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1. 发明申请

WO2005112902A3 MEDICINAL AEROSOL FORMULATION PRODUCTS WITH IMPROVED CHEMICAL STABILITY 审中-公开
公开(公告)号：WO2005112902A3
公开(公告)日：2005-12-01
申请号：PCT/EP2005/002041
申请日：2005-02-25
申请人： CHIESI FARMACEUTICI S.p.A. , MEAKIN, Brian , LEWIS, David , JOHNSON, Robert , CHURCH, Tanya
发明人： MEAKIN, Brian , LEWIS, David , JOHNSON, Robert , CHURCH, Tanya
IPC分类号： A61K9/72 , A61K31/4704 , B65D83/14
摘要： The present invention relates to a medicinal aerosol formulation product with improved chemical stability, comprising a pressurized metered dose inhaler, comprising an aerosol canister equipped with a metering valve provided with sealing rings and/or gaskets made of a vulcanisate of an elastomeric composition of a butyl rubber, a cross-linking agent for the butyl rubber, and an accelerator for the cross-linking agent, wherein the accelerator includes a polysulphide compound derived from a substituted dithiocarbonic acid or derivative thereof, wherein the pressurized metered dose inhaler contains in the aerosol canister a medicinal aerosol formulation containing a long acting ß2 agonist, a hydrofluorocarbon propellant, a co-solvent, and a mineral acid as a stabilizer for the active ingredient.

2. 发明申请

WO2012032010A1 METERED-DOSE INHALER AND METHOD OF USING THE SAME 审中-公开
标题翻译：计量吸入器及其使用方法
公开(公告)号：WO2012032010A1
公开(公告)日：2012-03-15
申请号：PCT/EP2011/065303
申请日：2011-09-05
申请人： CHIESI FARMACEUTICI S.P.A. , BRAMBILLA, Gaetano , LEWIS, David Andrew , JOHNSON, Robert , HOWLETT, David
发明人： BRAMBILLA, Gaetano , LEWIS, David Andrew , JOHNSON, Robert , HOWLETT, David
IPC分类号： A61M15/00 , A61J1/20 , B05B11/00 , B65D83/14
CPC分类号： A61M15/009 , A61J1/2037 , A61J1/2089 , A61M15/0003 , B65D83/54 , B65D83/682
摘要： A metered-dose inhaler includes at least one vessel (50) and an actuator for receiving the at least one vessel. The at least one vessel (50) includes a first reservoir (31) containing a first formulation and a second reservoir (32) containing a second formulation. The metered-dose inhaler is actuable when the at least one vessel (50) is received by the actuator. The metered-dose inhaler is configured to simultaneously deliver a first metered dose of the first formulation and a second metered dose of the second formulation upon actuation.
摘要翻译：计量吸入器包括至少一个容器（50）和用于容纳至少一个容器的致动器。所述至少一个容器（50）包括含有第一制剂的第一储存器（31）和含有第二制剂的第二储存器（32）。当至少一个容器（50）由致动器接收时，计量吸入器可致动。计量吸入器构造成在致动时同时递送第一制剂的第一计量剂量和第二制剂的第二计量剂量。

3. 发明申请

WO2012032008A1 METERED - DOSE INHALER ACTUATOR, METERED - DOSE INHALER 审中-公开
标题翻译：计量 - 剂量吸入器执行器，计量 - 剂量吸入器
公开(公告)号：WO2012032008A1
公开(公告)日：2012-03-15
申请号：PCT/EP2011/065301
申请日：2011-09-05
申请人： CHIESI FARMACEUTICI S.P.A. , BRAMBILLA, Gaetano , LEWIS, David Andrew , JOHNSON, Robert
发明人： BRAMBILLA, Gaetano , LEWIS, David Andrew , JOHNSON, Robert
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M2206/10 , A61M2206/16
摘要： Metered-dose inhaler actuator, metered-dose inhaler and method of using the same An actuator (11) for a metered-dose inhaler (1) is provided. The actuator (11) com- prises a housing having a mouthpiece portion (13) and a canister receiving portion (12) configured to receive a canister (2). The actuator (11) further comprises a member (14) disposed within the housing and defining a valve stem receptacle (15) con- figured to receive a valve stem (3) of the canister (2). An orifice (16) is formed in the member (14), which is in fluid communication with the valve stem receptacle (15) and extending to a face (19) of the member (14) opposite to the valve stem receptacle (15). A longitudinal axis (18) of the orifice (16) is aligned with a longitudinal axis (17) 15 of the valve stem receptacle (15). At least one air inlet opening (20) is provided in an outer shell of the housing so as to be spaced from an opening (21) for receiving the canister (2) and a mouthpiece opening (22).
摘要翻译：计量吸入器致动器，计量吸入器及其使用方法提供了用于计量吸入器（1）的致动器（11）。致动器（11）包括具有接口部分（13）的壳体和构造成接收罐（2）的罐接收部分（12）。致动器（11）还包括设置在壳体内的构件（14），并且限定配置成容纳罐（2）的阀杆（3）的阀杆容器（15）。在所述构件（14）中形成有与阀杆接收器（15）流体连通并且延伸到与阀杆插座（15）相对的构件（14）的面（19）的孔口（16）。孔口（16）的纵向轴线（18）与阀杆插座（15）的纵向轴线（17）15对准。至少一个空气入口开口（20）设置在壳体的外壳中，以便与用于容纳罐（2）的开口（21）和接口开口（22）间隔开。

