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1. 发明专利

JP2004231617A Therapeutic agent for rheumatoid arthritis 审中-公开
标题翻译：治疗风湿性关节炎的治疗药物
公开(公告)号：JP2004231617A
公开(公告)日：2004-08-19
申请号：JP2003025051
申请日：2003-01-31
申请人： Chemo Sero Therapeut Res Inst , 財団法人化学及血清療法研究所
发明人： SASAKI TAKUMI , NOZAKI CHIKAHIDE
IPC分类号： A61K38/00 , A61K38/55 , A61P19/02 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To obtain a new therapeutic agent for chronic rheumatoid arthritis and juvenile rheumatoid arthritis.
SOLUTION: This therapeutic agent comprises a highly purified antithrombin III as a main active ingredient, and as necessary, a suitable stabilizer such as gelatin, a salt, sugar or an amino acid, and a vehicle are added thereto.
COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：获得用于慢性类风湿性关节炎和幼年类风湿性关节炎的新治疗剂。解决方案：该治疗剂包含高纯度的抗凝血酶III作为主要活性成分，并根据需要加入合适的稳定剂如明胶，盐，糖或氨基酸和载体。版权所有（C）2004，JPO＆NCIPI

2. 发明专利

JP2003026598A New rheumatism-preventing and treating medicine 审中-公开
标题翻译：新型预防和治疗药物
公开(公告)号：JP2003026598A
公开(公告)日：2003-01-29
申请号：JP2001194617
申请日：2001-06-27
申请人： Chemo Sero Therapeut Res Inst , 財団法人化学及血清療法研究所
发明人： HIRASHIMA MASAKI , SASAKI TAKUMI , MAEDA HIROAKI , NOZAKI CHIKAHIDE , MARUYAMA YUKIRO , TAKAHASHI KAZUHIKO
IPC分类号： G01N33/53 , A61K38/00 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To provide a new rheumatism-preventing and treating medicine, and to provide a method for judging rheumatism diagnosis.
SOLUTION: This new rheumatism-preventing and treating medicine contains selenoprotein P or the C-terminal peptide or peptide group of the protein as a main active ingredient. And the method for judging the diagnosis of chronic articular rheumatism comprises assaying the content of the selenoprotein P in a biological specimen. Thereby, the preferable rheumatism-preventing and treating medicine and the method for judging the diagnosis of chronic articular rheumatism are provided.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供新的风湿病防治药物，并提供一种判断风湿病诊断方法。解决方案：该新型风湿病防治药含有蛋白质P或蛋白质的C-末端肽或肽基团作为主要活性成分。判断慢性关节风湿病诊断的方法包括测定生物标本中硒蛋白P的含量。因此，提供了优选的风湿病防治药和用于判断慢性关节风湿病的诊断方法。

3. 发明专利

JPH03103191A MONOCLONAL ANTIBODY RECOGNIZING CORE PROTEIN OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) AND HYBRIDOMA PRODUCING SAME ANTIBODY 失效
公开(公告)号：JPH03103191A
公开(公告)日：1991-04-30
申请号：JP24323689
申请日：1989-09-18
申请人： CHEMO SERO THERAPEUT RES INST
发明人： SASAKI TAKUMI , SAKUMA SUSUMU , NAKAJIMA TOSHIHIRO , MIAKE FUMIO , UNOKI MASANORI , KOITO ATSUSHI , HATTORI TOSHIO
IPC分类号： G01N33/577 , A61K39/395 , A61K39/42 , C07K14/005 , C07K14/155 , C07K14/195 , C07K16/00 , C07K16/10 , C12N5/10 , C12N5/18 , C12N15/02 , C12N15/06 , C12P21/08 , C12R1/91
摘要： NEW MATERIAL:A monoclonal antibody recognizing a core protein of human immunodeficiency virus(HIV). USE:A reagent for detecting human immunodeficiency virus(HIV) and diagnostic for acquired immune deficiency syndrome(AIDS). PREPARATION:For example, a HIV producing cell is cultured and the cultured cell is centrifuged to collect a cultured supernatant and the supernatant is subjected to saccharide density ingredient centrifugation to separate HIV-1, which is then administered into BALB/c mouse to immunize the mouse and after final immune, a spleen cell is collected and fused with a myeloma cell and then the fused cell is cultured to provide a hybridoma. Then the hybridoma is screened to select a clone producing anti-HIV antibody and the clone is subjected to cloning by a limiting dilution method, etc., and then the monoclonal hybridoma is cultured to provide the monoclonal antibody recognizing core protein of HIV.

