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    • 2. 发明申请
    • POLYSACCHARIDE DERIVATIVES AND USES IN INDUCTION OF AN IMMUNE RESPONSE
    • 多糖衍生物及其在诱导免疫反应中的应用
    • WO2006002402A3
    • 2006-05-04
    • PCT/US2005022590
    • 2005-06-23
    • CHILDRENS HOSP & RES CT OAKMOE GREGORY RGRANOFF DAN M
    • MOE GREGORY RGRANOFF DAN M
    • C08B37/00A61K39/095
    • C08L5/00A61K39/0258A61K39/095A61K2039/6037C08B37/0063
    • The present invention generally provides compositions comprising a polysaccharide derivative, and methods of their preparation and use for the prevention or treatment of diseases caused by Neisseria meningitidis bacteria, particularly group B (NmB) strains, and by E. coli K1. The invention provides a de-N-acetylated PS derivative in which one or more residues of the PS has been modified by de-N-acetylation. The invention also includes derivatives in which one or more of the N-acetyl groups of PS containing de-N-acetylated PS are replaced with other N-acyl groups, usually a lower acyl group of C 2 - C 3 . Further, the invention includes de-N-acetylated PS derivatives containing long chain hydrocarbons, as well as conjugates in which the de-N-acetylated PS derivative is linked to a carrier, e.g., a carrier protein.
    • 本发明一般提供包含多糖衍生物的组合物,以及它们的制备方法和用于预防或治疗由脑膜炎奈瑟氏菌细菌,特别是B组(NmB)菌株和大肠杆菌K1引起的疾病的方法。 本发明提供了一种去N-乙酰化的PS衍生物,其中PS的一个或多个残基已经通过去N-乙酰化修饰。 本发明还包括其中包含脱-N-乙酰化PS的PS的一个或多个N-乙酰基被其他N-酰基,通常为C 2- ç 3 。 此外,本发明包括含有长链烃的去N-乙酰化PS衍生物,以及其中去N-乙酰化PS衍生物与载体(例如载体蛋白)连接的缀合物。