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1. 发明专利

JPH10263070A IMPLANTATION METHOD FOR LARGE CAPACITY CELL ON POLYMERIZATION MATRIX 失效
公开(公告)号：JPH10263070A
公开(公告)日：1998-10-06
申请号：JP6912398
申请日：1998-03-18
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY
发明人： VACANTI JOSEPH P , LANGER ROBERT S , JOHNSON LYNT , GRIFFITH-CIMA LINDA
IPC分类号： C12N11/08 , A61F2/02 , A61L27/00 , A61L27/38 , C12N5/00 , C12N5/071
摘要： PROBLEM TO BE SOLVED: To implant large-capacity cell by implanting viable cell in a matrix at the time of implantation or before the implantation, and using biocompatible material having a clearance space of a specified range for enabling exchange of ingesta and gas from a blood vessel as this matrix. SOLUTION: In cell implantation of surgical operation, first a matric which can be implanted on a layer of texture is selected, and one or more matric structure are implanted between creases of the texture in such a manner as to form the layer structutre. The matrix sheet structure used in here is a porous or fibrous biocompatible material having viable parenchy cell adhering in a clearance space ranging from 100 to 200 μm, on the matrix and in the matrix, and the thickness of the matrix structure is set ranging from 200 μm to 2 mm. As such matrix sheet structure material, cited are poly-lactic acid, polyglycol acid, polyortho ester, polyanhydride, collagen and so on.

2. 发明专利

JP2001314498A METHOD OF TRANSPLANTING LARGE AMOUNT OF CELLS ON MATRIX POLYMERIZATION 失效
公开(公告)号：JP2001314498A
公开(公告)日：2001-11-13
申请号：JP2001144028
申请日：2001-05-14
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY
发明人： VACANTI JOSEPH P , LANGER ROBERT S , JOHNSON LYNT , GRIFFITH-CIMA LINDA
IPC分类号： C12N11/08 , A61F2/02 , A61L27/00 , A61L27/38 , C12N5/00 , C12N5/071
摘要： PROBLEM TO BE SOLVED: To provide a method and means to transplant a large amount of cells to form organs of internal secretion. SOLUTION: The method of manufacturing transplanting pieces for an operation to be used for the method of an surgical operation includes the process of selecting more than one matrices which are transplanted in the highly vascularized tissue as a layer and can form a single matrix structure and the process of transplanting more than one matrix structures between the creases of the tissue. The manufacturing method includes the process of transplanting the cells which survive on or in the matrix at the time of or before transplant. Here the matrix contains a biomaterial with a porous or fiber structure, which has a space of 100 to 200 μm to enable the exchange of nutrition and gas from many blood vessels so that the surviving condition of the surviving cells can be maintained.

3. 发明申请

WO2010011327A3 RADIATIVE HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：用于药物递送和其他应用的放射性加热
公开(公告)号：WO2010011327A3
公开(公告)日：2010-05-06
申请号：PCT/US2009004285
申请日：2009-07-23
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY , GEN HOSPITAL CORP , HOARE TODD R , KOHANE DANIEL S , FENN ALAN J , NEELEY WILLIAM L , LANGER ROBERT S
发明人： HOARE TODD R , KOHANE DANIEL S , FENN ALAN J , NEELEY WILLIAM L , LANGER ROBERT S
IPC分类号： C08J3/28 , A61K41/00 , A61K47/02 , A61K47/32 , A61K47/34 , C08L33/26 , C08L39/04 , C08L49/00 , C08L79/02 , C08L81/02
CPC分类号： A61K41/0028 , A61K9/0002 , A61K9/0024 , A61K9/0097 , A61K47/32 , C08G73/0266 , C08L79/02
摘要： The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using microwave radiation or other forms of radiation, e.g., radiofrequency radiation. Such systems and methods may be useful, for example, in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation- sensitive polymer or other radiation-sensitive material. Exposure of the radiation- sensitive material to radiation such as microwave and/or radiofrequency radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article. For instance, a drug may be contained in a heat-sensitive material positioned in thermal communication with the radiation-sensitive material, or a drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material positioned in thermal communication with the radiation-sensitive material. In another aspect of the invention, a receive antenna, such as a microwave receive antenna may be used to focus microwave and/or radiofrequency radiation on an article. For instance, the receive antenna may focus microwave and/or radiofrequency radiation on a radiation-sensitive material in the article. Such focusing may be useful, in some embodiments, to control release of a drug or other releasable species from the article. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, and the like.
摘要翻译：本发明一般涉及使用外部触发器（例如使用微波辐射或其他形式的辐射，例如射频辐射）从制品中释放可释放物质的系统和方法。这样的系统和方法可用于例如生物应用（例如，作为受试者内的植入物），工业应用，商业应用等。本发明的一个方面通常涉及含有辐射敏感聚合物或其它辐射敏感材料的制品。将辐射敏感材料暴露于辐射如微波和/或射频辐射可能导致材料温度升高。在某些情况下，可以使用这种温度升高来引起药物或其它可释放物质从制品中的释放。例如，药物可以包含在与辐射敏感材料热定位的热敏材料中，或者药物可以包含在外壳内，所述外壳至少部分地被定位的热敏材料隔离与辐射敏感材料进行热交换。在本发明的另一方面，诸如微波接收天线的接收天线可用于将微波和/或射频辐射聚焦在物品上。例如，接收天线可以将微波和/或射频辐射聚焦在制品中的辐射敏感材料上。在一些实施方案中，这种聚焦可能是有用的，以控制药物或其它可释放物质从制品的释放。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过将物品植入受试者内，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

