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1. 发明申请

WO9854574A3 CHEMILUMINESCENT ENERGY TRANSFER CONJUGATES AND THEIR USES AS LABELS IN BINDING ASSAYS 审中-公开
标题翻译：透明能量转移联合体及其作为绑定测定中的标签的用途
公开(公告)号：WO9854574A3
公开(公告)日：1999-03-04
申请号：PCT/IB9800831
申请日：1998-05-29
申请人： CHIRON DIAGNOSTICS CORP , JIANG QINGPING , XI JUN , NATRAJAN ANAND , SHARPE DAVID , BAUMANN MARCUS , HILFIKER ROLF , SCHMIDT ERIKA , SENN PAUL , THOMMEN FRITZ , WALDNER ADRIAN , ALDER ALEX , LAW SAY JONG
发明人： JIANG QINGPING , XI JUN , NATRAJAN ANAND , SHARPE DAVID , BAUMANN MARCUS , HILFIKER ROLF , SCHMIDT ERIKA , SENN PAUL , THOMMEN FRITZ , WALDNER ADRIAN , ALDER ALEX , LAW SAY-JONG
IPC分类号： C09B11/04 , C09B15/00 , C09K11/07 , G01N33/533 , G01N33/542 , G01N33/58
CPC分类号： C09B15/00 , C09B11/04 , G01N33/533 , G01N33/542 , G01N33/582 , Y10S436/80 , Y10S436/816 , Y10S436/817
摘要： A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emission wavelengths of acridinium or benzacridinium esters in order to further reduce or eliminate the emission spectral overlap between the parent polysubstituted aryl Acridinium Esters (DMAE) and Benzacridinium Esters (LEAE) is disclosed. The ETC's retain the unique desired properties of acridinium or benzacridinium compounds including complete light emission in very short period of time, monophasic emission spectrum, simplicity of triggering mechanism, ability of labeling the biological molecules of interest to form a tracer, and good stability. Additionally, the range of the emission spectrum of an acridinium or benzacridinium compound can now be shifted at will and at longer leap through the choice of a luminophore as the integral part of an ETC molecule. Disclosed are chemiluminescent labeled conjugates comprising an acridinium or benzacridinium moiety convalently attached to a luminophore via a spacer, said moiety further conjugated to a biological molecule of interest, wherein said spacer is of an appropriate length to allow the excited species generated from said moiety to transfer energy efficiently to said luminophore, resulting in the emission of light in the spectral region of said luminophore. Also disclosed are binding assays using said conjugates, test kits comprising said conjugates and methods of preparing the conjugates.

