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1. 发明申请

WO2006031878A3 IMIDAZOQUINOLINE COMPOUNDS 审中-公开
标题翻译：咪唑喹啉化合物
公开(公告)号：WO2006031878A3
公开(公告)日：2006-05-04
申请号：PCT/US2005032721
申请日：2005-09-14
申请人： CHIRON CORP , VALIANTE NICHOLAS , XU FENG , LIN XIAODONG , CHU DANIEL , WANG XIAOJING MICHAEL
发明人： VALIANTE NICHOLAS , XU FENG , LIN XIAODONG , CHU DANIEL , WANG XIAOJING MICHAEL
IPC分类号： C07D471/04 , A61K31/4745
CPC分类号： C07D471/14 , C07D471/04 , Y02P20/55
摘要： The invention provides novel compositions comprising imidazoquinoline compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an)other agent(s).
摘要翻译：本发明提供了包含咪唑并喹啉化合物的新型组合物。还提供了以有效量施用组合物以增强受试者的免疫应答的方法。进一步提供了与一种或多种其他药剂组合施用组合物的新组合物和方法。

2. 发明申请

WO2006002422A2 COMPOUNDS FOR IMMUNOPOTENTIATION 审中-公开
标题翻译：用于免疫原性的化合物
公开(公告)号：WO2006002422A2
公开(公告)日：2006-01-05
申请号：PCT/US2005022769
申请日：2005-06-24
申请人： CHIRON CORP , VALIANTE NICHOLAS , XU FENG
发明人： VALIANTE NICHOLAS , XU FENG
IPC分类号： A61K31/00
CPC分类号： A61K31/505 , A61K31/52 , A61K31/7068 , A61K31/708 , A61K45/06
摘要： Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed.
摘要翻译：刺激免疫应答和用3,4-二（1H-吲哚-3-基）-1H-吡咯-2,5-二酮，星形孢菌素类似物，衍生化哒嗪，色烯-4-酮，吲哚满酮，喹唑啉，核苷类似物和其他小分子。

3. 发明申请

WO2006115509A2 SMALL MOLECULE IMMUNOPOTENTIATORS AND ASSAYS FOR THEIR DETECTION 审中-公开
标题翻译：小分子免疫抑制剂及其检测方法
公开(公告)号：WO2006115509A2
公开(公告)日：2006-11-02
申请号：PCT/US2005022520
申请日：2005-06-24
申请人： CHIRON CORP , VALIANTE NICHOLAS , XU FENG
发明人： VALIANTE NICHOLAS , XU FENG
IPC分类号： A61K31/34 , A61K31/341 , A61K31/7056 , A61K31/7076 , A61K45/06 , A61P11/06 , A61P31/12 , A61P35/00 , A61P37/08
CPC分类号： A61K31/7076 , A61K31/404 , A61K31/4184 , A61K31/437 , A61K31/4439 , A61K31/47 , A61K31/4706 , A61K31/4725 , A61K31/497 , A61K31/517 , A61K31/5377 , A61K31/7028 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K45/06
摘要： The invention provides immunostimulatory compositions comprising a small molecule immuno-potentiator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma. In a further aspect, the invention relates generally to methods of screening for small molecule immuno-modulatory compositions.
摘要翻译：本发明提供包含小分子免疫增强剂（SMIP）化合物的免疫刺激组合物及其施用方法。还提供了有效量施用SMIP化合物以增强受试者对抗原的免疫应答的方法。还提供了单独或与另一种药物组合施用SMIP化合物以治疗癌症，感染性疾病和/或过敏/哮喘的新型组合物和方法。在另一方面，本发明一般涉及筛选小分子免疫调节组合物的方法。

4. 发明申请

WO2006002422A9 COMPOUNDS FOR IMMUNOPOTENTIATION 审中-公开
标题翻译：化学物质免疫
公开(公告)号：WO2006002422A9
公开(公告)日：2006-09-21
申请号：PCT/US2005022769
申请日：2005-06-24
申请人： CHIRON CORP , VALIANTE NICHOLAS , XU FENG
发明人： VALIANTE NICHOLAS , XU FENG
IPC分类号： A61K31/00 , A61K31/517 , A61K45/06 , A61P11/06 , A61P25/02 , A61P31/14 , A61P31/18 , A61P31/22 , A61P35/00 , A61P37/04 , A61P37/08
CPC分类号： A61K31/505 , A61K31/52 , A61K31/7068 , A61K31/708 , A61K45/06
摘要： Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed. In a preferred embodiment benzopyrimidine derivatives such as ZD-6474, MLN-518, lapatinib, gefitinib or erlotinib are used.
摘要翻译：刺激免疫反应并用3,4-二（1H-吲哚-3-基）-1H-吡咯-2,5-二酮，星形孢菌素类似物，衍生化哒嗪，色烯-4-酮，吲哚啉酮，喹唑啉，核苷类似物和其他小分子。在优选的实施方案中，使用苯并嘧啶衍生物如ZD-6474，MLN-518，拉帕替尼，吉非替尼或厄洛替尼。