4. 发明申请

WO2009142719A3 TYMPANIC MEMBRANE PERMEATING EAR DROPS AND USES THEREOF 审中-公开
标题翻译：透明膜渗透油墨及其用途
公开(公告)号：WO2009142719A3
公开(公告)日：2010-01-07
申请号：PCT/US2009003084
申请日：2009-05-19
申请人： MASSACHUSETTS INST TECHNOLOGY , CHILDRENS MEDICAL CENTER , SIMONS EMMANUEL JOHN , HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S
发明人： SIMONS EMMANUEL JOHN , HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S
IPC分类号： A61K8/00 , A61K8/18
CPC分类号： A61K9/0046 , A61K47/48023 , A61K47/48046 , A61K47/4823 , A61K47/48784 , A61K47/54 , A61K47/543 , A61K47/61 , A61K47/6903 , Y10S514/817
摘要： The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) across the tympanic membrane. Such compositions are particularly useful in the treatment of otitis media. Additionally, the composition may include a sustained release agents that, in some embodiments form sustained release reservoirs, in situ, once administered to a patient.
摘要翻译：本发明提供了用于在完整鼓膜上非侵入性递送治疗剂的组合物和方法。例如，组合物包括渗透促进剂，其增加穿过鼓膜的治疗剂（例如抗生素）的通量。这样的组合物特别可用于治疗中耳炎。另外，组合物可以包括在一些实施方案中形成持续释放储存器的持续释放剂，其一旦施用于患者就位。

5. 发明申请

WO2010011319A3 MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：用于药物递送和其他应用的磁性加热
公开(公告)号：WO2010011319A3
公开(公告)日：2010-06-10
申请号：PCT/US2009004268
申请日：2009-07-23
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY , GEN HOSPITAL CORP , HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S , SHAPIRO MIKHAIL G , YEO YOON , KIM GRACE Y , KHUSHRUSHAHI SHAHIAR R
发明人： HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S , SHAPIRO MIKHAIL G , YEO YOON , KIM GRACE Y , KHUSHRUSHAHI SHAHIAR R
IPC分类号： A61K47/02 , A61K9/16 , A61P3/10 , A61P9/00 , A61P35/00
CPC分类号： A61K9/06 , A61K9/0009 , A61K41/00
摘要： The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically- susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like.
摘要翻译：本发明一般涉及使用外部触发器例如磁场从物品释放化合物的系统和方法。本发明的一个方面通常涉及包含磁敏感材料的制品。将磁敏感材料暴露于诸如振荡磁场之类的磁场可能会导致磁敏感材料温度升高。在一些实施方式中，这种温度升高可以用于从制品释放药物或其他可释放材料。例如，药物可以包含在与磁敏感材料热连通的热敏材料中，或者药物可以包含在至少部分被热敏材料热隔离的外壳内与磁敏感材料进行通信。本发明的其它方面涉及制造或使用这种制品的系统和方法，例如通过将制品植入对象内，涉及这些制品的治疗方法，包括这些制品的试剂盒等。

6. 发明申请

WO2010011319A8 MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
公开(公告)号：WO2010011319A8
公开(公告)日：2010-04-22
申请号：PCT/US2009004268
申请日：2009-07-23
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY , GEN HOSPITAL CORP , HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S , SHAPIRO MIKHAIL G , YEO YOON , KIM GRACE Y , KHUSHRUSHAHI SHAHIAR R
发明人： HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S , SHAPIRO MIKHAIL G , YEO YOON , KIM GRACE Y , KHUSHRUSHAHI SHAHIAR R
IPC分类号： A61K47/02 , A61K9/16 , A61P3/10 , A61P9/00 , A61P35/00
CPC分类号： A61K9/06 , A61K9/0009 , A61K41/00
摘要： The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically- susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like.