4. 发明专利

JP2007254289A Autoimmune disease therapeutic agent having immunoglobulin as active ingredient 审中-公开
标题翻译：具有免疫球蛋白作为活性成分的自发性疾病治疗药物
公开(公告)号：JP2007254289A
公开(公告)日：2007-10-04
申请号：JP2006048809
申请日：2006-02-24
申请人： Chemo Sero Therapeut Res Inst , 財団法人化学及血清療法研究所
发明人： SASAKI TAKUMI , OKUMA KOICHI
IPC分类号： A61K39/395 , A61P25/00 , A61P37/02
摘要： PROBLEM TO BE SOLVED: To provide a method of inhibiting the differentiation of a monocyte into a dendritic cell and an autoimmune disease therapeutic agent containing IVIg as an active ingredient.
SOLUTION: The method of inhibiting the differentiation of a monocyte into a dendritic cell inhibits expression of CDla which takes part in the differentiation of a human monocyte into a premature dendritic cell and CD40, CD80, and CD49d which take part in the differentiation of the premature dendritic cell into a mature dendritic cell with the use of an immunoglobulin pharmaceutical formulation (IVIg) for intravenous injection. An inhibitor for the differentiation of a human monocyte into a dendritic cell contains IVIg as an active ingredient. The autoimmune disease therapeutic agent contains IVIg as an active ingredient.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供抑制单核细胞分化成树突状细胞的方法和含有IVIg作为活性成分的自身免疫疾病治疗剂。解决方案：抑制单核细胞分化为树突状细胞的方法抑制参与将人单核细胞分化为参与分化的早熟树突状细胞和CD40，CD80和CD49d的CD1a的表达使用免疫球蛋白药物制剂（IVIg）进行静脉内注射的早熟树突状细胞进入成熟树突状细胞。用于将人单核细胞分化成树突状细胞的抑制剂含有IVIg作为活性成分。自身免疫疾病治疗剂含有IVIg作为活性成分。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2001151700A MEDICINE FOR TREATING LYMPHATIC TUMOR DISEASE 失效
公开(公告)号：JP2001151700A
公开(公告)日：2001-06-05
申请号：JP33002099
申请日：1999-11-19
申请人： CHEMO SERO THERAPEUT RES INST
发明人： ARIMA NAOMICHI , SASAKI TAKUMI
IPC分类号： A61K45/00 , A61K31/40 , A61K38/00 , A61P35/00 , A61P35/02
摘要： PROBLEM TO BE SOLVED: To provide a medicine for treating lymphatic tumor diseases such as adult T cell leukemia and malignant lymphoma. SOLUTION: This medicine for treating lymphatic tumor diseases such as adult T cell leukemia and malignant lymphoma, containing an antioxidant such as PDTC(pyrrolidine dithiocarbamate) or its derivative as an active component.

6. 发明专利

JPH09110704A ORAL PREPARATION FOR PREVENTING AND TREATING IMMUNOPATHY DISEASE 失效
公开(公告)号：JPH09110704A
公开(公告)日：1997-04-28
申请号：JP29754895
申请日：1995-10-19
申请人： CHEMO SERO THERAPEUT RES INST
发明人： SASAKI TAKUMI , IDE TOSHIO , MORIYAMA TAKESHI , KOMORI KENJI , IMAGAWA YOSHITAKA , TOKIYOSHI YUKIO
IPC分类号： A61K9/08 , A61K35/74 , A61K39/085 , A61P1/00 , A61P37/00 , A61P37/08 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an oral preparation for preventing and treating immunopathy diseases such as rheumatoid arthritis or ulcerative colitis containing Staphylococcal-enterotoxins or their derivatives and is useful in preventing and treating these diseases. SOLUTION: This oral preparation contains Staphylococcal-enterotoxins or their derivatives, preferably in an amount of 0.02-0.5μg each dose. The enterotoxins are preferably purified at such a level that it shows a single band in the gel electrophoresis. As the enterotoxins, is preferably cited Staphylococcus aureus enterotoxins B, A, C1 , which bond to the VβT-cell antigen receptor. A liquid preparation in which the toxins or their derivatives are dissolved in physiological salt solution is preferred as an preparation form. The oral dose is 0.05-0.5μg/day on the basis of the enterotoxins and preferably given once or twice a day.

