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1. 发明公开

EP3532090A1 ENDOGLYCOSIDASE MUTANTS FOR GLYCOPROTEIN REMODELING AND METHODS OF USING IT 审中-公开
公开(公告)号：EP3532090A1
公开(公告)日：2019-09-04
申请号：EP17844364.4
申请日：2017-08-23
申请人： Cho Pharma Inc , Academia Sinica , Lin, Nan-Horng
发明人： LIN, Nan-Horng , HUANG, Lin-Ya , SHIVATARE, Sachin, S. , CHEN, Li-Tzu , WONG, Chi-Huey , WU, Chung-Yi , CHENG, Ting
IPC分类号： A61K38/47 , C12N9/24 , C12P21/02

2. 发明申请

WO2018039373A1 ENDOGLYCOSIDASE MUTANTS FOR GLYCOPROTEIN REMODELING AND METHODS OF USING IT 审中-公开
标题翻译：用于糖蛋白重塑的内切糖苷酶突变体及其使用方法
公开(公告)号：WO2018039373A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048252
申请日：2017-08-23
申请人： CHO PHARMA INC , ACADEMIA SINICA , LIN, Nan-Horng
发明人： LIN, Nan-Horng , HUANG, Lin-Ya , SHIVATARE, Sachin, S. , CHEN, Li-Tzu , WONG, Chi-Huey , WU, Chung-Yi , CHENG, Ting
IPC分类号： A61K38/47 , C12N9/24 , C12P21/02
摘要： A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO: 1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.
摘要翻译： EndoS2的突变体在野生型EndoS2（SEQ ID NO：1）的序列中包含一个或多个突变，其中所述一个或多个突变位于位于残基133- 143，残基177-182，残基184-189，残基221-231和/或残基227-237，其中与野生型相比，EndoS2的突变体具有低水解活性和高的高糖基化活性 EndoS2。使用EndoS2突变体制备工程化糖蛋白的方法包括将活化的寡糖偶联至糖蛋白受体。活化的寡糖是一种聚糖恶唑啉。

3. 发明申请

WO2017156192A1 METHODS FOR MODULAR SYNTHESIS OF N-GLYCANS AND ARRAYS THEREOF 审中-公开
标题翻译：用于模块化合成N-糖苷的方法及其阵列
公开(公告)号：WO2017156192A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021454
申请日：2017-03-08
申请人： ACADEMIA SINICA , WONG, Chi-Huey
发明人： WONG, Chi-Huey , WU, Chung-Yi , SHIVATARE, Sachin, S.
IPC分类号： C08B37/00 , C12P19/04 , G01N33/68 , G01N33/50 , G01N33/532
摘要： The present disclosure relates to novel modular methods for generating a diversity of N-glycans of high mannose, hybrid and complex types. The present disclosure also relates to exemplary arrays of the synthesized N-glycans spotted onto aluminium oxide coated slides. These arrays can be used to detect and analyze binding interactions between the synthesized N-glycansand glycan binding molecules, such as HIV-1 neutralizing antibodies. The present disclosure also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for general epitope identification, drug discovery and as analytical tools. The present disclosure also provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing pathological diseases such as HIV.
摘要翻译：本公开涉及用于产生高甘露糖，杂合体和复合体类型的N-聚糖多样性的新型模块化方法。本公开还涉及点样在氧化铝涂覆的载玻片上的合成N-聚糖的示例性阵列。这些阵列可用于检测和分析合成的N-聚糖和聚糖结合分子如HIV-1中和抗体之间的结合相互作用。本公开还涉及用于鉴定与阵列上的各种类型的分子结合的试剂以及定义阵列上与这些试剂结合的分子的结构元件的方法。本文提供的阵列和方法可用于普通表位鉴定，药物发现和分析工具。本公开还提供了用于检测，诊断，复发监测和预防病理性疾病例如HIV的有用的聚糖和表位决定簇。

4. 发明公开

EP3426693A1 METHODS FOR MODULAR SYNTHESIS OF N-GLYCANS AND ARRAYS THEREOF 审中-公开
公开(公告)号：EP3426693A1
公开(公告)日：2019-01-16
申请号：EP17764050.5
申请日：2017-03-08
申请人： Academia Sinica
发明人： WONG, Chi-Huey , WU, Chung-Yi , SHIVATARE, Sachin, S.
IPC分类号： C08B37/00 , C12P19/04 , G01N33/68 , G01N33/50 , G01N33/532

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