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1. 发明申请

WO2005009463A3 ANTIGEN-PRESENTING CELL VACCINES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗原呈递细胞疫苗及其使用方法
公开(公告)号：WO2005009463A3
公开(公告)日：2005-06-02
申请号：PCT/US2004023881
申请日：2004-07-23
申请人： CERUS CORP , DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , BAHJAT KEITH , HEARST JOHN E , COOK DAVID , LUCKETT WILLIAM STANFORD
发明人： DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , BAHJAT KEITH , HEARST JOHN E , COOK DAVID , LUCKETT WILLIAM STANFORD
IPC分类号： A61K39/02 , A61K39/04 , A61K39/07 , A61P31/00 , C12N1/21 , C12N15/01
CPC分类号： A61K39/07 , A61K2039/5254 , A61K2039/5256
摘要： Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigenpresenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.
摘要翻译：提供了自由生物微生物，其中核酸已经被修饰，使得微生物减毒增殖和/或其包含减弱微生物修复其核酸的能力的基因突变。还提供了使用修饰的微生物用于加载，激活和/或成熟抗原呈递细胞的方法。还提供了包含修饰的微生物和/或抗原呈递细胞的疫苗组合物以及使用疫苗的方法。微生物可被进一步修饰以包括异源抗原，如肿瘤抗原或传染病抗原，用作抗癌症或感染性疾病的疫苗。

2. 发明申请

WO2004084936A3 MODIFIED FREE-LIVING MICROBES, VACCINE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：改性免费生活微生物，疫苗组合物及其使用方法
公开(公告)号：WO2004084936A3
公开(公告)日：2005-06-16
申请号：PCT/US2004003671
申请日：2004-02-06
申请人： CERUS CORP , DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , BAHJAT KEITH , HEARST JOHN E , COOK DAVID
发明人： DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , BAHJAT KEITH , HEARST JOHN E , COOK DAVID
IPC分类号： A61K39/00 , A61K39/02 , A61K39/07 , A61K39/38 , C12R1/01 , A61K39/04 , A61P31/00 , C12N1/21 , C12N15/00
CPC分类号： A61K39/0011 , A61K39/0208 , A61K39/07 , A61K2039/5154 , A61K2039/522 , A61K2039/523
摘要： Free-living microbes are provided in which the nucleic acid has been modified so that the attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infections diseases.
摘要翻译：提供了自由活的微生物，其中已经修饰了核酸，使得减毒的增殖和/或包含减弱微生物修复其核酸的能力的遗传突变。还提供了使用修饰的微生物来加载，激活和/或成熟抗原呈递细胞的方法。还提供了包含修饰的微生物和/或抗原呈递细胞的疫苗组合物和使用疫苗的方法。可以进一步修饰微生物以包括异源抗原，例如肿瘤抗原或感染性疾病抗原，用作抗癌或感染疾病的疫苗。

3. 发明申请

WO2004084936A8 MODIFIED FREE-LIVING MICROBES, VACCINE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：修饰的自由活动微生物，疫苗组合物及其使用方法
公开(公告)号：WO2004084936A8
公开(公告)日：2004-12-16
申请号：PCT/US2004003671
申请日：2004-02-06
申请人： CERUS CORP , DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , BAHJAT KEITH , HEARST JOHN E , COOK DAVID
发明人： DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , BAHJAT KEITH , HEARST JOHN E , COOK DAVID
IPC分类号： A61K39/00 , A61K39/02 , A61K39/07 , A61K39/38 , C12R1/01
CPC分类号： A61K39/0011 , A61K39/0208 , A61K39/07 , A61K2039/5154 , A61K2039/522 , A61K2039/523
摘要： Free-living microbes are provided in which the nucleic acid has been modified so that the attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infections diseases.
摘要翻译：提供了自由生物微生物，其中核酸已经被修饰，从而减毒增殖和/或其包含减弱微生物修复其核酸的能力的基因突变。还提供了使用修饰的微生物用于加载，激活和/或成熟抗原呈递细胞的方法。还提供了包含修饰的微生物和/或抗原呈递细胞的疫苗组合物以及使用该疫苗的方法。微生物可以进一步修饰以包括异源抗原，如肿瘤抗原或传染病抗原，用作抗癌症或感染疾病的疫苗。