7. 发明专利

JPH0767689A ANTI-LD78 POLYPEPTIDE MONOCLONAL ANTIBODY 失效
公开(公告)号：JPH0767689A
公开(公告)日：1995-03-14
申请号：JP14257794
申请日：1994-05-31
申请人： CHEMO SERO THERAPEUT RES INST
发明人： FUJIYAMA YOSHIHIDE , IDE TOSHIO , SASAKI TAKUMI , TOKIYOSHI YUKIO , IMAGAWA YOSHITAKA
IPC分类号： A61K39/395 , A61P31/12 , C07K14/52 , C07K16/00 , C07K16/24 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/50 , G01N33/53 , G01N33/564 , G01N33/577
摘要： PURPOSE:To obtain an anti-LD78 polypeptide monoclonal antibody produced by a hybridoma of a mouse spleen cell immunized with LD78 polypeptide and a mouse myeloma, having affinity to LD78 polypeptide or its fragment and useful for the prevention and treatment of autolmmune diseases. CONSTITUTION:A gene coding LD78 polypeptide which is an inflammatory cytokine cloned with a cDNA prepared from mRNA induced by the stimulation of human amygdalolymphocyte is bonded to a vector. The vector is inserted into a yeast and the obtained transformant is cultured to obtain LD78 polypeptide. The polypeptide is administered to a mouse to immunize the mouse, the splenocyte is collected from the mouse 3 days after the final immunization and fused with a myeloma cell and the fused cell is cultured in HAT medium. A clone producing an antibody is selected and cloned to obtain the anti-LD78 polypeptide monoclonal antibody useful for the diagnosis of autoimmune diseases and diseases caused by globuliferous histocyte opsonic action and the prevention or treatment of these diseases.

8. 发明专利

JP2004182683A New agent for ameliorating inflammatory disease 有权
公开(公告)号：JP2004182683A
公开(公告)日：2004-07-02
申请号：JP2002354122
申请日：2002-12-05
申请人： Chemo Sero Therapeut Res Inst , 財団法人化学及血清療法研究所
发明人： MATSUYAMA REIKO , KAWAMURA RYOICHI , SASAKI TAKUMI , NARUSE TAKESHI , HIRASHIMA MASAKI , MAEDA HIROAKI
IPC分类号： A61K38/00 , A61P1/04 , A61P1/18 , A61P7/02 , A61P17/02 , A61P29/00 , A61P31/04 , A61P35/00 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide a new agent for ameliorating inflammatory diseases as a new use of a plasma protein belonging to the field of ethical pharmaceuticals.
SOLUTION: The inflammatory disease ameliorating agent contains a selenocysteine-containing protein preferably exemplified by selenoprotein P, the C-terminal peptide of the protein or the group of these peptides as main active components. For example, the invention provides an agent suitable for the amelioration of inflammatory diseases caused by various factors relating to the production of interleukin 6.
COPYRIGHT: (C)2004,JPO&NCIPI

9. 发明专利

JP2004231599A New therapeutic agent for rheumatoid arthritis 审中-公开
公开(公告)号：JP2004231599A
公开(公告)日：2004-08-19
申请号：JP2003024389
申请日：2003-01-31
申请人： Chemo Sero Therapeut Res Inst , 財団法人化学及血清療法研究所
发明人： SASAKI TAKUMI , NOZAKI CHIKAHIDE
IPC分类号： A61K9/08 , A61K38/16 , A61K47/10 , A61K47/18 , A61K47/26 , A61P19/02 , A61P29/00 , A61P37/02
摘要： PROBLEM TO BE SOLVED: To obtain a new therapeutic agent for chronic rheumatoid arthritis and juvenile rheumatoid arthritis.
SOLUTION: This therapeutic agent comprises highly purified lactoferrin as a main active ingredient, and as necessary, a suitable stabilizer such as gelatin, a salt, a sugar or an amino acid and a vehicle are added thereto.
COPYRIGHT: (C)2004,JPO&NCIPI

10. 发明公开

EP1609860A4 SEB MODIFICATION AND PREVENTIVE/REMEDY FOR DISEASES WITH IMMUNE ABNORMALITY CONTIANING THE SAME 有权
标题翻译： SEB修饰和那些含有预防剂/治疗与疾病WITH AIMMUNANOMALITÄT
公开(公告)号：EP1609860A4
公开(公告)日：2006-06-14
申请号：EP04723360
申请日：2004-03-25
申请人： CHEMO SERO THERAPEUT RES INST , KOWA CO
发明人： NAKASHIMA TOSHIHIRO , SASAKI TAKUMI , KIMACHI KAZUHIKO , KUWATA SHIGEKI , NISHIHARA TSUKASA , SAKATA ATSUKO , OHKUCHI MASAO , KOSHI TOMOYUKI , EDANO TOSHIYUKI
IPC分类号： A61K38/16 , A61P37/08 , C07K14/31 , C07K16/12 , C12N15/09 , A61K38/17 , C07K14/47
CPC分类号： A61K38/164 , C07K14/31 , C07K16/1271
摘要： It is intended to provide a novel preventive/remedy for diseases with immune abnormality which can effectively act as a super-antigen without being neutralized by a neutralizing antibody to Staphylococcus enterotoxin B (SEB) known as a super-antigen. Namely, an SEB modification having a lowered reactivity with a neutralizing antibody to SEB (anti-SEB antibody) and a preventive/remedy for diseases with immune abnormality which contains this modification as the active ingredient. This SEB modification can be obtained via amino acid substitution in the amino acid sequence of SEB, in particular the amino acid sequence at the epitope part recognized by the anti-SEB antibody by using evolutionary molecular engineering techniques.

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