2. 发明申请

WO0009487A9 NEAR INFRARED CHEMILUMINESCENT ACRIDINIUM COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：近红外化学发光吖啶化合物及其用途
公开(公告)号：WO0009487A9
公开(公告)日：2000-06-22
申请号：PCT/US9918076
申请日：1999-08-10
申请人： BAYER AG , NATRAJAN ANAND , JIANG QINGPING , SHARPE DAVID , LAW SAY JONG
发明人： NATRAJAN ANAND , JIANG QINGPING , SHARPE DAVID , LAW SAY-JONG
IPC分类号： C07D219/04 , C07D401/12 , C07K14/765 , C07K16/26 , C09K3/00 , C09K11/07 , C12N15/09 , C12Q1/68 , G01N21/76 , G01N33/532 , G01N33/58 , G01N33/533
CPC分类号： G01N33/582 , C07D219/04 , Y10S436/80 , Y10S436/815 , Y10S436/817 , Y10S530/812 , Y10T436/13
摘要： Our results thus identify two sets of necessary and sufficient criteria for observing long-wavelength emission from acridinium compounds: Set A: (a) the creation of an extended conjugation system by the attachment of appropriate functional groups on the acridinium nucleus (electronic requirement). (b) Coplanarity of the attached functional group and the acridone moiety during light emission (geometry requirement). (c) Said functional group must consist of at least one aromatic ring and one electron-donating atom or group with an extra pair of electrons which can readily delocalize into the extended pi system to which the heteroatom is directly attached or built into, and establish stable extended resonance with the electron-withdrawing carbonyl moiety of the light emitting acridone. Such electron-donating atom or group that exists in the form of an anion has particularly strong effect to further the bathochromic shift of the emission wavelength. Set B: (a) A direct attachment at one or more of positions C-2, C-4, C-5, or C-7 of the acridinium nucleus, of electron-donating atoms or groups having extra pair(s) of electrons. The electron-donating entities can be the same or different if more than one electron-donating entity is used. Such electron-donating atom or group that exists in the form of an anion has particularly strong effect to further the bathochromic shift of the emission wavelenth. For molecules for which the above criteria are met such as LEAE, 3-HS-DMAE, and 2-hydroxy-DMAE long wavelength-emission exceeding 500 nm and reaching into NIR region is expected and observed. Preferably, the utility of an NIR-AC of comparable quantum yield as the conventional acridinium compounds goes hand-in-hand with the employment of a luminescence detector of good to excellent detection efficiency. To achieve efficient NIR signal detection and facilitate the performing of diagnostic assays, a further objective of the present invention is the advance of a concept and the realization of substituting a state-of-the-art charge-coupled device (CCD) detector for the red-insensitive photomultiplier tube (PMT) in a conventional fully or semi-automatic analyzer such as MLA-II of Chiron Diagnostics, Walpole, MA.
摘要翻译：因此，我们的结果确定了观察吖啶鎓化合物长波长发射的两套必要和充分的标准：A组：（a）通过在吖啶鎓核上附加适当的官能团（电子要求）创建扩展的缀合系统。（b）发光期间附着的官能团和吖啶酮部分的共面性（几何要求）。（c）所述官能团必须由至少一个芳环和一个供电子原子或基团组成，所述原子或基团具有额外的一对电子，所述电子可以容易地离域到扩展的pI系统中，所述杂原子直接连接或构建到其中，与发光吖啶酮的吸电子羰基部分稳定的扩展共振。这种以阴离子形式存在的供电子原子或基团对于进一步发射波长的红移是特别有效的。组B：（a）在吖啶鎓核的C-2，C-4，C-5或C-7位置的一个或多个位置上直接连接电子给体原子或具有额外的一对或多对电子。如果使用多于一个供电子实体，则供电子实体可以相同或不同。这种以阴离子形式存在的供电子原子或基团对于进一步发射波长的红移是特别有效的。对于满足上述标准的分子如LEAE，期望并观察到3-HS-DMAE和超过500nm并且到达NIR区域的2-羟基-DMAE长波长发射。优选地，与传统的吖啶鎓化合物相比，具有可比量子产率的NIR-AC的效用与使用具有良好到极好的检测效率的发光检测器结合在一起。为了实现有效的NIR信号检测并促进诊断测定的执行，本发明的另一个目的是提出一种概念以及用现有技术的电荷耦合器件（CCD）检测器代替在传统的全自动或半自动分析仪如马萨诸塞州Walpole的Chiron Diagnostics的MLA-II中使用红色不敏感的光电倍增管（PMT）。

3. 发明申请

WO2007092847A2 SOLID PHASE SYNTHESIS OF ACRIDINIUM DERIVATIVES 审中-公开
标题翻译：茜素衍生物的固相合成
公开(公告)号：WO2007092847A2
公开(公告)日：2007-08-16
申请号：PCT/US2007061696
申请日：2007-02-06
申请人： SIEMENS MEDICAL SOLUTIONS DIAG , NATRAJAN ANAND , SHARPE DAVID , COSTELLO JIM , JIANG QINGPING
发明人： NATRAJAN ANAND , SHARPE DAVID , COSTELLO JIM , JIANG QINGPING
CPC分类号： C07D219/04
摘要： Acridinium-functionalized solid-phase supports and methods for making acridinium-functionalized solid-phase supports are disclosed. The acridinium-functionalized solid-phase supports comprise a solid phase support linked to a chemiluminescent substituted acridinium compound through a linker group covalently attached to the nitrogen atom of the acridinium nucleus and the solid phase support.
摘要翻译：公开了吖啶鎓官能化固相载体和制备吖啶酮官能化固相载体的方法。吖啶酮官能化的固相载体包括通过共价连接到吖啶核的氮原子的连接基团和固相载体连接到化学发光的取代的吖啶鎓化合物的固相载体。