4. 发明申请

WO2014033057A1 AEROSOL INHALATION DEVICE 审中-公开
标题翻译：气溶胶吸入装置
公开(公告)号：WO2014033057A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/067514
申请日：2013-08-23
申请人： CHIESI FARMACEUTICI S.P.A.
发明人： BRAMBILLA, Gaetano , JOHNSON, Robert , LEWIS, David Andrew
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M11/02 , A61M15/0021 , A61M15/0065 , A61M2205/0233 , A61M2205/0238 , A61M2209/06
摘要： The invention deals with an actuator (1) for an aerosol inhalation device comprising a housing adapted to receive an aerosol canister (2) containing a pressurised medicament formulation, a mouthpiece portion through which the user inhales, a nozzle block (5), an orifice (8), and a tubular element (11) extending in the mouthpiece portion from the orifice aperture in a longitudinal axis aligned with a longitudinal axis of the mouthpiece portion. In particular said tubular element is positioned to enclose the orifice aperture within a recess. The tubular element is configured such that one of its terminal openings may be close fit to the nozzle block external surface, around the orifice aperture, so as to be in a continuous flow path with the orifice. Such configuration provides for a significant reduction in the non-respirable, coarse fraction of the emitted aerosol medicament via inertial impaction and retention in the actuator than in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient. The presence of the tubular element has minimal, negligible impact on the fine particle dose and on the particle size distribution (PSD) of the delivered particles having aerodynamic diameter lower than 9 μm.
摘要翻译：本发明涉及一种用于气溶胶吸入装置的致动器（1），其包括适于容纳包含加压药剂配方的气溶胶罐（2）的壳体，使用者吸入的吸嘴部分，喷嘴块（5），孔（8），以及管状元件（11），其在所述接口部分中从所述孔口沿与所述接口部分的纵向轴线对准的纵向轴线延伸。特别地，所述管状元件定位成将孔口封闭在凹部内。管状元件构造成使得其端子开口中的一个可以紧密地配合到喷嘴块外表面，围绕孔口，以便与孔口处于连续的流动路径中。这种构造通过惯性冲击和在致动器中的滞留在方法中显着减少所发射的气溶胶药物的不可呼吸的粗部分，而不是在口咽中，从而导致患者中较少的相关副作用和口腔念珠菌病。管状元件的存在对细颗粒剂量和具有低于9μm的空气动力学直径的输送颗粒的粒度分布（PSD）具有最小的可忽略的影响。

5. 发明授权

EP2890437B1 AEROSOL INHALATION DEVICE 有权
公开(公告)号：EP2890437B1
公开(公告)日：2019-12-18
申请号：EP13759992.4
申请日：2013-08-23
申请人： Chiesi Farmaceutici S.p.A.
发明人： BRAMBILLA, Gaetano , JOHNSON, Robert , LEWIS, David Andrew
IPC分类号： A61M15/00

6. 发明授权

EP2613828B1 METERED-DOSE INHALER ACTUATOR, METERED-DOSE INHALER 有权转让
公开(公告)号：EP2613828B1
公开(公告)日：2019-11-27
申请号：EP11749866.7
申请日：2011-09-05
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： BRAMBILLA, Gaetano , LEWIS, David Andrew , JOHNSON, Robert
IPC分类号： A61M15/00

7. 发明公开

EP2613828A1 METERED-DOSE INHALER ACTUATOR, METERED-DOSE INHALER 有权转让
标题翻译：艾滋病感染者EINEN吸入器麻醉机吸入器DOSIS，吸入器麻省理工学院
公开(公告)号：EP2613828A1
公开(公告)日：2013-07-17
申请号：EP11749866.7
申请日：2011-09-05
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： BRAMBILLA, Gaetano , LEWIS, David Andrew , JOHNSON, Robert
IPC分类号： A61M15/00
摘要： An actuator for a metered-dose inhaler is provided. The actuator comprises a housing having a mouthpiece portion and a canister receiving portion configured to receive a canister. The actuator further comprises a member disposed within the housing and defining a valve stem receptacle configured to receive a valve stem of the canister. An orifice is formed in the member, which is in fluid communication with the valve stem receptacle and extending to a face of the member opposite to the valve stem receptacle. A longitudinal axis of the orifice is aligned with a longitudinal axis of the valve stem receptacle. At least one air inlet opening is provided in an outer shell of the housing so as to be spaced from an opening for receiving the canister and a mouthpiece opening.
摘要翻译：提供用于计量吸入器的致动器。致动器包括具有接口部分的壳体和被配置为容纳罐的罐接收部分。所述致动器还包括设置在所述壳体内的构件，并且限定构造成容纳所述罐的阀杆的阀杆容置口。在所述构件中形成有孔口，该孔口与阀杆容器流体连通并且延伸到与阀杆插座相对的构件的表面。孔口的纵向轴线与阀杆容座的纵向轴线对准。至少一个空气入口开口设置在壳体的外壳中，以与用于容纳罐的开口和接口开口间隔开。