7. 发明申请

WO9939702A3 METHOD FOR REGULATING SIZE AND GROWTH OF VASCULARIZED NORMAL TISSUE 审中-公开
标题翻译：调节血管正常组织尺寸和生长的方法
公开(公告)号：WO9939702A3
公开(公告)日：1999-10-14
申请号：PCT/US9822998
申请日：1998-10-30
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY
发明人： RUPNICK MARIA , LANGER ROBERT S , FOLKMAN JUDAH
IPC分类号： A61K45/00 , A61K31/00 , A61K31/336 , A61K31/454 , A61K38/00 , A61K38/39 , A61K38/48 , A61K38/55 , A61P3/04 , A61P9/00 , A61P13/08 , A61P15/00 , A61P35/00 , A61P43/00 , A61K31/335 , A61K31/445 , A61K38/17
CPC分类号： A61K38/484 , A61K31/00 , A61K31/336 , A61K31/454 , A61K38/39
摘要： The present invention is directed generally to the field of treatment of obesity and other disorders characterized by proliferation of normal vascularized tissues, by the administration of effective amount of angiogenesis inhibitors. Angiogenesis inhibitors are administered to regulate normal, non-transformed vascularized tissue size and/or growth by regulating its vascular compartment. Examples of tissues that can be controlled include adipose tissue, intestinal polyps, muscle (including cardiac) tissue, endometrial tissue and prostate tissue. The inhibitor is selected from the group consisting of TNP-470, angiostatin, endostatin, and thalidomide.
摘要翻译：本发明一般涉及通过施用有效量的血管发生抑制剂治疗肥胖症和其它特征在于正常血管化组织增殖的其它病症的疾病领域。施用血管发生抑制剂以通过调节其血管隔室来调节正常的，未转化的血管化组织尺寸和/或生长。可以控制的组织的实例包括脂肪组织，肠息肉，肌肉（包括心脏）组织，子宫内膜组织和前列腺组织。抑制剂选自TNP-470，血管抑素，内皮抑制素和沙利度胺。

8. 发明公开

EP0259463A4 HEPARIN ASSAY. 失效
标题翻译：肝素测试程序。
公开(公告)号：EP0259463A4
公开(公告)日：1988-07-14
申请号：EP87902003
申请日：1987-03-05
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY
发明人： FOLKMAN MOSES JUDAH , HANNAN ROBERT L , LANGER ROBERT S , THOMPSON ROBERT W
IPC分类号： G01N33/66 , C12M1/40 , C12Q1/48 , C12Q1/56 , G01N33/86
CPC分类号： G01N33/86 , C12Q1/56 , G01N2400/40 , Y10S435/81

9. 发明专利

IN3178DEN2012A "PHOTOTRIGGERED NANOPARTICLES FOR CELL AND TISSUE TARGETING" 未知
公开(公告)号：IN3178DEN2012A
公开(公告)日：2015-09-25
申请号：IN3178DEN2012
申请日：2012-04-12
申请人： MASSACHUSETTS INST TECHNOLOGY , HARVARD COLLEGE , CHILDRENS MEDICAL CENTER
发明人： DVIR TAL , KOHANE DENIEL S , BANGHART MATTHEW RYAN , LANGER ROBERT S
IPC分类号： A61N1/30
摘要： The present invention relates, in part, to a novel and simple particulate system that targets and binds any tissue selectively upon light illumination. The particulate system can be used for targeted delivery of substances to predefined cells or tissues in an individual.

10. 发明专利

CA2207286C LOCALIZED DELIVERY OF FACTORS ENHANCING SURVIVAL OF TRANSPLANTED CELLS 未知
公开(公告)号：CA2207286C
公开(公告)日：2003-10-07
申请号：CA2207286
申请日：1995-12-14
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY
发明人： LANGER ROBERT S , VACANTI JOSEPH P , MOONEY DAVID J
IPC分类号： A61K9/00 , A61K9/16 , A61K9/22 , A61K35/12 , A61K35/407 , A61K38/00 , A61K38/18 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/30 , A61P1/16 , A61P43/00 , C12N5/00 , C12N5/071 , A61K9/66 , A61K47/34
摘要： Growth factors and/or angiogenic factors are administered in combination with dissociated cells to be transplanted, preferably in microspheres with the cells on or in a polymeric matrix, to enhance survival and profileration of the transplanted cells. Examples demonstrate that epidermal growth factor (EGF) was incorporated into microspheres fabricated from a copolymer of lactic and glycolic acid using a double emulsion technique, the incorporated EGF was steadily released over one month in vitro, and it remained biologically active, as determined by its ability to stimulate DNA synthesis, division, and long-term survival of cultured hepatocytes. EGF-containing microspheres were mixed with a suspension of hepatocytes, seeded onto porous sponges, and implanted into the mesentery of two groups of Lewis rats, to demonstrate efficacy in vivo. Two weeks after implantation in PCS animals, devices which included EGF-containing microspheres showed a two-fold increase in the number of engrafted hepatocytes, as compared to implants which received blank microspheres.

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