4. 发明申请

WO2008067055A3 STABLE ACRIDINIUM ESTERS WITH FAST LIGHT EMISSION 审中-公开
标题翻译：具有快速发光的稳定的吖啶酯
公开(公告)号：WO2008067055A3
公开(公告)日：2008-08-28
申请号：PCT/US2007081375
申请日：2007-10-15
申请人： SIEMENS HEALTHCARE DIAGNOSTICS , JIANG QINGPING , SHARPE DAVID , NATRAJAN ANAND
发明人： JIANG QINGPING , SHARPE DAVID , NATRAJAN ANAND
IPC分类号： C07D219/04 , G01N33/532
CPC分类号： C07D219/04 , Y10T436/13 , Y10T436/143333 , Y10T436/21
摘要： Chemiluminescent acridinium esters are provided which are fast light emitting and hydrolytically stable. The chemiluminescent acridinium esters are useful labels in assays for detecting or quantifying analytes.
摘要翻译：提供化学发光吖啶酯，其具有快速发光和水解稳定性。化学发光吖啶酯在用于检测或定量分析物的测定中是有用的标记。

5. 发明申请

WO2011146595A2 ZWITTERIONIC REAGENTS 审中-公开
标题翻译： ZWITTERICIC试剂
公开(公告)号：WO2011146595A2
公开(公告)日：2011-11-24
申请号：PCT/US2011036971
申请日：2011-05-18
申请人： SIEMENS HEALTHCARE DIAGNOSTICS , NATRAJAN ANAND , SHARPE DAVID , WEN DAVID , JIANG QINGPING
发明人： NATRAJAN ANAND , SHARPE DAVID , WEN DAVID , JIANG QINGPING
IPC分类号： C07D403/02 , G01N33/53
CPC分类号： C07D207/452 , A61K47/48061 , A61K47/48284 , A61K47/545 , A61K47/643 , C07C309/14 , C07D207/46 , C07D403/12 , C07D493/10 , C07D495/04 , C07F9/091 , C07K1/13 , C07K7/06 , C07K14/765 , C09B11/24 , G01N33/5306
摘要： Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.
摘要翻译：用于改性疏水性分子以提高其溶解度和/或降低其非特异性结合的含两相元素的化合物。含有两性离子的化合物可适用于可检测标记如生物素和荧光素的改性以改善其溶解度。含有两性离子的化合物也可用于制备蛋白质，肽和其它大分子的缀合物或用于交联分子和/或大分子。

6. 发明专利

ES2392900T3 Esteres de acridinio estables con emisión de luz rápida 未知
公开(公告)号：ES2392900T3
公开(公告)日：2012-12-14
申请号：ES07871162
申请日：2007-10-15
申请人： SIEMENS HEALTHCARE DIAGNOSTICS , JIANG QINGPING , SHARPE DAVID
发明人： JIANG QINGPING , SHARPE DAVID , NATRAJAN ANAND
IPC分类号： C07D219/04 , G01N33/532
摘要： Éster de acridinio quimioluminiscente de emisión de luz rápida, hidrolíticamente estable que comprende la estructura de fórmula I: en la que Q se selecciona independientemente cada vez que aparece de un enlace, -O-, -S- o -N (R*) -; en la que R* se selecciona independientemente cada vez que aparece de hidrógeno, alquilo, alquenilo, alquinilo, arilo, alquil-arilo o aril-alquilo de cadena lineal o ramificada, sustituidos o no sustituidos y combinaciones de los mismos, que contienen opcionalmente desde uno hasta 20 heteroátomos seleccionados del grupo que consiste en oxígeno, nitrógeno, fósforo, azufre, halógeno, y combinaciones de los mismos; con la condición de que al menos una Q debe ser -O-, -S- o -N (R*) -; en la que R1 es un grupo alquilo, alquenilo, alquinilo, aril-alquilo o alquil-arilo que contiene hasta heteroátomos.

