会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 6. 发明申请
    • PROCESS FOR THE PREPARATION OF FUROPYRROLES
    • 制备氟化物的方法
    • WO2005005430A3
    • 2005-06-16
    • PCT/EP2004051259
    • 2004-06-28
    • CIBA SC HOLDING AGRIGGS RICHARD LEWISWESTWOOD NICHOLAS JAMESSMITH DAVID MACDONALDMORTON COLIN
    • RIGGS RICHARD LEWISWESTWOOD NICHOLAS JAMESSMITH DAVID MACDONALDMORTON COLIN
    • C07D487/04C07D491/04C07D491/048
    • C07D487/04C07D491/04
    • The present invention relates to a process for the preparation of furopyrroles of the general formula (I), comprising (a) heating a compound of the formula (II) under microwave irradiation optionally in the presence of an inert solvent, wherein A and A are Cl-C18alkyl, C2-Cl8alkenyl, C2-Cl8alkynyl, C5-C8cycloalkyl, C5- C8cycloalkenyl, aryl or heteroaryl, A is hydrogen, C1-C18alkyl, cyanomethyl, Ar ,-CR R -(CH2 )m -Ar or Y- R , wherein R and R independently of each other stand for hydrogen or C1-C4alkyl, or phenyl which can be substituted up to three times with C1-C4alkyl, Ar stands for aryl, C5-C8 cloalkyl, C5-C8 cycloalkenyl or heteroaryl, which can be substituted one to three times with C1-C8alkyl, C1-C8alkoxy, halogen or phenyl, which can be substituted with C1-C8alkyI or C1-C8alkoxy one to three times, and m stands for 0, 1, 2, 3 or 4, R is C1-C18alkyl, in particular C1-C4alkyl, aryl, in particular phenyl, or aralkyl, in particular benzyl, which can be substituted one to three times with C1-C8alkyl, C1-C8alkoxy, or halogen, Y is -C(O)-, -C(O)O-, -C(O)NH-, -SO2NH- or -SO2- and R is C1-Cl8alkyl, Ar , or aralkyl. The furopyrroles of the general formula (I) can be obtained in high yield and high purity by the process of the present invention.
    • 本发明涉及一种制备通式(I)的呋喃并吡咯的方法,其包括(a)在微波辐射下任选地在惰性溶剂存在下加热式(II)化合物,其中A 1, 和A 2是C 1 -C 18烷基,C 2 -C 18烯基,C 2 -C 18炔基,C 5 -C 8环烷基,C 5 -C 8环烯基,芳基或杂芳基,A 3是氢,C 1 -C 18烷基,氰甲基,Ar 3, R 31 - (CH 2)m -Ar 3或Y-R 32,其中R 30和R 31彼此独立地代表氢或C 1 -C 4烷基 或可以被C 1 -C 4烷基取代三次的苯基,Ar 3代表芳基,C 5 -C 8烷基,C 5 -C 8环烯基或杂芳基,其可以被C 1 -C 8烷基,C 1 -C 8烷基取代一至三次 C 1-8烷氧基,卤素或苯基,其可以被C 1 -C 8烷基或C 1 -C 8烷氧基取代一至三次,m代表0,1,2,3或4,R是C 1 -C 18烷基,特别是C 1 -C 4烷基, 芳基,特别是苯基或芳烷基,特别是苄基, 可以用C 1 -C 8烷基,C 1 -C 8烷氧基或卤素取代一至三次,Y是-C(O) - , - C(O)O-,-C(O)NH-,-SO 2 NH-或 - SO 2 - 和R 32是C 1 -C 8烷基,Ar 3或芳烷基。 通过本发明的方法可以高产率和高纯度获得通式(I)的呋喃并吡咯。