5. 发明申请

WO2007011776A2 PAMPS, PATHOGEN ASSOCIATED MOLECULAR PATTERNS 审中-公开
标题翻译： PAMPS，PATHOGEN相关的分子模式
公开(公告)号：WO2007011776A2
公开(公告)日：2007-01-25
申请号：PCT/US2006027484
申请日：2006-07-15
申请人： NOVARTIS AG , ULMER JEFFREY , DONATI CLAUDIO , COVACCI ANTONELLO , VALIANTE NICHOLAS , XU FENG
发明人： ULMER JEFFREY , DONATI CLAUDIO , COVACCI ANTONELLO , VALIANTE NICHOLAS , XU FENG
IPC分类号： A21D10/02
CPC分类号： G06F19/22 , G06F19/18 , Y02A90/22 , Y02A90/26
摘要： A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen.
摘要翻译：一种鉴定在宿主生物体中充当佐剂的多肽的方法。本发明进一步提供了包含所述多肽并任选地还包含抗原的佐剂组合物。

6. 发明申请

WO2005030122A3 INACTIVATED HOST CELL DELIVERY OF POLYNUCLEOTIDES ENCODING IMMUNOGENS 审中-公开
标题翻译：多核苷酸失活的宿主细胞分泌免疫调节
公开(公告)号：WO2005030122A3
公开(公告)日：2005-11-17
申请号：PCT/US2004025914
申请日：2004-08-12
申请人： CHIRON CORP , XU FENG
发明人： XU FENG
IPC分类号： A61K20060101 , A61K35/00 , A61K39/00 , A61K48/00 , C12N15/11 , C12N15/85 , C12N15/86
CPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/521 , A61K2039/523 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N2710/24143 , C12N2740/16222 , C12N2740/16234
摘要： Applicants have found that an immune response can be elicited via the administration of an inactivated host cell comprising a polynucleotide encoding an immunogen. Despite the inactivation of the host cell prior to administration to the mammal, the encoded immunogen is expressed in vivo, apparently by the mammalian cellular machinery. The resulting immune response is specific to the encoded immunogen.
摘要翻译：申请人已经发现可以通过施用包含编码免疫原的多核苷酸的灭活的宿主细胞来引发免疫应答。尽管在给予哺乳动物前宿主细胞失活，但编码的免疫原在体内表达，显然是由哺乳动物细胞机制表达。产生的免疫应答对编码的免疫原是特异性的。

7. 发明公开

EP2191876A4 BALANCE SIMULATOR FOR BICYCLING 有权
标题翻译：平衡模拟器骑自行车
公开(公告)号：EP2191876A4
公开(公告)日：2012-02-08
申请号：EP08800874
申请日：2008-09-17
申请人： XU FENG
发明人： XU FENG
IPC分类号： A63B69/16 , A63B22/04
CPC分类号： A63B69/16 , A63B26/003 , A63B2069/163 , A63B2069/164 , A63B2069/167 , A63B2225/055