4. 发明申请

WO2004110481A2 LISTERIA ATTENUATED FOR ENTRY INTO NON-PHAGOCYTIC CELLS, VACCINES COMPRISING THE LISTERIA, AND METHODS OF USE THEREOF 审中-公开
标题翻译：被引入非糖代谢细胞的肠梗阻，包含肠炎的疫苗及其使用方法
公开(公告)号：WO2004110481A2
公开(公告)日：2004-12-23
申请号：PCT/US2004003429
申请日：2004-02-06
申请人： CERUS CORP , DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , COOK DAVID
发明人： DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , COOK DAVID
IPC分类号： A61K39/02 , A61K39/07 , A61P31/00 , A61P35/00 , C12N1/21 , C12N15/00
CPC分类号： A61K39/07 , A61K2039/5154 , A61K2039/522 , A61K2039/523
摘要： The present invention provides Listeria that are attenuated for entry into non-phagocytic cells as well as a variety of methods of inducing immune responses involving administering compositions comprising the attenuated Listeria. Some of the attenuated Listeria are mutant Listeria that comprise at least one mutation in a gene encoding an invasin, such as an internalin. Some of the attenuated Listeria are further attenuated for cell-to-cell spread. Pharmaceutical compositions and vaccines useful in the methods of the invention are further provided. Methods of making and improving vaccines are also provided.
摘要翻译：本发明提供减毒以进入非吞噬细胞的李斯特菌以及诱导涉及施用包含减毒李斯特菌的组合物的免疫应答的多种方法。一些减毒李斯特氏菌是突变型李斯特菌，其在编码侵入素的基因（例如内含蛋白）中包含至少一个突变。一些减毒的李斯特菌进一步减弱细胞到细胞的扩散。还提供了可用于本发明方法的药物组合物和疫苗。还提供了制备和改进疫苗的方法。

5. 发明申请

WO03061379A3 METHODS FOR INACTIVATION OF PATHOGENS IN BIOLOGICAL MATERIALS 审中-公开
标题翻译：生物材料病原体失活的方法
公开(公告)号：WO03061379A3
公开(公告)日：2003-10-02
申请号：PCT/US0151624
申请日：2001-12-21
申请人： CERUS CORP , STASSINOPOULOS ADONIS , COOK DAVID
发明人： STASSINOPOULOS ADONIS , COOK DAVID
IPC分类号： A61K9/00 , A61L2/00 , A61M1/36 , A61P7/00 , A61K9/50 , A61K31/47 , A61K35/12 , A61K35/14 , A61K35/16 , A61K35/18
CPC分类号： A61K9/0026 , A61L2/0082 , A61L2/0088 , A61M1/3687
摘要： Methods are provided for inactivation of pathogens in biomaterials. Pathogen inactivating agents are added to and mixed with biomaterials in an additive solution that is low in chloride and/or hypotonic, resulting in substantial increases in inactivation of bacterial pathogens, particularly Gram negative bacterial pathogens.
摘要翻译：提供了用于灭活生物材料中病原体的方法。将病原体灭活剂加入到生物材料中并与氯化物和/或低渗的添加剂溶液混合，导致细菌病原体，特别是革兰氏阴性细菌病原体灭活的显着增加。

