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2. 发明专利

HU175064B PROCESS FOR PREPARING CONDENSED PYRIMIDINE DERIVATIVES 未知
公开(公告)号：HU175064B
公开(公告)日：1980-05-28
申请号：HUCI001666
申请日：1976-05-19
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： HERMECZ ISTVAN , MESZAROS ZOLTAN , HORVATH AGNES , VASVARI GEB DEBRECZY LELLE , NAGY GABOR , VIRAG SANDOR , RITLI PETER
IPC分类号： C07D471/04

3. 发明专利

HU174693B PROCESS FOR PRODUCING CONDENSED PYRIMIDINE DERIVATIVES 未知
公开(公告)号：HU174693B
公开(公告)日：1980-03-28
申请号：HUCI001642
申请日：1976-02-12
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： HERMECZ ISTVAN , MESZAROS ZOLTAN , HORVATH AGNES , VIRAG SANDOR , VASVARI GEB DEBRECZY LELLE , KNOLL JOZSEF , SEBESTYEN GYULA , DAVID AGOSTON
IPC分类号： C07D487/04 , A61K31/505 , A61K31/519 , A61P3/06 , A61P9/10 , A61P25/28 , C07D471/04

4. 发明专利

DE2728198A1 未知
公开(公告)号：DE2728198A1
公开(公告)日：1978-01-05
申请号：DE2728198
申请日：1977-06-23
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： MESZAROS ZOLTAN DR , KNOLL JOSEF DR , SZENTMIKLOSI PETER DR , HERMECZ ISTVAN DR , HORVATH AGNES , NAGY GABOR DR , VIRAG SANDOR DR , VASVARI GEB DEBRECZY LELLE , DAVID AGOSTON DR
IPC分类号： A61K31/505 , A61K31/519 , A61P3/06 , A61P25/00 , A61P25/04 , A61P25/24 , A61P25/26 , A61P29/00 , A61P43/00 , C07D471/04 , C07D487/04 , C07D487/02

5. 发明专利

DE2315422A1 未知
公开(公告)号：DE2315422A1
公开(公告)日：1973-10-04
申请号：DE2315422
申请日：1973-03-28
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： CEHMLNG ZOLTAN MESZAROS DR , KNOLL HOZSEF DR , HERMECZ ISTVAN , VASVARI GEB DEBRECZY LELLE , SZENTMIKLOSI PETER DR , SIMON GEB PARKANYI PIROSKA , HORVATH AGNES , DAVID AGOSTON DR , HORVATH GABOR DR , DVORTSAK PETER , KOVACS GEB MINDLER VERA DR
IPC分类号： C07D471/04 , C07D57/20
摘要： 1428845 Substituted pyrido-pyrimidines and 2-pyridyl-1-pyrroles and their pharmaceutical compositions CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT 28 March 1973 [29 March 1972] 14960/73 Heading C2C The invention comprises (a) pyridopyrimidines of general Formula Ia wherein R 4 is a carboxyl, alkoxyearbonyl, carbhydrazide, carboxamide or nitrile group; R 1 and R 2 are each hydrogen or together represent the group attached to two adjacent carbon atoms of the ring A; the ring A is optionally substituted by one or two substituents selected from alkyl, nitro, hydroxy, alkoxy, amino, carboxyl, alkoxycarbonyl, carboximide, alkylamino, and carboxylic acylamino group and halogen atoms and p is 1 or 2 which may be prepared by cyclizing a compound of Formula II wherein R 1 , R 2 , ring A and p are as defined above and R 5 and R 6 are independently carboxyl or alkoxycarbonyl groups to form a compound of Formula Va wherein R 1 , R 2 , ring A, R 6 and p are as defined above and optionally modifying the group R 6 by known methods to obtain a compound of Formula Ia, (b) pyridyl-pyrroles of general Formula Ib wherein R 1 , R 2 , R 4 and ring A are as defined above and R 3 is hydrogen, halogen, hydroxyl, alkoxy, aralkoxy, aryloxy, nitro, or amino which may be prepared by cyclizing a compound of Formula II in which p is 1 to obtain a compound of Formula Vb wherein R 1 , R 2 , ring A and R 5 are as defined above and R 7 is hydrogen, halogen or hydroxyl optionally followed by modification of the group R 7 by known methods to obtain a compound of Formula Ib and (c) tautomers of compounds of Formula Ib in which R 7 is OH and acid addition and quaternary ammonium salts of the compounds of Formulµ Ia and Ib. Pharmaceutical compositions having analgesic, anti-inflammatory and antipyretic activity comprise a compound of Formula Ia and Ib or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier.