8. 发明申请

WO2011126738A3 SURFACE-MODIFIED ZEOLITES AND METHODS FOR PREPARING THE SAME 审中-公开
标题翻译：表面改性的沸石及其制备方法
公开(公告)号：WO2011126738A3
公开(公告)日：2012-01-19
申请号：PCT/US2011029521
申请日：2011-03-23
申请人： UOP LLC , NEMETH LASZLO , XU FENG
发明人： NEMETH LASZLO , XU FENG
IPC分类号： C01B39/02 , B01J20/18 , B01J29/06
CPC分类号： B01J29/85 , B01J29/06 , B01J29/40 , B01J2229/123 , B01J2229/126 , B01J2229/32 , B01J2229/34 , B01J2229/42 , C01B39/026
摘要： Surface-modified zeolites and methods for preparing surface-modified zeolites are provided. A surface-modified zeolite is prepared by first forming a hybrid polymer from a silicon alkoxide and a metal alkoxide, a co-monomer, or both, which is then contacted with a zeolite suspension. The zeolite suspension comprises a sodium-, an ammonium-, or a hydrogen-form zeolite and a solvent. The hybrid polymer and zeolite suspension are contacted under conditions sufficient to deposit hybrid polymer on the external surfaces of the zeolite to form a treated zeolite which is subsequently dried and calcined to produce a surface-modified zeolite.
摘要翻译：提供表面改性沸石和制备表面改性沸石的方法。通过首先从硅醇盐和金属醇盐，共聚单体或两者形成杂化聚合物，然后与沸石悬浮液接触来制备表面改性的沸石。沸石悬浮液包含钠，铵或氢形式的沸石和溶剂。混合聚合物和沸石悬浮液在足以在沸石的外表面上沉积杂化聚合物的条件下接触以形成经处理的沸石，随后将其干燥和煅烧以产生表面改性的沸石。

9. 发明申请

WO2009059234A3 METHODS OF REDUCING THE INHIBITORY EFFECT OF A REDOX ACTIVE METAL ION ON THE ENZYMATIC HYDROLYSIS OF CELLULOSIC MATERIAL 审中-公开
标题翻译：减少氧化还原活性金属离子对纤维素材料酶解水解的抑制作用的方法
公开(公告)号：WO2009059234A3
公开(公告)日：2009-06-18
申请号：PCT/US2008082127
申请日：2008-10-31
申请人： NOVOZYMES INC , XU FENG
发明人： XU FENG
IPC分类号： C12P7/10 , C12P19/02
CPC分类号： C12P7/10 , C12P19/02 , Y02E50/16
摘要： The present invention relates to methods of producing a cellulosic material reduced in a redox active metal cation having a redox potential (E°) in the range of about -0.4 to about 1.2 volts, comprising treating the cellulosic material with an effective amount of a chelator to reduce the inhibitory effect of the redox active metal cation on enzymatically degrading or converting the cellulosic material and alternatively also treating the cellulosic material with an effective amount of an oxidant when the redox active metal cation has a low valence state to convert the redox active metal cation to a high valence state to preferentially chelate the redox active metal cation. The present invention also relates to methods for degrading or converting a cellulosic material and to methods of producing a fermentation product.
摘要翻译：本发明涉及减少氧化还原电位（E°）在约-0.4至约1.2伏范围内的氧化还原活性金属阳离子中还原的纤维素材料的方法，包括用有效量的螯合剂处理纤维素材料以减少氧化还原活性金属阳离子对酶促降解或转化纤维素材料的抑制作用，或者当氧化还原活性金属阳离子具有低价态以转化氧化还原活性金属时，用有效量的氧化剂处理纤维素材料阳离子成高价态以优先螯合氧化还原活性金属阳离子。本发明还涉及降解或转化纤维素材料的方法以及生产发酵产物的方法。

10. 发明申请

WO0230358A3 MODULATION OF CCR4 FUNCTION 审中-公开
标题翻译： CCR4功能的调节
公开(公告)号：WO0230358A3
公开(公告)日：2009-06-11
申请号：PCT/US0142625
申请日：2001-10-11
申请人： TULARIK INC , CHEMOCENTRYX INC , COLLINS TASSIE , DAIRAGHI DANIEL J , MAHMUD HOOSEN , MCMASTER BRIAN E , MEDINA JULIO C , SCHALL THOMAS J , XU FENG , WANG XUEMEI
发明人： COLLINS TASSIE , DAIRAGHI DANIEL J , MAHMUD HOOSEN , MCMASTER BRIAN E , MEDINA JULIO C , SCHALL THOMAS J , XU FENG , WANG XUEMEI
IPC分类号： C07D213/65 , A61K31/00 , A61K31/265 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/435 , C07D277/40 , C07D277/42 , C07D277/82 , C07D417/12 , C07D513/04
CPC分类号： C07D417/12 , A61K31/00 , A61K31/265 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/4245 , A61K31/426 , C07D277/42 , C07D277/82 , C07D513/04
摘要： Compounds and compositions are provided that bind to the CCR4 chemokine receptor and which are useful for treating diseases associated with CCR4 activity, such as contact hypersensitivity.
摘要翻译：提供了结合CCR4趋化因子受体的化合物和组合物，其可用于治疗与CCR4活性相关的疾病，例如接触性超敏反应。

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