8. 发明公开

EP2890437A1 AEROSOL INHALATION DEVICE 审中-公开
标题翻译： AEROSOLINHALATIONSVORRICHTUNG
公开(公告)号：EP2890437A1
公开(公告)日：2015-07-08
申请号：EP13759992.4
申请日：2013-08-23
申请人： Chiesi Farmaceutici S.p.A.
发明人： BRAMBILLA, Gaetano , JOHNSON, Robert , LEWIS, David Andrew
IPC分类号： A61M15/00
摘要： Actuators for an aerosol inhalation device containing a housing adapted to receive an aerosol canister containing a pressurized medicament formulation, a mouthpiece portion through which the user inhales, a nozzle block and an orifice and a tubular element extending in the mouthpiece portion from the orifice aperture in a longitudinal axis substantially aligned with a longitudinal axis of the mouthpiece portion provide a significant reduction in the non-respirable, coarse fraction of the emitted aerosol medicament via inertial impaction and retention in the actuator than in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient. In addition the presence of the tubular element has minimal, negligible impact on the fine particle dose and on the particle size distribution (PSD) of the delivered particles having aerodynamic diameter lower than 9 mum.
摘要翻译：用于气溶胶吸入装置的致动器，其包含适于容纳包含加压药剂配方的气溶胶罐的壳体，使用者吸入的吸口部分，喷嘴座和孔口以及从所述口部件中的孔口延伸的管状元件基本上与接口部分的纵向轴线对齐的纵向轴线通过惯性冲击和致动器中的保持在方法中比在口咽中显着减少所发射的气溶胶药物的不可呼吸的粗分数，从而导致较少的相关联效果和口腔念珠菌病。此外，管状元件的存在对细颗粒剂量和具有低于9μm的空气动力学直径的输送颗粒的粒度分布（PSD）具有最小的可忽略的影响。

9. 发明授权

EP1746981B1 MEDICINAL AEROSOL FORMULATION PRODUCTS WITH IMPROVED CHEMICAL STABILITY 有权
标题翻译：医疗气雾剂化学稳定性改善
公开(公告)号：EP1746981B1
公开(公告)日：2008-08-13
申请号：EP05715569.9
申请日：2005-02-25
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： MEAKIN, Brian , LEWIS, David , JOHNSON, Robert , CHURCH, Tanya
IPC分类号： A61K9/72 , A61K31/4704 , B65D83/14
CPC分类号： A61K9/008
摘要： The present invention relates to a medicinal aerosol formulation product with improved chemical stability, comprising a pressurized metered dose inhaler, comprising an aerosol canister equipped with a metering valve provided with sealing rings and/or gaskets made of a vulcanisate of an elastomeric composition of a butyl rubber, a cross-linking agent for the butyl rubber, and an accelerator for the cross-linking agent, wherein the accelerator includes a polysulphide compound derived from a substituted dithiocarbonic acid or derivative thereof, wherein the pressurized metered dose inhaler contains in the aerosol canister a medicinal aerosol formulation containing a long acting ß2 agonist, a hydrofluorocarbon propellant, a co-solvent, and a mineral acid as a stabilizer for the active ingredient.

10. 发明公开

EP1746981A2 MEDICINAL AEROSOL FORMULATION PRODUCTS WITH IMPROVED CHEMICAL STABILITY 有权
标题翻译：医疗气雾剂化学稳定性改善
公开(公告)号：EP1746981A2
公开(公告)日：2007-01-31
申请号：EP05715569.9
申请日：2005-02-25
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： MEAKIN, Brian , LEWIS, David , JOHNSON, Robert , CHURCH, Tanya
IPC分类号： A61K9/72 , A61K31/4704 , B65D83/14
CPC分类号： A61K9/008
摘要： The present invention relates to a medicinal aerosol formulation product with improved chemical stability, comprising a pressurized metered dose inhaler, comprising an aerosol canister equipped with a metering valve provided with sealing rings and/or gaskets made of a vulcanisate of an elastomeric composition of a butyl rubber, a cross-linking agent for the butyl rubber, and an accelerator for the cross-linking agent, wherein the accelerator includes a polysulphide compound derived from a substituted dithiocarbonic acid or derivative thereof, wherein the pressurized metered dose inhaler contains in the aerosol canister a medicinal aerosol formulation containing a long acting ß2 agonist, a hydrofluorocarbon propellant, a co-solvent, and a mineral acid as a stabilizer for the active ingredient.

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