变性疾病，炎性疾病和自身免疫性疾病以及代谢紊乱。

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