6. 发明专利

FI70218B 未知
公开(公告)号：FI70218B
公开(公告)日：1986-02-28
申请号：FI801515
申请日：1980-05-09
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： KOKOSI JOZSEF , HERMECZ ISTVAN , MESZAROS ZOLTAN , SZASZ GYOERGY , VASVARI GEB DEBRECZY LELLE , HORVATH AGNES , BREINING TIBOR
IPC分类号： A61K31/505 , A61P9/08 , A61P9/10 , C07D487/04
摘要： Chemical compounds having an effect on the circulatory system have the formulas (I) or (II) or a mixture thereof, or a pharmaceutically suitable acid-addition salt or quaternary salt thereof, wherein R is hydrogen or lower alkyl, R1 is lower alkyl, phenyl, carboxyl, lower alkoxycarbonyl, nitrile, carbamoyl or carbohydrazido, R2 is hydrogen or lower alkyl, and wherein the formula I R2 is hydrogen then R1 is other than nitrile, alkoxycarbonyl or propyl.

7. 发明专利

FI70217B 未知
公开(公告)号：FI70217B
公开(公告)日：1986-02-28
申请号：FI801514
申请日：1980-05-09
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： KOKOSI JOZSEF , HERMECZ ISTVAN , MESZAROS ZOLTAN , SZASZ GYOERGY , VASVARI GEB DEBRECZY LELLE , HORVATH AGNES , BREINING TIBOR
IPC分类号： A61K31/55 , A61K31/551 , A61P9/00 , A61P9/04 , C07D487/04

8. 发明专利

DE2433840A1 未知
公开(公告)号：DE2433840A1
公开(公告)日：1975-02-06
申请号：DE2433840
申请日：1974-07-15
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： MESZAROS ZOLTAN DR , HERMECZ ISTVAN , VASVARI GEB DEBRECZY LELLE , HORVATH AGNES , RITTLI PETER , MANDI ATTILA
IPC分类号： C07D213/74 , C07D471/04 , A01N9/22

9. 发明专利

DE2414751A1 未知
公开(公告)号：DE2414751A1
公开(公告)日：1974-10-10
申请号：DE2414751
申请日：1974-03-27
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： MESZAROS ZOLTAN DR , KNOLL JOZSEF DR , HERMECZ ISTVAN , VASVARI GEB DEBRECZY LELLE , HORVATH AGNES
IPC分类号： A61K31/505 , A61K31/519 , A61P25/04 , A61P29/00 , C07D471/04 , C07D57/20

10. 发明专利

HU174696B PROCESS FOR PREPARING 1H-1-OXO-PYRIMIDO/1,2A/QUINOLINE DERIVATIVES 未知
公开(公告)号：HU174696B
公开(公告)日：1980-03-28
申请号：HUCI001663
申请日：1976-05-06
申请人： CHINOIN GYOGYSZER ES VEGYESZET
发明人： HERMECZ ISTVAN , MESZAROS ZOLTAN , HORVATH AGNES , VASVARI GEB DEBRECZY LELLE , NAGY GABOR , VIRAG SANDOR , RITLI PETER
IPC分类号： C07D471/04

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