6. 发明专利

JP2007131639A Modified free-living microbe, vaccine composition and method of use thereof 审中-公开
标题翻译：改性免费生物微生物，疫苗组合物及其使用方法
公开(公告)号：JP2007131639A
公开(公告)日：2007-05-31
申请号：JP2007026192
申请日：2007-02-05
申请人： Cerus Corp , シーラスコーポレイション
发明人： DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , BAHJAT KEITH , HEARST JOHN E , COOK DAVID
IPC分类号： A61K39/00 , A61K39/02 , A61K39/07 , A61K39/38 , A61P25/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12R1/01
CPC分类号： A61K39/0011 , A61K39/0208 , A61K39/07 , A61K2039/5154 , A61K2039/522 , A61K2039/523
摘要： PROBLEM TO BE SOLVED: To provide a standard and effective method advantageous in cost for DC activation and combination with an antigen for loading maturation. SOLUTION: The vaccine contains free-living microbes of which the nucleic acids have been modified so that proliferation may be attenuated by the reaction with a nucleic acid-targeting compound directly reacting with the nucleic acid. The method for attenuating the free-living microbes and the vaccine composition comprising the attenuated microbes are also provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种有利于DC活化成本和与用于加载成熟的抗原组合的标准和有效方法。解决方案：疫苗含有游离微生物，其中核酸已经被修饰，使得通过与与核酸直接反应的核酸靶向化合物的反应可以减弱增殖。还提供了减弱自由活的微生物的方法和包含减毒微生物的疫苗组合物。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2010248245A Method for quenching pathogen inactivator in biological material 审中-公开
标题翻译：在生物材料中焚烧病原体灭活剂的方法
公开(公告)号：JP2010248245A
公开(公告)日：2010-11-04
申请号：JP2010171219
申请日：2010-07-29
申请人： Cerus Corp , シーラスコーポレイション
发明人： COOK DAVID , STASSINOPOULOS ADONIS
IPC分类号： A61K35/14 , A01N1/02 , A61L2/00 , A61M1/36 , A61P7/08 , C12N5/08
CPC分类号： A61L2/0088
摘要： PROBLEM TO BE SOLVED: To provide a method for preventing an undesired electrophilic side reaction of a pathogen inactivating compound to react electrophilically with a pathogen, while keeping ability to inactivate a harmful pathogen of the pathogen inactivating compound; and a method for inactivating the pathogen in a biological material, while reducing an undesired side reaction. SOLUTION: The method for quenching the undesired side reaction of the pathogen inactivating compound in the biological material includes a process to treat the biological material with the pathogen inactivating compound which includes a functional group to be an electrophilic group or a functional group to form the electrophilic group and a process to treat the biological material with a quencher including a nucleophilic group to covalently react with the electrophilic group. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种防止病原体灭活化合物与病原体亲电反应的不期望的亲电子反应的方法，同时保持灭活病原体灭活化合物的有害病原体的能力; 以及在减少不期望的副反应的同时灭活生物材料中的病原体的方法。解决方案：用于猝灭病原体灭活化合物在生物材料中的不期望的副反应的方法包括用包含官能团为亲电基团或官能团的病原体灭活化合物处理生物材料的方法，形成亲电子基团和用包含亲核基团的猝灭剂处理生物材料以与亲电子基团共价反应的方法。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2010095527A Fragile compound for pathogen inactivation 有权
标题翻译：用于病原体灭活的易碎化合物
公开(公告)号：JP2010095527A
公开(公告)日：2010-04-30
申请号：JP2009286996
申请日：2009-12-17
申请人： Cerus Corp , セラスコーポレーション
发明人： COOK DAVID , MERRITT JOHN , NERIO AILEEN , RAPOPORT HENRY , STASSINOPOULOS ADONIS , WOLLOWITZ SUSAN , MATEJOVIC JON
IPC分类号： C07D219/10 , A01N1/00 , A61K31/473 , A61K35/14 , A61L2/00 , A61M1/02 , A61P31/00 , B01J20/28 , C07D405/12 , C07D493/04 , C07F9/64 , C07F9/6561
CPC分类号： C07D405/12 , A61L2/0082 , A61M1/0209 , B01J20/28033 , C07D219/10 , C07D493/04 , C07F9/64
摘要： PROBLEM TO BE SOLVED: To provide compounds for inactivating pathogens in materials. SOLUTION: Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in red blood cell preparations and biological materials such as plasma. The compounds and methods may be used to treat materials for in vitro or in vivo use, such as clinical testing or transfusion. The compounds are designed to specifically bind to and react with nucleic acid, and then to degrade to form degraded products. The degradation reaction is preferably slower than reactions with nucleic acid. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供用于灭活材料中病原体的化合物。描述了用于灭活材料中的病原体的化合物和方法，包括用于灭活红细胞制剂中的病原体的组合物和方法以及诸如血浆的生物材料。化合物和方法可用于处理用于体外或体内使用的材料，例如临床测试或输血。这些化合物被设计成与核酸特异性结合并与核酸反应，然后降解以形成降解产物。降解反应优选比与核酸的反应更慢。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2007125040A Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the listeria, and methods of use thereof 审中-公开
标题翻译：被引入非糖代谢细胞的肠梗阻，包含肠炎的疫苗及其使用方法
公开(公告)号：JP2007125040A
公开(公告)日：2007-05-24
申请号：JP2007026201
申请日：2007-02-05
申请人： Cerus Corp , シーラスコーポレイション
发明人： DUBENSKY THOMAS W JR , BROCKSTEDT DIRK G , COOK DAVID
IPC分类号： C12N1/21 , A61K39/00 , A61K39/02 , A61K39/07 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C12N15/00 , C12N15/09
CPC分类号： A61K39/07 , A61K2039/5154 , A61K2039/522 , A61K2039/523
摘要： PROBLEM TO BE SOLVED: To reduce risks accompanied by the use of Listeria monocytogenes as a vaccine without affecting a latent ability for inducing adaptive cell-mediated immunization specific to heterogeneous encoded antigen related to selective infections and serious diseases. SOLUTION: An isolated Listeria bacterium attenuated for entry into non-phagocytic cells and containing a nucleic acid molecule encoding a non-Listeria antigen. The attenuated Listeria bacterium and the Listeria monocytogenes, and a method for especially using the Listeria in a vaccine. COPYRIGHT: (C)2007,JPO&INPIT

10. 发明公开

EP0773716A4 TREATING RED BLOOD CELL SOLUTIONS WITH ANTI-VIRAL AGENTS 失效
标题翻译：抗激活物质治疗红细胞体溶液
公开(公告)号：EP0773716A4
公开(公告)日：1999-08-04
申请号：EP96918369
申请日：1996-06-07
申请人： CERUS CORP
发明人： COOK DAVID , WOLLOWITZ SUSAN , NERIO AILEEN
IPC分类号： A61L2/00 , C07D493/04 , C12N7/06 , A01N1/02
CPC分类号： C07D493/04 , A61L2/0088 , C12N7/00 , C12N2795/18163

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