7. 发明申请

WO2006130736A3 HIGH QUANTUM YIELD ACRIDINIUM COMPOUNDS AND THEIR USES IN IMPROVING ASSAY SENSITIVITY 审中-公开
标题翻译：高量子化合物及其在提高测定灵敏度方面的用途
公开(公告)号：WO2006130736A3
公开(公告)日：2007-02-22
申请号：PCT/US2006021195
申请日：2006-06-01
申请人： BAYER HEALTHCARE LLC , NATRAJAN ANAND , JIANG QUINGPING , SHARPE DAVID , COSTELLO JAMES
发明人： NATRAJAN ANAND , JIANG QUINGPING , SHARPE DAVID , COSTELLO JAMES
IPC分类号： G01N33/532 , G01N33/566 , C07D219/04 , C07D219/06 , C07D401/12 , C07D473/08 , C07K1/10 , C09K11/07 , G01N21/76 , G01N21/78 , G01N33/53 , G01N33/533 , G01N33/542 , G01N33/58 , G01Q80/00
CPC分类号： G01N33/533 , B82Y15/00 , C07D219/04 , C07D219/06 , G01N33/542 , G01N33/582 , G01N33/588 , Y10S435/968 , Y10S436/80 , Y10S436/805
摘要： The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium compound when its chemiluminescence is triggered by alkaline peroxide. More specifically, it has been found that the placement of one or two hydrophilic, alkoxy groups at the C-2 and/or C-7 position of the acridinium ring system of acridinium compounds increases their quantum yield and enhances the aqueous solubility of these compounds. The present hydrophilic, high quantum yield, acridinium compounds are useful chemiluminescent labels for improving the sensitivity of immunoassays.
摘要翻译：本发明涉及亲水性高量子产率吖啶鎓化合物。已经发现，当其化学发光由碱性过氧化物触发时，电子给体基团在吖啶环体系中的放置增加了相应的吖啶鎓化合物发射的光的量。更具体地，已经发现，在吖啶鎓化合物的吖啶环体系的C-2和/或C-7位置上放置一个或两个亲水性烷氧基增加其量子产率并增强这些化合物的水溶性。本发明的亲水性，高量子产率的吖啶化合物是有用的化学发光标记，用于提高免疫测定的灵敏度。

8. 发明专利

AU7347298A Chemiluminescent energy transfer conjugates and their uses as labels in binding assays 未知
公开(公告)号：AU7347298A
公开(公告)日：1998-12-30
申请号：AU7347298
申请日：1998-05-29
申请人： CHIRON DIAGNOSTICS CORP
发明人： JIANG QINGPING , XI JUN , NATRAJAN ANAND , SHARPE DAVID , BAUMANN MARCUS , HILFIKER ROLF , SCHMIDT ERIKA , SENN PAUL , THOMMEN FRITZ , WALDNER ADRIAN , ALDER ALEX , LAW SAY-JONG
IPC分类号： C09B11/04 , C09B15/00 , C09K11/07 , G01N33/533 , G01N33/542 , G01N33/58
摘要： A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emission wavelengths of acridinium or benzacridinium esters in order to further reduce or eliminate the emission spectral overlap between the parent polysubstituted aryl Acridinium Esters (DMAE) and Benzacridinium Esters (LEAE) is disclosed. The ETC's retain the unique desired properties of acridinium or benzacridinium compounds including complete light emission in very short period of time, monophasic emission spectrum, simplicity of triggering mechanism, ability of labeling the biological molecules of interest to form a tracer, and good stability. Additionally, the range of the emission spectrum of an acridinium or benzacridinium compound can now be shifted at will and at longer leap through the choice of a luminophore as the integral part of an ETC molecule. Disclosed are chemiluminescent labeled conjugates comprising an acridinium or benzacridinium moiety covalently attached to a luminophore via a spacer, said moiety further conjugated to a biological molecule of interest, wherein said spacer is of an appropriate length to allow the excited species generated from said moiety to transfer energy efficiently to said luminophore, resulting in the emission of light in the spectral region of said luminophore. Also disclosed are binding assays using said conjugates, test kits comprising said conjugates and methods of preparing the conjugates.

9. 发明授权

US694678A Screen apparatus for paper-pulp. 失效
标题翻译：纸浆的筛选装置
公开(公告)号：US694678A
公开(公告)日：1902-03-04
申请号：US1901076340
申请日：1901-09-24
申请人： SHARPE DAVID
发明人： SHARPE DAVID
CPC分类号： D21D5/026

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